ES2159345T3 - Indazolcarboxamidas. - Google Patents
Indazolcarboxamidas.Info
- Publication number
- ES2159345T3 ES2159345T3 ES96301682T ES96301682T ES2159345T3 ES 2159345 T3 ES2159345 T3 ES 2159345T3 ES 96301682 T ES96301682 T ES 96301682T ES 96301682 T ES96301682 T ES 96301682T ES 2159345 T3 ES2159345 T3 ES 2159345T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- rent
- naftil
- sup
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- ZITFWUUYPONCCK-UHFFFAOYSA-N 1,2,3,4,5,6-hexachlorocyclohexane;naphthalen-1-yl n-methylcarbamate Chemical group ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl.C1=CC=C2C(OC(=O)NC)=CC=CC2=C1 ZITFWUUYPONCCK-UHFFFAOYSA-N 0.000 abstract 7
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 6
- -1 MONO- O Chemical class 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 108091005482 5-HT4 receptors Proteins 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical compound [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Paper (AREA)
- Luminescent Compositions (AREA)
Abstract
LAS INDAZOLCARBOXAMIDAS SE USAN COMO ANTAGONISTAS Y AGONISTAS PARCIALES DEL RECEPTOR DE LA SEROTONINA 5-HT4 Y PROPORCIONAN METODOS TERAPEUTICOS PARA EL TRATAMIENTO DE LOS DESORDENES CAUSADOS POR O AFECTADOS POR UNA DISFUNCION DEL RECEPTOR 5-HT4. LAS INDAZOLCARBOXAMIDAS TIENEN POR FORMULA EN DONDE R ES HIDROGENO, C{SUB,1}-C{SUB,6} ALQUIL, C{SUB,3}-C{SUB,6} CICLOALQUIL; R{SUP,1} ES HIDROGENO, HALO, C{SUB,1}-C{SUB,4} ALQUIL, HIDROXI, C{SUB,1}-C{SUB,4} ALCOXI O ALQUILTIO, CIANO, TRIFLUOROMETIL, CARBOXAMIDO, MONO- O DI(C{SUB,1}-C{SUB,4} ALQUIL)CARBOXAMIDO; M, N Y O SON INDEPENDIENTEMENTE 0-5, DE MODO QUE LA SUMA DE M,N Y O SEA 2-5; R{SUP,2} ES HIDROGENO O C{SUB,1}-C{SUB,4} ALQUIL; R{SUP,3} Y R{SUP,4} SE COMBINAN JUNTO CON EL ATOMO DE NITROGENO AL CUAL ESTAN ADHERIDOS PARA FORMAR 1-PIRROLIDINIL, 1PIPERAZINIL, 1,2,3,4 TETRAHIDRO-2-ISOQUINOLINIL, 2,3-DIHIDRO-1INDOLINIL, 4-MORFOLINIL, 1-PIPERIDINIL O 1-HEXAMETILENIMINIL, SUSTITUIDO CON FENIL, NAFTIL, (FENIL O NAFTIL) (C{SUB,1}-C{SUB,3} ALQUIL), (FENIL O NAFTIL) (C{SUB,1}-C{SUB,3} ALCANOIL), AMINO, MONO- O DI(C{SUB,1}-C{SUB,4} ALQUIL)AMINO O UN GRUPO DE LA FORMULA -NH-Y-R{SUP,5}; CON TAL QUE UN GRUPO PIPERAZINIL O MORFOLINIL NO PUEDA SER SUSTITUIDO CON AMINO, MONOO DI(C{SUB,1}-C{SUB,4} ALQUIL)AMINO O -NH-Y-R{SUP,5}; EN DONDE UN GRUPO FENIL O NAFTIL ES SUSTITUIDO O NO SUSTITUIDO CON 1-3 HALO, C{SUB,1}-C{SUB,3} ALQUIL O GRUPOS C{SUB,1}-C{SUB,3} DE ALCOXI; Y ES CARBONIL, SULFONIL, AMINOCARBONIL U OXICARBONIL; R{SUP,5} ES C{SUB,1}-C{SUB,6} ALQUIL, C{SUB,3}-C{SUB,8} CICLOALQUIL, C{SUB,6}-C{SUB,11} BICICLO- O TRICICLOALQUIL, (FENIL O NAFTIL) (C{SUB,1}-C{SUB,3} ALQUIL), FENIL O NAFTIL; EN DONDE UN GRUPO CICLOALQUIL, BICICLO- O TRICICLOALQUIL, FENIL O NAFTIL ES SUSTITUIDO O NO SUSTITUIDO CON GRUPOS DE 1-3 HIDROXI, HALO, C{SUB,1}-C{SUB,3} ALQUIL O C{SUB,1}-C{SUB,3} ALCOXI; O SALES DE ELLAS FARMACEUTICAMENTE ACEPTABLES.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40511995A | 1995-03-16 | 1995-03-16 | |
