DK1040107T3 - 6-O-alkyl-derivater af erythronolid B - Google Patents

6-O-alkyl-derivater af erythronolid B

Info

Publication number: DK1040107T3
Authority: DK; Denmark
Prior art keywords: erythronolide; alkyl derivatives; erythromycin; novel; derivatives
Prior art date: 1997-12-01

Application number

DK98959480T

Other languages

English (en)

Inventor

Howard E Gracey

Stephen H Montgomery

David A Riley

Jih-Hua Liu

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-01

Filing date

1998-11-17

Publication date

2003-05-05

1998-11-17 Application filed by Abbott Lab filed Critical Abbott Lab

2003-05-05 Application granted granted Critical

2003-05-05 Publication of DK1040107T3 publication Critical patent/DK1040107T3/da

Links

ZFBRGCCVTUPRFQ-UHFFFAOYSA-N erythronolide-B Natural products CCC1OC(=O)C(C)C(O)C(C)C(O)C(C)(O)CC(C)C(=O)C(C)C(O)C1C ZFBRGCCVTUPRFQ-UHFFFAOYSA-N 0.000 title abstract 4
IDRYSCOQVVUBIJ-UHFFFAOYSA-N Erythromycin-B Natural products CC1C(OC2C(C(CC(C)O2)N(C)C)O)C(C)(O)CC(C)C(=O)C(C)C(O)C(C)C(CC)OC(=O)C(C)C1OC1CC(C)(OC)C(O)C(C)O1 IDRYSCOQVVUBIJ-UHFFFAOYSA-N 0.000 abstract 1
MWFRKHPRXPSWNT-UHFFFAOYSA-N Erythromycin-C Natural products CC1C(OC2C(C(CC(C)O2)N(C)C)O)C(C)(O)CC(C)C(=O)C(C)C(O)C(O)(C)C(CC)OC(=O)C(C)C1OC1CC(C)(O)C(O)C(C)O1 MWFRKHPRXPSWNT-UHFFFAOYSA-N 0.000 abstract 1
IDRYSCOQVVUBIJ-PPGFLMPOSA-N erythromycin B Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@H]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)C)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 IDRYSCOQVVUBIJ-PPGFLMPOSA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrane Compounds (AREA)

DK98959480T 1997-12-01 1998-11-17 6-O-alkyl-derivater af erythronolid B DK1040107T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/980,919 US5919916A (en)	1997-12-01	1997-12-01	6-O-alkyl derivatives of erythronolide B
PCT/US1998/024497 WO1999028311A1 (en)	1997-12-01	1998-11-17	6-o-alkyl derivatives of erythronolide b

Publications (1)

Publication Number	Publication Date
DK1040107T3 true DK1040107T3 (da)	2003-05-05

Family

ID=25527957

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98959480T DK1040107T3 (da)	1997-12-01	1998-11-17	6-O-alkyl-derivater af erythronolid B

Country Status (13)

Country	Link
US (1)	US5919916A (da)
EP (1)	EP1040107B1 (da)
JP (1)	JP2001524549A (da)
KR (1)	KR20010032636A (da)
AT (1)	ATE231851T1 (da)
AU (1)	AU1526899A (da)
CA (1)	CA2309977A1 (da)
DE (1)	DE69811120T2 (da)
DK (1)	DK1040107T3 (da)
ES (1)	ES2191982T3 (da)
IL (1)	IL135792A0 (da)
PT (1)	PT1040107E (da)
WO (1)	WO1999028311A1 (da)

