DK0736039T3 - Forbindelser med væksthormon-frigivende egenskaber - Google Patents
Forbindelser med væksthormon-frigivende egenskaberInfo
- Publication number
- DK0736039T3 DK0736039T3 DK95903774T DK95903774T DK0736039T3 DK 0736039 T3 DK0736039 T3 DK 0736039T3 DK 95903774 T DK95903774 T DK 95903774T DK 95903774 T DK95903774 T DK 95903774T DK 0736039 T3 DK0736039 T3 DK 0736039T3
- Authority
- DK
- Denmark
- Prior art keywords
- growth hormone
- compounds
- pct
- releasing properties
- date jun
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK143993A DK143993D0 (da) | 1993-12-23 | 1993-12-23 | |
| DK12194 | 1994-01-28 | ||
| DK119194 | 1994-10-14 | ||
| PCT/DK1994/000485 WO1995017423A1 (en) | 1993-12-23 | 1994-12-22 | Compounds with growth hormone releasing properties |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0736039T3 true DK0736039T3 (da) | 2001-02-12 |
Family
ID=27220421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95903774T DK0736039T3 (da) | 1993-12-23 | 1994-12-22 | Forbindelser med væksthormon-frigivende egenskaber |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5767085A (da) |
| EP (1) | EP0736039B1 (da) |
| JP (1) | JP3181918B2 (da) |
| KR (1) | KR100354897B1 (da) |
| CN (1) | CN1052731C (da) |
| AT (1) | ATE197158T1 (da) |
| AU (1) | AU689181B2 (da) |
| BR (1) | BR9408377A (da) |
| CA (1) | CA2179597A1 (da) |
| CZ (1) | CZ293113B6 (da) |
| DE (1) | DE69426206T2 (da) |
| DK (1) | DK0736039T3 (da) |
| ES (1) | ES2153469T3 (da) |
| FI (1) | FI962584A0 (da) |
| GR (1) | GR3035150T3 (da) |
| HU (1) | HU224345B1 (da) |
| IL (1) | IL112112A (da) |
| MX (1) | MX9500072A (da) |
| NO (1) | NO315561B1 (da) |
| NZ (1) | NZ277486A (da) |
| PL (1) | PL181280B1 (da) |
| PT (1) | PT736039E (da) |
| RO (1) | RO115635B1 (da) |
| SG (1) | SG55069A1 (da) |
| SK (1) | SK281963B6 (da) |
| UA (1) | UA42747C2 (da) |
| WO (1) | WO1995017423A1 (da) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995014666A1 (en) * | 1993-11-24 | 1995-06-01 | Merck & Co., Inc. | Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s) |
| US5854211A (en) * | 1993-12-23 | 1998-12-29 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US20020111461A1 (en) * | 1999-05-21 | 2002-08-15 | Todd C. Somers | Low molecular weight peptidomimetic growth hormone secretagogues |
| US5798337A (en) * | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
| MY113488A (en) * | 1995-01-27 | 2002-03-30 | Novo Nordisk As | Compounds with growth hormone releasing properties |
| HUP9802821A3 (en) * | 1995-06-22 | 2000-03-28 | Novo Nordisk As | Compounds with growth hormone releasing properties |
| WO1997022004A1 (en) | 1995-12-13 | 1997-06-19 | Merck & Co., Inc. | Assays for growth hormone secretagogue receptors |
| US6531314B1 (en) | 1996-12-10 | 2003-03-11 | Merck & Co., Inc. | Growth hormone secretagogue receptor family |
| GB2308362A (en) * | 1995-12-19 | 1997-06-25 | Lilly Industries Ltd | Pharmaceutical indole derivatives |
| AU715856B2 (en) * | 1995-12-22 | 2000-02-10 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US6451970B1 (en) | 1996-02-21 | 2002-09-17 | Novo Nordisk A/S | Peptide derivatives |
| US5919777A (en) * | 1996-04-24 | 1999-07-06 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| WO1997040023A1 (en) * | 1996-04-24 | 1997-10-30 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| EP1184370B1 (en) * | 1996-07-22 | 2005-09-14 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| AU3938797A (en) * | 1996-08-29 | 1998-03-19 | Novo Nordisk A/S | Transdermal delivery of peptides |
| US6121416A (en) * | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
| US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
| WO1998058950A1 (en) | 1997-06-20 | 1998-12-30 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US6127341A (en) * | 1997-06-20 | 2000-10-03 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| IL137007A0 (en) | 1998-01-16 | 2001-06-14 | Novo Nordisk As | Compounds with growth hormone releasing properties |