| US08/485,956 US5654320A (en) | 1995-03-16 | 1995-06-07 | Indazolecarboxamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2159345T3 true ES2159345T3 (es) | 2001-10-01 |
Family
ID=27018928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96301682T Expired - Lifetime ES2159345T3 (es) | 1995-03-16 | 1996-03-12 | Indazolcarboxamidas. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US5798367A (es) |
| EP (1) | EP0732333B1 (es) |
| JP (1) | JPH11502230A (es) |
| CN (1) | CN1112923C (es) |
| AT (1) | ATE203748T1 (es) |
| AU (1) | AU700842B2 (es) |
| BR (1) | BR9608223A (es) |
| CA (1) | CA2215359A1 (es) |
| DE (1) | DE69614164T2 (es) |
| DK (1) | DK0732333T3 (es) |
| EA (1) | EA000699B1 (es) |
| ES (1) | ES2159345T3 (es) |
| GR (1) | GR3037029T3 (es) |
| HU (1) | HU223973B1 (es) |
| IL (1) | IL117438A (es) |
| NO (1) | NO312833B1 (es) |
| NZ (1) | NZ315971A (es) |
| PL (1) | PL183867B1 (es) |
| PT (1) | PT732333E (es) |
| RO (1) | RO119617B1 (es) |
| SK (1) | SK283924B6 (es) |
| TR (1) | TR199700956T1 (es) |
| WO (1) | WO1996033713A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1291569B1 (it) * | 1997-04-15 | 1999-01-11 | Angelini Ricerche Spa | Indazolammidi come agenti serotoninergici |
| US5914405A (en) * | 1997-10-07 | 1999-06-22 | Eli Lilly And Company | Process for preparing 3-substituted indazoles |
| US6069152A (en) * | 1997-10-07 | 2000-05-30 | Eli Lilly And Company | 5-HT4 agonists and antagonists |
| ID28510A (id) * | 1998-08-21 | 2001-05-31 | Novartis Ag | Formulasi oral yang baru untuk agonis atau antagonis 5-ht4 |
| JP3366323B2 (ja) | 1998-09-10 | 2003-01-14 | エフ．ホフマン−ラ ロシュ アーゲー | ５−ｈｔ４受容体アンタゴニストとしてのジヒドロベンゾジオキシンカルボキサミド及びケトン誘導体 |
| AU2001270304A1 (en) | 2000-07-07 | 2002-01-21 | The Administrators Of The Tulane Educational Fund | Methods for protection of stratified squamous epithelium against injury by noxious substances and novel agents for use therefor |
| MXPA03001210A (es) * | 2000-08-07 | 2004-08-12 | Smithkline Beecham Corp | Uso de antagonista del receptor 5-ht4 en la fabricacion de un medicamento para la profilaxis o tratamiento de fibrilacion atrial. |
| EP1321142A1 (en) * | 2001-12-21 | 2003-06-25 | Novartis AG | Solid pharmaceutical composition for oral administration of Tegaserod |
| ATE401072T1 (de) * | 2002-02-12 | 2008-08-15 | Organon Nv | 1-arylsulfonyl-3-substituierte indol und indolinederivate verwendbar zur behandlung von erkrankungen des zentralnervensystem |
| ITMI20030287A1 (it) * | 2003-02-18 | 2004-08-19 | Acraf | Indazolammidi dotate di attivita' analgesica metodo, per |
| ITMI20031468A1 (it) * | 2003-07-18 | 2005-01-19 | Acraf | Farmaco ativo nel dolore neuropatico |
| ITMI20031467A1 (it) * | 2003-07-18 | 2005-01-19 | Acraf | Farmaco attivo nel dolore neuropatico |
