DK0856516T3 - Adipoyl-7-aminodeacetylcephalosporansyre - Google Patents

Adipoyl-7-aminodeacetylcephalosporansyre

Info

Publication number: DK0856516T3
Authority: DK; Denmark
Prior art keywords: adipoyl; side chain; acid; aca; whose expression
Prior art date: 1991-10-15

Application number

DK97204046T

Other languages

English (en)

Inventor

Michael J Conder

Anthony Michael Stepan

Lorilee Crawford

John A Rambosek

Phyllis C Mcada

Christopher D Reeves

Original Assignee

Dsm Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-15

Filing date

1992-10-14

Publication date

2002-07-29

1992-10-14 Application filed by Dsm Nv filed Critical Dsm Nv

2002-07-29 Application granted granted Critical

2002-07-29 Publication of DK0856516T3 publication Critical patent/DK0856516T3/da

Links

239000000047 product Substances 0.000 abstract 4
BQIMPGFMMOZASS-CLZZGJSISA-N (6r,7r)-7-amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1CC(CO)=C(C(O)=O)N2C(=O)[C@@H](N)[C@H]21 BQIMPGFMMOZASS-CLZZGJSISA-N 0.000 abstract 3
HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 abstract 3
BQIMPGFMMOZASS-UHFFFAOYSA-N beta-amino-3-hydroxymethyl-3-cefem-4-carboxylic acid Natural products S1CC(CO)=C(C(O)=O)N2C(=O)C(N)C21 BQIMPGFMMOZASS-UHFFFAOYSA-N 0.000 abstract 3
241000228150 Penicillium chrysogenum Species 0.000 abstract 2
125000003651 hexanedioyl group Chemical group C(CCCCC(=O)*)(=O)* 0.000 abstract 2
NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 1
NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 1
229930186147 Cephalosporin Natural products 0.000 abstract 1
101710104123 Deacetoxycephalosporin C synthase Proteins 0.000 abstract 1
108010074633 Mixed Function Oxygenases Proteins 0.000 abstract 1
241000228417 Sarocladium strictum Species 0.000 abstract 1
108020002494 acetyltransferase Proteins 0.000 abstract 1
WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229940124587 cephalosporin Drugs 0.000 abstract 1
150000001780 cephalosporins Chemical class 0.000 abstract 1
238000003776 cleavage reaction Methods 0.000 abstract 1
239000012467 final product Substances 0.000 abstract 1
238000011065 in-situ storage Methods 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
238000006049 ring expansion reaction Methods 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/933—Penicillium
- Y10S435/935—Penicillium chrysogenum

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Cephalosporin Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK97204046T 1991-10-15 1992-10-14 Adipoyl-7-aminodeacetylcephalosporansyre DK0856516T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US77783391A	1991-10-15	1991-10-15
US95349292A	1992-10-06	1992-10-06

Publications (1)

Publication Number	Publication Date
DK0856516T3 true DK0856516T3 (da)	2002-07-29

Family

ID=27119363

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK97204046T DK0856516T3 (da)	1991-10-15	1992-10-14	Adipoyl-7-aminodeacetylcephalosporansyre
DK92309351T DK0540210T3 (da)	1991-10-15	1992-10-14	Ny biologisk fremgangsmåde til fremstilling af 7-ACA og 7-ADAC

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK92309351T DK0540210T3 (da)	1991-10-15	1992-10-14	Ny biologisk fremgangsmåde til fremstilling af 7-ACA og 7-ADAC

Country Status (27)

