DK0819687T3 - Benzothiophenforbindelser og anvendelser og formuleringer deraf - Google Patents

Benzothiophenforbindelser og anvendelser og formuleringer deraf

Info

Publication number: DK0819687T3
Authority: DK; Denmark
Prior art keywords: formulations; phenyl; benzothiophene compounds; oco; alkyl
Prior art date: 1996-07-15

Application number

DK97305119T

Other languages

English (en)

Inventor

Brian William Grinnell

David Thompson Berg

George Joseph Cullinan

Mark Alan Richardson

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-15

Filing date

1997-07-11

Publication date

2001-04-17

1997-07-11 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2001-04-17 Application granted granted Critical

2001-04-17 Publication of DK0819687T3 publication Critical patent/DK0819687T3/da

Links

FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title abstract 3
238000009472 formulation Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
-1 N-pyrrolidinyl Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
239000000543 intermediate Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK97305119T 1996-07-15 1997-07-11 Benzothiophenforbindelser og anvendelser og formuleringer deraf DK0819687T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US2178896P	1996-07-15	1996-07-15

Publications (1)

Publication Number	Publication Date
DK0819687T3 true DK0819687T3 (da)	2001-04-17

Family

ID=21806155

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97305119T DK0819687T3 (da)	1996-07-15	1997-07-11	Benzothiophenforbindelser og anvendelser og formuleringer deraf

Country Status (10)

Country	Link
US (2)	US5948795A (da)
EP (1)	EP0819687B1 (da)
JP (1)	JPH1067774A (da)
AT (1)	ATE199717T1 (da)
CA (1)	CA2207141A1 (da)
DE (1)	DE69704235T2 (da)
DK (1)	DK0819687T3 (da)
ES (1)	ES2155655T3 (da)
GR (1)	GR3035981T3 (da)
PT (1)	PT819687E (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2004531559A (ja) *	2001-05-22	2004-10-14	イーライ・リリー・アンド・カンパニー	エストロゲン欠乏または内因性エストロゲンに対する異常な生理反応に関連する疾患を抑制するためのテトラヒドロキノリン誘導体
EP1395563B1 (en) *	2001-05-22	2006-03-29	Eli Lilly And Company	2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods
TWI240723B (en)	2001-06-20	2005-10-01	Wyeth Corp	Substituted naphthyl benzofuran derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
TWI224101B (en) *	2001-06-20	2004-11-21	Wyeth Corp	Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
US7163954B2 (en) *	2003-09-25	2007-01-16	Wyeth	Substituted naphthyl benzothiophene acids
US7446201B2 (en) *	2003-09-25	2008-11-04	Wyeth	Substituted heteroaryl benzofuran acids
ES2291981T3 (es) *	2003-11-20	2008-03-01	Eli Lilly And Company	Moduladores del receptor de la vitamina d.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE339235B (da) *	1965-06-01	1971-10-04	Haessle Ab
US3598839A (en) *	1969-06-30	1971-08-10	Parke Davis & Co	Phenylbenzothiophene compounds
US3935231A (en) *	1972-10-17	1976-01-27	Sandoz Ltd., (Sandoz Ag)	Novel benzothiophene derivatives as stabilizers for organic compounds
US4133814A (en) *	1975-10-28	1979-01-09	Eli Lilly And Company	2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) *	1981-04-03	1983-11-29	Eli Lilly And Company	Antiestrogenic and antiandrugenic benzothiophenes
GB2097788B (en) *	1981-04-03	1985-04-24	Lilly Co Eli	Benzothiophene compounds and process for preparing them
US5175184A (en) *	1982-10-19	1992-12-29	Kotobuki Seiyaku Company Limited	Benzothiophene derivatives and antihyperuricemia thereof
GB8417559D0 (en) *	1984-07-10	1984-08-15	Pfizer Ltd	Anti-diarrhoeal agents
JPH04312526A (ja) *	1991-04-09	1992-11-04	Fujisawa Pharmaceut Co Ltd	骨疾患治療剤
JP3157882B2 (ja) *	1991-11-15	2001-04-16	帝国臓器製薬株式会社	新規なベンゾチオフエン誘導体
US5595722A (en) *	1993-01-28	1997-01-21	Neorx Corporation	Method for identifying an agent which increases TGF-beta levels
US5466810A (en) *	1994-06-10	1995-11-14	Eli Lilly And Company	2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[β]thiophenes
US5532382A (en) *	1995-03-13	1996-07-02	Eli Lilly And Company	Benzothiophenes substituted at the 3-carbonyl
US5731328A (en) *	1995-10-10	1998-03-24	Eli Lilly And Company	Methods of inhibiting plasminogen activator inhibitor 1

