DK0858324T3 - Fremgangsmåde til vandig granulering af clarithromycin - Google Patents

Fremgangsmåde til vandig granulering af clarithromycin

Info

Publication number: DK0858324T3
Authority: DK; Denmark
Prior art keywords: clarithromycin; aqueous granulation; macrolide antibiotic; carbomer; mixture
Prior art date: 1995-11-01

Application number

DK96937699T

Other languages

Danish (da)

English (en)

Inventor

Azita Saleki-Gerhardt

R Keske Ernest

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-01

Filing date

1996-10-18

Publication date

2003-09-29

1996-10-18 Application filed by Abbott Lab filed Critical Abbott Lab

2003-09-29 Application granted granted Critical

2003-09-29 Publication of DK0858324T3 publication Critical patent/DK0858324T3/da

Links

230000003179 granulation Effects 0.000 title abstract 2
238000005469 granulation Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 title 1
229960002626 clarithromycin Drugs 0.000 title 1
239000003120 macrolide antibiotic agent Substances 0.000 abstract 3
229920002125 Sokalan® Polymers 0.000 abstract 2
229960001631 carbomer Drugs 0.000 abstract 2
238000002156 mixing Methods 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000008187 granular material Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
238000009736 wetting Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK96937699T 1995-11-01 1996-10-18 Fremgangsmåde til vandig granulering af clarithromycin DK0858324T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US715095P	1995-11-01	1995-11-01
US08/722,288 US5919489A (en)	1995-11-01	1996-10-09	Process for aqueous granulation of clarithromycin
PCT/US1996/016794 WO1997016174A1 (en)	1995-11-01	1996-10-18	Process for aqueous granulation of clarithromycin

Publications (1)

Publication Number	Publication Date
DK0858324T3 true DK0858324T3 (da)	2003-09-29

Family

ID=26676595

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96937699T DK0858324T3 (da)	1995-11-01	1996-10-18	Fremgangsmåde til vandig granulering af clarithromycin

Country Status (13)