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US6565882B2 (en)	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
US6544555B2 (en)	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
KR20030047873A (ko) *	2000-02-29	2003-06-18	테바 파마슈티컬 인더스트리즈 리미티드	클라리트로마이신 및 클라리트로마이신 중간체의 제조방법, 실질적으로는 옥심이 제거된 클라리트로마이신 및이를 포함하는 약학적 조성물
RU2230748C2 (ru) *	2000-03-15	2004-06-20	Ханми Фарм. Ко., Лтд.	Способ получения кларитромицина в виде кристаллов формы ii
KR20000037126A (ko) *	2000-04-08	2000-07-05	김용규	6-메틸 에리스로마이신 ａ의 제조방법
US6541014B2 (en)	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
US20020068078A1 (en)	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
US6455680B1 (en)	2000-12-21	2002-09-24	Abbott Laboratories	Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
TWI246515B (en)	2001-05-30	2006-01-01	Abbott Lab	An arylation method for the functionalization of O-allyl erythromycin derivatives
US7825200B2 (en) *	2003-02-28	2010-11-02	The Regents Of The University Of California	Controlled free radical grafting from polyolefins
EP1638549A4 (en) *	2003-03-10	2011-06-15	Optimer Pharmaceuticals Inc	NEW ANTIBACTERIAL AGENTS
AU2004258949B2 (en)	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
JP2006528185A (ja)	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
AU2004258953B2 (en)	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
CA2535177A1 (en)	2003-08-11	2005-02-24	Advancis Pharmaceutical Corporation	Robust pellet
US8062672B2 (en)	2003-08-12	2011-11-22	Shionogi Inc.	Antibiotic product, use and formulation thereof
AU2004270170B2 (en)	2003-08-29	2011-01-27	Shionogi, Inc.	Antibiotic product, use and formulation thereof
CA2538064C (en)	2003-09-15	2013-12-17	Advancis Pharmaceutical Corporation	Antibiotic product, use and formulation thereof
CA2572292A1 (en)	2004-07-02	2006-02-09	Advancis Pharmaceutical Corporation	Tablet for pulsed delivery
US8778924B2 (en)	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
US8299052B2 (en)	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
EP2214484A4 (en)	2007-10-25	2013-01-02	Cempra Pharmaceuticals Inc	PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS
JP5711135B2 (ja)	2008-10-24	2015-04-30	センプラファーマシューティカルズ，インコーポレイテッド	胃腸疾患を治療するための方法
US9937194B1 (en)	2009-06-12	2018-04-10	Cempra Pharmaceuticals, Inc.	Compounds and methods for treating inflammatory diseases
ES2608285T3 (es)	2009-09-10	2017-04-07	Cempra Pharmaceuticals, Inc.	Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC
MX361413B (es)	2010-03-22	2018-12-05	Cempra Pharmaceuticals Inc Star	Formas cristalinas de un macrólido y usos para las mismas.
CN102917708B (zh)	2010-05-20	2015-11-25	森普拉制药公司	制备大环内酯和酮内酯及其中间体的方法
EP2613630A4 (en)	2010-09-10	2014-01-15	Cempra Pharmaceuticals Inc	HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES
NZ700182A (en)	2012-03-27	2017-02-24	Cempra Pharmaceuticals Inc	Parenteral formulations for administering macrolide antibiotics
AU2014239959A1 (en)	2013-03-14	2015-10-01	Cempra Pharmaceuticals, Inc.	Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh)	2013-03-15	2015-12-23	森普拉制药公司	用于制备大环内酯抗菌剂的收敛方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3697547A (en) *	1970-12-18	1972-10-10	Abbott Lab	Erythronolide b derivatives
US4331803A (en) *	1980-06-04	1982-05-25	Taisho Pharmaceutical Co., Ltd.	Novel erythromycin compounds
JPS5896097A (ja) *	1981-12-01	1983-06-07	Taisho Pharmaceut Co Ltd	エリスロマイシンｂ誘導体
JPS60214796A (ja) *	1984-04-06	1985-10-28	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja) *	1984-10-26	1986-05-22	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシンａ誘導体
US4670549A (en) *	1985-03-18	1987-06-02	Taisho Pharmaceutical Co., Ltd.	Method for selective methylation of erythromycin a derivatives
JPS61229895A (ja) *	1985-04-03	1986-10-14	Nippon Zeon Co Ltd	保護化デス−ｎ−メチルエリスロマイシン誘導体
EP0260938B1 (en) *	1986-09-18	1992-12-09	Taisho Pharmaceutical Co. Ltd	Erythromycin a derivatives and method for preparing the same
JP2751385B2 (ja) *	1988-05-19	1998-05-18	大正製薬株式会社	エリスロマイシンａオキシム及びその塩の製造方法
US5141926A (en) *	1990-04-18	1992-08-25	Abbott Laboratories	Erythromycin derivatives
JPH08149986A (ja) *	1994-09-28	1996-06-11	Taisho Pharmaceut Co Ltd	１２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法
US5756473A (en) *	1995-11-21	1998-05-26	Abbott Laboratories	6-O-methyl erythromycin D and process for making

1988
- 1988-11-17 IL IL13579288A patent/IL135792A0/xx unknown
1997
- 1997-12-01 US US08/980,919 patent/US5919916A/en not_active Expired - Lifetime
1998
- 1998-11-17 AT AT98959480T patent/ATE231851T1/de not_active IP Right Cessation
- 1998-11-17 DE DE69811120T patent/DE69811120T2/de not_active Expired - Fee Related
- 1998-11-17 EP EP98959480A patent/EP1040107B1/en not_active Expired - Lifetime
- 1998-11-17 ES ES98959480T patent/ES2191982T3/es not_active Expired - Lifetime
- 1998-11-17 WO PCT/US1998/024497 patent/WO1999028311A1/en not_active Ceased
- 1998-11-17 AU AU15268/99A patent/AU1526899A/en not_active Abandoned
- 1998-11-17 PT PT98959480T patent/PT1040107E/pt unknown
- 1998-11-17 KR KR1020007005914A patent/KR20010032636A/ko not_active Withdrawn
- 1998-11-17 CA CA002309977A patent/CA2309977A1/en not_active Abandoned
- 1998-11-17 DK DK98959480T patent/DK1040107T3/da active
- 1998-11-17 JP JP2000523203A patent/JP2001524549A/ja active Pending

