DK0708778T3 - Derivater af imidazol(1,2-a)pyrazin-4-on, fremgangsmåde til deres fremstilling og lægemidler indeholdende disse forbindelser - Google Patents

Derivater af imidazol(1,2-a)pyrazin-4-on, fremgangsmåde til deres fremstilling og lægemidler indeholdende disse forbindelser

Info

Publication number: DK0708778T3
Authority: DK; Denmark
Prior art keywords: compounds; pct; preparation; drugs containing; alk
Prior art date: 1993-07-16

Application number

DK94922903.3T

Other languages

English (en)

Inventor

Jean-Claude Aloup

Serge Mignani

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-16

Filing date

1994-07-11

Publication date

1997-03-10

1994-07-11 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1997-03-10 Application granted granted Critical

1997-03-10 Publication of DK0708778T3 publication Critical patent/DK0708778T3/da

Links

150000001875 compounds Chemical class 0.000 title abstract 3
239000003814 drug Substances 0.000 title abstract 2
229940079593 drug Drugs 0.000 title abstract 2
150000002460 imidazoles Chemical class 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
229910006069 SO3H Inorganic materials 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000004442 acylamino group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
-1 nitro, cyano, phenyl Chemical group 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Anesthesiology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK94922903.3T 1993-07-16 1994-07-11 Derivater af imidazol(1,2-a)pyrazin-4-on, fremgangsmåde til deres fremstilling og lægemidler indeholdende disse forbindelser DK0708778T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9308753A FR2707645B1 (fr)	1993-07-16	1993-07-16	Dérivés d'imidazo[1,2-a]pirazine-4-one, leur préparation et les médicaments les contenant.

Publications (1)

Publication Number	Publication Date
DK0708778T3 true DK0708778T3 (da)	1997-03-10

Family

ID=9449311

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94922903.3T DK0708778T3 (da)	1993-07-16	1994-07-11	Derivater af imidazol(1,2-a)pyrazin-4-on, fremgangsmåde til deres fremstilling og lægemidler indeholdende disse forbindelser

Country Status (13)

Country	Link
US (1)	US5672705A (da)
EP (1)	EP0708778B1 (da)
JP (1)	JPH09500123A (da)
AT (1)	ATE148704T1 (da)
AU (1)	AU7265194A (da)
DE (1)	DE69401716T2 (da)
DK (1)	DK0708778T3 (da)
ES (1)	ES2098158T3 (da)
FR (1)	FR2707645B1 (da)
GR (1)	GR3022498T3 (da)
IL (1)	IL110328A0 (da)
WO (1)	WO1995002602A1 (da)
ZA (1)	ZA945157B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2717814B1 (fr) *	1994-03-28	1996-04-26	Rhone Poulenc Rorer Sa	Dérivés de 1,2,4-triazolo(4,3-a)pyrazine-4-one, leur préparation et les médicaments les contenant.
FR2717813B1 (fr) *	1994-03-28	1996-05-10	Rhone Poulenc Rorer Sa	Dérivés d'imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant .
FR2717812B1 (fr) *	1994-03-28	1996-05-10	Rhone Poulenc Rorer Sa	Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant.
FR2717805B1 (fr) *	1994-03-28	1996-05-10	Rhone Poulenc Rorer Sa	Dérivés de 5H-indeno[1,2-b]pyrazine-2,3-dione, leur préparation et les médicaments les contenant .
FR2743365A1 (fr) *	1996-01-10	1997-07-11	Rhone Poulenc Rorer Sa	Derives de 5h,10h-imidazo(1,2-a)indolo(3,2-e)pyrazine-4-one, leur preparation et les medicaments les contenant
GB9908175D0 (en) *	1999-04-09	1999-06-02	Lilly Co Eli	Method of treating neurological disorders
ES2291628T3 (es) *	2002-04-03	2008-03-01	Bristol-Myers Squibb Company	Compuestos triciclicos a base de tiofeno y composiciones farmaceuticas que comprenden dichos compuestos.
US20040152694A1 (en) *	2003-02-04	2004-08-05	Istvan Kurucz	Methods and compositions for treating inflammatory disorders of the airways
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
EP2089383B1 (en)	2006-11-09	2015-09-16	Probiodrug AG	3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
US9126987B2 (en)	2006-11-30	2015-09-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase
AU2008220785B2 (en)	2007-03-01	2013-02-21	Vivoryon Therapeutics N.V.	New use of glutaminyl cyclase inhibitors
JP5667440B2 (ja)	2007-04-18	2015-02-12	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
JP5934645B2 (ja)	2009-09-11	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
EP2338492A1 (en)	2009-12-24	2011-06-29	Universidad del Pais Vasco	Methods and compositions for the treatment of alzheimer
WO2011107530A2 (en)	2010-03-03	2011-09-09	Probiodrug Ag	Novel inhibitors
JP5688745B2 (ja)	2010-03-10	2015-03-25	プロビオドルグエージー	グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤
WO2011131748A2 (en)	2010-04-21	2011-10-27	Probiodrug Ag	Novel inhibitors
EP2686313B1 (en)	2011-03-16	2016-02-03	Probiodrug AG	Benzimidazole derivatives as inhibitors of glutaminyl cyclase
ES2812698T3 (es)	2017-09-29	2021-03-18	Probiodrug Ag	Inhibidores de glutaminil ciclasa

