DK0782448T3 - Ikke-irriterende, ikke-sensibiliserende, ikke-ototoksiske antibakterielle ørepræparater - Google Patents

Ikke-irriterende, ikke-sensibiliserende, ikke-ototoksiske antibakterielle ørepræparater

Info

Publication number: DK0782448T3
Authority: DK; Denmark
Prior art keywords: amount effective; ototoxic; sensitizing; irritating; composition
Prior art date: 1995-06-06

Application number

DK96917172T

Other languages

Danish (da)

English (en)

Inventor

Shivaji Purwar

David Goldman

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-06

Filing date

1996-06-05

Publication date

2002-07-08

1996-06-05 Application filed by Bayer Ag filed Critical Bayer Ag

2002-07-08 Application granted granted Critical

2002-07-08 Publication of DK0782448T3 publication Critical patent/DK0782448T3/da

Links

230000000844 anti-bacterial effect Effects 0.000 title abstract 3
231100001200 nonototoxic Toxicity 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
231100000344 non-irritating Toxicity 0.000 title 1
230000001235 sensitizing effect Effects 0.000 title 1
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 4
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 3
MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 abstract 2
229960000890 hydrocortisone Drugs 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
229920001213 Polysorbate 20 Polymers 0.000 abstract 1
239000004372 Polyvinyl alcohol Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
235000019445 benzyl alcohol Nutrition 0.000 abstract 1
229960003405 ciprofloxacin Drugs 0.000 abstract 1
239000000470 constituent Substances 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
230000002209 hydrophobic effect Effects 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
235000010445 lecithin Nutrition 0.000 abstract 1
239000000787 lecithin Substances 0.000 abstract 1
229940067606 lecithin Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 abstract 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 abstract 1
229920000136 polysorbate Polymers 0.000 abstract 1
229950008882 polysorbate Drugs 0.000 abstract 1
229940068977 polysorbate 20 Drugs 0.000 abstract 1
229920002451 polyvinyl alcohol Polymers 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1
239000000725 suspension Substances 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Dermatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Dispersion Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Inorganic Chemistry (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Endoscopes (AREA)

DK96917172T 1995-06-06 1996-06-05 Ikke-irriterende, ikke-sensibiliserende, ikke-ototoksiske antibakterielle ørepræparater DK0782448T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US46504895A	1995-06-06	1995-06-06
PCT/US1996/008864 WO1996039146A1 (en)	1995-06-06	1996-06-05	Non-irritation, non-sensitizing, non-ototoxic otic antibacterial compositions

Publications (1)

Publication Number	Publication Date
DK0782448T3 true DK0782448T3 (da)	2002-07-08

Family

ID=23846298

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96917172T DK0782448T3 (da)	1995-06-06	1996-06-05	Ikke-irriterende, ikke-sensibiliserende, ikke-ototoksiske antibakterielle ørepræparater

Country Status (16)