Country	Link
US (1)	US5919489A (de)
EP (1)	EP0858324B1 (de)
JP (1)	JP4334015B2 (de)
KR (1)	KR100524202B1 (de)
AT (1)	ATE241963T1 (de)
AU (1)	AU706837B2 (de)
CA (1)	CA2235607C (de)
DE (1)	DE69628575T2 (de)
DK (1)	DK0858324T3 (de)
ES (1)	ES2200075T3 (de)
IL (1)	IL123571A (de)
PT (1)	PT858324E (de)
WO (1)	WO1997016174A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6551616B1 (en)	1997-04-11	2003-04-22	Abbott Laboratories	Extended release formulations of erythromycin derivatives
US6010718A (en) *	1997-04-11	2000-01-04	Abbott Laboratories	Extended release formulations of erythromycin derivatives
IN191239B (de)	1999-06-11	2003-10-11	Ranbaxy Lab Ltd
ATE248588T1 (de) *	1999-06-11	2003-09-15	Ranbaxy Lab Ltd	Geschmacksmaskierte zubereitungen
AU1169601A (en) *	1999-11-16	2001-05-30	Ranbaxy Laboratories Limited	Taste masked oral compositions
US6565882B2 (en)	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
US6544555B2 (en)	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
KR20030047873A (ko) *	2000-02-29	2003-06-18	테바 파마슈티컬 인더스트리즈 리미티드	클라리트로마이신 및 클라리트로마이신 중간체의 제조방법, 실질적으로는 옥심이 제거된 클라리트로마이신 및이를 포함하는 약학적 조성물
AU2001263812B2 (en) *	2000-03-28	2004-09-23	Sandoz Ag	Granulated particles with masked taste
US20020068078A1 (en)	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
US6541014B2 (en)	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
DE10133546A1 (de) *	2001-07-11	2003-03-06	Petra Bastian	Mischkomplexe zur Maskierung bitter schmeckender Substanzen
FR2827517B1 (fr) *	2001-07-23	2003-10-24	Bioalliance Pharma	Systemes therapeutiques bioadhesifs a liberation prolongee
ES2323264T3 (es) *	2001-08-01	2009-07-10	Novartis Ag	Composicion para enmascaramiento del sabor.
WO2003105810A1 (en) *	2002-06-14	2003-12-24	Andrx Corporation	Pharmaceutical compositions for drugs having ph-dependentsolubility
US20060083759A1 (en) *	2002-07-17	2006-04-20	Aleksander Resman	Stabilization of the profile of release of active substances from a formulation
EP1417958A1 (de) *	2002-11-08	2004-05-12	Pari GmbH	Feuchtgranulierungsverfahren
EP1638529B1 (de) *	2003-06-16	2016-08-10	ANDRX Pharmaceuticals, LLC.	Orale zusammensetzung mit verlängerter freisetzung
JP2006528185A (ja)	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
AU2004258949B2 (en)	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
AU2004258953B2 (en)	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
CA2535177A1 (en)	2003-08-11	2005-02-24	Advancis Pharmaceutical Corporation	Robust pellet
US8062672B2 (en)	2003-08-12	2011-11-22	Shionogi Inc.	Antibiotic product, use and formulation thereof
AU2004270170B2 (en)	2003-08-29	2011-01-27	Shionogi, Inc.	Antibiotic product, use and formulation thereof
CA2538064C (en)	2003-09-15	2013-12-17	Advancis Pharmaceutical Corporation	Antibiotic product, use and formulation thereof
KR100844628B1 (ko) *	2003-12-04	2008-07-07	화이자 프로덕츠 인크.	제약상 다입자의 제조 방법
WO2005053639A2 (en) *	2003-12-04	2005-06-16	Pfizer Products Inc.	Controlled release multiparticulates formed with dissolution enhancers
MXPA06005913A (es) *	2003-12-04	2006-06-27	Pfizer Prod Inc	Formas de dosificacion de multiparticulas de azitromicina por procedimientos basados en liquidos.
EP1701702A1 (de) *	2003-12-04	2006-09-20	Pfizer Products Inc.	Srüh-erstarrungsverfahren mit einem extrudierer zur herstellung von multiteilchenförmigen azitrhomycin-zusammensetzungen, die vorzugsweise ein poloxamer und ein glycerid enthalten
WO2005053652A1 (en)	2003-12-04	2005-06-16	Pfizer Products Inc.	Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
US6984403B2 (en) *	2003-12-04	2006-01-10	Pfizer Inc.	Azithromycin dosage forms with reduced side effects
CA2547597A1 (en) *	2003-12-04	2005-06-16	Pfizer Products Inc.	Multiparticulate compositions with improved stability
ES2600577T3 (es) *	2003-12-04	2017-02-09	Bend Research, Inc.	Procedimiento de pulverización-solidificación que usa un extrusor para preparar composiciones en multipartículas de fármacos cristalinos
RU2268051C2 (ru) *	2003-12-15	2006-01-20	Закрытое акционерное общество "Фармацевтическое предприятие "Оболенское"	Лекарственная форма, обладающая бактериостатическим действием, и способ ее изготовления
US7943585B2 (en)	2003-12-22	2011-05-17	Sandoz, Inc.	Extended release antibiotic composition
CA2572292A1 (en)	2004-07-02	2006-02-09	Advancis Pharmaceutical Corporation	Tablet for pulsed delivery
CN1883456B (zh) *	2005-06-20	2010-12-15	常州市第四制药厂有限公司	掩味药物颗粒及其制备方法和用途
JP2009500356A (ja) *	2005-07-07	2009-01-08	エランファーマインターナショナルリミテッド	ナノ粒子クラリスロマイシン製剤
US20070048364A1 (en) *	2005-08-04	2007-03-01	Yingxu Peng	Free flowing granules containing carbomer
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en)	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
EP1837020A1 (de)	2006-03-24	2007-09-26	Bioalliance Pharma	Bioadhäsive Schleimhautträger zur langsamen Verabreichung von aktiven Substanzen
US8299052B2 (en)	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
US20070286903A1 (en) *	2006-06-13	2007-12-13	Becicka Brian T	Composition and method for taste masking
EP2030613A1 (de)	2007-08-17	2009-03-04	Abbott GmbH & Co. KG	Herstellung von Zusammensetzungen mit hauptsächlich nichtkristallinen eingebetteten Makrolid-Antibiotika
JP5585920B2 (ja) *	2010-12-27	2014-09-10	富田製薬株式会社	粒子状製剤
CN102813633A (zh) *	2011-06-10	2012-12-12	塔科敏斯基制药厂波尔法合资公司	用湿法制粒制备包含大环内酯类抗生素的药物组合物的方法
RU2692469C1 (ru) *	2018-06-25	2019-06-25	ООО "Новые Антибиотики"	Лекарственное средство для лечения и предупреждения возникновения осложнений, связанных с химиотерапией и рентгенотерапией, а также состояний, связанных с повышенной проницаемостью кишки
JP7442193B2 (ja) *	2018-08-10	2024-03-04	日本臓器製薬株式会社	粒状組成物及びその製造方法
CN118511875A (zh) *	2024-05-17	2024-08-20	镇江先锋植保科技有限公司	一种高性能水分散粒剂的制备方法及一种自冷却挤压造粒机

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4608278A (en) *	1983-06-22	1986-08-26	The Ohio State University Research Foundation	Small particule formation and encapsulation
US4808411A (en) *	1987-06-05	1989-02-28	Abbott Laboratories	Antibiotic-polymer compositions

