DK0733207T3 - Fremgangsmåder til diagnose af allergi og screening af anti-allergi-terapeutika - Google Patents
Fremgangsmåder til diagnose af allergi og screening af anti-allergi-terapeutikaInfo
- Publication number
- DK0733207T3 DK0733207T3 DK95905357.0T DK95905357T DK0733207T3 DK 0733207 T3 DK0733207 T3 DK 0733207T3 DK 95905357 T DK95905357 T DK 95905357T DK 0733207 T3 DK0733207 T3 DK 0733207T3
- Authority
- DK
- Denmark
- Prior art keywords
- patient serum
- allergen
- pct
- host cells
- allergy
- Prior art date
Links
- 208000026935 allergic disease Diseases 0.000 title abstract 2
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 title 1
- 230000007815 allergy Effects 0.000 title 1
- 230000003266 anti-allergic effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000012216 screening Methods 0.000 title 1
- 210000002966 serum Anatomy 0.000 abstract 6
- 239000013566 allergen Substances 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 4
- 239000005557 antagonist Substances 0.000 abstract 3
- 230000000144 pharmacologic effect Effects 0.000 abstract 3
- 102000009438 IgE Receptors Human genes 0.000 abstract 1
- 108010073816 IgE Receptors Proteins 0.000 abstract 1
- 210000003651 basophil Anatomy 0.000 abstract 1
- 210000003630 histaminocyte Anatomy 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16543693A | 1993-12-10 | 1993-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0733207T3 true DK0733207T3 (da) | 1998-04-20 |
Family
ID=22598886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95905357.0T DK0733207T3 (da) | 1993-12-10 | 1994-12-09 | Fremgangsmåder til diagnose af allergi og screening af anti-allergi-terapeutika |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5714338A (da) |
| EP (1) | EP0733207B1 (da) |
| JP (1) | JP3507852B2 (da) |
| AT (1) | ATE157455T1 (da) |
| CA (1) | CA2176811C (da) |
| DE (1) | DE69405251T2 (da) |
| DK (1) | DK0733207T3 (da) |
| ES (1) | ES2108566T3 (da) |
| GR (1) | GR3025089T3 (da) |
| WO (1) | WO1995016203A2 (da) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9526599D0 (en) * | 1995-12-28 | 1996-02-28 | Sandoz Ltd | Elisa test system |
| DE19643427C1 (de) * | 1996-10-22 | 1998-02-12 | Bundesrep Deutschland | Verfahren zur Bestimmung von Allergenen in der Luft |
| US6165799A (en) * | 1996-12-10 | 2000-12-26 | Heska Corporation | Detection of anti-Fc.sub.ε R autoantibodies in asthmatics |
| US7122636B1 (en) * | 1997-02-21 | 2006-10-17 | Genentech, Inc. | Antibody fragment-polymer conjugates and uses of same |
| US6060326A (en) * | 1997-04-07 | 2000-05-09 | Heska Corporation | Method to detect canine IgE and kit therefor |
| FR2765341A1 (fr) * | 1997-06-25 | 1998-12-31 | Alain Funes | Methode pour l'analyse de l'activation des basophiles humains par mesure de l'expression membranaire du marqueur cd63 |
| AU1727500A (en) * | 1998-11-17 | 2000-06-05 | Tanox, Inc. | Bispecific molecules cross-linking itim and itam for therapy |
| WO2001051076A1 (en) * | 2000-01-14 | 2001-07-19 | Tanox, Inc. | ADMINISTERING IgE ANTAGONISTS DURING PREGNANCY TO AMELIORATE ALLERGIC DISEASES IN THE OFFSPRING |
| US6889145B1 (en) | 2000-03-15 | 2005-05-03 | Northwestern University | Three-dimensional model of a Fc region of an IgE antibody and uses thereof |
| RU2195666C2 (ru) * | 2000-09-13 | 2002-12-27 | Амурская государственная медицинская академия | Способ комплексной диагностики аллергии у детей с инфекционной патологией |
