DK0835257T3 - Mellemprodukter og fremgangsmåde til fremstilling af camptothecin-derivater (CPT-11) og beslægtede forbindelser - Google Patents

Mellemprodukter og fremgangsmåde til fremstilling af camptothecin-derivater (CPT-11) og beslægtede forbindelser

Info

Publication number: DK0835257T3
Authority: DK; Denmark
Prior art keywords: intermediates; cpt; pct; related compounds; camptothecin derivatives
Prior art date: 1995-04-07

Application number

DK96912468T

Other languages

Danish (da)

English (en)

Inventor

John C Sih

Kevin E Henegar

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-07

Filing date

1996-04-01

Publication date

2003-02-03

1996-04-01 Application filed by Upjohn Co filed Critical Upjohn Co

2003-02-03 Application granted granted Critical

2003-02-03 Publication of DK0835257T3 publication Critical patent/DK0835257T3/da

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000000543 intermediate Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title 1
238000000034 method Methods 0.000 abstract 2
WSXJPXFVULHYMX-KRWDZBQOSA-N 7-[(1s)-1-hydroxypropyl]-8-methyl-11h-indolizino[1,2-b]quinolin-9-one Chemical compound C1=CC=C2C=C(CN3C4=CC(=C(C3=O)C)[C@@H](O)CC)C4=NC2=C1 WSXJPXFVULHYMX-KRWDZBQOSA-N 0.000 abstract 1
WSXJPXFVULHYMX-UHFFFAOYSA-N S-Mappicine Natural products C1=CC=C2C=C(CN3C4=CC(=C(C3=O)C)C(O)CC)C4=NC2=C1 WSXJPXFVULHYMX-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 abstract 1
229960004768 irinotecan Drugs 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C07D213/643—2-Phenoxypyridines; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heat Sensitive Colour Forming Recording (AREA)
Paper (AREA)
Lubricants (AREA)
Steroid Compounds (AREA)

DK96912468T 1995-04-07 1996-04-01 Mellemprodukter og fremgangsmåde til fremstilling af camptothecin-derivater (CPT-11) og beslægtede forbindelser DK0835257T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US41964395A	1995-04-07	1995-04-07
PCT/US1996/004163 WO1996031513A1 (en)	1995-04-07	1996-04-01	Novel intermediates and process for the manufacture of camptothecin derivatives (cpt-11) and related compounds

Publications (1)

Publication Number	Publication Date
DK0835257T3 true DK0835257T3 (da)	2003-02-03

Family

ID=23663114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96912468T DK0835257T3 (da)	1995-04-07	1996-04-01	Mellemprodukter og fremgangsmåde til fremstilling af camptothecin-derivater (CPT-11) og beslægtede forbindelser

Country Status (25)

Country	Link
US (3)	US6121451A (cs)
EP (1)	EP0835257B1 (cs)
JP (2)	JP4281075B2 (cs)
KR (1)	KR100423627B1 (cs)
CN (5)	CN1100058C (cs)
AT (1)	ATE224899T1 (cs)
AU (1)	AU717179B2 (cs)
CA (1)	CA2214793C (cs)
CZ (1)	CZ297862B6 (cs)
DE (1)	DE69623960T2 (cs)
DK (1)	DK0835257T3 (cs)
ES (1)	ES2183943T3 (cs)
HK (2)	HK1054234B (cs)
HU (1)	HUP9801436A3 (cs)
IL (1)	IL117684A (cs)
MX (1)	MX9707706A (cs)
NO (2)	NO320482B1 (cs)
NZ (1)	NZ306664A (cs)
PL (2)	PL186564B1 (cs)
PT (1)	PT835257E (cs)
RU (1)	RU2164917C2 (cs)
SI (1)	SI0835257T1 (cs)
TW (1)	TW438775B (cs)
WO (1)	WO1996031513A1 (cs)
ZA (1)	ZA962747B (cs)

