DK0747391T3 - Fremstilling af et acyleret proteinpulver - Google Patents

Fremstilling af et acyleret proteinpulver

Info

Publication number
DK0747391T3
DK0747391T3 DK96303974T DK96303974T DK0747391T3 DK 0747391 T3 DK0747391 T3 DK 0747391T3 DK 96303974 T DK96303974 T DK 96303974T DK 96303974 T DK96303974 T DK 96303974T DK 0747391 T3 DK0747391 T3 DK 0747391T3
Authority
DK
Denmark
Prior art keywords
protein
preparation
protein powder
acylated protein
acylated
Prior art date
Application number
DK96303974T
Other languages
Danish (da)
English (en)
Inventor
Jeffrey Clayton Baker
Brian A Moser
Warren E Schrader
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0747391T3 publication Critical patent/DK0747391T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK96303974T 1995-06-07 1996-05-31 Fremstilling af et acyleret proteinpulver DK0747391T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/484,220 US5700904A (en) 1995-06-07 1995-06-07 Preparation of an acylated protein powder

Publications (1)

Publication Number Publication Date
DK0747391T3 true DK0747391T3 (da) 2004-07-19

Family

ID=23923252

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96303974T DK0747391T3 (da) 1995-06-07 1996-05-31 Fremstilling af et acyleret proteinpulver

Country Status (21)

