DK0739355T3 - Kallikrein-inhiberende "Kunitz-domæne"-proteiner og analoger deraf - Google Patents

Kallikrein-inhiberende "Kunitz-domæne"-proteiner og analoger deraf

Info

Publication number
DK0739355T3
DK0739355T3 DK95909223T DK95909223T DK0739355T3 DK 0739355 T3 DK0739355 T3 DK 0739355T3 DK 95909223 T DK95909223 T DK 95909223T DK 95909223 T DK95909223 T DK 95909223T DK 0739355 T3 DK0739355 T3 DK 0739355T3
Authority
DK
Denmark
Prior art keywords
proteins
kallikrein
analogs
inhibiting
disclosed
Prior art date
Application number
DK95909223T
Other languages
Danish (da)
English (en)
Inventor
Robert Charles Ladner
William Markland
Original Assignee
Dyax Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/208,264 external-priority patent/US6057287A/en
Application filed by Dyax Corp filed Critical Dyax Corp
Application granted granted Critical
Publication of DK0739355T3 publication Critical patent/DK0739355T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK95909223T 1994-01-11 1995-01-11 Kallikrein-inhiberende "Kunitz-domæne"-proteiner og analoger deraf DK0739355T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17996494A 1994-01-11 1994-01-11
US08/208,264 US6057287A (en) 1994-01-11 1994-03-10 Kallikrein-binding "Kunitz domain" proteins and analogues thereof
PCT/US1995/000299 WO1995021601A2 (fr) 1994-01-11 1995-01-11 Proteines de 'domaine de kunitz' a activite antikallikreine, et leurs analogues

Publications (1)

Publication Number Publication Date
DK0739355T3 true DK0739355T3 (da) 2005-01-24

Family

ID=26875859

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95909223T DK0739355T3 (da) 1994-01-11 1995-01-11 Kallikrein-inhiberende "Kunitz-domæne"-proteiner og analoger deraf

Country Status (10)

Country Link
US (3) US5795865A (fr)
EP (1) EP0739355B1 (fr)
JP (1) JP3805785B2 (fr)
AT (1) ATE275583T1 (fr)
CA (1) CA2180950C (fr)
DE (1) DE69533472T2 (fr)
DK (1) DK0739355T3 (fr)
ES (1) ES2227545T3 (fr)
PT (1) PT739355E (fr)
WO (1) WO1995021601A2 (fr)

