DK0732333T3 - Indazolcarboxamider - Google Patents

Indazolcarboxamider

Info

Publication number: DK0732333T3
Authority: DK; Denmark
Prior art keywords: alkyl; phenyl; naphthyl; amino; substituted
Prior art date: 1995-03-16

Application number

DK96301682T

Other languages

English (en)

Inventor

John Mehnert Schaus

Marlene Lois Cohen

John Thomas Catlow

Michael John Martinelli

Steven Phillip Swanson

Dennis Charles Thompson

Thomas Michael Wilson

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-16

Filing date

1996-03-12

Publication date

2001-10-08

1995-06-07 Priority claimed from US08/485,956 external-priority patent/US5654320A/en

1996-03-12 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2001-10-08 Application granted granted Critical

2001-10-08 Publication of DK0732333T3 publication Critical patent/DK0732333T3/da

Links

DITBWPUMEUDVLU-UHFFFAOYSA-N 1h-indazole-3-carboxamide Chemical class C1=CC=C2C(C(=O)N)=NNC2=C1 DITBWPUMEUDVLU-UHFFFAOYSA-N 0.000 title abstract 3
125000001624 naphthyl group Chemical group 0.000 abstract 7
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
125000001475 halogen functional group Chemical group 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
-1 1-piperazinyl Chemical group 0.000 abstract 2
125000005518 carboxamido group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
108091005482 5-HT4 receptors Proteins 0.000 abstract 1
108091032151 5-hydroxytryptamine receptor family Proteins 0.000 abstract 1
102000040125 5-hydroxytryptamine receptor family Human genes 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000004064 dysfunction Effects 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
125000002757 morpholinyl group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 abstract 1
239000004031 partial agonist Substances 0.000 abstract 1
125000004193 piperazinyl group Chemical group 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Paper (AREA)
Luminescent Compositions (AREA)

DK96301682T 1995-03-16 1996-03-12 Indazolcarboxamider DK0732333T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US40511995A	1995-03-16	1995-03-16
US08/485,956 US5654320A (en)	1995-03-16	1995-06-07	Indazolecarboxamides

Publications (1)

Publication Number	Publication Date
DK0732333T3 true DK0732333T3 (da)	2001-10-08

Family

ID=27018928

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96301682T DK0732333T3 (da)	1995-03-16	1996-03-12	Indazolcarboxamider

Country Status (23)

