DK0845988T3 - Hidtil ukendte kondenserede isoquinoliner som dopaminreceptorligander - Google Patents

Hidtil ukendte kondenserede isoquinoliner som dopaminreceptorligander

Info

Publication number
DK0845988T3
DK0845988T3 DK96928941T DK96928941T DK0845988T3 DK 0845988 T3 DK0845988 T3 DK 0845988T3 DK 96928941 T DK96928941 T DK 96928941T DK 96928941 T DK96928941 T DK 96928941T DK 0845988 T3 DK0845988 T3 DK 0845988T3
Authority
DK
Denmark
Prior art keywords
receptor ligands
isoquinolines
dopamine receptor
newly condensed
condensed
Prior art date
Application number
DK96928941T
Other languages
Danish (da)
English (en)
Inventor
Debasis Ghosh
David E Nichols
Richard Mailman
Original Assignee
Purdue Research Foundation
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation, Univ North Carolina filed Critical Purdue Research Foundation
Application granted granted Critical
Publication of DK0845988T3 publication Critical patent/DK0845988T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DK96928941T 1995-08-18 1996-08-16 Hidtil ukendte kondenserede isoquinoliner som dopaminreceptorligander DK0845988T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US251995P 1995-08-18 1995-08-18
PCT/US1996/013416 WO1997006799A1 (fr) 1995-08-18 1996-08-16 Nouvelles isoquinoleines fusionnees utilisees en tant que ligands pour recepteurs de la dopamine

Publications (1)

Publication Number Publication Date
DK0845988T3 true DK0845988T3 (da) 2002-04-02

Family

ID=21701148

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96928941T DK0845988T3 (da) 1995-08-18 1996-08-16 Hidtil ukendte kondenserede isoquinoliner som dopaminreceptorligander

Country Status (18)

Country Link
US (2) US5959110A (fr)
EP (1) EP0845988B1 (fr)
JP (1) JP2000505046A (fr)
CN (1) CN1199338A (fr)
AT (1) ATE209915T1 (fr)
AU (1) AU700688B2 (fr)
BR (1) BR9610323A (fr)
CA (1) CA2227585A1 (fr)
DE (1) DE69617700T2 (fr)
DK (1) DK0845988T3 (fr)
ES (1) ES2169257T3 (fr)
IL (1) IL122974A (fr)
MX (1) MX9801179A (fr)
NO (1) NO308658B1 (fr)
NZ (1) NZ316312A (fr)
PT (1) PT845988E (fr)
RU (1) RU2177001C2 (fr)
WO (1) WO1997006799A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU700688B2 (en) * 1995-08-18 1999-01-14 Purdue Research Foundation Novel fused isoquinolines as dopamine receptor ligands
KR20030027020A (ko) * 2000-08-11 2003-04-03 펄듀 리서치 파운데이션 디나프솔린의 제조 공정
MXPA03006265A (es) * 2001-01-16 2004-06-25 Purdue Research Foundation Metodo de tratamiento de disfuncion relacionada con dopamina mediante administracion de un agonista de receptor de dopamina d1 completo, sin generacion de tolerancia.
DE60220800D1 (de) * 2001-08-10 2007-08-02 Purdue Research Foundation Chirales dinapsolin
AU2003217430B2 (en) * 2002-02-15 2008-10-23 Darpharma, Inc. Mono-ester and asymmetrically substituted Di-ester pro-drugs of the dopamine D1 receptor agonists
JP2004190007A (ja) * 2002-11-27 2004-07-08 Konica Minolta Holdings Inc 色素およびインクジェット記録液
WO2005029077A1 (fr) * 2003-09-24 2005-03-31 Biacore Ab Procede et systeme d'analyse d'interactions moleculaires
WO2007098462A2 (fr) * 2006-02-21 2007-08-30 Purdue Research Foundation Synthèse et méthodes d'utilisation de chroménoisoquinolines trans-fusionnées
RS53866B1 (sr) * 2008-07-16 2015-08-31 Richter Gedeon Nyrt. Farmaceutske formulacije koje sadrže ligande dopaminskih receptora
US9359303B2 (en) 2009-04-21 2016-06-07 Purdue Research Foundation Octahydrobenzoisoquinoline modulators of dopamine receptors and uses therefor
CN110068645B (zh) * 2019-04-03 2021-09-03 上海药明奥测医疗科技有限公司 液质联用检测尿液中环磷酸腺苷的方法
CA3148598A1 (fr) 2019-07-30 2021-02-04 Mayo Foundation For Medical Education And Research Composes et methodes de traitement de pathologies fibrotiques
WO2022164996A1 (fr) * 2021-01-29 2022-08-04 Mayo Foundation For Medical Education And Research Méthodes de traitement de pathologies fibrotiques oculaires

