DK0801651T3 - Hydroxymethyl-imidazodiazepiner og deres estere - Google Patents

Hydroxymethyl-imidazodiazepiner og deres estere

Info

Publication number: DK0801651T3
Authority: DK; Denmark
Prior art keywords: imidazodiazepines; hydroxymethyl; esters; anxiolytic; anticonvulsant
Prior art date: 1995-01-06

Application number

DK96900024T

Other languages

English (en)

Inventor

Rene Borer

Bernd Buettelmann

Max Gerecke

Andre Szente

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-01-06

Filing date

1996-01-03

Publication date

2001-10-22

1996-01-03 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2001-10-22 Application granted granted Critical

2001-10-22 Publication of DK0801651T3 publication Critical patent/DK0801651T3/da

Links

150000002148 esters Chemical class 0.000 title abstract 2
MOFVQBGGYJDZMA-UHFFFAOYSA-N imidazo[4,5-c]diazepin-3-ylmethanol Chemical class N1=NC(CO)=CC=C2N=CN=C21 MOFVQBGGYJDZMA-UHFFFAOYSA-N 0.000 title abstract 2
239000013543 active substance Substances 0.000 abstract 1
230000001773 anti-convulsant effect Effects 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
229960003965 antiepileptics Drugs 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003158 myorelaxant agent Substances 0.000 abstract 1
230000004799 sedative–hypnotic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK96900024T 1995-01-06 1996-01-03 Hydroxymethyl-imidazodiazepiner og deres estere DK0801651T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH2895		1995-01-06
PCT/CH1996/000001 WO1996020941A1 (de)	1995-01-06	1996-01-03	Hydroxymethyl-imidazodiazepine und deren ester

Publications (1)

Publication Number	Publication Date
DK0801651T3 true DK0801651T3 (da)	2001-10-22

Family

ID=4177731

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96900024T DK0801651T3 (da)	1995-01-06	1996-01-03	Hydroxymethyl-imidazodiazepiner og deres estere

Country Status (16)

