DK0711292T3 - Aza-spiro-forbindelser, der virker på det cholinerge system med muskarin-agonist aktivitet - Google Patents

Aza-spiro-forbindelser, der virker på det cholinerge system med muskarin-agonist aktivitet

Info

Publication number: DK0711292T3
Authority: DK; Denmark
Prior art keywords: image; aza; agonist activity; spiro compounds; compounds acting
Prior art date: 1993-07-20

Application number

DK94921036T

Other languages

English (en)

Inventor

Abraham Fisher

Yishai Karton

Daniele Marciano

Dov Barak

Haim Meshulam

Original Assignee

Israel State

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-20

Filing date

1994-07-15

Publication date

2002-05-06

1994-07-15 Application filed by Israel State filed Critical Israel State

2002-05-06 Application granted granted Critical

2002-05-06 Publication of DK0711292T3 publication Critical patent/DK0711292T3/da

Links

150000008627 azaspiro compounds Chemical class 0.000 title 1
230000001713 cholinergic effect Effects 0.000 title 1
230000000694 effects Effects 0.000 title 1
239000000472 muscarinic agonist Substances 0.000 title 1
241000124008 Mammalia Species 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
210000001428 peripheral nervous system Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Psychology (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

DK94921036T 1993-07-20 1994-07-15 Aza-spiro-forbindelser, der virker på det cholinerge system med muskarin-agonist aktivitet DK0711292T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/094,855 US5534520A (en)	1990-04-10	1993-07-20	Spiro compounds containing five-membered rings
PCT/GB1994/001543 WO1995003303A2 (en)	1993-07-20	1994-07-15	Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity

Publications (1)

Publication Number	Publication Date
DK0711292T3 true DK0711292T3 (da)	2002-05-06

Family

ID=22247578

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94921036T DK0711292T3 (da)	1993-07-20	1994-07-15	Aza-spiro-forbindelser, der virker på det cholinerge system med muskarin-agonist aktivitet

Country Status (25)

Country	Link
US (1)	US5534520A (da)
EP (1)	EP0711292B1 (da)
JP (1)	JP3802050B2 (da)
KR (1)	KR100341683B1 (da)
CN (1)	CN1129942B (da)
AT (1)	ATE212347T1 (da)
AU (1)	AU696530B2 (da)
BG (1)	BG62774B1 (da)
BR (1)	BR9407088A (da)
CA (1)	CA2167584C (da)
CZ (1)	CZ295929B6 (da)
DE (1)	DE69429724T2 (da)
DK (1)	DK0711292T3 (da)
ES (1)	ES2171458T3 (da)
FI (1)	FI113777B (da)
HU (1)	HU224638B1 (da)
IL (1)	IL110340A (da)
NO (1)	NO310075B1 (da)
NZ (1)	NZ268637A (da)
PL (1)	PL178931B1 (da)
PT (1)	PT711292E (da)
RO (1)	RO117851B1 (da)
RU (1)	RU2129555C1 (da)
WO (1)	WO1995003303A2 (da)
ZA (1)	ZA945284B (da)

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IL97726A (en) *	1990-04-10	1994-12-29	Israel Inst Biolog Res	Pharmaceutical compositions containing compounds with bridged and unbridged heterocyclic groups, spiro-connected with oxazoline and thiazoline groups, and some new such compounds
US5073560A (en) *	1990-07-20	1991-12-17	Fisons Corporation	Spiro-isoxazolidine derivatives as cholinergic agents
TW201312B (en) *	1991-04-09	1993-03-01	Israel State	Spiro bridged and unbridged heterocyclic compounds