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PL1928883T3 (pl) *	2005-02-08	2014-03-31	Fermion Oy	Sposób otrzymywania chlorowodorku irynotekanu
CA2591071C (en) *	2005-02-08	2014-04-29	Fermion Oy	Process for producing [1,4'] bipiperidinyl-1'-carbonyl chloride or hydrochloride thereof
TWI375678B (en)	2005-06-09	2012-11-01	Yakult Honsha Kk	A method of preparation of a tricyclic ketone
EP1803725A1 (en) *	2005-12-13	2007-07-04	W.C. Heraeus GmbH	Methods for preparing irinotecan
US7671067B2 (en) *	2006-02-09	2010-03-02	Enzon Pharmaceuticals, Inc.	Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
US7462627B2 (en) *	2006-02-09	2008-12-09	Enzon Pharmaceuticals, Inc.	Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
CN101583380B (zh) *	2006-11-30	2013-07-10	尼克塔治疗公司	用于制备聚合物轭合物的方法
KR20090108082A (ko) *	2007-02-09	2009-10-14	엔존 파마슈티컬즈, 인코포레이티드	7-에틸-10-하이드록시캄토테신 다분지형 고분자 접합체를 이용한 내성 또는 불응성 암의 치료방법
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LT2349346T (lt)	2008-09-23	2019-09-25	Nektar Therapeutics	Kamptotecino provaistų (pvz., peg-irinotekano) metronominio dozavimo būdas
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WO2012088445A1 (en)	2010-12-22	2012-06-28	Nektar Therapeutics	Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
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EA035674B1 (ru)	2014-07-18	2020-07-24	Санофи	Способ определения того, является ли пациент, предположительно страдающий от рака, кандидатом для терапии афлиберцептом
CN106937529B (zh)	2015-10-27	2021-02-05	加州太平洋医疗中心	鬼臼毒素衍生物及其应用
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US5405963A (en) *	1993-06-10	1995-04-11	Smithkline Beecham Corporation	Process for asymmetric total synthesis of camptothecin analogues
GB9316352D0 (en) *	1993-08-06	1993-09-22	Erba Carlo Spa	Process for the preparation of 9-amino camptothecin
GB9319944D0 (en) *	1993-09-28	1993-11-17	Erba Carlo Spa	Process for the preparation of 9-amino camptothecin

1996
- 1996-03-27 TW TW085103680A patent/TW438775B/zh not_active IP Right Cessation
- 1996-03-27 IL IL11768496A patent/IL117684A/en not_active IP Right Cessation
- 1996-04-01 CN CN96193138A patent/CN1100058C/zh not_active Expired - Fee Related
- 1996-04-01 CN CN03103098XA patent/CN1434043B/zh not_active Expired - Fee Related
- 1996-04-01 CN CNB031031005A patent/CN100537538C/zh not_active Expired - Fee Related
- 1996-04-01 DK DK96912468T patent/DK0835257T3/da active
- 1996-04-01 US US09/230,245 patent/US6121451A/en not_active Expired - Fee Related
- 1996-04-01 CA CA002214793A patent/CA2214793C/en not_active Expired - Fee Related
- 1996-04-01 HU HU9801436A patent/HUP9801436A3/hu unknown
- 1996-04-01 SI SI9630551T patent/SI0835257T1/xx unknown
- 1996-04-01 KR KR1019970707091A patent/KR100423627B1/ko not_active Expired - Fee Related
- 1996-04-01 PL PL96355318A patent/PL186564B1/pl not_active IP Right Cessation
- 1996-04-01 ES ES96912468T patent/ES2183943T3/es not_active Expired - Lifetime
- 1996-04-01 DE DE69623960T patent/DE69623960T2/de not_active Expired - Lifetime
- 1996-04-01 CN CNB031030971A patent/CN100396682C/zh not_active Expired - Fee Related
- 1996-04-01 JP JP53035696A patent/JP4281075B2/ja not_active Expired - Fee Related
- 1996-04-01 MX MX9707706A patent/MX9707706A/es not_active IP Right Cessation
- 1996-04-01 RU RU97118673/04A patent/RU2164917C2/ru not_active IP Right Cessation
- 1996-04-01 NZ NZ306664A patent/NZ306664A/xx not_active IP Right Cessation
- 1996-04-01 AU AU55278/96A patent/AU717179B2/en not_active Ceased
- 1996-04-01 CN CNB031030998A patent/CN1241926C/zh not_active Expired - Fee Related
- 1996-04-01 PL PL96322651A patent/PL186446B1/pl not_active IP Right Cessation
- 1996-04-01 PT PT96912468T patent/PT835257E/pt unknown
- 1996-04-01 WO PCT/US1996/004163 patent/WO1996031513A1/en not_active Ceased
- 1996-04-01 AT AT96912468T patent/ATE224899T1/de active
- 1996-04-01 EP EP96912468A patent/EP0835257B1/en not_active Expired - Lifetime
- 1996-04-01 CZ CZ0311097A patent/CZ297862B6/cs not_active IP Right Cessation
- 1996-04-04 ZA ZA9602747A patent/ZA962747B/xx unknown
1997
- 1997-10-06 NO NO19974608A patent/NO320482B1/no not_active IP Right Cessation
2000
- 2000-02-22 US US09/511,006 patent/US6235907B1/en not_active Expired - Fee Related
- 2000-10-13 US US09/687,227 patent/US6444820B1/en not_active Expired - Fee Related
2003
- 2003-09-11 HK HK03106488.3A patent/HK1054234B/zh not_active IP Right Cessation
- 2003-09-11 HK HK03106509.8A patent/HK1054236B/zh not_active IP Right Cessation
2005
- 2005-01-25 NO NO20050408A patent/NO329776B1/no not_active IP Right Cessation
2007
- 2007-10-25 JP JP2007277903A patent/JP2008069170A/ja active Pending

