DK0804200T3 - Anvendelse af noribogain-derivater til behandling af kemisk afhængighed hos pattedyr - Google Patents

Anvendelse af noribogain-derivater til behandling af kemisk afhængighed hos pattedyr

Info

Publication number: DK0804200T3
Authority: DK; Denmark
Prior art keywords: noribogain; mammals; derivatives; treatment; chemical dependence
Prior art date: 1994-07-25

Application number

DK95927295T

Other languages

Danish (da)

English (en)

Inventor

Deborah Mash

Juan University Sanchez-Ramos

W Lee Hearn

Original Assignee

Nda Int Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-25

Filing date

1995-07-25

Publication date

2006-09-11

1995-07-25 Application filed by Nda Int Inc filed Critical Nda Int Inc

2006-09-11 Application granted granted Critical

2006-09-11 Publication of DK0804200T3 publication Critical patent/DK0804200T3/da

Links

241000124008 Mammalia Species 0.000 title 1
206010013663 drug dependence Diseases 0.000 title 1
208000011117 substance-related disease Diseases 0.000 title 1
RAUCDOKTMDOIPF-UHFFFAOYSA-N hydroxyibogamine Natural products CCC1CC(C2)CC3C1N2CCC1=C3NC2=CC=C(O)C=C12 RAUCDOKTMDOIPF-UHFFFAOYSA-N 0.000 abstract 3
-1 noribogaine compound Chemical class 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
RAUCDOKTMDOIPF-RYRUWHOVSA-N noribogaine Chemical compound N1([C@@H]2[C@H]3C[C@H](C1)C[C@@H]2CC)CCC1=C3NC2=CC=C(O)C=C12 RAUCDOKTMDOIPF-RYRUWHOVSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Addiction (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK95927295T 1994-07-25 1995-07-25 Anvendelse af noribogain-derivater til behandling af kemisk afhængighed hos pattedyr DK0804200T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US28018794A	1994-07-25	1994-07-25

Publications (1)

Publication Number	Publication Date
DK0804200T3 true DK0804200T3 (da)	2006-09-11

Family

ID=23072046

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95927295T DK0804200T3 (da)	1994-07-25	1995-07-25	Anvendelse af noribogain-derivater til behandling af kemisk afhængighed hos pattedyr

Country Status (11)

Country	Link
US (1)	US6348456B1 (de)
EP (1)	EP0804200B1 (de)
AT (1)	ATE324897T1 (de)
AU (1)	AU4613296A (de)
DE (1)	DE69534975T2 (de)
DK (1)	DK0804200T3 (de)
ES (1)	ES2264562T3 (de)
IL (1)	IL114726A (de)
MX (1)	MX9701430A (de)
PT (1)	PT804200E (de)
WO (1)	WO1996003127A1 (de)

Families Citing this family (40)