Country	Link
US (4)	US5559005A (da)
EP (2)	EP0540210B1 (da)
JP (1)	JP2655790B2 (da)
KR (1)	KR100227711B1 (da)
CN (1)	CN1074484A (da)
AT (2)	ATE216700T1 (da)
AU (1)	AU657800B2 (da)
BG (1)	BG62261B1 (da)
CA (1)	CA2080573C (da)
CZ (1)	CZ288721B6 (da)
DE (2)	DE69227750T2 (da)
DK (2)	DK0856516T3 (da)
ES (2)	ES2176613T3 (da)
FI (1)	FI106965B (da)
GR (1)	GR3029343T3 (da)
HU (1)	HU219370B (da)
IL (3)	IL103419A (da)
MX (1)	MX9205902A (da)
NO (1)	NO315802B1 (da)
NZ (1)	NZ244714A (da)
RO (1)	RO116648B1 (da)
RU (1)	RU2002130702A (da)
SK (1)	SK280569B6 (da)
TW (1)	TW272233B (da)
UA (1)	UA47385C2 (da)
WO (1)	WO1993008287A1 (da)
YU (1)	YU48930B (da)

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US5318896A (en) *	1991-09-11	1994-06-07	Merck & Co., Inc.	Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
PT711348E (pt) *	1993-07-30	2003-08-29	Dsm Nv	Processo para a eficiente producao de 7-adca por via de 3-(carboxietiltio)propionil-7-adca
RU2139350C1 (ru) *	1993-07-30	1999-10-10	Гист-Брокейдс Б.В.	Способ эффективного производства 7-адцк через 3-(карбоксиэтилтио)пропионил-7-адцк
KR100336174B1 (ko) *	1993-07-30	2002-11-01	디에스엠 기스트 베.파우.	2-(카르복시에틸티오)아세틸-7-adca및3-(카르복시메틸티오)프로피오닐-7-adca를경유하여7-adca를제조하는효율적인방법
WO1996010084A1 (en) *	1994-09-28	1996-04-04	Novo Nordisk A/S	Process for the production of secondary metabolites
DE4437420A1 (de) *	1994-10-19	1996-04-25	Hoechst Ag	Verbessertes, induktionsfreies Verfahren zur gentechnischen Herstellung von Glutarylamidase
RU2192471C2 (ru) *	1995-06-02	2002-11-10	Гист-Брокейдс Б.В.	Способ получения 7-адцк путем воздействия активности экспандазы на пенициллин g
US5731165A (en) *	1995-06-02	1998-03-24	Gist-Brocades, B.V.	Process for the production of 7-ADCA via expandase activity on penicillin G
WO1997038107A1 (en) *	1996-04-04	1997-10-16	Gist-Brocades B.V.	An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof
AU4201897A (en)	1996-07-16	1998-02-09	Gist-Brocades B.V.	Novel process for the preparation of cephalosporins using (acremonium chrysogenum)
AU7648898A (en) *	1997-04-22	1998-11-13	Gist-Brocades B.V.	Process for the fermentative production of deacylated cephalosporins
WO1998048037A1 (en) *	1997-04-22	1998-10-29	Dsm N.V.	A METHOD FOR CONTROLLING THE SOLUBILITY OF A β-LACTAM NUCLEUS
US6319684B1 (en)	1997-04-22	2001-11-20	Dms N.V.	Process for the fermentative production of cephalosporin
SI0915988T1 (en) *	1997-04-22	2003-06-30	Dsm N.V.	Process for the fermentative production of deacylated cephalosporins
AU9264598A (en) *	1997-08-22	1999-03-16	Gist-Brocades B.V.	Statin production by fermentation
ES2186347T3 (es)	1998-03-27	2003-05-01	Dsm Nv	Nuevo procedimiento de produccion por fermentacion de cefalosporina.
US6383773B2 (en)	1998-04-23	2002-05-07	Massachusetts Institute Of Technology	Penicillin conversion
PL344863A1 (en) *	1998-05-19	2001-11-19	Dsm Nv	Improved in vivo
EP1141372A2 (en) *	1998-12-22	2001-10-10	Dsm N.V.	Improved in vivo production of cephalosporins
ES2165276B1 (es) *	1999-06-18	2003-03-01	Antibioticos Sau	Procedimiento biotecnologico para la produccion de acido 7-aminocefal osporanico (7-adca) y compuestos de sintesis intermedios particularmente penicilina n y desacetoxicefalosporina c (daoc)
BRPI0110774B8 (pt)	2000-05-13	2021-05-25	Smithkline Beecham Plc	processo para purificação de um sal de ácido clavulânico
US6699699B2 (en) *	2002-03-26	2004-03-02	Synmax Biochemical Co., Ltd.	Mutated penicillin expandases
JP2006528970A (ja) *	2003-05-28	2006-12-28	デーエスエムアイピーアセッツベー．ヴェー．	セフェム化合物
ES2423454T3 (es) *	2006-02-23	2013-09-20	Dsm Sinochem Pharmaceuticals Netherlands B.V.	Producción mejorada de cefalosporina
KR101569832B1 (ko) *	2008-11-19	2015-11-18	삼성전자주식회사	시료 중의 게놈 ｄｎａ 및 플라스미드 ｄｎａ를 서로 분리하는 방법 및 그를 위한 키트
CN101429538B (zh) *	2008-12-12	2011-05-25	河北九派制药有限公司	7-α-甲氧基-3-去乙酰基头孢噻吩苄星盐的制备方法
WO2010115838A1 (en)	2009-04-03	2010-10-14	Dsm Ip Assets B.V.	Fermentation process
US8863444B2 (en)	2010-05-31	2014-10-21	Feature Walters	Assembly system for modular building units
HUE035540T2 (en)	2010-06-22	2018-05-02	Dsm Sinochem Pharm Nl Bv	Air bubble fermentation process
EP2614066B1 (en)	2010-09-07	2017-11-29	DSM Sinochem Pharmaceuticals Netherlands B.V.	Process for the production of cephalosporins
CN102702229A (zh) *	2011-08-04	2012-10-03	重庆天地药业有限责任公司	一种头孢唑肟钠关键中间体的制备及高含量头孢唑肟钠的制备
WO2015091455A1 (en)	2013-12-17	2015-06-25	Dpx Holdings B.V.	Bioreactor
KR101808192B1 (ko) *	2016-08-26	2018-01-18	아미코젠주식회사	7-아미노세팔로스포란산의 고농도 생산 재조합 아크레모니움 크리소제눔 균주의 제조방법 및 이 방법으로 제조된 균주