Also Published As

Publication number	Publication date
HK1054236B (zh)	2010-02-05
PL322651A1 (en)	1998-02-16
RU2164917C2 (ru)	2001-04-10
PL186564B1 (pl)	2004-01-30
PT835257E (pt)	2003-01-31
CN100537538C (zh)	2009-09-09
EP0835257B1 (en)	2002-09-25
IL117684A (en)	2002-02-10
NO329776B1 (no)	2010-12-13
NZ306664A (en)	1999-11-29
MX9707706A (es)	1997-12-31
WO1996031513A1 (en)	1996-10-10
DE69623960T2 (de)	2003-06-05
HK1055118A1 (zh)	2003-12-24
CN1434043B (zh)	2010-04-28
CN1181083A (zh)	1998-05-06
KR19980703691A (ko)	1998-12-05
CZ311097A3 (cs)	1998-03-18
ZA962747B (en)	1998-04-06
KR100423627B1 (ko)	2004-07-27
AU717179B2 (en)	2000-03-16
JPH11503156A (ja)	1999-03-23
HUP9801436A3 (en)	1998-11-30
TW438775B (en)	2001-06-07
CA2214793A1 (en)	1996-10-10
JP2008069170A (ja)	2008-03-27
SI0835257T1 (en)	2003-04-30
HK1009448A1 (en)	1999-09-10
HK1054234B (zh)	2010-12-24
ES2183943T3 (es)	2003-04-01
CN1434046A (zh)	2003-08-06
HK1054236A1 (zh)	2003-11-21
US6121451A (en)	2000-09-19
IL117684A0 (en)	1996-07-23
EP0835257A1 (en)	1998-04-15
CZ297862B6 (cs)	2007-04-18
HUP9801436A2 (hu)	1998-10-28
HK1055119A1 (en)	2003-12-24
CN1434044A (zh)	2003-08-06
NO320482B1 (no)	2005-12-12
DE69623960D1 (de)	2002-10-31
US6235907B1 (en)	2001-05-22
ATE224899T1 (de)	2002-10-15
US6444820B1 (en)	2002-09-03
NO20050408L (no)	1997-12-08
CN100396682C (zh)	2008-06-25
CN1100058C (zh)	2003-01-29
CN1434043A (zh)	2003-08-06
CN1434037A (zh)	2003-08-06
NO974608L (no)	1997-12-08
PL186446B1 (pl)	2004-01-30
HK1054234A1 (zh)	2003-11-21
CN1241926C (zh)	2006-02-15
NO974608D0 (no)	1997-10-06
CA2214793C (en)	2009-10-20
JP4281075B2 (ja)	2009-06-17
AU5527896A (en)	1996-10-23

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