DK0720655T3 - Racematspaltning af primære og sekundære aminer ved enzymkatalyseret acylering - Google Patents

Racematspaltning af primære og sekundære aminer ved enzymkatalyseret acylering

Info

Publication number
DK0720655T3
DK0720655T3 DK94928365T DK94928365T DK0720655T3 DK 0720655 T3 DK0720655 T3 DK 0720655T3 DK 94928365 T DK94928365 T DK 94928365T DK 94928365 T DK94928365 T DK 94928365T DK 0720655 T3 DK0720655 T3 DK 0720655T3
Authority
DK
Denmark
Prior art keywords
amine
pct
secondary amines
optically active
primary
Prior art date
Application number
DK94928365T
Other languages
Danish (da)
English (en)
Inventor
Friedhelm Balkenhohl
Bernhard Hauer
Wolfgang Ladner
Uwe Pressler
Bling Christoph N
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Application granted granted Critical
Publication of DK0720655T3 publication Critical patent/DK0720655T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK94928365T 1993-09-25 1994-09-16 Racematspaltning af primære og sekundære aminer ved enzymkatalyseret acylering DK0720655T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4332738A DE4332738A1 (de) 1993-09-25 1993-09-25 Racematspaltung primärer und sekundärer Amine durch Enzym-katalysierte Acylierung
PCT/EP1994/003102 WO1995008636A1 (fr) 1993-09-25 1994-09-16 Clivage de racemates d'amines primaires et secondaires par acylation catalysee par enzyme

Publications (1)

Publication Number Publication Date
DK0720655T3 true DK0720655T3 (da) 2000-04-10

Family

ID=6498657

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94928365T DK0720655T3 (da) 1993-09-25 1994-09-16 Racematspaltning af primære og sekundære aminer ved enzymkatalyseret acylering

Country Status (10)

