ZA964653B - Non-irritation non-sensitizing non-ototoxic otic anti-bacterial compositions - Google Patents

Non-irritation non-sensitizing non-ototoxic otic anti-bacterial compositions

Info

Publication number: ZA964653B
Authority: ZA; South Africa
Prior art keywords: amount effective; ototoxic; sensitizing; irritation; composition
Prior art date: 1995-06-06

Application number

ZA964653A

Other languages

English (en)

Inventor

Shivaji Purwar

David Goldman

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-06

Filing date

1996-06-05

Publication date

1996-12-12

1996-06-05 Application filed by Bayer Ag filed Critical Bayer Ag

1996-12-12 Publication of ZA964653B publication Critical patent/ZA964653B/xx

Links

230000000844 anti-bacterial effect Effects 0.000 title abstract 3
239000000203 mixture Substances 0.000 title abstract 3
231100001200 nonototoxic Toxicity 0.000 title abstract 2
230000001235 sensitizing effect Effects 0.000 title 1
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 4
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 3
MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 abstract 2
229960000890 hydrocortisone Drugs 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
229920001213 Polysorbate 20 Polymers 0.000 abstract 1
239000004372 Polyvinyl alcohol Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
235000019445 benzyl alcohol Nutrition 0.000 abstract 1
229960003405 ciprofloxacin Drugs 0.000 abstract 1
239000000470 constituent Substances 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
230000002209 hydrophobic effect Effects 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
235000010445 lecithin Nutrition 0.000 abstract 1
239000000787 lecithin Substances 0.000 abstract 1
229940067606 lecithin Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 abstract 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 abstract 1
229920000136 polysorbate Polymers 0.000 abstract 1
229950008882 polysorbate Drugs 0.000 abstract 1
229940068977 polysorbate 20 Drugs 0.000 abstract 1
229920002451 polyvinyl alcohol Polymers 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1
239000000725 suspension Substances 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Dispersion Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Organic Chemistry (AREA)
Inorganic Chemistry (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Endoscopes (AREA)

ZA964653A 1995-06-06 1996-06-05 Non-irritation non-sensitizing non-ototoxic otic anti-bacterial compositions ZA964653B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US46504895A	1995-06-06	1995-06-06

Publications (1)

Publication Number	Publication Date
ZA964653B true ZA964653B (en)	1996-12-12

Family

ID=23846298

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA964653A ZA964653B (en)	1995-06-06	1996-06-05	Non-irritation non-sensitizing non-ototoxic otic anti-bacterial compositions

Country Status (16)

Country	Link
US (1)	US5965549A (de)
EP (1)	EP0782448B1 (de)
CN (1)	CN1137685C (de)
AT (1)	ATE214931T1 (de)
AU (1)	AU708540B2 (de)
CA (1)	CA2199294C (de)
DE (1)	DE69620136T2 (de)
DK (1)	DK0782448T3 (de)
ES (1)	ES2173287T3 (de)
IL (1)	IL120317A (de)
MX (1)	MX9701731A (de)
NZ (1)	NZ309624A (de)
PT (1)	PT782448E (de)
TW (1)	TW464499B (de)
WO (1)	WO1996039146A1 (de)
ZA (1)	ZA964653B (de)