| SE0401969D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Piperidine derivatives |
| WO2007010390A1 (en) * | 2005-07-22 | 2007-01-25 | Pfizer Japan Inc. | Indazolecarboxamide derivatives as 5ht4 receptor agonists |
| WO2009106980A2 (en) * | 2008-02-29 | 2009-09-03 | Pfizer Inc. | Indazole derivatives |
| GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
| CN119997982A (zh) | 2022-09-09 | 2025-05-13 | 迈里克斯制药有限公司 | 包含nmt抑制剂的抗体药物偶联物及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3145215A (en) * | 1961-12-19 | 1964-08-18 | Sterling Drug Inc | Indazole derivatives |
| JP2795460B2 (ja) * | 1988-06-20 | 1998-09-10 | 協和醗酵工業株式会社 | ピラゾロアクリドン誘導体 |
| NZ230068A (en) * | 1988-07-29 | 1991-07-26 | Dainippon Pharmaceutical Co | Indazole-3-carboxylic acid esters and amides of diaza compounds having 6,7, or 8 ring members: preparatory processes and pharmaceutical compositions |
| EP0410509A1 (en) * | 1989-07-25 | 1991-01-30 | Duphar International Research B.V | New substituted 1H-indazole-3-carboxamides |
| HU211081B (en) * | 1990-12-18 | 1995-10-30 | Sandoz Ag | Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same |
| NZ243993A (en) * | 1991-08-20 | 1994-10-26 | Smithkline Beecham Plc | Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity |
| WO1993005040A1 (en) * | 1991-09-12 | 1993-03-18 | Smithkline Beecham Plc | Azabicyclic compounds as 5-ht4 receptor antagonists |
| US5763459A (en) * | 1992-05-23 | 1998-06-09 | Smithkline Beecham P.L.C. | Medicaments for the treatment of anxiety |
| JPH07508276A (ja) * | 1992-06-27 | 1995-09-14 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５−ｈｔ↓４受容体アンタゴニスト含有医薬品 |
| MX9305947A (es) * | 1992-09-29 | 1994-06-30 | Smithkline Beecham Plc | Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen. |
| TW251287B (es) * | 1993-04-30 | 1995-07-11 | Nissei Co Ltd | |
| GB9310582D0 (en) * | 1993-05-22 | 1993-07-07 | Smithkline Beecham Plc | Pharmaceuticals |
-
1996
- 1996-03-11 IL IL11743896A patent/IL117438A/en active IP Right Grant
- 1996-03-12 ES ES96301682T patent/ES2159345T3/es not_active Expired - Lifetime
- 1996-03-12 PT PT96301682T patent/PT732333E/pt unknown
- 1996-03-12 EP EP96301682A patent/EP0732333B1/en not_active Expired - Lifetime
- 1996-03-12 DE DE69614164T patent/DE69614164T2/de not_active Expired - Fee Related
- 1996-03-12 DK DK96301682T patent/DK0732333T3/da active
- 1996-03-12 AT AT96301682T patent/ATE203748T1/de not_active IP Right Cessation
- 1996-03-14 BR BR9608223A patent/BR9608223A/pt not_active IP Right Cessation
- 1996-03-14 CA CA002215359A patent/CA2215359A1/en not_active Abandoned
- 1996-03-14 RO RO97-01719A patent/RO119617B1/ro unknown
- 1996-03-14 SK SK1242-97A patent/SK283924B6/sk unknown
- 1996-03-14 CN CN96193677A patent/CN1112923C/zh not_active Expired - Fee Related
- 1996-03-14 WO PCT/US1996/003551 patent/WO1996033713A1/en not_active Ceased
