GR3036867T3 - Hydroxymethylimidazodiazepines and their esters - Google Patents

Hydroxymethylimidazodiazepines and their esters

Info

Publication number
GR3036867T3
GR3036867T3 GR20010401730T GR20010401730T GR3036867T3 GR 3036867 T3 GR3036867 T3 GR 3036867T3 GR 20010401730 T GR20010401730 T GR 20010401730T GR 20010401730 T GR20010401730 T GR 20010401730T GR 3036867 T3 GR3036867 T3 GR 3036867T3
Authority
GR
Greece
Prior art keywords
esters
hydroxymethylimidazodiazepines
imidazodiazepines
anxiolytic
anticonvulsant
Prior art date
Application number
GR20010401730T
Other languages
English (en)
Inventor
Rene Borer
Bernd Buettelmann
Max Gerecke
Andre Szente
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of GR3036867T3 publication Critical patent/GR3036867T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
GR20010401730T 1995-01-06 2001-10-11 Hydroxymethylimidazodiazepines and their esters GR3036867T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH2895 1995-01-06
PCT/CH1996/000001 WO1996020941A1 (de) 1995-01-06 1996-01-03 Hydroxymethyl-imidazodiazepine und deren ester

Publications (1)

Publication Number Publication Date
GR3036867T3 true GR3036867T3 (en) 2002-01-31

Family

ID=4177731

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20010401730T GR3036867T3 (en) 1995-01-06 2001-10-11 Hydroxymethylimidazodiazepines and their esters

Country Status (16)

Country Link
US (1) US6174881B1 (el)
EP (1) EP0801651B1 (el)
JP (1) JP3001979B2 (el)
CN (1) CN1168140A (el)
AT (1) ATE203026T1 (el)
AU (1) AU4296196A (el)
BR (1) BR9606823A (el)
CA (1) CA2209424A1 (el)
DE (1) DE59607274D1 (el)
DK (1) DK0801651T3 (el)
ES (1) ES2159714T3 (el)
FI (1) FI972865A7 (el)
GR (1) GR3036867T3 (el)
PT (1) PT801651E (el)
TR (1) TR199700587T1 (el)
WO (1) WO1996020941A1 (el)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0875247B1 (en) * 1997-04-18 2003-05-28 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Method for controlling the plasma level of lipoproteins
US6444664B1 (en) 1997-04-18 2002-09-03 Nederlandse Organisatie Voor Toegepast - Natuurweten Schappelijk Onderzoek (Tno) Method for controlling the plasma level of lipoproteins to treat alzheimeris disease
CA2372040C (en) * 1999-05-12 2008-12-02 Francois Jenck Imidazodiazepine derivative
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
TWI232863B (en) * 2001-06-11 2005-05-21 Akzo Nobel Nv Benzoxazepine derivatives
HUP0400196A3 (en) * 2001-06-14 2007-05-02 Organon Nv (pyrido/thieno)[f]oxazepin-5-one derivatives, their use and pharmaceutical compositions containing them
KR20150081370A (ko) 2006-07-10 2015-07-13 파이온 유케이 리미티드 속효형 벤조디아제핀 염 및 이의 중합체 형태
GB0613693D0 (en) 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
US20100234359A1 (en) * 2007-08-20 2010-09-16 Evotec Neurosciences Gmbh Treatment of sleep disorders
US9301962B2 (en) 2010-05-14 2016-04-05 Baylor College Of Medicine Male contraceptive compositions and methods of use
MX384074B (es) 2010-05-14 2025-03-12 Dana Farber Cancer Inst Inc Composiciones y métodos para tratar neoplasias, enfermedades inflamatorias y otros trastornos.
MX373121B (es) 2010-05-14 2020-04-30 Dana Farber Cancer Inst Inc Composiciones y metodos para el tratamiento de leucemia.
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
AP2014008084A0 (en) 2012-05-22 2014-11-30 Paion Uk Ltd Compositions comprising shortacting benzodiazepines
CN103012408B (zh) * 2012-11-28 2015-02-04 中国科学院广州生物医药与健康研究院 依匹斯汀的合成方法
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
WO2015013635A2 (en) 2013-07-25 2015-01-29 Dana-Farber Cancer Institute, Inc. Inhibitors of transcription factors and uses thereof
EP3066101B1 (en) 2013-11-08 2020-07-29 Dana-Farber Cancer Institute, Inc. Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
EP3099677A4 (en) 2014-01-31 2017-07-26 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
KR20160130778A (ko) 2014-02-28 2016-11-14 텐샤 세러퓨틱스 인코포레이티드 고인슐린혈증과 관련된 질환의 치료
EP3160969B1 (en) * 2014-06-26 2023-09-13 The Johns Hopkins University Peripherally restricted gaba positive allosteric modulators for the treatment of irritable bowel syndrome and other ailments of the peripheral nervous system
EP3177626A4 (en) 2014-08-08 2017-12-27 Dana Farber Cancer Institute, Inc. Diazepane derivatives and uses thereof
MX2017001757A (es) 2014-08-08 2017-05-30 Dana Farber Cancer Inst Inc Derivados de dihidropteridinona y sus usos.
AU2015339511B2 (en) 2014-10-27 2020-05-14 Tensha Therapeutics, Inc. Bromodomain inhibitors
EP3307728A4 (en) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. COMBINATION THERAPY OF TRANSCRIPTION INHIBITORS AND CHINESE INHIBITORS
UA123946C2 (uk) 2015-09-11 2021-06-30 Дана-Фарбер Кенсер Інстітьют, Інк. Ацетамідтієнотриазолодіазепіни й шляхи їх застосування
PE20181287A1 (es) 2015-09-11 2018-08-07 Dana Farber Cancer Inst Inc Ciano tienotriazolpirazinas y usos de las mismas
CA3003288A1 (en) 2015-11-25 2017-06-01 Dana-Farber Cancer Institute, Inc. Bivalent bromodomain inhibitors and uses thereof
JP2019513796A (ja) 2016-04-14 2019-05-30 パイオン ユーケー リミティド 経口吸入及び経鼻用ベンゾジアゼピン
CN107325101B (zh) * 2017-06-29 2019-03-26 上海合全药物研发有限公司 6-羟甲基-6,7-二氢-5h,9h-咪唑并二氮杂卓-8-羧酸叔丁酯的合成方法
CN113087713B (zh) * 2021-03-29 2022-10-04 中国人民解放军军事科学院军事医学研究院 一类苯并二氮䓬衍生物及其制备方法和用途
USD1017893S1 (en) * 2022-03-03 2024-03-12 Elc Management Llc Cosmetic applicator
USD1023445S1 (en) * 2022-03-03 2024-04-16 Elc Management Llc Cosmetic applicator