| EP1195606A1 (en) * | 2000-10-03 | 2002-04-10 | VBC-Genomics Forschungsges.m.b.H. | Allergen-microarray assay |
| DE10110838C2 (de) * | 2001-03-06 | 2003-04-03 | Mlu Halle Wittenberg | Verfahren zur Diagnostik von Allergien, Pseudoallergien und Intoleranzen |
| FR2831186B1 (fr) * | 2001-10-22 | 2004-06-18 | Aventis Pharma Sa | Production d'heparine a partir de cultures de mastocytes |
| AU2003210802B2 (en) | 2002-02-05 | 2009-09-10 | Genentech Inc. | Protein purification |
| CA2478925C (en) | 2002-04-26 | 2016-06-07 | Robert Lee Fahrner | Non-affinity purification of proteins |
| EP1648940B1 (en) | 2003-07-28 | 2016-04-27 | Genentech, Inc. | Reducing protein a leaching during protein a affinity chromatography |
| US7613619B1 (en) * | 2004-03-30 | 2009-11-03 | Harter Michael R | Method for identifying allergens and other influencing agents that may cause a reaction |
| WO2006028956A2 (en) * | 2004-09-02 | 2006-03-16 | Genentech, Inc. | Anti-fc-gamma riib receptor antibody and uses therefor |
| US7662926B2 (en) * | 2004-09-02 | 2010-02-16 | Genentech, Inc. | Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor |
| US7655229B2 (en) * | 2004-09-02 | 2010-02-02 | Chan Andrew C | Anti-FC-gamma RIIB receptor antibody and uses therefor |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| WO2006098612A1 (en) * | 2005-03-16 | 2006-09-21 | N.V. Nutricia | Method for determining an allergic response |
| JP2009509124A (ja) * | 2005-06-16 | 2009-03-05 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 大型のパラレルの免疫ベースのアレルギー試験および蛍光のエバネセント場励起のためのデバイス |
| US20080011058A1 (en) * | 2006-03-20 | 2008-01-17 | The Regents Of The University Of California | Piezoresistive cantilever based nanoflow and viscosity sensor for microchannels |
| FR2902799B1 (fr) | 2006-06-27 | 2012-10-26 | Millipore Corp | Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide |
| DK2087348T3 (da) * | 2006-12-01 | 2014-07-07 | Statens Seruminstitut | Analysemetode under brug af prøveadsorption på filterpapir |
| US8569464B2 (en) | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
| WO2008079280A1 (en) | 2006-12-21 | 2008-07-03 | Millipore Corporation | Purification of proteins |
| US8362217B2 (en) * | 2006-12-21 | 2013-01-29 | Emd Millipore Corporation | Purification of proteins |
| NZ577933A (en) | 2007-01-22 | 2011-12-22 | Genentech Inc | Polyelectrolyte precipitation and purification of antibodies |
| US8191403B2 (en) * | 2007-03-27 | 2012-06-05 | Richmond Chemical Corporation | Petroleum viscosity measurement and communication system and method |
| KR20190140090A (ko) | 2007-07-09 | 2019-12-18 | 제넨테크, 인크. | 폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지 |
| CN101889025B (zh) | 2007-10-30 | 2013-11-13 | 健泰科生物技术公司 | 通过阳离子交换层析进行的抗体纯化 |
| WO2009151514A1 (en) * | 2008-06-11 | 2009-12-17 | Millipore Corporation | Stirred tank bioreactor |
| MX2011001506A (es) | 2008-08-14 | 2011-03-15 | Genentech Inc | Metodos para eliminar un contaminante utilizado cromatografia de membrana de intercambio de ion en desplazamiento de proteina indigena. |
| BRPI0918978A2 (pt) | 2008-09-10 | 2015-12-01 | Genentech Inc | composições e métodos a prevenção da degradação oxidativa das proteínas |
| US20110020327A1 (en) * | 2008-12-16 | 2011-01-27 | Millipore Corporation | Purification of proteins |
| CN102257122B (zh) | 2008-12-16 | 2015-07-29 | Emd密理博公司 | 搅拌槽反应器及方法 |
