DK0807112T3 - Antimikrobiel heteroaromatisk ringsubstitueret phenyloxazolidinon - Google Patents

Antimikrobiel heteroaromatisk ringsubstitueret phenyloxazolidinon

Info

Publication number: DK0807112T3
Authority: DK; Denmark
Prior art keywords: optionally substituted; alkoxy; pct; acyloxy; hydroxy
Prior art date: 1995-02-03

Application number

DK96905168T

Other languages

Danish (da)

English (en)

Inventor

Douglas K Hutchinson

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-02-03

Filing date

1996-01-29

Publication date

2001-12-17

1996-01-29 Application filed by Upjohn Co filed Critical Upjohn Co

2001-12-17 Application granted granted Critical

2001-12-17 Publication of DK0807112T3 publication Critical patent/DK0807112T3/da

Links

125000001072 heteroaryl group Chemical group 0.000 title abstract 4
NCTCGHLIHJJIBK-UHFFFAOYSA-N 3-phenyl-1,3-oxazolidin-2-one Chemical class O=C1OCCN1C1=CC=CC=C1 NCTCGHLIHJJIBK-UHFFFAOYSA-N 0.000 title abstract 2
230000000845 anti-microbial effect Effects 0.000 title abstract 2
239000000460 chlorine Substances 0.000 abstract 5
229910052731 fluorine Inorganic materials 0.000 abstract 5
229910052801 chlorine Inorganic materials 0.000 abstract 4
125000004423 acyloxy group Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
239000011737 fluorine Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
101100295741 Gallus gallus COR4 gene Proteins 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
-1 or O2CCH2N(CH3)2 Chemical group 0.000 abstract 1
230000000063 preceeding effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

DK96905168T 1995-02-03 1996-01-29 Antimikrobiel heteroaromatisk ringsubstitueret phenyloxazolidinon DK0807112T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US38427895A	1995-02-03	1995-02-03
PCT/US1996/000718 WO1996023788A1 (fr)	1995-02-03	1996-01-29	Phenyloxazolidinone substituee par un noyau heteroaromatique comme agent antimicrobien

Publications (1)

Publication Number	Publication Date
DK0807112T3 true DK0807112T3 (da)	2001-12-17

Family

ID=23516681

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96905168T DK0807112T3 (da)	1995-02-03	1996-01-29	Antimikrobiel heteroaromatisk ringsubstitueret phenyloxazolidinon

Country Status (19)

Country	Link
US (1)	US5910504A (fr)
EP (1)	EP0807112B1 (fr)
JP (1)	JPH10513446A (fr)
KR (1)	KR100441334B1 (fr)
CN (1)	CN1075073C (fr)
AT (1)	ATE205205T1 (fr)
BR (1)	BR9607017A (fr)
CA (1)	CA2208603A1 (fr)
CZ (1)	CZ231497A3 (fr)
DE (1)	DE69615002T2 (fr)
DK (1)	DK0807112T3 (fr)
ES (1)	ES2163004T3 (fr)
FI (1)	FI973217A7 (fr)
NO (1)	NO309526B1 (fr)
NZ (1)	NZ302844A (fr)
PL (1)	PL185872B1 (fr)
PT (1)	PT807112E (fr)
RU (1)	RU2154645C2 (fr)
WO (1)	WO1996023788A1 (fr)

Families Citing this family (70)