| US6919315B1 (en) | 1998-06-30 | 2005-07-19 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US6682908B1 (en) | 1998-07-10 | 2004-01-27 | Merck & Co., Inc. | Mouse growth hormone secretagogue receptor |
| WO2000002919A1 (en) | 1998-07-13 | 2000-01-20 | Merck & Co., Inc. | Growth hormone secretagogue related receptors and nucleic acids |
| JP2002522058A (ja) | 1998-08-10 | 2002-07-23 | メルク・アンド・カンパニー・インコーポレーテッド | イヌ成長ホルモン分泌促進物質受容体 |
| US6696063B1 (en) * | 1998-12-30 | 2004-02-24 | Applied Research Systems Ars Holding N.V. | Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy |
| AU762351B2 (en) | 1999-01-06 | 2003-06-26 | Genentech Inc. | Insulin-like growth factor (IGF) I mutant variants |
| KR100699404B1 (ko) | 1999-02-18 | 2007-03-23 | 가켄 세야쿠 가부시키가이샤 | 성장 호르몬 분비촉진제로서의 신규 아미드 유도체 |
| EP1200111A1 (en) * | 1999-06-04 | 2002-05-02 | Novo Nordisk A/S | Compositions for the treatment of the catabolic state of prolonged critical illness |
| AU2001263215A1 (en) | 2000-05-16 | 2001-11-26 | Genentech Inc. | Method for treating cartilage disorders |
| ATE446758T1 (de) | 2000-05-31 | 2009-11-15 | Pfizer Prod Inc | Verwendung von wachstumshormonsekretagoga zur förderung der beweglichkeit des verdauungstrakts |
| TWI331922B (en) | 2002-08-09 | 2010-10-21 | Ipsen Pharma Sas | Growth hormone releasing peptides |
| JP2007513065A (ja) * | 2003-05-19 | 2007-05-24 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 粒径が制御された酸化チタンを含むハードゼラチンカプセルおよびそれを製造する方法 |
| US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
| DK2274978T3 (da) | 2003-09-12 | 2015-06-15 | Ipsen Biopharmaceuticals Inc | Fremgangsmåder til behandling af en insulin-lignende vækstfaktor-I(IGF-I)-mangel |
| WO2005027913A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue |
| US20050261201A1 (en) * | 2004-03-30 | 2005-11-24 | Rejuvenon Corporation | Method of reducing C-reactive protein using growth hormone secretagogues |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| AU2005272598B2 (en) * | 2004-08-12 | 2011-11-17 | Helsinn Therapeutics (U.S.), Inc. | Method of stimulating the motility of the gastrointestinal system using growth hormone secretagogues |
| CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
| EP2021015A2 (en) * | 2006-04-28 | 2009-02-11 | The Administrators Of The Tulane Educational Fund | Ghrelin/growth hormone releasing peptide/growth hormone secretatogue receptor antagonists and uses thereof |
| ES2602789T3 (es) | 2007-02-09 | 2017-02-22 | Ocera Therapeutics, Inc. | Productos intermedios conectores para la síntesis de moduladores macrocíclicos del receptor de la grelina |
| KR20090112720A (ko) * | 2007-02-13 | 2009-10-28 | 헬신 세라퓨틱스 (유.에스.) 인크. | 성장 호르몬 분비촉진제를 이용한 세포 증식 질환의 치료방법 |
| TWI429436B (zh) * | 2007-04-10 | 2014-03-11 | Helsinn Therapeutics Us Inc | 使用生長激素促泌素治療或預防嘔吐之方法 |
| EP2155769B1 (en) | 2007-05-04 | 2012-06-27 | Katholieke Universiteit Leuven KU Leuven Research & Development | Tissue degeneration protection |
| US8466151B2 (en) | 2007-12-26 | 2013-06-18 | Critical Outcome Technologies, Inc. | Compounds and method for treatment of cancer |
| EP3023426A1 (en) | 2008-07-17 | 2016-05-25 | Critical Outcome Technologies, Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
| UA105657C2 (uk) | 2009-02-27 | 2014-06-10 | Хелсінн Терапьютікс (Ю.Ес.), Інк. | Поліпшені способи лікування мігрені на основі анамореліну |
| US9724381B2 (en) | 2009-05-12 | 2017-08-08 | The Administrators Of The Tulane Educational Fund | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| SG176717A1 (en) | 2009-06-12 | 2012-01-30 | Helsinn Therapeutics Us Inc | Ipamorelin diacetate injection and infusion solutions |
| WO2011120153A1 (en) | 2010-04-01 | 2011-10-06 | Critical Outcome Technologies Inc. | Compounds and method for treatment of hiv |