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US5082772A (en) *	1988-10-24	1992-01-21	Eli Lilly And Company	Process for preparing deacetylcephalosporin c
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EP0465600B1 (en) *	1989-04-04	1995-06-07	Biopure Corporation	Enzymatic production of 7-amino cephalosporanic acid
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IL95766A (en) *	1989-09-27	1996-12-05	Lilly Co Eli	Recombinant DNA expression vectors And DNA compounds. Which encode Aspergillus acyltransferase activity
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ATE180279T1 (de) *	1990-01-12	1999-06-15	Glaxo Group Ltd	Für ein enzym der antibiotika-biosynthese kodierende dna-sequenz
JPH03254684A (ja) *	1990-03-02	1991-11-13	Asahi Chem Ind Co Ltd	新規ｃＤＮＡ化合物
CA2045951A1 (en) *	1990-07-06	1992-01-07	Steven Kovacevic	Recombinant dna expression vectors and dna compounds that encode deacetylcephalosporin c synthase activity
US5318896A (en) *	1991-09-11	1994-06-07	Merck & Co., Inc.	Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)

1992
- 1992-10-08 SK SK431-94A patent/SK280569B6/sk unknown
- 1992-10-08 HU HU9401073A patent/HU219370B/hu not_active IP Right Cessation
- 1992-10-08 WO PCT/US1992/008585 patent/WO1993008287A1/en not_active Ceased
- 1992-10-08 CZ CZ1994884A patent/CZ288721B6/cs not_active IP Right Cessation
- 1992-10-08 KR KR1019940701210A patent/KR100227711B1/ko not_active Expired - Fee Related
- 1992-10-08 RO RO94-00603A patent/RO116648B1/ro unknown
- 1992-10-08 UA UA94005496A patent/UA47385C2/uk unknown
- 1992-10-13 NZ NZ244714A patent/NZ244714A/en not_active IP Right Cessation
- 1992-10-14 AT AT97204046T patent/ATE216700T1/de not_active IP Right Cessation
- 1992-10-14 DK DK97204046T patent/DK0856516T3/da active
- 1992-10-14 DK DK92309351T patent/DK0540210T3/da active
- 1992-10-14 DE DE69227750T patent/DE69227750T2/de not_active Expired - Fee Related
- 1992-10-14 AT AT92309351T patent/ATE174057T1/de not_active IP Right Cessation
- 1992-10-14 ES ES97204046T patent/ES2176613T3/es not_active Expired - Lifetime
- 1992-10-14 CA CA002080573A patent/CA2080573C/en not_active Expired - Fee Related
- 1992-10-14 CN CN92113331A patent/CN1074484A/zh active Pending
- 1992-10-14 IL IL10341992A patent/IL103419A/xx not_active IP Right Cessation
- 1992-10-14 ES ES92309351T patent/ES2127205T3/es not_active Expired - Lifetime
- 1992-10-14 EP EP92309351A patent/EP0540210B1/en not_active Expired - Lifetime
- 1992-10-14 EP EP97204046A patent/EP0856516B1/en not_active Expired - Lifetime
- 1992-10-14 AU AU27016/92A patent/AU657800B2/en not_active Ceased