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CA2208603A1 (fr) *	1995-02-03	1996-08-08	The Upjohn Company	Phenyloxazolidinone substituee par un noyau heteroaromatique comme agent antimicrobien
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GB9609919D0 (en) *	1996-05-11	1996-07-17	Zeneca Ltd	Chemical compounds
DE19709443C1 (de) *	1997-03-07	1998-10-08	Clariant Gmbh	Verfahren zur Herstellung von N-Carboxyalkyl-3-fluor-4-dialkylaminoanilinen und N-Carboxymethyl-3-fluor-4-morpholinoanilin und N-Carboxyisobutyl-3-fluor-4-morpholinoanilin
DE19750968A1 (de) *	1997-03-07	1998-09-10	Clariant Gmbh	Verfahren zur Herstellung von N-Carboxyalkyl-3-fluor-4-dialkylaminoanilinen
WO1999002525A1 (fr) *	1997-07-11	1999-01-21	Pharmacia & Upjohn Company	Agents antibacteriens de type phenyloxazolidinones de thiadiazolyle et d'oxadiazolyle
GB9717807D0 (en)	1997-08-22	1997-10-29	Zeneca Ltd	Chemical compounds
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EP1054874B1 (fr) *	1998-02-13	2002-08-28	PHARMACIA & UPJOHN COMPANY	Derives d'isoxazoline aminophenyle substitues utilises comme agents antimicrobiens
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US6297242B1 (en)	1999-08-12	2001-10-02	Ortho-Mcneil Pharmaceutical, Inc.	N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof
US6413981B1 (en) *	1999-08-12	2002-07-02	Ortho-Mcneil Pharamceutical, Inc.	Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
GB9928568D0 (en)	1999-12-03	2000-02-02	Zeneca Ltd	Chemical compounds
US6518285B2 (en)	1999-12-21	2003-02-11	Ortho Mcneil Pharmaceutical, Inc.	Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
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GB0009803D0 (en) *	2000-04-25	2000-06-07	Astrazeneca Ab	Chemical compounds
PE20020300A1 (es) *	2000-08-22	2002-05-10	Pharmacia Corp	Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco
US6861433B2 (en) *	2000-12-15	2005-03-01	Pharmacia & Upjohn Company	Oxazolidinone photoaffinity probes
CA2405532A1 (fr) *	2001-02-07	2002-08-22	Ortho-Mcneil Pharmaceutical, Inc.	Antibacteriens a base de pyridoarylphenyle oxazolidinone, compositions et procedes associes
DE10129725A1 (de) *	2001-06-20	2003-01-02	Bayer Ag	Kombinationstherapie substituierter Oxazolidinone
AR038536A1 (es)	2002-02-25	2005-01-19	Upjohn Co	N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7141588B2 (en)	2002-02-25	2006-11-28	Pfizer, Inc.	N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
WO2003106454A1 (fr) *	2002-06-12	2003-12-24	Orchid Chemicals & Pharmaceuticals Ltd	Derives de 1h-isoquinoline-oxazolidinone, et leur utilisation comme agents antibacteriens
ES2258234T3 (es)	2002-08-12	2006-08-16	PHARMACIA & UPJOHN COMPANY LLC	N-aril-2-oxazolidinonas y sus derivados.
AU2002339721A1 (en) *	2002-09-20	2004-04-08	Lupin Limited	Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents
US7141570B2 (en)	2002-11-21	2006-11-28	Pharmacia & Upjohn Company	N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
DE10300111A1 (de) *	2003-01-07	2004-07-15	Bayer Healthcare Ag	Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
US7304050B2 (en)	2003-09-16	2007-12-04	Pfizer Inc.	Antibacterial agents
DE10355461A1 (de)	2003-11-27	2005-06-23	Bayer Healthcare Ag	Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
DE102004062475A1 (de) *	2004-12-24	2006-07-06	Bayer Healthcare Ag	Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
EP1685841A1 (fr) *	2005-01-31	2006-08-02	Bayer Health Care Aktiengesellschaft	Prevention et traitement de troubles thromboemboliques