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902794A (en) 1971-04-28 1990-02-20 The Upjohn Company Triazolo-benzodiazepines
US3763179A (en) * 1972-05-05 1973-10-02 Upjohn Co 2-imidazol-1-yl benzophenones
US4280957A (en) 1974-09-11 1981-07-28 Hoffmann-La Roche Inc. Imidazodiazepines and processes therefor
DE2547652A1 (de) * 1974-11-15 1976-05-20 Upjohn Co Pharmazeutische zubereitung
DE3432974A1 (de) 1983-09-12 1985-04-04 The Upjohn Co., Kalamazoo, Mich. Arzneimittel zur prophylaxe oder therapie der negativen shizophreniesymtome bei menschen
DE3435973A1 (de) * 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
US5439906A (en) 1993-11-22 1995-08-08 Merck & Co., Inc. Antiarrhythmic benzodiazepines
JP2840454B2 (ja) 1993-11-22 1998-12-24 メルク エンド カンパニー インコーポレーテッド ベンゾジアゼピン類

Also Published As

Publication number Publication date
JP3001979B2 (ja) 2000-01-24
FI972865L (fi) 1997-09-03
JPH10500998A (ja) 1998-01-27
AU4296196A (en) 1996-07-24
FI972865A0 (fi) 1997-07-04
EP0801651B1 (de) 2001-07-11
PT801651E (pt) 2001-12-28
CA2209424A1 (en) 1996-07-11
TR199700587T1 (xx) 1998-02-21
MX9705061A (es) 1997-10-31
BR9606823A (pt) 1997-12-30
DE59607274D1 (de) 2001-08-16
ES2159714T3 (es) 2001-10-16
DK0801651T3 (da) 2001-10-22
CN1168140A (zh) 1997-12-17
WO1996020941A1 (de) 1996-07-11
EP0801651A1 (de) 1997-10-22
US6174881B1 (en) 2001-01-16
ATE203026T1 (de) 2001-07-15
FI972865A7 (fi) 1997-09-03

Similar Documents

Publication Publication Date Title
AU4296196A (en) Hydroxymethylimidazodiazepines and their esters
TW270115B (el)
ZA981936B (en) Novel benzimidazole inhibitors of fructose 1,6-bisphosphatase.
DE69619443D1 (de) Ungesättigte Hydroxycarbonsäureverbindungen als Zwischenprodukte zur Herstellung von Schmierstoff- und Kraftstoffadditiven
AU3102697A (en) Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
AP9600804A0 (en) Therapeutic amides.
AU5621594A (en) 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
TW225534B (el)
ATE242234T1 (de) Bicyclische arylcarboxamide und ihre therapeutische verwendung
ES2157992T3 (es) Alcoxi-alquil-carbamatos de imidazo(1,2-a)piridinas.
GR3034602T3 (en) Novel n-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3y l)-3-amides
HU9601646D0 (en) 4-benzoylisoxazoles and their use as herbicides
AU4345096A (en) Use of pyrazole derivatives with hydrophobic groups as nitrification inhibitors
HU9500857D0 (en) Use of hyaluronic acid and forms to prevent arterial restenosis
FI940999L (fi) Piperidin-2-alkyylikarboksylaattien entsymaattinen toisiintuminen ja saatujen yhdisteiden käyttö synteesin välituotteina
MX9603087A (es) Procedimiento para la obtencion de aminocarboniltriazolinonas substituidas.
NO952949D0 (no) Forlöpere av anti-inflamatoriske 3-acyl-2-oksindol-1-karboksamider
GB9505293D0 (en) Stabilization of organic sludges
AU6217794A (en) Use of triazine compounds as anxiolytics
TW226021B (el)
GR960100054A (el) Βιολοντσελλο μελετης.
PL341071A1 (en) Method of obtaining cleistogamouic mutants of hybridized plants
MX9706968A (es) Compuesto de tiocarbamoilo.
ECSP951578A (es) Oxazolyl y thiazolylimidazo- benzo- y thienodiazepines,
FI970064A0 (fi) Foermedling av en galvaniskt isolerad styrningssignal mellan primaer- och sekundaersidan i en effektkaella

Legal Events

Date Code Title Description
ML Lapse due to non-payment of fees