Country Link
US (1) US5700904A (2)
EP (1) EP0747391B1 (2)
JP (1) JP3844504B2 (2)
KR (1) KR19990022590A (2)
CN (1) CN1192218A (2)
AT (1) ATE263185T1 (2)
AU (1) AU703032B2 (2)
BR (1) BR9608729A (2)
CA (1) CA2223389A1 (2)
CZ (1) CZ388197A3 (2)
DE (1) DE69631996T2 (2)
DK (1) DK0747391T3 (2)
EA (1) EA199800042A1 (2)
ES (1) ES2216039T3 (2)
HU (1) HUP9900877A3 (2)
IL (1) IL122460A0 (2)
NO (1) NO975583D0 (2)
NZ (1) NZ309371A (2)
PL (1) PL323994A1 (2)
TR (1) TR199701528T1 (2)
WO (1) WO1996040730A1 (2)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9316895D0 (en) 1993-08-13 1993-09-29 Guy S And St Thomas Hospitals Hepatoselective insulin analogues
US5986050A (en) * 1996-12-26 1999-11-16 Poly-Med, Inc. Peracylated proteins and synthetic polypeptides and process for making the same
US5898067A (en) * 1997-02-07 1999-04-27 Novo Nordisk A/S Crystallization of proteins
ES2242270T3 (es) * 1997-02-07 2005-11-01 Novo Nordisk A/S Cristalizacion de proteinas.
US5898028A (en) * 1997-03-20 1999-04-27 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
US6310038B1 (en) * 1997-03-20 2001-10-30 Novo Nordisk A/S Pulmonary insulin crystals
ES2260832T3 (es) * 1997-03-20 2006-11-01 Novo Nordisk A/S Cristales de insulina desprovistos de zinc utilizados en composiciones pulmonares.
EA200000453A1 (ru) * 1997-10-24 2000-10-30 Эли Лилли Энд Компани Композиции нерастворимого инсулина
EP0911035A3 (en) * 1997-10-24 2002-08-21 Eli Lilly And Company Insoluble insulin compositions
ZA989744B (en) * 1997-10-31 2000-04-26 Lilly Co Eli Method for administering acylated insulin.
EP1396272A1 (en) * 1997-12-23 2004-03-10 Eli Lilly & Company Insoluble Insulin Compositions for Controlling Blood Glucose
US6531448B1 (en) * 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
US6526675B1 (en) * 1999-06-07 2003-03-04 Roe-Hoan Yoon Methods of using natural products as dewatering aids for fine particles
US6855260B1 (en) 1999-06-07 2005-02-15 Roe-Hoan Yoon Methods of enhancing fine particle dewatering
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6799682B1 (en) 2000-05-16 2004-10-05 Roe-Hoan Yoon Method of increasing flotation rate
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7166571B2 (en) 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
DE60302454T2 (de) * 2002-04-19 2006-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Beta-agonisten-verbindungen mit stickoxid-donatoren-gruppen und reaktionsfähige sauerstoffspezies-fängergruppen und ihre verwendung bei der behandlung von atemwegsstörungen
AU2003236521A1 (en) 2002-06-13 2003-12-31 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US20060247216A1 (en) * 2002-10-25 2006-11-02 Haj-Yehia Abdullah I Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
EP1617888B1 (en) 2003-04-23 2019-06-12 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration
BRPI0413018B8 (pt) 2003-07-30 2021-05-25 Rigel Pharmaceuticals Inc composto, e, uso de um composto
WO2006014425A1 (en) 2004-07-02 2006-02-09 Biovalve Technologies, Inc. Methods and devices for delivering glp-1 and uses thereof
BRPI0513508B1 (pt) 2004-07-19 2021-06-01 Biocon Limited Conjugados de insulina-oligômero, formulações e usos desses
US7686786B2 (en) 2004-10-21 2010-03-30 Novo Nordiks A/S Dial-down mechanism for wind-up pen
JP4022595B2 (ja) * 2004-10-26 2007-12-19 コニカミノルタオプト株式会社 撮影装置
US8007754B2 (en) 2005-02-04 2011-08-30 Mineral And Coal Technologies, Inc. Separation of diamond from gangue minerals
CN101163514B (zh) 2005-04-24 2012-01-25 诺和诺德公司 注射装置
WO2006133426A2 (en) 2005-06-08 2006-12-14 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
US20070203161A1 (en) * 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
US7741281B2 (en) * 2005-11-03 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
CA2642229C (en) 2006-02-24 2015-05-12 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
WO2007104636A1 (en) 2006-03-10 2007-09-20 Novo Nordisk A/S An injection device and a method of changing a cartridge in the device
WO2007104697A2 (en) 2006-03-10 2007-09-20 Novo Nordisk A/S An injection device having a gearing arrangement
EP2004671B1 (en) * 2006-03-30 2015-12-09 Novo Nordisk A/S Two-phase precipitation of proteins
CN103239773B (zh) 2006-03-30 2015-08-26 瓦莱里塔斯公司 多筒式流体递送器械
US7714025B2 (en) * 2006-05-10 2010-05-11 Arizona Biomedical Research Commission Modified chalcone compounds as antimitotic agents
ATE458517T1 (de) 2006-05-16 2010-03-15 Novo Nordisk As Getriebemechanismus für ein injektionsgerät
PL2023982T3 (pl) 2006-05-18 2012-11-30 Novo Nordisk As Urządzenie wstrzykujące ze środkami blokującymi
CA2681023C (en) 2007-03-23 2015-11-03 Novo Nordisk A/S An injection device comprising a locking nut
JP5868594B2 (ja) 2007-10-16 2016-02-24 バイオコン・リミテッドＢｉｏｃｏｎ Ｌｉｍｉｔｅｄ 経口投与可能な固形医薬組成物及びそのプロセス
PL2565193T3 (pl) 2009-01-23 2014-07-31 Rigel Pharmaceuticals Inc Kompozycje i sposoby hamowania szlaku JAK
BR112012012945A2 (pt) 2009-11-25 2020-12-29 Arisgen Sa Composição de liberação mucosal, seu método de produção, complexo de peptídeo pré-formado, kit e uso de um agente ativo de peptídeo
AU2011282742B2 (en) 2010-07-28 2015-08-27 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway
CN103998077B (zh) 2011-12-29 2017-05-31 诺沃—诺迪斯克有限公司 具有向上拨动/向下拨动定量机构的基于扭力弹簧的卷紧自动注射器笔
CA2865504A1 (en) 2012-03-23 2013-09-26 Oxigene, Inc. Compositions and methods for inhibition of cathepsins
US11206846B2 (en) * 2017-05-02 2021-12-28 Leprino Foods Company High purity alpha lactalbumin and methods of making
JP7213254B2 (ja) 2017-09-26 2023-01-26 バイオコン バイオロジックス インディア リミテッド ペプチド結晶の分離、洗浄および乾燥のための統合され、自動化された濾過
US20220000880A1 (en) 2018-11-01 2022-01-06 Rigel Pharmaceuticals, Inc. Method and composition embodiments for treating acute myeloid leukemia
US20200377518A1 (en) 2019-05-29 2020-12-03 Rigel Pharmaceuticals, Inc. Method of preventing and treating thrombosis
BR112022001418A2 (pt) 2019-08-08 2022-06-07 Rigel Pharmaceuticals Inc Compostos e método para tratar a síndrome de liberação de citocinas
ES2970382T3 (es) 2019-08-14 2024-05-28 Rigel Pharmaceuticals Inc Método para bloquear o mejorar el síndrome de liberación de citocinas
JP2025513716A (ja) 2022-03-23 2025-04-30 ライジェル・ファーマシューティカルズ・インコーポレイテッド Ｉｒａｋ阻害剤としてのピリミド－２－イル－ピラゾール化合物