WO2006124897A2 (fr) *	2005-05-13	2006-11-23	Lexicon Genetics Incorporated	Procedes et compositions d'amelioration de la cognition
WO2007024789A1 (fr) *	2005-08-24	2007-03-01	Lexicon Genetics Incorporated	Dérivés de pyrrolopyridine, pyrrolopyrimidine et pyrazolopyridine, préparations les incluant et méthodes d'application
DE102005045518A1 (de) *	2005-09-23	2007-03-29	Bayer Healthcare Ag	2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
DE102005047558A1 (de) *	2005-10-04	2008-02-07	Bayer Healthcare Ag	Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen
DE102005047561A1 (de)	2005-10-04	2007-04-05	Bayer Healthcare Ag	Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
MY145616A (en)	2005-10-04	2012-03-15	Bayer Schering Pharma Ag	Novel polymorphous form and the amorphous form of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidine-5-yl}-methyl)-2-thiophene carboxamide
US7547421B2 (en) *	2006-10-18	2009-06-16	Ecolab Inc.	Apparatus and method for making a peroxycarboxylic acid
DE102006051625A1 (de) *	2006-11-02	2008-05-08	Bayer Materialscience Ag	Kombinationstherapie substituierter Oxazolidinone
US20100298384A1 (en) *	2006-12-04	2010-11-25	Mohamed Takhi	Novel oxazolidinone compounds as antiinfective agents
KR100872059B1 (ko)	2007-02-21	2008-12-05	주식회사 레고켐 바이오사이언스	아미독심 또는 하이드록사마이드 기를 가지는 신규한옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
EP2072514A1 (fr) *	2007-12-17	2009-06-24	Ferrer Internacional, S.A.	1(2)H-Tétrazol-5-yl-phényl-oxazolidinone en tant qu'agents antibactériens
US8946436B2 (en)	2011-06-17	2015-02-03	Sichuan Gooddoctor Pharmaceutical Group Co., Ltd.	Oxazolidinone compounds and their uses in preparation of antibiotics
EP2602248A1 (fr)	2011-12-05	2013-06-12	University Of Leicester	Nouveaux composés pyrroliques
WO2013182070A1 (fr) *	2012-06-08	2013-12-12	四川贝力克生物技术有限责任公司	Médicament pour la prévention ou le traitement de maladies mycobactériennes
CN104873510B (zh) *	2014-02-28	2019-03-19	四川好医生药业集团有限公司	噁唑烷酮类化合物抗生物膜用途
CN103965183B (zh) *	2014-03-17	2017-05-03	上海应用技术学院	一种含氟噁唑烷酮类化合物及其制备方法和应用
CN105272976B (zh) *	2014-07-22	2018-11-20	四川好医生药业集团有限公司	一种噁唑烷酮类化合物
CN105399737B (zh) *	2014-09-10	2018-09-21	四川好医生药业集团有限公司	噁唑烷酮类化合物及其用途
MX379156B (es)	2015-05-20	2025-03-10	Amgen Inc	Agonistas de triazol del receptor apj.
US9988369B2 (en)	2016-05-03	2018-06-05	Amgen Inc.	Heterocyclic triazole compounds as agonists of the APJ receptor
US11046680B1 (en)	2016-11-16	2021-06-29	Amgen Inc.	Heteroaryl-substituted triazoles as APJ receptor agonists
EP3541802B1 (fr)	2016-11-16	2025-01-01	Amgen Inc.	Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj
WO2018093577A1 (fr)	2016-11-16	2018-05-24	Amgen Inc.	Composés de triazole à substitution cycloalkyle en tant qu'agonistes du récepteur apj
EP3541803B1 (fr)	2016-11-16	2020-12-23	Amgen Inc.	Composés de triazole pyridyle en tant qu'agonistes du récepteur apj
EP3541792B1 (fr)	2016-11-16	2020-12-23	Amgen Inc.	Composés de triazole furane utilisés en tant qu'agonistes du récepteur apj
WO2018093579A1 (fr)	2016-11-16	2018-05-24	Amgen Inc.	Composés phényle triazole en tant qu'agonistes du récepteur apj
CN106831615B (zh) *	2017-02-15	2019-02-15	南京农业大学	一类1，2，3－三唑－5－酰胺类化合物作为农用杀菌剂的应用
EP3704122B1 (fr)	2017-11-03	2021-09-01	Amgen Inc.	Agonistes de triazole fusionnés du récepteur apj
EP3788037A1 (fr)	2018-05-01	2021-03-10	Amgen Inc.	Pyrimidinones substituées en tant qu'agonistes du récepteur apj
GB201905721D0 (en)	2019-04-24	2019-06-05	Univ Dundee	Compounds
CN113372276B (zh) *	2021-05-25	2022-04-22	三峡大学	吲唑类衍生物及其应用