Country	Link
US (1)	US6174881B1 (da)
EP (1)	EP0801651B1 (da)
JP (1)	JP3001979B2 (da)
CN (1)	CN1168140A (da)
AT (1)	ATE203026T1 (da)
AU (1)	AU4296196A (da)
BR (1)	BR9606823A (da)
CA (1)	CA2209424A1 (da)
DE (1)	DE59607274D1 (da)
DK (1)	DK0801651T3 (da)
ES (1)	ES2159714T3 (da)
FI (1)	FI972865L (da)
GR (1)	GR3036867T3 (da)
PT (1)	PT801651E (da)
TR (1)	TR199700587T1 (da)
WO (1)	WO1996020941A1 (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0875247B1 (en) *	1997-04-18	2003-05-28	Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno	Method for controlling the plasma level of lipoproteins
US6444664B1 (en)	1997-04-18	2002-09-03	Nederlandse Organisatie Voor Toegepast - Natuurweten Schappelijk Onderzoek (Tno)	Method for controlling the plasma level of lipoproteins to treat alzheimeris disease
ES2189759T3 (es) *	1999-05-12	2003-07-16	Hoffmann La Roche	Derivados de imidazoiacepina.
US7160880B1 (en)	1999-05-14	2007-01-09	Cenes Limited	Short-acting benzodiazepines
TWI232863B (en) *	2001-06-11	2005-05-21	Akzo Nobel Nv	Benzoxazepine derivatives
CN1255413C (zh) *	2001-06-14	2006-05-10	阿克佐诺贝尔公司	作为ampa受体正性调节剂的(吡啶并/噻吩并)－[f]－氧杂吖庚因－5－酮衍生物
GB0613693D0 (en)	2006-07-10	2006-08-16	Cenes Ltd	Benzodiazepine salts (3)
BRPI0714886B8 (pt)	2006-07-10	2021-05-25	Paion Uk Ltd	sais de benzodiazepina, seus usos e seus processos de preparação, e composição farmacêutica
US20090054412A1 (en) *	2007-08-20	2009-02-26	John Alan Kemp	Treatment of Sleep Disorders
CN101827597B (zh) *	2007-08-20	2013-03-13	伊沃泰克国际有限责任公司	睡眠障碍的治疗
CN103180318B (zh)	2010-05-14	2017-05-10	达那-法伯癌症研究所	雄性避孕组合物以及使用方法
CN103154246B (zh)	2010-05-14	2015-11-25	达那-法伯癌症研究所	用于治疗白血病的组合物和方法
ES2606958T3 (es)	2010-05-14	2017-03-28	Dana-Farber Cancer Institute, Inc.	Compuestos de tienotriazolodiazepina para tratar una neoplasia
EP2450039A1 (en)	2010-11-08	2012-05-09	PAION UK Ltd.	Dosing regimen for sedation with CNS 7056 (Remimazolam)
GEAP201813666A (en)	2012-05-22	2018-01-25	Paion Uk Ltd	Compositions comprising short-acting benzodiazepines
CN103012408B (zh) *	2012-11-28	2015-02-04	中国科学院广州生物医药与健康研究院	依匹斯汀的合成方法
AR094963A1 (es)	2013-03-04	2015-09-09	Ono Pharmaceutical Co	Reacción de oxidación excelente en el índice de conversión
BR112016001457A2 (pt)	2013-07-25	2017-08-29	Dana Farber Cancer Inst Inc	Inibidores de fatores de transcrição e usos dos mesmos
US11446309B2 (en)	2013-11-08	2022-09-20	Dana-Farber Cancer Institute, Inc.	Combination therapy for cancer using bromodomain and extra-terminal (BET) protein inhibitors
EP3099693A4 (en)	2014-01-31	2017-08-16	Dana-Farber Cancer Institute, Inc.	Uses of diazepane derivatives
MX2016009974A (es)	2014-01-31	2016-10-31	Dana Farber Cancer Inst Inc	Derivados de diaminopirimidina bencensulfona y sus usos.
WO2015131113A1 (en)	2014-02-28	2015-09-03	Tensha Therapeutics, Inc.	Treatment of conditions associated with hyperinsulinaemia
JP6715830B2 (ja)	2014-06-26	2020-07-01	ザ・ジョンズ・ホプキンス・ユニバーシティ	過敏性腸症候群および末梢神経系の他の病気の治療のための末梢限局性ｇａｂａポジティブアロステリックモジュレーター
RU2017104897A (ru)	2014-08-08	2018-09-10	Дана-Фарбер Кэнсер Инститьют, Инк.	Производные диазепана и их применения
WO2016022970A1 (en)	2014-08-08	2016-02-11	Dana-Farber Cancer Institute, Inc.	Dihydropteridinone derivatives and uses thereof
UA122130C2 (uk)	2014-10-27	2020-09-25	Тенша Терапеутікс, Інк.	Інгібітори бромодомену
CA2986441A1 (en)	2015-06-12	2016-12-15	Dana-Farber Cancer Institute, Inc.	Combination therapy of transcription inhibitors and kinase inhibitors
RU2018112953A (ru)	2015-09-11	2019-10-14	Дана-Фарбер Кэнсер Инститьют, Инк.	Ацетамидтиенотриазолодиазепины и пути их применения
US11306105B2 (en)	2015-09-11	2022-04-19	Dana-Farber Cancer Institute, Inc.	Cyano thienotriazolodiazepines and uses thereof
CR20180336A (es)	2015-11-25	2018-08-06	Dana Farber Cancer Inst Inc	Inhibidores de bromodominio bivalentes y usos de los mismos
WO2017178663A1 (en)	2016-04-14	2017-10-19	Paion Uk Limited	Orally inhaled and nasal benzodiazepines
CN107325101B (zh) *	2017-06-29	2019-03-26	上海合全药物研发有限公司	6-羟甲基-6,7-二氢-5h,9h-咪唑并二氮杂卓-8-羧酸叔丁酯的合成方法
CN113087713B (zh) *	2021-03-29	2022-10-04	中国人民解放军军事科学院军事医学研究院	一类苯并二氮䓬衍生物及其制备方法和用途
USD1017893S1 (en) *	2022-03-03	2024-03-12	Elc Management Llc	Cosmetic applicator
USD1023445S1 (en) *	2022-03-03	2024-04-16	Elc Management Llc	Cosmetic applicator

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4902794A (en)	1971-04-28	1990-02-20	The Upjohn Company	Triazolo-benzodiazepines
US3763179A (en) *	1972-05-05	1973-10-02	Upjohn Co	2-imidazol-1-yl benzophenones
US4280957A (en) *	1974-09-11	1981-07-28	Hoffmann-La Roche Inc.	Imidazodiazepines and processes therefor
DE2547652A1 (de) *	1974-11-15	1976-05-20	Upjohn Co	Pharmazeutische zubereitung
DE3432974A1 (de)	1983-09-12	1985-04-04	The Upjohn Co., Kalamazoo, Mich.	Arzneimittel zur prophylaxe oder therapie der negativen shizophreniesymtome bei menschen
DE3435973A1 (de) *	1984-10-01	1986-04-10	Boehringer Ingelheim KG, 6507 Ingelheim	Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
US5679672A (en)	1993-11-22	1997-10-21	Merck & Co., Inc.	Benzodiazepines
US5439906A (en)	1993-11-22	1995-08-08	Merck & Co., Inc.	Antiarrhythmic benzodiazepines