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US7220737B1 (en)	1997-09-04	2007-05-22	Novoneuron, Inc	Noribogaine in the treatment of pain and drug addiction
EP1009407B1 (de) *	1997-09-04	2004-04-28	Novoneuron, Inc.	Noribogain zur behandlung von schmerzen und drogenabhängigkeit
AU2003200404B2 (en) *	1997-09-04	2006-06-29	Demerx, Inc.	Noribogaine in the treatment of pain and drug addiction
BR0106261A (pt) *	2001-12-26	2003-09-02	Fundacao Oswaldo Cruz	Composições medicamentosas contendo alcalóides indólicos para o tratamento da aids
US20030153552A1 (en) *	2002-02-14	2003-08-14	Mash Deborah C.	Method of treating chemical dependency in mammals and a composition therefor
GB2480632A (en)	2010-05-25	2011-11-30	Kythera Biopharmaceuticals Inc	Preparation of 12-keto and 12-alpha-hydroxy steroids
US9394294B2 (en)	2010-05-11	2016-07-19	Demerx, Inc.	Methods and compositions for preparing and purifying noribogaine
US8765737B1 (en)	2010-05-11	2014-07-01	Demerx, Inc.	Methods and compositions for preparing and purifying noribogaine
US8362007B1 (en)	2010-05-11	2013-01-29	Demerx, Inc.	Substituted noribogaine
US9586954B2 (en)	2010-06-22	2017-03-07	Demerx, Inc.	N-substituted noribogaine prodrugs
US8637648B1 (en)	2010-06-22	2014-01-28	Demerx, Inc.	Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8741891B1 (en)	2010-06-22	2014-06-03	Demerx, Inc.	N-substituted noribogaine prodrugs
US8802832B2 (en)	2010-06-22	2014-08-12	Demerx, Inc.	Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
EP2595632A1 (de)	2010-07-23	2013-05-29	DemeRx, Inc.	Noribogain-zusammensetzungen
AU2012202509B2 (en) *	2010-07-23	2014-02-13	Demerx, Inc.	Noribogaine compositions
EP2481740B1 (de)	2011-01-26	2015-11-04	DemeRx, Inc.	Verfahren und Zusammensetzungen zur Herstellung von Noribogain aus Voacangin
US9617274B1 (en)	2011-08-26	2017-04-11	Demerx, Inc.	Synthetic noribogaine
WO2013040471A2 (en) *	2011-09-15	2013-03-21	Demerx, Inc.	Noribogaine salt ansolvates
CA3122767C (en)	2011-12-08	2023-03-28	Demerx, Inc.	Stereoselective total synthesis of noribogaine
JP2015509075A (ja) *	2011-12-09	2015-03-26	デメレックス，インコーポレイテッド	ノルイボガインの硫酸エステル
CA2855994A1 (en)	2011-12-09	2013-06-13	Demerx, Inc.	Phosphate esters of noribogaine
US8877921B2 (en)	2012-01-25	2014-11-04	Demerx, Inc.	Synthetic voacangine
US9150584B2 (en)	2012-01-25	2015-10-06	Demerx, Inc.	Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
WO2013112163A1 (en) *	2012-01-25	2013-08-01	Demerx, Inc.	Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
US8940728B2 (en)	2012-12-20	2015-01-27	Demerx, Inc.	Substituted noribogaine
US9045481B2 (en)	2012-12-20	2015-06-02	Demerx, Inc.	Substituted noribogaine
US9783535B2 (en)	2012-12-20	2017-10-10	Demerx, Inc.	Substituted noribogaine
CA2942638C (en) *	2013-03-15	2026-03-10	Demerx, Inc.	Method for noribogaine treatment of addiction in patients on methadone
AU2014379612A1 (en) *	2014-01-24	2016-08-11	Demerx, Inc.	Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US9345711B2 (en)	2014-02-18	2016-05-24	Demerx, Inc.	Methods for acute and long-term treatment of drug addiction
JP2017509612A (ja) *	2014-02-18	2017-04-06	デメルクス，インコーポレイテッド	薬物中毒の急性および長期間での治療方法。
US9561232B2 (en)	2014-02-18	2017-02-07	Demerx, Inc.	Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use
WO2015126836A2 (en) *	2014-02-18	2015-08-27	Demerx, Inc.	Therapeutic methods employing noribogaine and related compounds
US9591978B2 (en)	2014-03-13	2017-03-14	Demerx, Inc.	Methods and compositions for pre-screening patients for treatment with noribogaine
CA2989550C (en)	2014-06-18	2023-08-08	Demerx, Inc.	Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
US9549935B2 (en)	2014-07-14	2017-01-24	Demerx, Inc.	Methods and compositions for treating migraines using noribogaine
AU2015353414B2 (en)	2014-11-26	2021-04-29	Demerx, Inc.	Methods and compositions for potentiating the action of opioid analgesics using iboga alkaloids
US12459965B2 (en)	2017-10-09	2025-11-04	Compass Pathfinder Limited	Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
GB2571696B (en)	2017-10-09	2020-05-27	Compass Pathways Ltd	Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
KR20220009954A (ko)	2019-04-17	2022-01-25	컴퍼스 패쓰파인더 리미티드	신경인지 장애, 만성 통증을 치료하고 염증을 감소시키는 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3516989A (en) *	1967-10-02	1970-06-23	American Home Prod	Intermediates for total synthesis of iboga alkaloids and means of preparation
US4499096A (en) *	1983-11-18	1985-02-12	Lotsof Howard S	Rapid method for interrupting the narcotic addiction syndrome
US4587243A (en) *	1985-07-15	1986-05-06	Lotsof Howard S	Rapid method for interrupting the cocaine and amphetamine abuse syndrome
US5152994A (en) *	1990-05-31	1992-10-06	Lotsof Howard S	Rapid method for interrupting or attenuating poly-drug dependency syndromes
US5591738A (en) *	1994-10-14	1997-01-07	Nda International, Inc.	Method of treating chemical dependency using β-carboline alkaloids, derivatives and salts thereof