| EP2400992B1 (en) | 2009-02-27 | 2015-07-22 | Genentech, Inc. | Methods and compositions for protein labelling |
| US10184937B2 (en) * | 2009-03-31 | 2019-01-22 | United Arab Emirates University | Minimally invasive assessment of IgE mediated allergy |
| DE102009030845A1 (de) * | 2009-06-26 | 2010-12-30 | Siemens Aktiengesellschaft | Verfahren und Kit zur Diagnose oder Prognose einer Kontrastmittelallergie |
| CN104059955A (zh) | 2009-08-11 | 2014-09-24 | 弗·哈夫曼-拉罗切有限公司 | 在无谷氨酰胺的细胞培养基中的蛋白质生产 |
| JP5787891B2 (ja) | 2009-09-01 | 2015-09-30 | ジェネンテック， インコーポレイテッド | 改変されたプロテインａ溶離による向上したタンパク質精製 |
| CN104998269B (zh) | 2010-03-22 | 2019-06-11 | 弗·哈夫曼-拉罗切有限公司 | 对于稳定含有蛋白质的制剂有用的组合物和方法 |
| KR20130060227A (ko) | 2010-05-03 | 2013-06-07 | 제넨테크, 인크. | 단백질-함유 제제의 점도 감소에 유용한 조성물 및 방법 |
| CN107312062B (zh) | 2010-05-17 | 2021-03-16 | Emd密理博公司 | 用于纯化生物分子的刺激响应性聚合物 |
| PL2576580T3 (pl) | 2010-05-28 | 2017-03-31 | F.Hoffmann-La Roche Ag | Zmniejszenie poziomu mleczanu i zwiększenie wytwarzania polipeptydu przez obniżenie poziomu ekspresji dehydrogenazy mleczanowej i kinazy dehydrogenazy pirogronianowej |
| SG186783A1 (en) | 2010-06-24 | 2013-02-28 | Genentech Inc | Compositions and methods containing alkylgycosides for stabilizing protein- containing formulations |
| RU2013110844A (ru) | 2010-08-13 | 2014-09-20 | Дженентек, Инк. | АНТИТЕЛА ПРОТИВ IL-1β И IL-18, ИСПОЛЬЗУЕМЫЕ ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ |
| WO2012030512A1 (en) | 2010-09-03 | 2012-03-08 | Percivia Llc. | Flow-through protein purification process |
| CN103649297B (zh) | 2011-07-08 | 2017-03-01 | Emd密理博公司 | 用于一次性生物技术方法的改良深层滤器 |
| RU2648999C2 (ru) | 2011-12-22 | 2018-03-29 | Дженентек, Инк. | Способы повышения эффективности этапов очистки белка, находящихся ниже по потоку, с использованием мембранной ионообменной хроматографии |
| AU2013240280A1 (en) | 2012-03-27 | 2014-10-16 | Genentech, Inc. | Improved harvest operations for recombinant proteins |
| NZ701915A (en) | 2012-05-18 | 2016-11-25 | Genentech Inc | High-concentration monoclonal antibody formulations |
| CN104994885B (zh) | 2012-12-19 | 2017-09-29 | 基因泰克公司 | 用于放射性卤素蛋白质标记的方法和组合物 |
| BR112017000142B1 (pt) | 2014-07-09 | 2021-08-17 | Genentech, Inc | Métodos para melhorar a recuperação por descongelamento de bancos de células e para congelamento de células cho para armazenamento, grupo de células cho para o congelamento de células de mamíferos, e banco de células |
| SG11201808562SA (en) | 2016-03-29 | 2018-10-30 | Geltor Inc | Expression of proteins in gram-negative bacteria wherein the ratio of periplasmic volume to cytoplasmic volume is between 0.5:1 and 10:1 |
| MX2019007433A (es) | 2016-12-22 | 2019-08-16 | Genentech Inc | Metodos y formulaciones para reducir el tiempo de reconstitucion de los polipeptidos liofilizados. |
| US11180541B2 (en) | 2017-09-28 | 2021-11-23 | Geltor, Inc. | Recombinant collagen and elastin molecules and uses thereof |
| EP3818078B1 (en) | 2018-07-03 | 2024-02-28 | Bristol-Myers Squibb Company | Methods of producing recombinant proteins |
| US12415980B2 (en) | 2018-10-10 | 2025-09-16 | Boehringer Ingelheim International Gmbh | Method for membrane gas transfer in high density bioreactor culture |
| BR112021019612A2 (pt) | 2019-04-01 | 2021-11-30 | Genentech Inc | Formulações, recipiente, artigo de fabricação, método para produzir a formulação e método para inibir a agregação de uma proteína presente em uma solução aquosa |