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US6716830B2 (en)	1998-09-30	2004-04-06	Alcon, Inc.	Ophthalmic antibiotic compositions containing moxifloxacin
AR020661A1 (es) *	1998-09-30	2002-05-22	Alcon Lab Inc	Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento
US6509327B1 (en)	1998-09-30	2003-01-21	Alcon Manufacturing, Ltd.	Compositions and methods for treating otic, ophthalmic and nasal infections
AU6275999A (en) *	1998-09-30	2000-04-17	Alcon Laboratories, Inc.	Antibiotic compositions for treatment of the eye, ear and nose
US6395746B1 (en) *	1998-09-30	2002-05-28	Alcon Manufacturing, Ltd.	Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
US6500360B2 (en) *	1999-06-18	2002-12-31	Bernard Bendiner	Sorbic acid and/or its derivatives, such as potassium sorbate, as a preventative for rust, corrosion and scale on metal surfaces
US7064132B2 (en) *	1999-11-28	2006-06-20	Scientific Development And Research, Inc.	Composition and method for treatment of otitis external
US6156294A (en)	1999-11-28	2000-12-05	Scientific Development And Research, Inc.	Composition and method for treatment of otitis media
ES2160090B1 (es) *	2000-03-16	2002-07-01	Vita Invest Sa	Composiciones acuosas de ciprofloxacino, contenidas en envases monodosis y su utilizacion.
WO2002007704A2 (en) *	2000-07-26	2002-01-31	Alcon Universal Ltd.	Improved process for manufacturing compositions containing ciprofloxacin and hydrocortisone
BR0114104A (pt)	2000-09-25	2003-07-29	Bayer Healthcare Llc	Combinações microbianas óticas para tratamento de animais com membrana do tìmpano rompida
BR0212898A (pt)	2001-09-21	2004-10-13	Alcon Inc	Método de tratamento de infecções do ouvido médio
US7718189B2 (en)	2002-10-29	2010-05-18	Transave, Inc.	Sustained release of antiinfectives
US20040101506A1 (en) *	2002-11-25	2004-05-27	Fust Charles A.	Composition for the prevention and treatment of inflammation of the ear
US7842791B2 (en) *	2002-12-19	2010-11-30	Nancy Jean Britten	Dispersible pharmaceutical compositions
CN1761487A (zh) *	2003-03-20	2006-04-19	法玛西雅公司	抗炎剂的可分散制剂
US20050004098A1 (en) *	2003-03-20	2005-01-06	Britten Nancy Jean	Dispersible formulation of an anti-inflammatory agent
US20050009931A1 (en) *	2003-03-20	2005-01-13	Britten Nancy Jean	Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
US20040214753A1 (en) *	2003-03-20	2004-10-28	Britten Nancy Jean	Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
RU2329064C2 (ru) *	2003-07-31	2008-07-20	Фармация Энд Апджон Компани Ллс	Диспергируемая фармацевтическая композиция для лечения мастита и поражений уха
CA2533101A1 (en) *	2003-07-31	2005-02-03	Pharmacia & Upjohn Company Llc	Dispersible formulation of an anti-inflammatory agent
US8940321B2 (en)	2003-12-12	2015-01-27	Otic Pharma Ltd.	Compositions for treatment of ear disorders and methods of use thereof
US8030362B2 (en) *	2003-12-12	2011-10-04	Otic Pharma Ltd.	Compositions for treatment of ear disorders and methods of use thereof
US20060019987A1 (en) *	2004-07-23	2006-01-26	Fust Charles A	Methods and compositions for inhibiting, destroying, and/or inactivating viruses
JP5324223B2 (ja)	2005-12-08	2013-10-23	トランセイブ，インク．	肺感染症を治療する抗感染薬の脂質ベースの組成物及びその使用法
US20100196455A1 (en)	2007-05-04	2010-08-05	Transave, Inc.	Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof
US9114081B2 (en)	2007-05-07	2015-08-25	Insmed Incorporated	Methods of treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en)	2007-05-07	2015-09-01	Insmed Incorporated	Method of treating pulmonary disorders with liposomal amikacin formulations
UA111147C2 (uk) *	2009-11-11	2016-04-11	Байєр Б.В.	Способи та композиції для лікування або профілактики зовнішнього отиту
DK2366408T3 (da)	2010-03-01	2012-10-22	Salvat Lab Sa	Vandige, klare opløsninger af fluocinolonacetonid til behandling af inflammation i øret
HU227743B1 (en) *	2011-07-22	2012-02-28	Debreceni Egyetem	Eardrop composition and process for producing this
MX2014006803A (es) *	2011-12-09	2014-07-09	Lupin Ltd	Composiciones farmaceuticas topicas de agentes antimicrobianos y agentes antiinflamatorios.
MX2015006681A (es)	2012-11-29	2016-04-06	Insmed Inc	Formulaciones de vancomicina estabilizadas.
SMT202000516T1 (it)	2014-05-15	2020-11-10	Insmed Inc	Metodi per trattamento di infezioni micobatteriche polmonati non tubercolari
US9393243B1 (en)	2015-07-14	2016-07-19	Nilesh Parikh	Topical Ciprofloxacin compositions
WO2019191627A1 (en)	2018-03-30	2019-10-03	Insmed Incorporated	Methods for continuous manufacture of liposomal drug products
WO2019213398A1 (en)	2018-05-02	2019-11-07	Insmed Incorporated	Methods for the manufacture of liposomal drug formulations