Country Link
US (1) US5728876A (fr)
EP (1) EP0720655B1 (fr)
JP (1) JP3594602B2 (fr)
AT (1) ATE187774T1 (fr)
CA (1) CA2170059C (fr)
DE (2) DE4332738A1 (fr)
DK (1) DK0720655T3 (fr)
ES (1) ES2141254T3 (fr)
PT (1) PT720655E (fr)
WO (1) WO1995008636A1 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1087348C (zh) 1995-02-03 2002-07-10 巴斯福股份公司 通过酶催化酰化拆分杂原子取代的伯胺和仲胺的外消旋体
DE19517421A1 (de) * 1995-05-12 1996-11-14 Basf Ag Synthese von optisch aktivem Aminoindanol
DE19529293A1 (de) 1995-08-09 1997-02-13 Bayer Ag Verfahren zur Herstellung von racemischen Amino-Derivaten
DE19530204A1 (de) * 1995-08-17 1997-02-20 Bayer Ag Verfahren zur Herstellung von optisch aktiven l-Aryl-alkylaminen
TW328945B (en) * 1995-08-30 1998-04-01 Basf Ag Carbamoylcarboxamides
DE19534208A1 (de) * 1995-09-15 1997-03-20 Basf Ag Spaltung von optisch aktiven Amiden
WO1997020946A1 (fr) * 1995-12-06 1997-06-12 Bayer Aktiengesellschaft Procede de production d'amines optiquement actives
DE19603575A1 (de) * 1996-02-01 1997-08-07 Bayer Ag Verfahren zur Herstellung von optisch aktiven Aminen
US6235516B1 (en) 1996-04-25 2001-05-22 Novartis Ag Biocatalysts with amine acylase activity
DE19621686A1 (de) 1996-05-30 1997-12-04 Bayer Ag Verfahren zur Herstellung von optisch aktiven Aminen
DE19629692A1 (de) * 1996-07-23 1998-01-29 Bayer Ag Verfahren zur Herstellung von racemischen Phenethylaminen
TW438575B (en) * 1996-08-28 2001-06-07 Basf Ag Compositions and methods for controlling harmful fungi
DE19641693A1 (de) 1996-10-10 1998-04-16 Bayer Ag Substituierte 2-Amino-4-alkylamino-1,3,5-triazine
DE19641694A1 (de) 1996-10-10 1998-04-16 Bayer Ag Substituierte 2,4-Diamino-1,3,5-triazine
DE19641691A1 (de) 1996-10-10 1998-04-16 Bayer Ag Substituierte 2-Amino-4-alkylamino-1,3,5-triazine
DE19703426A1 (de) * 1997-01-30 1998-08-06 Basf Ag Verfahren zur Reinigung von alpha-, beta- oder gamma-substituierten Carbonsäuren
CA2287171A1 (fr) * 1997-05-01 1998-11-12 G.D. Searle & Co. Procede et appareil de preparation de beta amino-acides chiraux
DE19727517A1 (de) * 1997-06-30 1999-01-07 Basf Ag Racematspaltung von Aminosäureestern durch Enzym-katalysierte Acylierung
DE19735198A1 (de) * 1997-08-14 1999-02-18 Bayer Ag Verfahren zur Racematspaltung von cis- und trans-Pyrrolopiperidin
GB9726229D0 (en) 1997-12-12 1998-02-11 Zeneca Ltd Resolution of chiral amines
DE19837745A1 (de) * 1998-08-20 2000-02-24 Basf Ag Enzymkatalysierte Racematspaltung von primären Aminen
GB9823334D0 (en) 1998-10-23 1998-12-23 Darwin Discovery Ltd Enzyme coupling
DE19913256A1 (de) 1999-03-24 2000-09-28 Basf Ag Verfahren zur Hydrolyse von optisch aktiven Amiden
DE19956786A1 (de) 1999-11-25 2001-05-31 Basf Ag Verfahren zur Herstellung optisch aktiver Amine
JP3813152B2 (ja) 2002-03-12 2006-08-23 メルク エンド カムパニー インコーポレーテッド 置換アミド類
US7067291B2 (en) * 2002-12-20 2006-06-27 Pfizer Inc. Biocatalytic preparation of enantiomerically enriched aminopentanenitrile
DE102005028492A1 (de) * 2005-06-20 2006-12-28 Basf Ag Verfahren zur Herstellung von optisch aktiven Aminoalkylphenolen
JP5329973B2 (ja) * 2005-12-28 2013-10-30 ビーエーエスエフ ソシエタス・ヨーロピア リパーゼ触媒を用いるエナンチオ選択的アシル化とその後の硫酸による沈殿によって、ラセミ体の４−（１−アミノエチル）安息香酸メチルエステルから（ｒ）−および（ｓ）−４−（１−アンモニウムエチル）安息香酸メチルエステル硫酸塩を調製する方法
DE102005062966A1 (de) * 2005-12-28 2007-07-05 Basf Ag Verfahren zur Herstellung von (R)- und (S)-4-(Ammoniumethyl)benzoesäuremethylester-sulfat
DE102006028818A1 (de) * 2006-06-21 2007-12-27 Evonik Degussa Gmbh Verfahren zur Herstellung enantiomerenangereicherter Amine und Amide durch enzymatische Racematspaltung
JP5039787B2 (ja) * 2006-09-13 2012-10-03 ビーエーエスエフ ソシエタス・ヨーロピア 光学活性な２−ベンジルオキシシクロヘキシルアミンの製造方法
WO2011009849A2 (fr) 2009-07-21 2011-01-27 Basf Se Procédé pour la préparation d'esters d'hydroxyacides optiquement actifs
RU2442770C1 (ru) * 2010-07-23 2012-02-20 Федеральное государственное учреждение "33 Центральный научно-исследовательский испытательный институт Министерства обороны Российской Федерации" Способ ацилирования аминов
US20130345475A1 (en) 2012-06-25 2013-12-26 Basf Se Process for the racemization of optically active arylalkylamines
US10544434B2 (en) * 2015-06-29 2020-01-28 Noramco, Inc. Process for the preparation of lisdexamfetamine and related derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK255889D0 (da) * 1989-05-25 1989-05-25 Novo Nordisk As Fremgangsmaade til fremstilling af organiske forbindelser
JPH03191797A (ja) * 1989-12-20 1991-08-21 Fuji Photo Film Co Ltd Ｄ，ｌ―アミン類の酵素的光学分割方法
DE4005150A1 (de) * 1990-02-17 1991-08-22 Hoechst Ag Verfahren zur enzymatischen racematspaltung von pantolacton
WO1991019002A1 (fr) * 1990-06-01 1991-12-12 Carlbiotech Ltd. A/S Procede d'enrichissement chiral d'amines primaires asymetriques
US5057607A (en) * 1990-06-08 1991-10-15 Eli Lilly And Company Enantiomerically selective biocatalyzed acylation