Country	Link
US (2)	US5798367A (da)
EP (1)	EP0732333B1 (da)
JP (1)	JPH11502230A (da)
CN (1)	CN1112923C (da)
AT (1)	ATE203748T1 (da)
AU (1)	AU700842B2 (da)
BR (1)	BR9608223A (da)
CA (1)	CA2215359A1 (da)
DE (1)	DE69614164T2 (da)
DK (1)	DK0732333T3 (da)
EA (1)	EA000699B1 (da)
ES (1)	ES2159345T3 (da)
GR (1)	GR3037029T3 (da)
HU (1)	HU223973B1 (da)
IL (1)	IL117438A (da)
NO (1)	NO312833B1 (da)
NZ (1)	NZ315971A (da)
PL (1)	PL183867B1 (da)
PT (1)	PT732333E (da)
RO (1)	RO119617B1 (da)
SK (1)	SK283924B6 (da)
TR (1)	TR199700956T1 (da)
WO (1)	WO1996033713A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1291569B1 (it) *	1997-04-15	1999-01-11	Angelini Ricerche Spa	Indazolammidi come agenti serotoninergici
US5914405A (en) *	1997-10-07	1999-06-22	Eli Lilly And Company	Process for preparing 3-substituted indazoles
US6069152A (en) *	1997-10-07	2000-05-30	Eli Lilly And Company	5-HT4 agonists and antagonists
ES2257869T3 (es) *	1998-08-21	2006-08-01	Novartis Ag	Nueva formulacion oral para agonistas o antagonistas de 5-ht4.
CA2340952C (en)	1998-09-10	2009-12-08	F. Hoffmann-La Roche Ag	Dihydrobenzodioxine carboxamide and ketone derivatives as 5-ht4 receptor antagonists
AU2001270304A1 (en)	2000-07-07	2002-01-21	The Administrators Of The Tulane Educational Fund	Methods for protection of stratified squamous epithelium against injury by noxious substances and novel agents for use therefor
BR0113073A (pt) *	2000-08-07	2004-06-22	Glaxosmithkline Lab Sas	Uso de antagonistas receptores 5ht4 na fabricação de um medicamento para a profilaxia ou tratamento de fibrilação atrial
EP1321142A1 (en) *	2001-12-21	2003-06-25	Novartis AG	Solid pharmaceutical composition for oral administration of Tegaserod
EP1476151B1 (en)	2002-02-12	2008-07-16	N.V. Organon	1-arylsulfonyl-3-substitued indole and indoline derivates useful in the treatment of central nervous system disorders
ITMI20030287A1 (it)	2003-02-18	2004-08-19	Acraf	Indazolammidi dotate di attivita' analgesica metodo, per
ITMI20031467A1 (it) *	2003-07-18	2005-01-19	Acraf	Farmaco attivo nel dolore neuropatico
ITMI20031468A1 (it) *	2003-07-18	2005-01-19	Acraf	Farmaco ativo nel dolore neuropatico
SE0401969D0 (sv) *	2004-08-02	2004-08-02	Astrazeneca Ab	Piperidine derivatives
JP5075818B2 (ja)	2005-07-22	2012-11-21	ファイザー株式会社	５ｈｔ４受容体アゴニストとしてのインダゾールカルボキサミド誘導体
WO2009106980A2 (en) *	2008-02-29	2009-09-03	Pfizer Inc.	Indazole derivatives
GB201511382D0 (en)	2015-06-29	2015-08-12	Imp Innovations Ltd	Novel compounds and their use in therapy
WO2024052684A1 (en)	2022-09-09	2024-03-14	MyricX Pharma Limited	Antibody drug conjugate comprising nmt inhibitor and its use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3145215A (en) *	1961-12-19	1964-08-18	Sterling Drug Inc	Indazole derivatives
JP2795460B2 (ja) *	1988-06-20	1998-09-10	協和醗酵工業株式会社	ピラゾロアクリドン誘導体
NZ230068A (en) *	1988-07-29	1991-07-26	Dainippon Pharmaceutical Co	Indazole-3-carboxylic acid esters and amides of diaza compounds having 6,7, or 8 ring members: preparatory processes and pharmaceutical compositions
EP0410509A1 (en) *	1989-07-25	1991-01-30	Duphar International Research B.V	New substituted 1H-indazole-3-carboxamides
HU211081B (en) *	1990-12-18	1995-10-30	Sandoz Ag	Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same
NZ243993A (en) *	1991-08-20	1994-10-26	Smithkline Beecham Plc	Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity
US5552398A (en) *	1991-09-12	1996-09-03	Smithkline Beecham P.L.C.	Azabicyclic compounds as 5-HT4 receptor antagonists
EP0641198A1 (en) *	1992-05-23	1995-03-08	Smithkline Beecham Plc	Medicaments for the treatment of anxiety
JPH07508276A (ja) *	1992-06-27	1995-09-14	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	５−ｈｔ↓４受容体アンタゴニスト含有医薬品
MX9305947A (es) *	1992-09-29	1994-06-30	Smithkline Beecham Plc	Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
TW251287B (da) *	1993-04-30	1995-07-11	Nissei Co Ltd
GB9310582D0 (en) *	1993-05-22	1993-07-07	Smithkline Beecham Plc	Pharmaceuticals