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US4025620A (en) *	1975-10-22	1977-05-24	Leo Pharmaceutical Products Ltd., A/S	Treatment of canine otitis and composition therefor
US4670444B1 (en) *	1980-09-03	1999-02-09	Bayer Ag	and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds
DE3471639D1 (en) *	1983-03-31	1988-07-07	Payne Packaging Ltd	Improvements in or relating to tapes
DE3537761A1 (de) *	1985-10-24	1987-04-30	Bayer Ag	Infusionsloesungen der 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-chinolin-3-carbonsaeure
DE3704907A1 (de) *	1987-02-17	1988-08-25	Bayer Ag	Topisch anwendbare zubereitungen von gyrase-inhibitoren in kombination mit kortikosteroiden
DE3902079A1 (de) *	1988-04-15	1989-10-26	Bayer Ag	I.m. injektionsformen von gyrase-inhibitoren
US5061729A (en) *	1988-06-08	1991-10-29	Biogal Gyogyszergyar	Pharmaceutical composition and process for preparing the same
US5271939A (en) *	1988-10-03	1993-12-21	Alcon Laboratories, Inc.	Pharmaceutical compositions and methods of treatment to prevent and treat corneal scar formation produced by laser irradiation
US5260073A (en) *	1990-05-21	1993-11-09	Norwich Eaton Pharmaceuticals, Inc.	Use of phenylpropanolamine as a mucus secretogogue in the upper airways
AU5599594A (en) *	1992-11-16	1994-06-08	Ciba-Geigy Ag	Polyvinyl alcohol/borate ophthalmic drug delivery system
US5422116A (en) *	1994-02-18	1995-06-06	Ciba-Geigy Corporation	Liquid ophthalmic sustained release delivery system
ES2088742B1 (es) *	1994-06-29	1997-03-16	Salvat Lab Sa	Composicion antibiotica de aplicacion otica.

1996
- 1996-06-05 ES ES96917172T patent/ES2173287T3/es not_active Expired - Lifetime
- 1996-06-05 MX MX9701731A patent/MX9701731A/es unknown
- 1996-06-05 NZ NZ309624A patent/NZ309624A/en not_active IP Right Cessation
- 1996-06-05 WO PCT/US1996/008864 patent/WO1996039146A1/en not_active Ceased
- 1996-06-05 EP EP96917172A patent/EP0782448B1/de not_active Expired - Lifetime
- 1996-06-05 AU AU59840/96A patent/AU708540B2/en not_active Expired
- 1996-06-05 DK DK96917172T patent/DK0782448T3/da active
- 1996-06-05 PT PT96917172T patent/PT782448E/pt unknown
- 1996-06-05 CN CNB96190870XA patent/CN1137685C/zh not_active Expired - Lifetime
- 1996-06-05 DE DE69620136T patent/DE69620136T2/de not_active Expired - Lifetime
- 1996-06-05 IL IL12031796A patent/IL120317A/xx not_active IP Right Cessation
- 1996-06-05 AT AT96917172T patent/ATE214931T1/de active
- 1996-06-05 CA CA002199294A patent/CA2199294C/en not_active Expired - Lifetime
- 1996-06-05 ZA ZA964653A patent/ZA964653B/xx unknown
- 1996-06-06 TW TW085106748A patent/TW464499B/zh not_active IP Right Cessation
1997
- 1997-02-18 US US08/801,891 patent/US5965549A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2199294C (en)	2000-09-19
DE69620136D1 (de)	2002-05-02
NZ309624A (en)	1999-04-29
CN1160999A (zh)	1997-10-01
EP0782448B1 (de)	2002-03-27
IL120317A (en)	2000-08-13
AU708540B2 (en)	1999-08-05
TW464499B (en)	2001-11-21
MX9701731A (es)	1997-10-31
HK1002552A1 (en)	1998-09-04
PT782448E (pt)	2002-07-31
CN1137685C (zh)	2004-02-11
CA2199294A1 (en)	1996-12-12
EP0782448A1 (de)	1997-07-09
EP0782448A4 (de)	1998-05-20
US5965549A (en)	1999-10-12
WO1996039146A1 (en)	1996-12-12
IL120317A0 (en)	1998-06-15
ES2173287T3 (es)	2002-10-16
DK0782448T3 (da)	2002-07-08
AU5984096A (en)	1996-12-24
DE69620136T2 (de)	2002-08-01
ATE214931T1 (de)	2002-04-15