Also Published As

Publication number Publication date
DE4332738A1 (de) 1995-03-30
ES2141254T3 (es) 2000-03-16
JP3594602B2 (ja) 2004-12-02
US5728876A (en) 1998-03-17
EP0720655B1 (fr) 1999-12-15
JPH09503658A (ja) 1997-04-15
CA2170059A1 (fr) 1995-03-30
ATE187774T1 (de) 2000-01-15
DE59409010D1 (de) 2000-01-20
EP0720655A1 (fr) 1996-07-10
WO1995008636A1 (fr) 1995-03-30
PT720655E (pt) 2000-04-28
CA2170059C (fr) 2009-01-27

Similar Documents

Publication Publication Date Title
DK0720655T3 (da) Racematspaltning af primære og sekundære aminer ved enzymkatalyseret acylering
DK0801683T3 (da) Racematspaltning af primære og sekundære heteroatomsubstituerede aminer ved enzymkatalyseret acylering
ATE232909T1 (de) Mikrobielle stämme zur produktion von sphingolipidbasen
ATE205475T1 (de) Verfahren zur herstellung von azetidinonen
MXPA04003829A (es) Inhibidores de proteasa que escinden la post-prolina.
AU6598990A (en) Method of inhibiting synaptic norepinerphrine uptake and synapitc serotionin uptake in a depressed patient
DE69425940D1 (de) Enzymatische synthese von ceramiden und hybrid-ceramiden
ATE221533T1 (de) Verfahren zur racematspaltung von etodolac unter verwendung von glucamin-derivaten
MXPA04000817A (es) Metodo para tratar la estenosis bronquial y el broncoespasmo.
DE59609103D1 (de) Verfahren zur racematspaltung
HUP0104010A2 (hu) Eljárás 2-hidroxi-propionsavak racemát reszolválására
PT904348E (pt) Processo para a producao de aminoalcoois e seus derivados
EA199800034A1 (ru) Способ получения n-монозамещенных и n,n'-дизамещенных асимметричных циклических мочевин
DE69432176D1 (de) Verfahren zur herstellung von hiv protease inhibitoren
DE59608211D1 (de) Verfahren zur umwandlung der achiralen meso-form oder des racemats eines ansa-metallocenkomplexes oder deren mischungen in eines seiner enantiomeren
EA199901059A1 (ru) Способ получения энантиомерно обогащенных n-производных лактамов
MY119626A (en) Method for hydrogenating compounds from the group of imines or enamines.
DE69416424D1 (de) Verfahren zur herstellung von tert-leucin und analoge in enantiemerer form und zwischenprodukte
AU5516499A (en) Enzyme-catalyzed racemic cleavage of primary amines
DE59705175D1 (de) Verfahren zur herstellung von dialkylcarbonaten
DK0589285T3 (da) Fremgangsmåde til fremstilling af biotin
GB9614804D0 (en) Resolution process
DK0627432T3 (da) 6-Piperazinyl-1H-pyrazolo(3,4-b)pyridin-3-carboxylsyrer, deres estere, amider og beslægtede forbindelser, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
ATE192501T1 (de) Bakteriologisches verfahren zur trennung von racematartigen cis-diolen
ATE296126T1 (de) Gelenkimplantat sowie verfahren zum herstellen eines solchen