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4346090A (en) * 1977-07-21 1982-08-24 Ayerst, Mckenna & Harrison Ltd. 13-Chloro-benzocycloheptapyridoisoquinolines and use as neuroleptics
HU180234B (en) * 1979-01-22 1983-02-28 Lilly Co Eli Process for producing oktahydro-pyrasolo-aracket-3,4-g-bracket closed-quinolines
DE3624607A1 (de) * 1986-07-21 1988-01-28 Boehringer Ingelheim Kg Neue tetrahydrobenzothiazolo-chinoline ihre herstellung und verwendung
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5047536A (en) * 1989-03-17 1991-09-10 Purdue Research Foundation Hexahydrobenzo(A)phenanthridine compounds
IE912999A1 (en) * 1990-09-07 1992-03-11 Abbott Lab Phenanthridine compounds
CA2054569A1 (fr) * 1990-11-07 1992-05-08 Masanobu Suzuki Procede pour la preparation de derives du benzo¬c|phenanthridinium, et nouveaux composes prepares suivant ce procede
AU4391493A (en) * 1992-05-26 1993-12-30 Purdue Research Foundation Substituted-hexahydrobenzo(A)phenanthridines
AU700688B2 (en) * 1995-08-18 1999-01-14 Purdue Research Foundation Novel fused isoquinolines as dopamine receptor ligands

Also Published As

Publication number Publication date
AU700688B2 (en) 1999-01-14
AU6851396A (en) 1997-03-12
PT845988E (pt) 2002-05-31
RU2177001C2 (ru) 2001-12-20
IL122974A (en) 2000-11-21
NZ316312A (en) 1999-06-29
ES2169257T3 (es) 2002-07-01
EP0845988A4 (fr) 1998-11-11
EP0845988B1 (fr) 2001-12-05
DE69617700T2 (de) 2002-07-18
DE69617700D1 (de) 2002-01-17
NO980688D0 (no) 1998-02-18
CN1199338A (zh) 1998-11-18
US5959110A (en) 1999-09-28
MX9801179A (es) 1998-04-30
WO1997006799A1 (fr) 1997-02-27
BR9610323A (pt) 1999-12-21
EP0845988A1 (fr) 1998-06-10
US6194423B1 (en) 2001-02-27
ATE209915T1 (de) 2001-12-15
IL122974A0 (en) 1998-08-16
JP2000505046A (ja) 2000-04-25
NO308658B1 (no) 2000-10-09
CA2227585A1 (fr) 1997-02-27
NO980688L (no) 1998-02-18

Similar Documents

Publication Publication Date Title
RO115522B1 (ro) Derivaţi de indolină, procedee pentru prepararea acestora, compoziţii farmaceutice care îi conţin şi metodă de tratament
DK0845988T3 (da) Hidtil ukendte kondenserede isoquinoliner som dopaminreceptorligander
AU2733297A (en) Pharmaceutical compositions for prevention and treatment of central nervous system disorders
UA66865C2 (uk) Інденопіролокарбазоли, фармацевтична композиція, спосіб інгібування кіназної активності та спосіб лікування (варіанти)
ATE272398T1 (de) Verwendung von ep4 rezeptorliganden zur behandlung von neuropathischen schmerz
YU47902A (sh) Novi polimorfi sertralin hidrohlorida, postupci za njihovo dobijanje, preparati koji ih sadrže i postupci za njihovu upotrebu
ID24228A (id) (+)norcisaprida yang berguna untuk gangguan tertular 5-ht3 dan 5-ht4
EA199700242A1 (ru) Индазолкарбоксамиды, способ их получения, фармкомпозиция и способ ингибирования 5-нтрецептора
HRP20010969B1 (en) Novel piperazinylalkylthiopyrimidine derivatives,
BR0011122A (pt) Antagonistas de receptor il-8
MXPA02000242A (es) Analogos de 2-aminoindano.
DK0823909T3 (da) Hidtil ukendte heterocykliske forbindelser
NO984245D0 (no) Nasal administrasjon av midler for behandling av emesis med forsinket begynnelse
NZ320522A (en) Piperazinylalkylthiopyrimidine derivatives, pharmaceutical compositions containing the same and a process for the preparation of the compounds
ATE243695T1 (de) 5-bicycloindolverbindungen
NO912985D0 (no) Forbedret system for transdermal applikasjon av farmasoeytisk aktive forbindelser ved regulert ph.
ATE283269T1 (de) 5-(heteroaryl)alkyl)-3-oxo-pyrido(1,2- a)benzimidazol-4-carboxamid (pbi) derivate zur behandlung von störungen des zentralen nervensystems
EA199901049A2 (ru) Спироимидазолиновые соединения, способ их получения и фармацевтическая композиция, содержащая их
DE60129846D1 (de) Isochinolin-aroylpyrrole für die behandlung von krankheiten des zentralnervensystems
ATE242766T1 (de) Neue derivate von benzoylalkyl-1,2,3,6- tetrahydropyridinen