Country	Link
US (1)	US5965549A (de)
EP (1)	EP0782448B1 (de)
CN (1)	CN1137685C (de)
AT (1)	ATE214931T1 (de)
AU (1)	AU708540B2 (de)
CA (1)	CA2199294C (de)
DE (1)	DE69620136T2 (de)
DK (1)	DK0782448T3 (de)
ES (1)	ES2173287T3 (de)
IL (1)	IL120317A (de)
MX (1)	MX9701731A (de)
NZ (1)	NZ309624A (de)
PT (1)	PT782448E (de)
TW (1)	TW464499B (de)
WO (1)	WO1996039146A1 (de)
ZA (1)	ZA964653B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR020661A1 (es) *	1998-09-30	2002-05-22	Alcon Lab Inc	Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento
US6716830B2 (en)	1998-09-30	2004-04-06	Alcon, Inc.	Ophthalmic antibiotic compositions containing moxifloxacin
US6509327B1 (en)	1998-09-30	2003-01-21	Alcon Manufacturing, Ltd.	Compositions and methods for treating otic, ophthalmic and nasal infections
US6395746B1 (en)	1998-09-30	2002-05-28	Alcon Manufacturing, Ltd.	Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
CA2344050A1 (en) *	1998-09-30	2000-04-06	Alcon Laboratories, Inc.	Antibiotic compositions for treatment of the eye, ear and nose
US6500360B2 (en) *	1999-06-18	2002-12-31	Bernard Bendiner	Sorbic acid and/or its derivatives, such as potassium sorbate, as a preventative for rust, corrosion and scale on metal surfaces
US7064132B2 (en) *	1999-11-28	2006-06-20	Scientific Development And Research, Inc.	Composition and method for treatment of otitis external
US6156294A (en)	1999-11-28	2000-12-05	Scientific Development And Research, Inc.	Composition and method for treatment of otitis media
ES2160090B1 (es) *	2000-03-16	2002-07-01	Vita Invest Sa	Composiciones acuosas de ciprofloxacino, contenidas en envases monodosis y su utilizacion.
US6462033B2 (en)	2000-07-26	2002-10-08	Alcon Universal Ltd.	Process for manufacturing compositions containing ciprofloxacin and hydrocortisone
HUP0303696A3 (en)	2000-09-25	2005-05-30	Bayer Healthcare Llc Tarrytown	Otic microbial combinations for treatment of animals with ruptured tympanic membrane
RU2295346C2 (ru)	2001-09-21	2007-03-20	Алькон, Инк.	Способ лечения инфекций среднего уха
US7718189B2 (en)	2002-10-29	2010-05-18	Transave, Inc.	Sustained release of antiinfectives
US20040101506A1 (en) *	2002-11-25	2004-05-27	Fust Charles A.	Composition for the prevention and treatment of inflammation of the ear
US7842791B2 (en)	2002-12-19	2010-11-30	Nancy Jean Britten	Dispersible pharmaceutical compositions
PL1608407T3 (pl) *	2003-03-20	2006-12-29	Pharmacia Corp	Dyspergowana kompozycja środka przeciw-zapalnego
US20050009931A1 (en) *	2003-03-20	2005-01-13	Britten Nancy Jean	Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
US20040214753A1 (en) *	2003-03-20	2004-10-28	Britten Nancy Jean	Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
US20050004098A1 (en) *	2003-03-20	2005-01-06	Britten Nancy Jean	Dispersible formulation of an anti-inflammatory agent
JP2007500692A (ja) *	2003-07-31	2007-01-18	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	乳房炎及び耳障害を治療するための分散性医薬組成物
RU2319508C2 (ru) *	2003-07-31	2008-03-20	ФАРМАЦИЯ ЭНД АПДЖОН КОМПАНИ ЭлЭлСи	Диспергируемый препарат противовоспалительного агента
US8940321B2 (en)	2003-12-12	2015-01-27	Otic Pharma Ltd.	Compositions for treatment of ear disorders and methods of use thereof
WO2005055921A2 (en)	2003-12-12	2005-06-23	Eran Eilat	Compositions for treatment of ear disorders and methods of use thereof
US20060019987A1 (en) *	2004-07-23	2006-01-26	Fust Charles A	Methods and compositions for inhibiting, destroying, and/or inactivating viruses
HUE029994T2 (en)	2005-12-08	2017-04-28	Insmed Inc	Lipid-based compositions of antiinfectives for treating pulmonary infections
WO2008137717A1 (en)	2007-05-04	2008-11-13	Transave, Inc.	Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
US9114081B2 (en)	2007-05-07	2015-08-25	Insmed Incorporated	Methods of treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en)	2007-05-07	2015-09-01	Insmed Incorporated	Method of treating pulmonary disorders with liposomal amikacin formulations
UA111147C2 (uk) *	2009-11-11	2016-04-11	Байєр Б.В.	Способи та композиції для лікування або профілактики зовнішнього отиту
ES2391721T3 (es)	2010-03-01	2012-11-29	Laboratorios Salvat, S.A.	Disoluciones acuosas transparentes de acetónido de fluocinolona para el tratamiento de la infamación de oído
HU227743B1 (en) *	2011-07-22	2012-02-28	Debreceni Egyetem	Eardrop composition and process for producing this
BR112014013564A8 (pt) *	2011-12-09	2017-06-13	Lupin Ltd	composição farmacêutica tópica destinada à aplicação ao olho, ouvido ou nariz
RU2018135921A (ru)	2012-11-29	2019-02-05	Инсмед Инкорпорейтед	Стабилизированные составы ванкомицина
SMT202000516T1 (it)	2014-05-15	2020-11-10	Insmed Inc	Metodi per trattamento di infezioni micobatteriche polmonati non tubercolari
US9393243B1 (en)	2015-07-14	2016-07-19	Nilesh Parikh	Topical Ciprofloxacin compositions
EP3773505B1 (de)	2018-03-30	2026-04-29	Insmed Incorporated	Verfahren zur kontinuierlichen herstellung von liposomalen arzneimittelprodukten
WO2019213398A1 (en)	2018-05-02	2019-11-07	Insmed Incorporated	Methods for the manufacture of liposomal drug formulations