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1468831A (fr) * 1965-10-05 1967-02-10 Roussel Uclaf Procédé de préparation de nouveaux composés polypeptidiques et produits en résultant
DE1902865A1 (de) * 1968-02-01 1969-09-11 American Home Prod Substituierte Insulin-Derivate,Verfahren zu ihrer Herstellung und ihre Verwendung in pharmazeutischen Zubereitungen
US3591574A (en) * 1968-05-29 1971-07-06 American Home Prod Tri-n-phenylglycyl derivatives of insulin
US3528960A (en) * 1968-10-07 1970-09-15 Lilly Co Eli N-carboxyaroyl insulins
US3823125A (en) * 1969-10-14 1974-07-09 American Home Prod N-aminoacyl-substituted insulins
US3752798A (en) * 1969-12-02 1973-08-14 G Amird Tris-na1,nb1,nepsilonb29 - (3-x-3-oxo - 1-y-prop-1-en-1-yl)(ndelta-(4-z-6-r-pyrimidin - 2 - yl) ornithine b22)-insulins and their preparation
US3950517A (en) * 1970-05-08 1976-04-13 National Research Development Corporation Insulin derivatives
US3869437A (en) * 1970-05-08 1975-03-04 Nat Res Dev Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin
GB1381274A (en) * 1971-01-28 1975-01-22 Nat Res Dev Insulin derivatives
GB1381273A (en) * 1971-01-28 1975-01-22 Nat Res Dev Insulin derivatives
US3864325A (en) * 1971-11-18 1975-02-04 Nat Res Dev (N{HU Al{b , N{HU Bl{b , N{HU B29{B , carbamoyl)-(O{HU A14{B , O{HU B16{B , O{HU B26{B aryl) insulin derivatives
BE791949A (fr) * 1971-11-27 1973-05-28 Schering Ag Derives d'insuline, leur preparation et leur utilisation
US3843815A (en) * 1972-02-10 1974-10-22 Gen Foods Corp Inhibiting gel formation in meat-in-gravy products
US3755569A (en) * 1972-07-25 1973-08-28 American Home Prod Acyl substituted insulins
DE2252157C3 (de) * 1972-10-25 1976-03-18 Hoechst Ag Zwischenprodukte zur herstellung von insulin, insulin-analogen und -derivaten und verfahren zur herstellung von insulin, insulin analogen und derivaten
NL7314766A (2) * 1972-10-31 1974-05-02
DE2253327A1 (de) * 1972-10-31 1974-05-09 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
DE2428412A1 (de) * 1974-06-12 1976-01-15 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
DE2439296A1 (de) * 1974-08-16 1976-02-26 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
GB1492997A (en) * 1976-07-21 1977-11-23 Nat Res Dev Insulin derivatives
EP0014815A3 (de) * 1978-12-20 1980-10-29 Ciba-Geigy Ag Peptidderivate, Verfahren zu deren Herstellung und Zwischenprodukte sowie pharmazeutische Präparate mit einer dieser Verbindungen
US4486458A (en) * 1982-09-07 1984-12-04 A. E. Staley Manufacturing Company Non-gelling corn steep liquor
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
JPS6255096A (ja) * 1986-06-12 1987-03-10 Nippon Shinyaku Co Ltd 新規な脂肪酸アシル化合物
JPH01254699A (ja) * 1988-04-05 1989-10-11 Kodama Kk インスリン誘導体及びその用途
PT93057B (pt) * 1989-02-09 1995-12-29 Lilly Co Eli Processo para a preparacao de analogos da insulina
WO1992001476A1 (en) * 1990-07-26 1992-02-06 University Of Iowa Research Foundation Novel drug delivery systems for proteins and peptides using albumin as a carrier molecule
US5304473A (en) * 1991-06-11 1994-04-19 Eli Lilly And Company A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
WO1994012530A1 (en) * 1992-11-30 1994-06-09 Biosignal Kutató Fejlesztó Kft. Polyunsaturated fatty acyl-peptide composition

Also Published As

Publication number Publication date
HUP9900877A3 (en) 1999-11-29
JPH11506738A (ja) 1999-06-15
DE69631996D1 (de) 2004-05-06
NO975583L (no) 1997-12-03
EP0747391A2 (en) 1996-12-11
WO1996040730A1 (en) 1996-12-19
ATE263185T1 (de) 2004-04-15
IL122460A0 (en) 1998-06-15
JP3844504B2 (ja) 2006-11-15
AU5951396A (en) 1996-12-30
HUP9900877A2 (hu) 1999-07-28
ES2216039T3 (es) 2004-10-16
PL323994A1 (en) 1998-04-27
CA2223389A1 (en) 1996-12-19
DE69631996T2 (de) 2005-01-27
EA199800042A1 (ru) 1998-08-27
AU703032B2 (en) 1999-03-11
NO975583D0 (no) 1997-12-03
KR19990022590A (ko) 1999-03-25
EP0747391A3 (en) 1997-05-21
NZ309371A (en) 1999-09-29
TR199701528T1 (xx) 1998-03-21
US5700904A (en) 1997-12-23
CN1192218A (zh) 1998-09-02
CZ388197A3 (cs) 1998-05-13
EP0747391B1 (en) 2004-03-31
MX9709657A (es) 1998-07-31
BR9608729A (pt) 1999-06-29

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