1993
- 1993-07-20 US US08/094,855 patent/US5534520A/en not_active Expired - Lifetime
1994
- 1994-07-15 RU RU96103370A patent/RU2129555C1/ru not_active IP Right Cessation
- 1994-07-15 CZ CZ1996182A patent/CZ295929B6/cs not_active IP Right Cessation
- 1994-07-15 ES ES94921036T patent/ES2171458T3/es not_active Expired - Lifetime
- 1994-07-15 PT PT94921036T patent/PT711292E/pt unknown
- 1994-07-15 BR BR9407088A patent/BR9407088A/pt not_active Application Discontinuation
- 1994-07-15 DK DK94921036T patent/DK0711292T3/da active
- 1994-07-15 RO RO96-00099A patent/RO117851B1/ro unknown
- 1994-07-15 IL IL11034094A patent/IL110340A/xx not_active IP Right Cessation
- 1994-07-15 EP EP94921036A patent/EP0711292B1/en not_active Expired - Lifetime
- 1994-07-15 WO PCT/GB1994/001543 patent/WO1995003303A2/en not_active Ceased
- 1994-07-15 CN CN94192839XA patent/CN1129942B/zh not_active Expired - Fee Related
- 1994-07-15 CA CA002167584A patent/CA2167584C/en not_active Expired - Fee Related
- 1994-07-15 PL PL94312684A patent/PL178931B1/pl not_active IP Right Cessation
- 1994-07-15 JP JP50499595A patent/JP3802050B2/ja not_active Expired - Fee Related
- 1994-07-15 NZ NZ268637A patent/NZ268637A/en not_active IP Right Cessation
- 1994-07-15 AU AU71915/94A patent/AU696530B2/en not_active Ceased
- 1994-07-15 KR KR1019960700296A patent/KR100341683B1/ko not_active Expired - Fee Related
- 1994-07-15 AT AT94921036T patent/ATE212347T1/de not_active IP Right Cessation
- 1994-07-15 DE DE69429724T patent/DE69429724T2/de not_active Expired - Lifetime
- 1994-07-15 HU HU9600126A patent/HU224638B1/hu not_active IP Right Cessation
- 1994-07-19 ZA ZA945284A patent/ZA945284B/xx unknown
1996
- 1996-01-17 FI FI960238A patent/FI113777B/fi active
- 1996-01-18 NO NO960225A patent/NO310075B1/no not_active IP Right Cessation
- 1996-02-19 BG BG100370A patent/BG62774B1/bg unknown

Also Published As

Publication number	Publication date
HU224638B1 (hu)	2005-12-28
HU9600126D0 (en)	1996-03-28
FI960238A7 (fi)	1996-03-18
CN1129942B (zh)	2011-08-10
CN1129942A (zh)	1996-08-28
PT711292E (pt)	2002-07-31
BR9407088A (pt)	1996-08-13
WO1995003303A3 (en)	1995-03-02
PL312684A1 (en)	1996-05-13
AU7191594A (en)	1995-02-20
DE69429724T2 (de)	2002-08-29
IL110340A0 (en)	1994-10-21
AU696530B2 (en)	1998-09-10
JPH09503491A (ja)	1997-04-08
RU2129555C1 (ru)	1999-04-27
JP3802050B2 (ja)	2006-07-26
DE69429724D1 (de)	2002-03-14
BG100370A (bg)	1996-11-29
RO117851B1 (ro)	2002-08-30
ES2171458T3 (es)	2002-09-16
FI113777B (fi)	2004-06-15
CZ18296A3 (en)	1996-07-17
IL110340A (en)	1999-06-20
CA2167584C (en)	2006-10-24
EP0711292B1 (en)	2002-01-23
PL178931B1 (pl)	2000-06-30
NO310075B1 (no)	2001-05-14
NO960225D0 (no)	1996-01-18
CZ295929B6 (cs)	2005-12-14
KR100341683B1 (ko)	2002-11-30
ZA945284B (en)	1995-10-12
HUT74588A (en)	1997-01-28
NO960225L (no)	1996-03-12
US5534520A (en)	1996-07-09
NZ268637A (en)	1998-01-26
WO1995003303A2 (en)	1995-02-02
KR960703914A (ko)	1996-08-31
EP0711292A1 (en)	1996-05-15
FI960238A0 (fi)	1996-01-17
ATE212347T1 (de)	2002-02-15
BG62774B1 (bg)	2000-07-31
CA2167584A1 (en)	1995-02-02

Publication	Publication Date	Title
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MY131641A (en)	2007-08-30	Indoline derivatives, process of preparation and use
PT963756E (pt)	2004-06-30	Inibicao da oxidacao do ldl e da aterosclerose
DK382089A (da)	1990-02-05	Benzamidderivater
ES2163401T3 (es)	2002-02-01	5,8-dihidrodiazaantracenos con actividad antitumoral.
MY106979A (en)	1995-08-30	Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents.
MY104090A (en)	1993-11-30	Thaz derivatives for enhancement of cerebral function.
FI895139A0 (fi)	1989-10-30	Pyrrolidinderivat.
NZ336249A (en)	2000-11-24	parenteral composition of a dihydropolyprenol and a pharmaceutically acceptable oil
CA2148593A1 (en)	1994-05-11	Use of piperazine derivatives for the treatment of cognitive disorders
CA2228393A1 (en)	1997-02-13	Use of adamantane derivatives for treating diseases of the inner ear
MX9800925A (es)	1998-10-31	Uso de derivados de adamantano para tratar enfermedades del oido interno.