1995
- 1995-07-25 MX MX9701430A patent/MX9701430A/es not_active IP Right Cessation
- 1995-07-25 AU AU46132/96A patent/AU4613296A/en not_active Abandoned
- 1995-07-25 WO PCT/US1995/009136 patent/WO1996003127A1/en not_active Ceased
- 1995-07-25 DE DE69534975T patent/DE69534975T2/de not_active Expired - Lifetime
- 1995-07-25 DK DK95927295T patent/DK0804200T3/da active
- 1995-07-25 AT AT95927295T patent/ATE324897T1/de not_active IP Right Cessation
- 1995-07-25 IL IL11472695A patent/IL114726A/en not_active IP Right Cessation
- 1995-07-25 PT PT95927295T patent/PT804200E/pt unknown
- 1995-07-25 ES ES95927295T patent/ES2264562T3/es not_active Expired - Lifetime
- 1995-07-25 EP EP95927295A patent/EP0804200B1/de not_active Expired - Lifetime
1996
- 1996-10-08 US US08/727,123 patent/US6348456B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IL114726A (en)	2002-04-21
EP0804200B1 (de)	2006-05-03
PT804200E (pt)	2006-09-29
EP0804200A4 (de)	1999-06-23
AU4613296A (en)	1996-04-19
MX9701430A (es)	1997-12-31
ES2264562T3 (es)	2007-01-01
DE69534975T2 (de)	2007-01-11
IL114726A0 (en)	1995-11-27
ATE324897T1 (de)	2006-06-15
EP0804200A1 (de)	1997-11-05
WO1996003127A1 (en)	1996-02-08
DE69534975D1 (de)	2006-06-08
US6348456B1 (en)	2002-02-19

Publication	Publication Date	Title
DK0804200T3 (da)	2006-09-11	Anvendelse af noribogain-derivater til behandling af kemisk afhængighed hos pattedyr
MX154758A (es)	1987-12-10	Procedimiento para preparacion de derivados de succinimida
ID17851A (id)	1998-01-29	Persenyawaan heterosiklis, produksi dan pemakaiannya
TW370450B (en)	1999-09-21	Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives
BG105457A (en)	2001-12-29	Method for the preparation of citalopram
DE3781716D1 (de)	1992-10-22	Mittel zur ortsspezifischen alkylierung.
HUP9903836A2 (hu)	2001-05-28	Új eljárás Cox-2 inhibítor hatású fenil-szubsztituált 2(5H)-furanonok előállítására
NZ503912A (en)	2002-09-27	Piperidinylaminomethyl trifluoromethyl cyclic ether compounds and their use as substance P antagonists
ATE263771T1 (de)	2004-04-15	Totalsynthese von acylfulvenen mit antitumorwirkung
EP0945764A3 (de)	2000-04-19	Fotoresistzusammensetzung
EA200100310A1 (ru)	2001-10-22	Кислородсодержащие гетероциклические соединения
DK1447400T3 (da)	2008-12-08	Bicyklisk forbindelse
SE0003186D0 (sv)	2000-09-07	New process
JO2433B1 (en)	2008-04-17	Preparation of heterocyclic lindane landscapes
YU166291A (sh)	1994-04-05	Indenoindol jedinjenja
MY133207A (en)	2007-10-31	Substituted benzolactam compaunds
BR9911402A (pt)	2001-03-20	Uso de corantes amino azóicos, e, compostos
DE60007848D1 (de)	2004-02-26	Herstellung von 2'-substitutierter rns
TR199900922T2 (xx)	1999-07-21	Lipoprotein (A)'n�n plazma seviyesini d��rmek i�in bir y�ntem.
ATE231514T1 (de)	2003-02-15	Substituierte isophosphindoline und ihre verwendung
DE60114889D1 (de)	2005-12-15	Verfahren zur herstellung von fluconazole und kristallmodifikationen davon
TWI256383B (en)	2006-06-11	Anthraquinone compound
WO2002100804A3 (en)	2003-05-08	Novel use of sulfamic acids as resolving agent.
DE69903930D1 (de)	2002-12-19	N-aryloxyethyl-indolyl-alkylamine zur behandlung von depressionen
AU557502B2 (en)	1986-12-24	Dithiino(1,4)(2,3-c)pyrrole derivatives