- 1996-03-14 AU AU68948/96A patent/AU700842B2/en not_active Ceased
- 1996-03-14 EA EA199700242A patent/EA000699B1/ru not_active IP Right Cessation
- 1996-03-14 NZ NZ315971A patent/NZ315971A/xx unknown
- 1996-03-14 PL PL96322362A patent/PL183867B1/pl not_active IP Right Cessation
- 1996-03-14 JP JP8528690A patent/JPH11502230A/ja not_active Ceased
- 1996-03-14 TR TR97/00956T patent/TR199700956T1/xx unknown
- 1996-03-14 HU HU9801386A patent/HU223973B1/hu not_active IP Right Cessation
-
1997
- 1997-01-10 US US08/781,421 patent/US5798367A/en not_active Expired - Fee Related
- 1997-01-10 US US08/782,478 patent/US5817676A/en not_active Expired - Fee Related
- 1997-09-12 NO NO19974221A patent/NO312833B1/no unknown
-
2001
- 2001-10-26 GR GR20010401899T patent/GR3037029T3/el not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2149215T3 (es) | Bencilaminoquinuclidinas sustituidas como antagonistas de la sustancia p. | |
| ES2121896T3 (es) | Derivados de acido hidroxamico como inhibidores de colagenasa. | |
| BR0313942A (pt) | Derivados de benzimidazol úteis como agentes antiproliferativos | |
| ES2128092T3 (es) | Derivados de anilina. | |
| CY1106674T1 (el) | Αζαδικυκλικοι ετεροκυκλοι σαν ρυθμιστες υποδοχεα κανναβινοειδους | |
| ES2115985T3 (es) | Dihidropirazolopirroles. | |
| EA200201277A1 (ru) | Замещенные бициклические производные для лечения аномального роста клеток | |
| YU30702A (sh) | Novi derivati benzoimidazola, korisni agensi protiv proliferacije | |
| ES2138977T3 (es) | Agonistas muscarinicos. | |
| RU95106649A (ru) | Производные бензимидазола в качестве непептидильных антагонистов рецепторов тахикинина, способ получения, фармацевтическая композиция | |
| ES2150567T3 (es) | Antagonistas del factor de liberacion de la corticotropina. | |
| NO990433L (no) | Nye forbindelser og blandinger for behandling av sykdommer i forbindelse med tryptase-aktivitet | |
| EA200100971A1 (ru) | Новые соединения и композиции в качестве ингибиторов протеазы | |
| CA2497868A1 (en) | Heterocyclic compounds | |
| ES2153491T3 (es) | Derivados de quinazolina. | |
| NO20012194D0 (no) | CRF-reseptorantagonister og tilhörende fremgangsmåter | |
| MX9304524A (es) | Nuevos derivados de indol y composiciones que los contienen. | |
| ES2117281T3 (es) | Nuevos analogos de la vitamina d. | |
| ES2101026T3 (es) | Derivados sulfatados de glicosaminoglicanoides. | |
| ES2123873T3 (es) | Pirrolocarbazol. | |
| CO4290299A1 (es) | Derivados de 1,5-benzodiazepina | |
| ES2111930T3 (es) | Antagonistas del acido amp y procedimientos de tratamiento con la ayuda de estos. | |
| EA199700242A1 (ru) | Индазолкарбоксамиды, способ их получения, фармкомпозиция и способ ингибирования 5-нтрецептора | |
| ES2029879T3 (es) | Procedimiento para producir derivados de aminas sustituidas. | |
| ES2179218T3 (es) | Derivados de pirroloacepina. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 732333 Country of ref document: ES |