Also Published As

Publication number	Publication date
EP1040107A1 (en)	2000-10-04
AU1526899A (en)	1999-06-16
CA2309977A1 (en)	1999-06-10
JP2001524549A (ja)	2001-12-04
WO1999028311A1 (en)	1999-06-10
ES2191982T3 (es)	2003-09-16
US5919916A (en)	1999-07-06
KR20010032636A (ko)	2001-04-25
PT1040107E (pt)	2003-06-30
DE69811120D1 (de)	2003-03-06
DE69811120T2 (de)	2003-10-09
ATE231851T1 (de)	2003-02-15
IL135792A0 (en)	2001-05-20
EP1040107B1 (en)	2003-01-29

Publication	Publication Date	Title
DK1040107T3 (da)	2003-05-05	6-O-alkyl-derivater af erythronolid B
ATE256138T1 (de)	2003-12-15	9-oximsilyl erythromycin a derivate
FI931109L (fi)	1993-09-14	Peptider och nukleinsyrasekvenser, som haenfoer sig till epstein-barr-virus
DK1015466T3 (da)	2003-09-01	Derivater af 9-hydrazon og 9-azinerythromycin og en fremgangsmåde til fremstilling af samme
NO904839D0 (no)	1990-11-07	Fremgangsmaate for fremstilling av benzoxazinderivater.
FI971609L (fi)	1997-06-02	Menetelmä 4a,5,9,10,11,12-heksahydro-6H-bentsofuro-(3a,3,2-ef)(2)-bentsatsepiinijohdannaisten valmistamiseksi
FI20040310A7 (fi)	2004-02-27	Menetelmä bentsosykloalkyyliatsolitionijohdannaisten valmistamiseksi
DK90393D0 (da)	1993-08-04	Fremgangsmaade til fremstilling af macrolidforbindelser
DK0768310T3 (da)	2000-04-17	Fremgangsmåde til fremstilling af imidazo-benzodiazepin-derivater
DK0451094T3 (da)	1995-04-03	Fremgangsmåde til fremstilling af pigmenter
DK0877738T3 (da)	2003-09-08	Fremgangsmåde til fremstilling af phenylimidazolidinderivater
NO901070D0 (no)	1990-03-07	Fremgangsmaate for fremstilling av tieno-triazolo-diazepin-derivater.
DK0970939T3 (da)	2003-04-07	Fremgangsmåde til fremstilling af methanol
DK0815092T3 (da)	1999-12-06	Fremgangsmåde til fremstilling af 1,2-benzisothiazolin-3-oner
DK603088D0 (da)	1988-10-28	Fremgangsmaade til fremstilling af multiglucosylforgrenede cyclodextriner
DK0749947T4 (da)	2002-06-17	Kontinuerlig fremgangsmåde til fremstilling af natrium-C(4-8)alkoxid
PT88158A (pt)	1989-06-30	Process for the preparation of a novel diosmin derivative
IS1853B (is)	2003-02-21	Ný aðferð til að búa til 3-N,N-dísýklóbútýlamínó-8-flúor-3,4-díhýdró-2H-1-bensópýran-5-karboxamíð
FI872073A0 (fi)	1987-05-11	Derivat av propargyloxybenzener, deras framstaellning och fungicida sammansaettningar i vilka de ingaor.
DK0729971T3 (da)	2000-11-06	Fremgangsmåde til fremstilling af ivermectin
ES2079569T3 (es)	1996-01-16	Calicheamicinona, sus derivados y analogos y procedimientos de fabricacion de los mismos.
DK1080076T3 (da)	2004-03-22	Forbedret fremgangsmåde til fremstilling af farmaceutisk værdifulde norbenzomorphanderivater
DK162191D0 (da)	1991-09-20	Fremgangsmaade til fremstilling af prolinderivat
DK587287D0 (da)	1987-11-10	Fremgangsmaade til fremstilling af 2-guanidinotiazolderivater
DK0783491T3 (da)	2002-01-21	Fremgangsmåde til fremstilling af 3,3,5-trichlorglutarimid