Publication	Publication Date	Title
AU5984096A (en)	1996-12-24	Non-irritation, nonsensitizing, non-ototoxic otic anti-bacterial compositions
CA2289717A1 (en)	1998-11-12	Novel therapy for constipation
ID26221A (id)	2000-12-07	Komposisi-komposisi farmasi yang dapat dijadikan gel
IE831611L (en)	1984-01-13	Topical anti-inflammatory compositions
FI980822A7 (fi)	1998-04-09	Farmaseuttinen koostumus vaikuttavan aineen iho- tai limakalvopintaan tai iho- tai limakalvopinnan läpi
WO2002047715A3 (en)	2003-01-30	Compositions of peptide crystals
ATE526956T1 (de)	2011-10-15	Viruzide zusammensetzungen
WO2001030802A3 (en)	2002-02-14	Therapeutic treatments comprising administration of certain steroids for blood cell deficiencies
BR0109515A (pt)	2004-08-10	Derivados da apomorfina e métodos para seu uso
US5744167A (en)	1998-04-28	Methods for the treatment of herpes virus infections
MX9603596A (es)	1997-06-28	Perfluoropolieteres o composiciones de los mismos para prevencion y tratamiento de infecciones virales topicas.
KR950016760A (ko)	1995-07-20	치질 치료제
HUP9902415A2 (hu)	1999-11-29	Azonnal felszabaduló szilárd beadási formák és eljárás azok előállítására
MXPA01013460A (es)	2003-09-04	Formulaciones topicas que comprenden agentes de penetracion de la piel y uso de las mismas.
JPH07277988A (ja)	1995-10-24	局所用掻痒除去、治療剤
ES2145740T3 (es)	2000-07-16	Composiciones de factor de crecimiento, preparacion y uso.
FR2754824B1 (fr)	1999-03-05	Nouvelle composition contenant du chitosan
WO1998014193A1 (en)	1998-04-09	The use of a substance p antagonist for the manufacture of a medicament for the treatment of ocular pain
PT1140001E (pt)	2005-09-30	Composicao para tratamento de queimaduras
WO2000078772A3 (en)	2002-03-21	Antibiotic agents
Braun-Falco et al.	1991	Topical Treatment of Dermatoses
MX9801538A (es)	1998-05-31	Metodos y composiciones para el tratamiento de infecciones fungales en mamiferos.
MX9500324A (es)	1998-07-31	Compuestos farmaceuticos y el uso de los mismos en el tratamiento de enfermedades neurologicas y sus etiologias sintomaticas relacionadas.
MY100229A (en)	1990-05-29	Topical anti-inflammatory compositions.
IT1276940B1 (it)	1997-11-03	Uso topico di acido ialuronico e bacillo di doderlein nella prevenzione e nel trattamento terapeutico di patologie vaginali