DK0808325T3 - Androstan- og pregnanserier til allosterisk modulering af GABA-receptor - Google Patents

Androstan- og pregnanserier til allosterisk modulering af GABA-receptor

Info

Publication number
DK0808325T3
DK0808325T3 DK95942879T DK95942879T DK0808325T3 DK 0808325 T3 DK0808325 T3 DK 0808325T3 DK 95942879 T DK95942879 T DK 95942879T DK 95942879 T DK95942879 T DK 95942879T DK 0808325 T3 DK0808325 T3 DK 0808325T3
Authority
DK
Denmark
Prior art keywords
androstan
pregnancies
gaba receptor
allosteric modulation
allosteric
Prior art date
Application number
DK95942879T
Other languages
Danish (da)
English (en)
Inventor
Michael B Bolger
Hasan Tahir
Nancy C Lan
Kelvin W Gee
Robert Purdy
Ravindra B Upasani
Original Assignee
Cocensys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cocensys Inc filed Critical Cocensys Inc
Application granted granted Critical
Publication of DK0808325T3 publication Critical patent/DK0808325T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK95942879T 1994-11-23 1995-11-22 Androstan- og pregnanserier til allosterisk modulering af GABA-receptor DK0808325T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34692694A 1994-11-23 1994-11-23
PCT/US1995/015210 WO1996016076A1 (en) 1994-11-23 1995-11-22 Androstane and pregnane series for allosteric modulation of gaba receptor

Publications (1)

Publication Number Publication Date
DK0808325T3 true DK0808325T3 (da) 2001-01-29

Family

ID=23361616

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95942879T DK0808325T3 (da) 1994-11-23 1995-11-22 Androstan- og pregnanserier til allosterisk modulering af GABA-receptor

Country Status (27)

Country Link
EP (1) EP0808325B1 (cs)
JP (1) JPH10509458A (cs)
KR (1) KR100394548B1 (cs)
CN (1) CN1171114A (cs)
AP (1) AP653A (cs)
AT (1) ATE198753T1 (cs)
AU (1) AU707486B2 (cs)
BR (1) BR9509764A (cs)
CA (1) CA2205919A1 (cs)
CZ (1) CZ292881B6 (cs)
DE (1) DE69519945T2 (cs)
DK (1) DK0808325T3 (cs)
ES (1) ES2155543T3 (cs)
FI (1) FI972202L (cs)
GE (1) GEP20002033B (cs)
GR (1) GR3035562T3 (cs)
HU (1) HUT77087A (cs)
IL (1) IL116108A (cs)
IS (1) IS4488A (cs)
MX (1) MX9703826A (cs)
NO (1) NO308950B1 (cs)
NZ (1) NZ298567A (cs)
PL (1) PL182898B1 (cs)
PT (1) PT808325E (cs)
RU (1) RU2176248C2 (cs)
UA (1) UA48154C2 (cs)
WO (1) WO1996016076A1 (cs)

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CN1270718C (zh) 1998-03-11 2006-08-23 托布乔恩·贝克斯托罗姆 表别孕烷醇酮在制备治疗甾族化合物诱导的疾病的药物中的应用
US8771740B2 (en) 1999-12-20 2014-07-08 Nicholas J. Kerkhof Process for producing nanoparticles by spray drying
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WO2006012563A2 (en) * 2004-07-23 2006-02-02 The Regents Of The University Of California Method for the treatment and diagnosis of certain psychiatric disorders related to the menstrual cycle
RU2413516C2 (ru) * 2004-11-18 2011-03-10 Умекрин Аб Гамк-стероидные антагонисты и их применение в лечении нарушений цнс
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
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EP1942879A1 (en) 2005-10-31 2008-07-16 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
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Also Published As

Publication number Publication date
CZ155397A3 (cs) 1998-03-18
KR100394548B1 (ko) 2004-02-05
JPH10509458A (ja) 1998-09-14
EP0808325A1 (en) 1997-11-26
BR9509764A (pt) 1998-07-07
DE69519945D1 (de) 2001-02-22
CN1171114A (zh) 1998-01-21
ATE198753T1 (de) 2001-02-15
PL182898B1 (pl) 2002-03-29
RU2176248C2 (ru) 2001-11-27
GR3035562T3 (en) 2001-06-29
ES2155543T3 (es) 2001-05-16
AU4408596A (en) 1996-06-17
NO972320D0 (no) 1997-05-21
IL116108A (en) 2002-08-14
MX9703826A (es) 1998-02-28
EP0808325A4 (cs) 1997-12-17
IL116108A0 (en) 1996-01-31
NO308950B1 (no) 2000-11-20
AU707486B2 (en) 1999-07-08
UA48154C2 (uk) 2002-08-15
CA2205919A1 (en) 1996-05-30
DE69519945T2 (de) 2001-06-07
FI972202A7 (fi) 1997-07-17
CZ292881B6 (cs) 2003-12-17
EP0808325B1 (en) 2001-01-17
PT808325E (pt) 2001-06-29
NO972320L (no) 1997-07-23
FI972202L (fi) 1997-07-17
GEP20002033B (en) 2000-04-10
NZ298567A (en) 2000-01-28
PL320416A1 (en) 1997-09-29
AP9700998A0 (en) 1997-07-31
FI972202A0 (fi) 1997-05-23
HUT77087A (hu) 1998-03-02
AP653A (en) 1998-07-21
WO1996016076A1 (en) 1996-05-30
IS4488A (is) 1997-05-23

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