| KR20210151930A (ko) | 2019-04-12 | 2021-12-14 | 젤터, 인코포레이티드 | 재조합 엘라스틴 및 이의 제조 |
| JP2022543781A (ja) | 2019-08-01 | 2022-10-14 | ブリストル－マイヤーズ スクイブ カンパニー | フェッドバッチ細胞培養におけるタンパク質産生性の改良方法 |
| JP7808097B2 (ja) | 2020-09-22 | 2026-01-28 | ブリストル－マイヤーズ スクイブ カンパニー | 治療タンパク質を生産するための方法 |
| CN113495139A (zh) * | 2021-07-07 | 2021-10-12 | 上海清芮科技有限公司 | 一种宠物特应性体质的检测方法 |
| US20250115666A1 (en) | 2021-08-05 | 2025-04-10 | Bristol-Myers Squibb Company | Cell culture methods for producing therapeutic proteins |
| WO2023049687A1 (en) | 2021-09-21 | 2023-03-30 | Bristol-Myers Squibb Company | Methods of controlling the level of dissolved oxygen (do) in a solution comprising a recombinant protein in a storage container |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4559310A (en) * | 1983-05-20 | 1985-12-17 | Dana Farber Cancer Institute | Assay methods and systems utilizing mast cell clones |
| US4946788A (en) * | 1985-06-11 | 1990-08-07 | Ciba-Geigy Corporation | Purified immunoglobulin-related factor, novel monoclonal antibodies, hybridoma cell lines, processes and applications |
| DE3777245D1 (de) * | 1986-04-30 | 1992-04-16 | Junji Yodoi | Protein und verfahren zu dessen herstellung. |
| US5180805A (en) * | 1986-07-02 | 1993-01-19 | Research Corporation Limited | Polypeptide competitor for immunoglobulin E |
| GB8727045D0 (en) * | 1987-11-19 | 1987-12-23 | Research Corp Ltd | Immunoglobulin e competitor |
| US4962035A (en) * | 1987-12-01 | 1990-10-09 | President And Fellows Of Harvard College | DNA encoding IgE receptor alpha-subunit or fragment thereof |
| JPH03127997A (ja) * | 1989-10-11 | 1991-05-31 | Kuraray Co Ltd | ヒト１ｇＥ結合因子に特異的なモノクローン抗体、それを産生するハイブリドーマおよびその用途 |
| CA2059842A1 (en) * | 1991-02-11 | 1992-08-12 | Richard A. Chizzonite | Ige-receptor-antibodies |
| WO1993011437A1 (en) * | 1991-12-05 | 1993-06-10 | Board Of Regents Of The University Of Nebraska | Allergen specific immunoglobulin-e producer test for diagnosing allergies |
| GB9224956D0 (en) * | 1992-11-28 | 1993-01-20 | Euro Dpc Ltd | Improvements relating to allergen testing & apparatus |
-
1994
- 1994-12-09 DK DK95905357.0T patent/DK0733207T3/da active
- 1994-12-09 CA CA002176811A patent/CA2176811C/en not_active Expired - Lifetime
- 1994-12-09 DE DE69405251T patent/DE69405251T2/de not_active Expired - Lifetime
- 1994-12-09 WO PCT/US1994/014282 patent/WO1995016203A2/en not_active Ceased
- 1994-12-09 ES ES95905357T patent/ES2108566T3/es not_active Expired - Lifetime
- 1994-12-09 US US08/393,014 patent/US5714338A/en not_active Expired - Lifetime
- 1994-12-09 JP JP51638795A patent/JP3507852B2/ja not_active Expired - Lifetime
- 1994-12-09 AT AT95905357T patent/ATE157455T1/de active
- 1994-12-09 EP EP95905357A patent/EP0733207B1/en not_active Expired - Lifetime
-
1997
- 1997-10-20 GR GR970402730T patent/GR3025089T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0733207B1 (en) | 1997-08-27 |
| ES2108566T3 (es) | 1997-12-16 |
| WO1995016203A3 (en) | 1995-06-29 |
| WO1995016203A2 (en) | 1995-06-15 |
| GR3025089T3 (en) | 1998-01-30 |
| DE69405251D1 (de) | 1997-10-02 |
| EP0733207A1 (en) | 1996-09-25 |
| ATE157455T1 (de) | 1997-09-15 |
| CA2176811A1 (en) | 1995-06-15 |
| DE69405251T2 (de) | 1998-02-05 |
| CA2176811C (en) | 2008-01-29 |
| US5714338A (en) | 1998-02-03 |
| JP3507852B2 (ja) | 2004-03-15 |
| JPH09506435A (ja) | 1997-06-24 |
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