1996
- 1996-03-11 IL IL11743896A patent/IL117438A/en active IP Right Grant
- 1996-03-12 DK DK96301682T patent/DK0732333T3/da active
- 1996-03-12 AT AT96301682T patent/ATE203748T1/de not_active IP Right Cessation
- 1996-03-12 PT PT96301682T patent/PT732333E/pt unknown
- 1996-03-12 EP EP96301682A patent/EP0732333B1/en not_active Expired - Lifetime
- 1996-03-12 ES ES96301682T patent/ES2159345T3/es not_active Expired - Lifetime
- 1996-03-12 DE DE69614164T patent/DE69614164T2/de not_active Expired - Fee Related
- 1996-03-14 PL PL96322362A patent/PL183867B1/pl not_active IP Right Cessation
- 1996-03-14 SK SK1242-97A patent/SK283924B6/sk unknown
- 1996-03-14 TR TR97/00956T patent/TR199700956T1/xx unknown
- 1996-03-14 AU AU68948/96A patent/AU700842B2/en not_active Ceased
- 1996-03-14 WO PCT/US1996/003551 patent/WO1996033713A1/en not_active Ceased
- 1996-03-14 CN CN96193677A patent/CN1112923C/zh not_active Expired - Fee Related
- 1996-03-14 BR BR9608223A patent/BR9608223A/pt not_active IP Right Cessation
- 1996-03-14 NZ NZ315971A patent/NZ315971A/xx unknown
- 1996-03-14 JP JP8528690A patent/JPH11502230A/ja not_active Ceased
- 1996-03-14 RO RO97-01719A patent/RO119617B1/ro unknown
- 1996-03-14 HU HU9801386A patent/HU223973B1/hu not_active IP Right Cessation
- 1996-03-14 EA EA199700242A patent/EA000699B1/ru not_active IP Right Cessation
- 1996-03-14 CA CA002215359A patent/CA2215359A1/en not_active Abandoned
1997
- 1997-01-10 US US08/781,421 patent/US5798367A/en not_active Expired - Fee Related
- 1997-01-10 US US08/782,478 patent/US5817676A/en not_active Expired - Fee Related
- 1997-09-12 NO NO19974221A patent/NO312833B1/no unknown
2001
- 2001-10-26 GR GR20010401899T patent/GR3037029T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
BR9608223A (pt)	1998-12-29
IL117438A (en)	2001-12-23
NO974221L (no)	1997-10-27
EP0732333B1 (en)	2001-08-01
WO1996033713A1 (en)	1996-10-31
CA2215359A1 (en)	1996-10-31
US5817676A (en)	1998-10-06
NZ315971A (en)	1999-01-28
MX9706967A (es)	1997-11-29
RO119617B1 (ro)	2005-01-28
ATE203748T1 (de)	2001-08-15
EP0732333A1 (en)	1996-09-18
PL183867B1 (pl)	2002-07-31
US5798367A (en)	1998-08-25
NO312833B1 (no)	2002-07-08
PT732333E (pt)	2001-11-30
HU223973B1 (hu)	2005-03-29
EA199700242A1 (ru)	1998-04-30
HUP9801386A3 (en)	2000-03-28
CN1183041A (zh)	1998-05-27
HUP9801386A2 (hu)	1999-06-28
GR3037029T3 (en)	2002-01-31
EA000699B1 (ru)	2000-02-28
ES2159345T3 (es)	2001-10-01
DE69614164T2 (de)	2002-04-25
SK283924B6 (sk)	2004-05-04
JPH11502230A (ja)	1999-02-23
AU6894896A (en)	1996-11-18
AU700842B2 (en)	1999-01-14
PL322362A1 (en)	1998-01-19
TR199700956T1 (xx)	1998-02-21
CN1112923C (zh)	2003-07-02
DE69614164D1 (de)	2001-09-06
IL117438A0 (en)	1996-07-23
SK124297A3 (en)	1998-02-04
NO974221D0 (no)	1997-09-12

Publication	Publication Date	Title
NO974221D0 (no)	1997-09-12	Indazolkarboksamider
WO2020140005A3 (en)	2020-07-30	1 h-pyrrolo[2,3-b]pyridine derivatives and related compounds as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
KR0131327B1 (en)	1998-04-17	Indole derivatives
GB9524157D0 (en)	1996-01-24	Therapeutic agents
NO933452L (no)	1994-03-29	Et terapeutisk middel for Parkinson's sykdom
CO5550421A2 (es)	2005-08-31	Derivados de indol utiles para el tratamiento de enfermeda- des
SE0104330D0 (sv)	2001-12-19	Therapeutic agents
HUP0400343A2 (hu)	2004-09-28	Ciklopropil-indol-származékok mint szelektív szerotonin-újrafelvétel inhibitorok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
DK391289D0 (da)	1989-08-09	Indolderivater
PE20030332A1 (es)	2003-04-05	Terapia de combinacion para el tratamiento del cancer
TW370529B (en)	1999-09-21	Pyrazolopyrimidines
ATE104145T1 (de)	1994-04-15	4-substituierten imidazolen zur senkung des intraokularen druckes.
ATE177096T1 (de)	1999-03-15	4-substituierte 1,2,4-triazolderivate
NO920438D0 (no)	1992-02-03	N-(aryloksyalkyl)heteroaryl-8-azabicyklo(3.2.1.)oktaner, mellomprodukter og en fremgangsmaate for fremstilling deravsamt anvendelse som medikamenter
MX2025008544A (es)	2025-08-01	Derivados de 3-(2-(dimetilamino)etil)-1h-indol-4-ilo
TR200200969T2 (tr)	2002-07-22	Karbonilamino türevlerinin CNS bozukluklarına karşı kullanılması
SE9904177D0 (sv)	1999-11-18	Novel compounds
ES8705405A1 (es)	1987-05-16	Procedimiento de preparar nuevos derivados morfolinicos
PL364794A1 (en)	2004-12-13	2-aminotetralin derivatives for the therapy of glaucoma
ES2181387T3 (es)	2003-02-16	Derivados de azetidinocarboxamida para el tratamiento de trastornos del sistema nervioso central.