1996
- 1996-01-03 CN CN96191369A patent/CN1168140A/zh active Pending
- 1996-01-03 FI FI972865A patent/FI972865L/fi unknown
- 1996-01-03 CA CA002209424A patent/CA2209424A1/en not_active Abandoned
- 1996-01-03 PT PT96900024T patent/PT801651E/pt unknown
- 1996-01-03 DK DK96900024T patent/DK0801651T3/da not_active Application Discontinuation
- 1996-01-03 EP EP96900024A patent/EP0801651B1/de not_active Expired - Lifetime
- 1996-01-03 DE DE59607274T patent/DE59607274D1/de not_active Expired - Fee Related
- 1996-01-03 BR BR9606823A patent/BR9606823A/pt not_active Application Discontinuation
- 1996-01-03 US US08/860,785 patent/US6174881B1/en not_active Expired - Fee Related
- 1996-01-03 ES ES96900024T patent/ES2159714T3/es not_active Expired - Lifetime
- 1996-01-03 AU AU42961/96A patent/AU4296196A/en not_active Abandoned
- 1996-01-03 WO PCT/CH1996/000001 patent/WO1996020941A1/de not_active Ceased
- 1996-01-03 JP JP8520662A patent/JP3001979B2/ja not_active Expired - Lifetime
- 1996-01-03 AT AT96900024T patent/ATE203026T1/de not_active IP Right Cessation
- 1996-01-03 TR TR97/00587T patent/TR199700587T1/xx unknown
2001
- 2001-10-11 GR GR20010401730T patent/GR3036867T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE59607274D1 (de)	2001-08-16
FI972865A0 (fi)	1997-07-04
JPH10500998A (ja)	1998-01-27
GR3036867T3 (en)	2002-01-31
AU4296196A (en)	1996-07-24
WO1996020941A1 (de)	1996-07-11
TR199700587T1 (xx)	1998-02-21
JP3001979B2 (ja)	2000-01-24
ATE203026T1 (de)	2001-07-15
FI972865A7 (fi)	1997-09-03
BR9606823A (pt)	1997-12-30
EP0801651A1 (de)	1997-10-22
US6174881B1 (en)	2001-01-16
CN1168140A (zh)	1997-12-17
FI972865L (fi)	1997-09-03
CA2209424A1 (en)	1996-07-11
ES2159714T3 (es)	2001-10-16
EP0801651B1 (de)	2001-07-11
PT801651E (pt)	2001-12-28
MX9705061A (es)	1997-10-31

Legal Events

Date	Code	Title	Description
1998-03-16	AHS	Application shelved for other reasons than non-payment

Publication	Publication Date	Title
FI972865A0 (fi)	1997-07-04	Hydroksimetyyli-imidatsodiatseptiinejä ja niiden esterit
ZA981936B (en)	1999-09-06	Novel benzimidazole inhibitors of fructose 1,6-bisphosphatase.
EA199700061A1 (ru)	1997-12-30	Способ получения силденафила
ATE182892T1 (de)	1999-08-15	Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren
MX9700557A (es)	1997-12-31	Dihidrobenzofuranos.
ATE214928T1 (de)	2002-04-15	Thrombininhibitoren
DE59310137D1 (de)	2001-02-15	Verwendung von substituierten Benzimidazolen zur Bekämpfung parasitärer Protozoen
DE69528528D1 (de)	2002-11-14	Thrombin-inhibitoren
DE69615682D1 (de)	2001-11-08	N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1-h-benzo[b][1,5]-diazepin-3-yl)-acetamide
ATE164593T1 (de)	1998-04-15	Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
TR199900856T2 (xx)	1999-07-21	Bron�la ilgili terapi maddeleri olarak benzonaftiridinler
BR9606799A (pt)	1997-12-30	Formulações inibidoras de corrosão aperfeiçoadas com nitrito de cálcio
DE59601878D1 (de)	1999-06-17	Verwendung von schwerflüchtigen pyrazolderivaten mit hydrophilen gruppen als nitrifikationsinhibitoren
ATE267180T1 (de)	2004-06-15	Phosphorderivate zur behandlung von aids
NO992337D0 (no)	1999-05-14	Bicykliske arylkarboksamider og deres terapeutiske anvendelse
ES2157992T3 (es)	2001-09-01	Alcoxi-alquil-carbamatos de imidazo(1,2-a)piridinas.
DK0696278T3 (da)	1999-04-26	Herbicidtvirkende substituerede 1-phenyl- eller 1-pyridinylbenzotriazoler
DE69531048D1 (de)	2003-07-17	Verwendung von steroidsulphatase-hemmern
DE69737718D1 (de)	2007-06-21	Nachweis von mikroorganismen
ATE236888T1 (de)	2003-04-15	N-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5- benzodiazepin-3-yl)-3-amide
FI962481A0 (fi)	1996-06-14	4-bentsoyyli-isokatsolit ja niiden käyttö herbisideinä
BG100248A (bg)	1996-07-31	Инхибитори на скваленсинтетаза
FI940999A7 (fi)	1994-09-04	Piperidin-2-alkyylikarboksylaattien entsymaattinen toisiintuminen ja saatujen yhdisteiden käyttö synteesin välituotteina
DE69312093D1 (de)	1997-08-14	Prodrug von entzündungshemmenden 3-acyl-2-oxindol-1-carboxamiden
ES2187656T3 (es)	2003-06-16	Derivados de acido fosfinico con actividad inhibidora de metalopeptidasa.