- 1992-10-14 MX MX9205902A patent/MX9205902A/es not_active IP Right Cessation
- 1992-10-14 DE DE69232581T patent/DE69232581T2/de not_active Expired - Fee Related
- 1992-10-15 YU YU92592A patent/YU48930B/sh unknown
- 1992-10-15 JP JP4319194A patent/JP2655790B2/ja not_active Expired - Fee Related
- 1992-10-22 TW TW081108424A patent/TW272233B/zh not_active IP Right Cessation
1994
- 1994-04-13 BG BG98714A patent/BG62261B1/bg unknown
- 1994-04-14 FI FI941730A patent/FI106965B/fi not_active IP Right Cessation
- 1994-04-14 NO NO19941345A patent/NO315802B1/no unknown
- 1994-05-27 US US08/250,310 patent/US5559005A/en not_active Expired - Fee Related
1995
- 1995-05-11 US US08/439,404 patent/US5629171A/en not_active Expired - Fee Related
1997
- 1997-04-17 US US08/839,327 patent/US6017726A/en not_active Expired - Fee Related
1999
- 1999-02-10 GR GR990400429T patent/GR3029343T3/el unknown
- 1999-06-28 US US09/340,781 patent/US6071713A/en not_active Expired - Fee Related
- 1999-12-27 IL IL13373499A patent/IL133734A0/xx unknown
- 1999-12-27 IL IL13373399A patent/IL133733A0/xx unknown
2002
- 2002-11-15 RU RU2002130702/13A patent/RU2002130702A/ru not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2176613T3 (es)	2002-12-01
IL103419A (en)	2003-06-24
FI941730L (fi)	1994-04-14
RU2002130702A (ru)	2004-05-20
YU92592A (sh)	1995-10-03
RO116648B1 (ro)	2001-04-30
US5559005A (en)	1996-09-24
HU9401073D0 (en)	1994-07-28
DK0540210T3 (da)	1999-06-23
CZ88494A3 (en)	1995-03-15
NZ244714A (en)	1994-03-25
CZ288721B6 (cs)	2001-08-15
ES2127205T3 (es)	1999-04-16
GR3029343T3 (en)	1999-05-28
US5629171A (en)	1997-05-13
UA47385C2 (uk)	2002-07-15
TW272233B (da)	1996-03-11
AU2701692A (en)	1993-04-22
CA2080573A1 (en)	1993-04-16
SK43194A3 (en)	1996-11-06
IL133733A0 (en)	2001-04-30
NO315802B1 (no)	2003-10-27
BG98714A (bg)	1995-02-28
DE69232581T2 (de)	2002-11-14
DE69227750T2 (de)	1999-04-22
ATE216700T1 (de)	2002-05-15
KR100227711B1 (ko)	1999-12-01
NO941345L (no)	1994-06-15
JPH06113884A (ja)	1994-04-26
YU48930B (sh)	2002-12-10
MX9205902A (es)	1994-06-30
EP0856516B1 (en)	2002-04-24
FI106965B (fi)	2001-05-15
HU219370B (en)	2001-03-28
DE69232581D1 (de)	2002-05-29
EP0540210B1 (en)	1998-12-02
BG62261B1 (bg)	1999-06-30
CA2080573C (en)	2004-01-06
EP0540210A1 (en)	1993-05-05
NO941345D0 (no)	1994-04-14
FI941730A0 (fi)	1994-04-14
WO1993008287A1 (en)	1993-04-29
HUT69783A (en)	1995-09-28
CN1074484A (zh)	1993-07-21
IL103419A0 (en)	1993-03-15
US6071713A (en)	2000-06-06
US6017726A (en)	2000-01-25
ATE174057T1 (de)	1998-12-15
IL133734A0 (en)	2001-04-30
AU657800B2 (en)	1995-03-23
EP0856516A1 (en)	1998-08-05
JP2655790B2 (ja)	1997-09-24
SK280569B6 (sk)	2000-03-13
DE69227750D1 (de)	1999-01-14