| WO2013190520A2 (en) | 2012-06-22 | 2013-12-27 | The General Hospital Corporation | Gh-releasing agents in the treatment of vascular stenosis and associated conditions |
| US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
| ES2864079T3 (es) | 2014-05-30 | 2021-10-13 | Pfizer | Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos |
| WO2017075535A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
| US12012467B2 (en) | 2017-03-28 | 2024-06-18 | Regents Of The University Of Michigan | Small molecule DCN1 inhibitors and therapeutic methods using the same |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
| CN119930744B (zh) * | 2025-01-20 | 2025-12-19 | 昆明理工大学 | 一种发酵马乳源小分子肽及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4223019A (en) * | 1979-03-30 | 1980-09-16 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| US4228156A (en) * | 1979-03-30 | 1980-10-14 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| US4223020A (en) * | 1979-03-30 | 1980-09-16 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| WO1983002272A1 (en) * | 1981-12-28 | 1983-07-07 | Beckman Instruments Inc | Synthetic peptides having pituitary growth hormone releasing activity |
| US4410512A (en) * | 1981-12-28 | 1983-10-18 | Beckman Instruments, Inc. | Combinations having synergistic pituitary growth hormone releasing activity |
| US4803261A (en) * | 1986-06-27 | 1989-02-07 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide |
| IL98910A0 (en) * | 1990-07-24 | 1992-07-15 | Polygen Holding Corp | Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them |
| US5663146A (en) * | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
| JPH08502250A (ja) * | 1992-09-25 | 1996-03-12 | スミスクライン・ビーチャム・コーポレイション | 成長ホルモン放出ペプチド |
| WO1995014666A1 (en) * | 1993-11-24 | 1995-06-01 | Merck & Co., Inc. | Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s) |
-
1994
- 1994-12-22 CA CA002179597A patent/CA2179597A1/en not_active Abandoned
- 1994-12-22 RO RO96-01293A patent/RO115635B1/ro unknown
- 1994-12-22 AT AT95903774T patent/ATE197158T1/de not_active IP Right Cessation
- 1994-12-22 SG SG1996004604A patent/SG55069A1/en unknown
- 1994-12-22 UA UA96062486A patent/UA42747C2/uk unknown
- 1994-12-22 DK DK95903774T patent/DK0736039T3/da active
- 1994-12-22 JP JP51710995A patent/JP3181918B2/ja not_active Expired - Lifetime
- 1994-12-22 CN CN94194590A patent/CN1052731C/zh not_active Expired - Fee Related
- 1994-12-22 PT PT95903774T patent/PT736039E/pt unknown
- 1994-12-22 PL PL94315113A patent/PL181280B1/pl not_active IP Right Cessation
- 1994-12-22 KR KR1019960703336A patent/KR100354897B1/ko not_active Expired - Fee Related
- 1994-12-22 CZ CZ19961834A patent/CZ293113B6/cs not_active IP Right Cessation
- 1994-12-22 HU HU9501947A patent/HU224345B1/hu not_active IP Right Cessation
- 1994-12-22 ES ES95903774T patent/ES2153469T3/es not_active Expired - Lifetime
- 1994-12-22 US US08/448,623 patent/US5767085A/en not_active Expired - Lifetime
- 1994-12-22 AU AU12724/95A patent/AU689181B2/en not_active Ceased
- 1994-12-22 EP EP95903774A patent/EP0736039B1/en not_active Expired - Lifetime
- 1994-12-22 WO PCT/DK1994/000485 patent/WO1995017423A1/en not_active Ceased
- 1994-12-22 IL IL11211294A patent/IL112112A/xx not_active IP Right Cessation
- 1994-12-22 FI FI962584A patent/FI962584A0/fi not_active IP Right Cessation
- 1994-12-22 BR BR9408377A patent/BR9408377A/pt not_active Application Discontinuation
- 1994-12-22 SK SK820-96A patent/SK281963B6/sk unknown
- 1994-12-22 DE DE69426206T patent/DE69426206T2/de not_active Expired - Lifetime
- 1994-12-22 NZ NZ277486A patent/NZ277486A/en unknown
-
1995
- 1995-01-02 MX MX9500072A patent/MX9500072A/es unknown
-
1996
- 1996-06-21 NO NO19962665A patent/NO315561B1/no not_active IP Right Cessation
-
2000
- 2000-12-27 GR GR20000402838T patent/GR3035150T3/el not_active IP Right Cessation
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