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK101290D0 (da) *	1990-04-24	1990-04-24	Novo Nordisk As	Heterocykliske forbindelser, deres fremstilling og anvendelse

1993
- 1993-07-16 FR FR9308753A patent/FR2707645B1/fr not_active Expired - Fee Related
1994
- 1994-07-11 DK DK94922903.3T patent/DK0708778T3/da active
- 1994-07-11 AU AU72651/94A patent/AU7265194A/en not_active Abandoned
- 1994-07-11 US US08/583,036 patent/US5672705A/en not_active Expired - Fee Related
- 1994-07-11 WO PCT/FR1994/000865 patent/WO1995002602A1/fr not_active Ceased
- 1994-07-11 EP EP94922903A patent/EP0708778B1/fr not_active Expired - Lifetime
- 1994-07-11 ES ES94922903T patent/ES2098158T3/es not_active Expired - Lifetime
- 1994-07-11 JP JP7504375A patent/JPH09500123A/ja active Pending
- 1994-07-11 AT AT94922903T patent/ATE148704T1/de not_active IP Right Cessation
- 1994-07-11 DE DE69401716T patent/DE69401716T2/de not_active Expired - Fee Related
- 1994-07-14 IL IL11032894A patent/IL110328A0/xx unknown
- 1994-07-14 ZA ZA945157A patent/ZA945157B/xx unknown
1997
- 1997-02-06 GR GR960402774T patent/GR3022498T3/el unknown

Also Published As

Publication number	Publication date
EP0708778B1 (fr)	1997-02-05
ATE148704T1 (de)	1997-02-15
DE69401716D1 (de)	1997-03-20
ES2098158T3 (es)	1997-04-16
EP0708778A1 (fr)	1996-05-01
JPH09500123A (ja)	1997-01-07
DE69401716T2 (de)	1997-06-05
IL110328A0 (en)	1994-10-21
AU7265194A (en)	1995-02-13
FR2707645B1 (fr)	1995-08-11
ZA945157B (en)	1995-02-24
FR2707645A1 (fr)	1995-01-20
GR3022498T3 (en)	1997-05-31
WO1995002602A1 (fr)	1995-01-26
US5672705A (en)	1997-09-30

Publication	Publication Date	Title
DK0708778T3 (da)	1997-03-10	Derivater af imidazol(1,2-a)pyrazin-4-on, fremgangsmåde til deres fremstilling og lægemidler indeholdende disse forbindelser
DK0464465T3 (da)	1995-05-22	Substituerede aminoalkylbiphenylderivater, antimykotiske præparater indeholdende disse derivater og mellemprodukter til fremstilling deraf
DK0708774T3 (da)	1999-10-11	Derivater af imidazo[1,2-a]pyrazin-4-on, deres fremstilling og lægemidler indeholdende disse forbindelser
DK0766696T3 (da)	1999-02-15	Thiazolidinderivater, fremstilling af disse forbindelser og lægemidler indeholdende disse forbindelser
DK0759027T3 (da)	2000-03-27	Bicykliske amidinderivater som inhibitorer af nitrogenoxidsynthetase
NO985335L (no)	1999-01-15	2,4-Diaminopyrimidinderivater
DK0662971T3 (da)	1998-10-07	5H,10H-Imidazo[1,2-a]indeno[1,2-e]pyrazin-4-on-derivater, fremstilling af disse forbindelser samt lægemidler indeholdende f
TW429253B (en)	2001-04-11	Novel pyrazole compounds
NO955328L (no)	1996-02-28	Pyridazinon-derivater
NZ337749A (en)	2000-09-29	Benzimidazole derivative and their use in allergy-related disease
MX9708552A (es)	1997-12-31	(het)ariloxi-, -tio- y -aminocrotonatos, su preparacion y uso.
NO961404L (no)	1996-10-11	4-indolylpiperazinyl-derivater
ES8707718A1 (es)	1987-08-16	Procedimiento para la obtencion de 1-aril-5-alcoxiiminoalquilamino-pirazoles
DE59604901D1 (de)	2000-05-11	Carbamoylcarbonsäureamide
DK0667863T3 (da)	1999-02-01	2-Perhalogenalkyl-substituerede benzimidazoler, deres fremstilling samt deres anvendelse som pesticider