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US4921869A (en) *	1987-10-09	1990-05-01	E. I. Du Pont De Nemours And Company	Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
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EP0316594B1 (fr) *	1987-10-21	1993-09-29	The Du Pont Merck Pharmaceutical Company	Dérivés d'aminométhyl-oxo-oxazolidinyl éthénylbenzène comme agents antibactériens
US4948801A (en) *	1988-07-29	1990-08-14	E. I. Du Pont De Nemours And Company	Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5254577A (en) *	1988-07-29	1993-10-19	The Du Pont Merck Pharmaceutical Company	Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
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CA2119556C (fr) *	1991-11-01	2004-07-06	Michael Robert Barbachyn	Derives de substitution aryliques ou heteroaryliques de phenylaxazolidinones
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DE4425613A1 (de) *	1994-07-20	1996-01-25	Bayer Ag	5-gliedrige Heteroaryl-oxazolidinone
CA2208603A1 (fr) *	1995-02-03	1996-08-08	The Upjohn Company	Phenyloxazolidinone substituee par un noyau heteroaromatique comme agent antimicrobien
GB9604301D0 (en) *	1996-02-29	1996-05-01	Zeneca Ltd	Chemical compounds

1996
- 1996-01-29 CA CA002208603A patent/CA2208603A1/fr not_active Abandoned
- 1996-01-29 AT AT96905168T patent/ATE205205T1/de not_active IP Right Cessation
- 1996-01-29 KR KR1019970705305A patent/KR100441334B1/ko not_active Expired - Fee Related
- 1996-01-29 PT PT96905168T patent/PT807112E/pt unknown
- 1996-01-29 EP EP96905168A patent/EP0807112B1/fr not_active Expired - Lifetime
- 1996-01-29 JP JP8523572A patent/JPH10513446A/ja not_active Withdrawn
- 1996-01-29 CZ CZ972314A patent/CZ231497A3/cs unknown
- 1996-01-29 ES ES96905168T patent/ES2163004T3/es not_active Expired - Lifetime
- 1996-01-29 US US08/875,800 patent/US5910504A/en not_active Expired - Fee Related
- 1996-01-29 NZ NZ302844A patent/NZ302844A/xx unknown
- 1996-01-29 BR BR9607017A patent/BR9607017A/pt not_active Application Discontinuation
- 1996-01-29 WO PCT/US1996/000718 patent/WO1996023788A1/fr not_active Ceased
- 1996-01-29 PL PL96321663A patent/PL185872B1/pl not_active IP Right Cessation
- 1996-01-29 DK DK96905168T patent/DK0807112T3/da active
- 1996-01-29 CN CN96191740A patent/CN1075073C/zh not_active Expired - Fee Related
- 1996-01-29 DE DE69615002T patent/DE69615002T2/de not_active Expired - Fee Related
- 1996-01-29 RU RU97114833/04A patent/RU2154645C2/ru not_active IP Right Cessation
1997
- 1997-08-01 NO NO973550A patent/NO309526B1/no not_active IP Right Cessation
- 1997-08-04 FI FI973217A patent/FI973217A7/fi unknown

Also Published As

Publication number	Publication date
EP0807112B1 (fr)	2001-09-05
DE69615002D1 (de)	2001-10-11
ATE205205T1 (de)	2001-09-15
PL321663A1 (en)	1997-12-22
ES2163004T3 (es)	2002-01-16
AU4899896A (en)	1996-08-21
FI973217A0 (fi)	1997-08-04
CZ231497A3 (cs)	1998-08-12
BR9607017A (pt)	1997-10-28
EP0807112A1 (fr)	1997-11-19
JPH10513446A (ja)	1998-12-22
FI973217A7 (fi)	1997-08-04
NO309526B1 (no)	2001-02-12
DE69615002T2 (de)	2002-06-13
HK1008898A1 (en)	1999-07-23
CN1075073C (zh)	2001-11-21
WO1996023788A1 (fr)	1996-08-08
KR100441334B1 (ko)	2004-10-20
NO973550D0 (no)	1997-08-01
PL185872B1 (pl)	2003-08-29
PT807112E (pt)	2002-02-28
CA2208603A1 (fr)	1996-08-08
NZ302844A (en)	1999-06-29
CN1172484A (zh)	1998-02-04
KR19980701908A (ko)	1998-06-25
RU2154645C2 (ru)	2000-08-20
US5910504A (en)	1999-06-08
NO973550L (no)	1997-10-03
AU703465B2 (en)	1999-03-25

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