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4025620A (en) *	1975-10-22	1977-05-24	Leo Pharmaceutical Products Ltd., A/S	Treatment of canine otitis and composition therefor
US4670444B1 (en) *	1980-09-03	1999-02-09	Bayer Ag	and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds
ATE34720T1 (de) *	1983-03-31	1988-06-15	Payne Packaging Ltd	Streifen.
DE3537761A1 (de) *	1985-10-24	1987-04-30	Bayer Ag	Infusionsloesungen der 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-chinolin-3-carbonsaeure
DE3704907A1 (de) *	1987-02-17	1988-08-25	Bayer Ag	Topisch anwendbare zubereitungen von gyrase-inhibitoren in kombination mit kortikosteroiden
DE3902079A1 (de) *	1988-04-15	1989-10-26	Bayer Ag	I.m. injektionsformen von gyrase-inhibitoren
US5061729A (en) *	1988-06-08	1991-10-29	Biogal Gyogyszergyar	Pharmaceutical composition and process for preparing the same
US5271939A (en) *	1988-10-03	1993-12-21	Alcon Laboratories, Inc.	Pharmaceutical compositions and methods of treatment to prevent and treat corneal scar formation produced by laser irradiation
US5260073A (en) *	1990-05-21	1993-11-09	Norwich Eaton Pharmaceuticals, Inc.	Use of phenylpropanolamine as a mucus secretogogue in the upper airways
WO1994010976A1 (en) *	1992-11-16	1994-05-26	Ciba Vision Ag, Hettlingen	Polyvinyl alcohol/borate ophthalmic drug delivery system
US5422116A (en) *	1994-02-18	1995-06-06	Ciba-Geigy Corporation	Liquid ophthalmic sustained release delivery system
ES2088742B1 (es) *	1994-06-29	1997-03-16	Salvat Lab Sa	Composicion antibiotica de aplicacion otica.