1996
- 1996-10-09 US US08/722,288 patent/US5919489A/en not_active Expired - Lifetime
- 1996-10-18 AU AU75176/96A patent/AU706837B2/en not_active Expired
- 1996-10-18 JP JP51738497A patent/JP4334015B2/ja not_active Expired - Lifetime
- 1996-10-18 EP EP96937699A patent/EP0858324B1/de not_active Expired - Lifetime
- 1996-10-18 DK DK96937699T patent/DK0858324T3/da active
- 1996-10-18 ES ES96937699T patent/ES2200075T3/es not_active Expired - Lifetime
- 1996-10-18 PT PT96937699T patent/PT858324E/pt unknown
- 1996-10-18 IL IL12357196A patent/IL123571A/xx not_active IP Right Cessation
- 1996-10-18 DE DE69628575T patent/DE69628575T2/de not_active Expired - Lifetime
- 1996-10-18 CA CA002235607A patent/CA2235607C/en not_active Expired - Lifetime
- 1996-10-18 KR KR1019980703233A patent/KR100524202B1/ko not_active Expired - Lifetime
- 1996-10-18 AT AT96937699T patent/ATE241963T1/de active
- 1996-10-18 WO PCT/US1996/016794 patent/WO1997016174A1/en not_active Ceased

Also Published As

Publication number	Publication date
US5919489A (en)	1999-07-06
MX9803480A (es)	1998-09-30
JPH11514646A (ja)	1999-12-14
EP0858324B1 (de)	2003-06-04
KR100524202B1 (ko)	2006-07-06
EP0858324A1 (de)	1998-08-19
DE69628575D1 (de)	2003-07-10
CA2235607A1 (en)	1997-05-09
WO1997016174A1 (en)	1997-05-09
KR19990067265A (ko)	1999-08-16
CA2235607C (en)	2003-05-13
ES2200075T3 (es)	2004-03-01
PT858324E (pt)	2003-10-31
JP4334015B2 (ja)	2009-09-16
ATE241963T1 (de)	2003-06-15
AU706837B2 (en)	1999-06-24
AU7517696A (en)	1997-05-22
IL123571A0 (en)	1998-10-30
IL123571A (en)	2005-07-25
DE69628575T2 (de)	2004-04-29

Publication	Publication Date	Title
DK0858324T3 (da)	2003-09-29	Fremgangsmåde til vandig granulering af clarithromycin
AU6447794A (en)	1994-10-11	Concrete mixing system with cement/water premixer
DK1040107T3 (da)	2003-05-05	6-O-alkyl-derivater af erythronolid B
EA200100473A1 (ru)	2002-02-28	Способ реакционной кристаллизации для улучшения размера частиц
ATA49296A (de)	1997-02-15	Zementspritzmischung
FR2656297B1 (fr)	1994-01-14	Nouveaux agents de dispersion du ciment.
DK0839126T3 (da)	2001-08-06	Fremgangsmåde til fremstilling af organiske nitrogenforbindelser, specielle organiske nitrogenforbindelser og blandinger af sådanne forbindelser samt deres anvendelse som brændstof- og smøremiddeladditiver
MXPA02011900A (es)	2003-04-22	Composicion fotosensible para fabricacion de fotorresistente.
BR9808385A (pt)	2003-04-22	Sistema de recebimento de difusão compreendendo um computador e um decodificador
BR9608440A (pt)	1999-02-17	Válvula misturadora de torneira termostática
DK1053217T3 (da)	2003-09-15	Fremgangsmåde til fremstilling af n-propanol
ITRM950541A0 (it)	1995-07-31	Miscela di aerazione. (caso 154-0272)
BR9501008A (pt)	1995-10-24	Sistema automático de mistura de gás
DE69633163D1 (de)	2004-09-23	Kraftstoff-Luft Mischrohr
DE69810472D1 (de)	2003-02-06	Hydrophob modifizierte anionische celluloseether
DK15398A (da)	1999-08-05	Ovnanlæg, samt fremgangsmåde til fremstilling af cement
DK0701623T3 (da)	1997-08-25	Fremgangsmåde til fremstilling af N-acetyl-neuraminsyre
PT871612E (pt)	2003-06-30	Isoindolonas fundidas como inibidores de proteina cinase c
DK0767829T3 (da)	1999-06-07	Fremstilling af flerenzymgranulater samt deres anvendelse
PT912167E (pt)	2003-03-31	Granulos de derivados de hexa-hidropirazina administraveis por via oral
BR9811334A (pt)	2000-09-19	Processo para preparação e/ou purificação de amido ácido fenil éster sulfonatos
DK1075473T3 (da)	2007-11-05	Fremgangsmåde til fremstilling af 1,3-disubstituerede-4-oxocykliske urinstoffer
DK0981950T3 (da)	2001-07-09	Fremgangsm,åde til formering af phyllocactus
FR2774375B1 (fr)	2000-03-24	Procede perfectionne de fabrication d'anhydrides (meth)acryliques mixtes de haute purete
RU98122051A (ru)	1999-06-20	Способ получения удобрения с биоактивной добавкой