Publication	Publication Date	Title
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CA2077921A1 (en)	1993-03-12	Bioprocess for preparing 7-adca
RU94017674A (ru)	1996-03-10	Способ получения соединения, вектор, клетка
US6518039B2 (en)	2003-02-11	Process for the fermentative production of deacylated cephalosporins
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EP0915988B1 (en)	2003-01-29	Process for the fermentative production of deacylated cephalosporins
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Conder et al.	1997	Bioprocess for preparing 7-ACA and 7-ADAC
HUT45006A (en)	1988-05-30	Process for producing 4-halogeno-2-/oxy-imino/-3-oxo-butiric acid derivatives
EP0638649B1 (en)	1999-11-17	New use of alcaligenes faecalis penicillin G acylase
CA2168923A1 (en)	1996-08-29	Process for the enzymatic synthesis of .beta.-lactam antibiotics in the presence of an enzyme inhibitor
SE9401706L (sv)	1994-07-07	Process för framställning av cephemderivat
GB1480850A (en)	1977-07-27	Enzymatic hydrolysis and synthesis
GB1344707A (en)	1974-01-23	Cephalosporins via penicillin sulphoxide conversion
HUP9801906A2 (hu)	1998-11-30	Eljárás 7-amino-dezacetoxi-cefalosporánsav (7-ADCA) előállítására G-penicillinre kifejtett expandáz aktivitás útján
YU89892A (sh)	1995-10-03	Novi biopostupak za izradu 7-adck
AU553682B2 (en)	1986-07-24	Cephalosporins
GB1355804A (en)	1974-06-05	Penicillins and cephalosporinesters
RU94022268A (ru)	1997-08-20	Способы получения промежуточных продуктов для синтеза цефалоспориновых антибиотиков, векторы, клетка
NL7016560A (en)	1972-05-16	Cephalosporins penicillins and cycloheha- - dienyl alkanoic acids
YU104980A (en)	1983-01-21	Process for preparing a stable preparation of extracellular proteases from fermentation broths of the microorganism cephalosporium acremonium the producer of the antibiotic cephalosporin c