1996
- 1996-06-05 DE DE69620136T patent/DE69620136T2/de not_active Expired - Lifetime
- 1996-06-05 CN CNB96190870XA patent/CN1137685C/zh not_active Expired - Lifetime
- 1996-06-05 AT AT96917172T patent/ATE214931T1/de active
- 1996-06-05 IL IL12031796A patent/IL120317A/xx not_active IP Right Cessation
- 1996-06-05 NZ NZ309624A patent/NZ309624A/en not_active IP Right Cessation
- 1996-06-05 AU AU59840/96A patent/AU708540B2/en not_active Expired
- 1996-06-05 WO PCT/US1996/008864 patent/WO1996039146A1/en not_active Ceased
- 1996-06-05 ES ES96917172T patent/ES2173287T3/es not_active Expired - Lifetime
- 1996-06-05 ZA ZA964653A patent/ZA964653B/xx unknown
- 1996-06-05 PT PT96917172T patent/PT782448E/pt unknown
- 1996-06-05 DK DK96917172T patent/DK0782448T3/da active
- 1996-06-05 EP EP96917172A patent/EP0782448B1/de not_active Expired - Lifetime
- 1996-06-05 CA CA002199294A patent/CA2199294C/en not_active Expired - Lifetime
- 1996-06-05 MX MX9701731A patent/MX9701731A/es unknown
- 1996-06-06 TW TW085106748A patent/TW464499B/zh not_active IP Right Cessation
1997
- 1997-02-18 US US08/801,891 patent/US5965549A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IL120317A0 (en)	1998-06-15
AU708540B2 (en)	1999-08-05
CN1137685C (zh)	2004-02-11
DE69620136T2 (de)	2002-08-01
WO1996039146A1 (en)	1996-12-12
CA2199294C (en)	2000-09-19
IL120317A (en)	2000-08-13
HK1002552A1 (en)	1998-09-04
ZA964653B (en)	1996-12-12
NZ309624A (en)	1999-04-29
TW464499B (en)	2001-11-21
EP0782448A1 (de)	1997-07-09
DE69620136D1 (de)	2002-05-02
CN1160999A (zh)	1997-10-01
ES2173287T3 (es)	2002-10-16
US5965549A (en)	1999-10-12
EP0782448A4 (de)	1998-05-20
ATE214931T1 (de)	2002-04-15
EP0782448B1 (de)	2002-03-27
AU5984096A (en)	1996-12-24
CA2199294A1 (en)	1996-12-12
PT782448E (pt)	2002-07-31
MX9701731A (es)	1997-10-31

Publication	Publication Date	Title
DK0782448T3 (da)	2002-07-08	Ikke-irriterende, ikke-sensibiliserende, ikke-ototoksiske antibakterielle ørepræparater
PT1079806E (pt)	2006-06-30	Preparacoes para a aplicacao de anti-inflamatorios, especialmente, agentes anti-septicos e/ou agentes de promocao da cura de feridas, no tracto respiratorio superior e/ou no ouvido
IE831611L (en)	1984-01-13	Topical anti-inflammatory compositions
RU94041223A (ru)	1996-10-20	Средство для лечения мотонейроновых заболеваний
TR200003158T2 (tr)	2001-03-21	Jelleşebilen farmasötik bileşimler
AU6029096A (en)	1996-12-30	Compositions and methods for topical administration of pharm aceutically active agents
WO1996028148A3 (en)	1996-11-14	Use of a r-nsaid in a protective composition for the treatment of colorectal cancer
BRPI9708706C8 (pt)	2021-01-05	composição farmacêutica para administração intravenosa a um paciente
SE9704833D0 (sv)	1997-12-22	New formulation
PT902789E (pt)	2002-07-31	Derivados de androsteno
WO2001030802A3 (en)	2002-02-14	Therapeutic treatments comprising administration of certain steroids for blood cell deficiencies
AU2002231889A1 (en)	2002-08-06	Halogenated composition, method for preparing same and uses thereof
AU1865100A (en)	2000-07-31	Hyaluronate lyase used for promoting penetration in topical agents
KR950016760A (ko)	1995-07-20	치질 치료제
HUP9902415A2 (hu)	1999-11-29	Azonnal felszabaduló szilárd beadási formák és eljárás azok előállítására
DK1194109T3 (da)	2004-10-25	Topiske formuleringer omfattende hud-gennemtrængningsmidler samt anvendelse deraf
JPH07277988A (ja)	1995-10-24	局所用掻痒除去、治療剤
PT1140001E (pt)	2005-09-30	Composicao para tratamento de queimaduras
IT1276940B1 (it)	1997-11-03	Uso topico di acido ialuronico e bacillo di doderlein nella prevenzione e nel trattamento terapeutico di patologie vaginali
MY100229A (en)	1990-05-29	Topical anti-inflammatory compositions.
MX9801538A (es)	1998-05-31	Metodos y composiciones para el tratamiento de infecciones fungales en mamiferos.
IT1275987B1 (it)	1997-10-24	Composizione farmaceutica attiva nella cura di affezioni dermatologiche
MX9605153A (es)	1998-05-31	Agentes farmaceuticos para el tratamiento de enfermedades inflamatorias cronicas y agudas.
UA30359A (uk)	2000-11-15	Спосіб лікування гнійних ран