1997
- 1997-06-05 CA CA002207141A patent/CA2207141A1/en not_active Abandoned
- 1997-06-25 US US08/882,711 patent/US5948795A/en not_active Expired - Fee Related
- 1997-07-11 AT AT97305119T patent/ATE199717T1/de not_active IP Right Cessation
- 1997-07-11 ES ES97305119T patent/ES2155655T3/es not_active Expired - Lifetime
- 1997-07-11 PT PT97305119T patent/PT819687E/pt unknown
- 1997-07-11 DE DE69704235T patent/DE69704235T2/de not_active Expired - Fee Related
- 1997-07-11 DK DK97305119T patent/DK0819687T3/da active
- 1997-07-11 EP EP97305119A patent/EP0819687B1/en not_active Expired - Lifetime
- 1997-07-14 JP JP9188233A patent/JPH1067774A/ja not_active Withdrawn
1998
- 1998-06-03 US US09/089,521 patent/US5962698A/en not_active Expired - Fee Related
2001
- 2001-05-31 GR GR20010400832T patent/GR3035981T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2207141A1 (en)	1998-01-15
GR3035981T3 (en)	2001-08-31
DE69704235D1 (de)	2001-04-19
EP0819687A1 (en)	1998-01-21
JPH1067774A (ja)	1998-03-10
DE69704235T2 (de)	2001-09-06
PT819687E (pt)	2001-06-29
EP0819687B1 (en)	2001-03-14
US5962698A (en)	1999-10-05
ATE199717T1 (de)	2001-03-15
US5948795A (en)	1999-09-07
ES2155655T3 (es)	2001-05-16

Publication	Publication Date	Title
DE69725230D1 (de)	2003-11-06	Benzothiophenverbindungen, ihre Anwendungen und Zusammensetzungen
BE2018C008I2 (da)	2021-02-04
DK0792641T3 (da)	2001-10-08	Anvendelse af estrogenantagonister og estrogenagonister til hæmning af patologiske tilstande
ES2088537T3 (es)	1996-08-16	Derivados de piranil cianoguanidina.
ATE283253T1 (de)	2004-12-15	Substituierte aminopropoxyarylderivate als lxr agonisten
IL160304A (en)	2010-12-30	Compounds and composition for activating peroxisome proliferators-responsive receptor ??
FI943561A0 (fi)	1994-07-29	Uudet ainekoostumukset
PT918776E (pt)	2004-07-30	Sintese total de acilfulvenos antitumorais
ATE277011T1 (de)	2004-10-15	Flouride von 4-substituierten piperidin-derivaten
DE60223904D1 (de)	2008-01-17	Benzylaminanalogen
NO902336D0 (no)	1990-05-25	Antispasmotiske midler.
DK0819687T3 (da)	2001-04-17	Benzothiophenforbindelser og anvendelser og formuleringer deraf
DK1209151T3 (da)	2007-08-20	4-substituerede piperidinderivativer
AU571734B2 (en)	1988-04-21	Acylated saccharin derivatives
DK1559714T3 (da)	2008-03-25	Fremgangsmåde til fremstilling af 2-alkyl-3-aminothiophenderivater og 3-aminothiophenderivater
MXPA03008033A (es)	2003-12-04	Composicion medicinal que contiene derivados de 1,3-tiazina.
ATE284379T1 (de)	2004-12-15	Aminderivate
BR9006967A (pt)	1991-12-17	Derivados de sulfamidos sulfonilureia e herbicidas
ES2077697T3 (es)	1995-12-01	Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos.
PT1140932E (pt)	2004-08-31	Derivados de 1,8-benzonaftiridina