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PT739355E (pt) * 1994-01-11 2005-01-31 Dyax Corp Proteinas de 'dominio de kunitz' inibidoras de calicreina e seus analogos
ES2229236T3 (es) 1994-01-11 2005-04-16 Dyax Corporation Inhibidores de la plasmina humana derivados de los dominios de kunitz.
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US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
IL126115A (en) 1996-03-11 2007-03-08 Aerovance Inc Significantly purified protein with suppressive activity for sirin protease and its pharmaceutical preparations
US20060025329A1 (en) * 1997-02-06 2006-02-02 Todd Hembrough Compositions and methods for inhibiting cellular proliferation comprising TFPI fragments
US6946439B2 (en) 1997-02-06 2005-09-20 Entre Med, Inc. Compositions and methods for inhibiting cellular proliferation comprising TFPI fragments
US5981471A (en) 1997-02-06 1999-11-09 Entremed, Inc. Compositions and methods for inhibiting cellular proliferation
WO1998051788A2 (fr) * 1997-05-12 1998-11-19 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Procede et construction pouvant inhiber une migration cellulaire
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US6544760B2 (en) 1999-12-22 2003-04-08 Zymogenetics, Inc. Kunitz domain polypeptide Zkun11
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US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
WO2003103475A2 (fr) 2002-06-07 2003-12-18 Dyax Corp. Prevention et reduction de la perte sanguine
JP2005537006A (ja) 2002-08-28 2005-12-08 ダイアックス、コープ 臓器及び組織の保存方法
DK1587907T3 (da) * 2003-01-07 2011-04-04 Dyax Corp Kunitz-domænebibliotek
US6989369B2 (en) * 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
CA2521410C (fr) 2003-04-04 2014-06-03 Universite De Lausanne Proteines inhibitrices d'une protease et leurs utilisations
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US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
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EP1835926A4 (fr) * 2004-11-22 2009-04-01 Dyax Corp Therapies inhibitrices de la plasmine
EP2500031A3 (fr) 2005-02-24 2012-12-26 Joslin Diabetes Center, Inc. Compositions et procédés de traitement de la perméabilité vasculaire
WO2007009069A2 (fr) * 2005-07-13 2007-01-18 Amgen Mountain View Inc. Production de proteines par lyse thermique
US20080090760A2 (en) * 2005-12-09 2008-04-17 Todd Hembrough Compositions and Methods for Inhibiting Cellular Proliferation
ES2431526T3 (es) * 2005-12-29 2013-11-26 The Regents Of The University Of California Office Of Technology Transfer Procedimientos y composiciones relacionadas con el dominio Kunitz I mutante de TFPI-2
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US7276480B1 (en) 2005-12-30 2007-10-02 Dyax Corp. Prevention and reduction of blood loss
US20070213275A1 (en) * 2006-03-10 2007-09-13 Dyax Corp. Formulations for ecallantide
EP2374472B9 (fr) * 2006-03-16 2019-06-12 Dyax Corp. Compositions et procédé de traitement de troubles ophtalmiques
DK1854477T3 (en) 2006-03-16 2016-11-28 Dyax Corp Peptide inhibitors of plasma kallikrein for use in the treatment of eye disorders
WO2008077478A1 (fr) * 2006-12-22 2008-07-03 Bayer Schering Pharma Aktiengesellschaft Préparation et utilisation de variants du domaine 2 de kunitz du gène de la bikunine placentaire humaine
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CA2695012A1 (fr) * 2007-08-23 2009-02-26 Genzyme Corporation Traitement avec des inhibiteurs de kallikreine
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CA2744235A1 (fr) 2009-01-06 2010-07-15 Dyax Corp. Traitement de la mucosite par des inhibiteurs de kallikreine
EP3459564B1 (fr) 2010-01-06 2021-10-27 Takeda Pharmaceutical Company Limited Protéines de liaison de kallicréine plasmatique
CA2823776A1 (fr) 2011-01-06 2012-07-12 Dyax Corp. Proteines se liant a la kallikreine plasmatique
EP2850095B1 (fr) 2012-05-17 2019-10-09 RA Pharmaceuticals, Inc. Inhibiteurs peptidiques et peptidomimétiques
WO2014113712A1 (fr) 2013-01-20 2014-07-24 Dyax Corp. Évaluation et traitement de troubles médiés par la bradykinine
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JP6757252B2 (ja) 2013-10-21 2020-09-16 ダイアックス コーポレーション 血漿カリクレイン系バイオマーカーを決定するためのアッセイ
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MX2021011110A (es) 2019-03-14 2022-01-19 Takeda Pharmaceuticals Co Tratamiento de ataque de angioedema hereditario con dosis reducida de anticuerpos que se unen a calicreína plasmática humana.
US12528880B2 (en) 2020-01-13 2026-01-20 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack
WO2021198534A1 (fr) 2020-04-04 2021-10-07 Oxurion NV Inhibiteurs de la kallicréine plasmique destinés à être utilisés dans le traitement d'une maladie à coronavirus
JP2023521667A (ja) 2020-04-04 2023-05-25 武田薬品工業株式会社 血漿カリクレイン阻害剤及び急性呼吸窮迫症候群を処置するためのその使用
WO2023144030A1 (fr) 2022-01-31 2023-08-03 Oxurion NV Thérapie par inhibiteur de la kallicréine plasmatique pour une sensibilisation aux anti-vegf
WO2023148016A1 (fr) 2022-02-04 2023-08-10 Oxurion NV Biomarqueur pour la réponse à une thérapie par inhibiteur de la kallicréine plasmatique
EP4548103A2 (fr) 2022-06-30 2025-05-07 Takeda Pharmaceutical Company Limited Biomarqueurs protéiques pour traitement au lanadelumab
WO2024069200A2 (fr) 2022-09-29 2024-04-04 Evolveritas Biotechnológiai Korlátolt Felelősségű Társaság Échafaudage protéique modifié et son utilisation

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PT739355E (pt) * 1994-01-11 2005-01-31 Dyax Corp Proteinas de 'dominio de kunitz' inibidoras de calicreina e seus analogos

Also Published As

Publication number Publication date
DE69533472T2 (de) 2006-01-12
CA2180950A1 (fr) 1995-08-17
US5795865A (en) 1998-08-18
DE69533472D1 (de) 2004-10-14
EP0739355B1 (fr) 2004-09-08
EP0739355A1 (fr) 1996-10-30
WO1995021601A3 (fr) 1995-09-21
JPH09511131A (ja) 1997-11-11
PT739355E (pt) 2005-01-31
US6333402B1 (en) 2001-12-25
JP3805785B2 (ja) 2006-08-09
ES2227545T3 (es) 2005-04-01
ATE275583T1 (de) 2004-09-15
US5994125A (en) 1999-11-30
WO1995021601A2 (fr) 1995-08-17
CA2180950C (fr) 2005-03-29

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