DK0870014T3 - Katalytiske antistoffer mod aldolase - Google Patents
Katalytiske antistoffer mod aldolaseInfo
- Publication number
- DK0870014T3 DK0870014T3 DK96943772T DK96943772T DK0870014T3 DK 0870014 T3 DK0870014 T3 DK 0870014T3 DK 96943772 T DK96943772 T DK 96943772T DK 96943772 T DK96943772 T DK 96943772T DK 0870014 T3 DK0870014 T3 DK 0870014T3
- Authority
- DK
- Denmark
- Prior art keywords
- aldolase
- antibodies
- catalytic
- antibody
- catalytic antibodies
- Prior art date
Links
- 230000003197 catalytic effect Effects 0.000 title abstract 4
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 title abstract 2
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 title abstract 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 238000005575 aldol reaction Methods 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/901—Antibodies with enzymatic activity; e.g. abzymes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/573,415 US5733757A (en) | 1995-12-15 | 1995-12-15 | Aldolase catalytic antibody |
| PCT/US1996/020052 WO1997021803A1 (en) | 1995-12-15 | 1996-12-16 | Aldolase catalytic antibody |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0870014T3 true DK0870014T3 (da) | 2007-06-11 |
Family
ID=24291910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96943772T DK0870014T3 (da) | 1995-12-15 | 1996-12-16 | Katalytiske antistoffer mod aldolase |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US5733757A (da) |
| EP (1) | EP0870014B9 (da) |
| JP (1) | JP3996642B2 (da) |
| AT (1) | ATE354644T1 (da) |
| AU (1) | AU729055B2 (da) |
| CA (1) | CA2239167C (da) |
| DE (1) | DE69636923T2 (da) |
| DK (1) | DK0870014T3 (da) |
| ES (1) | ES2283009T3 (da) |
| PT (1) | PT870014E (da) |
| SI (1) | SI0870014T1 (da) |
| WO (1) | WO1997021803A1 (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002508188A (ja) * | 1997-12-18 | 2002-03-19 | ザ スクリップス リサーチ インスティテュート | 触媒性抗体によるアルドール縮合 |
| US6326176B1 (en) | 1997-12-18 | 2001-12-04 | The Scripps Research Institute | Aldol condensations by catalytic antibodies |
| US6440710B1 (en) | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| US6294374B1 (en) * | 1999-10-08 | 2001-09-25 | The Scripps Research Institute | Use of catalytic antibodies for synthesizing epothilone |
| CA2481922A1 (en) * | 2002-04-12 | 2003-10-23 | Raven Biotechnologies, Inc. | Antibodies that bind to integrin alpha-v-beta-6 and methods of use thereof |
| AU2006235781B2 (en) * | 2004-04-27 | 2008-04-03 | Teddy Yeung Man Lo | LED illuminated glow stick |
| EP1853294A4 (en) * | 2005-03-03 | 2010-01-27 | Covx Technologies Ireland Ltd | ANTIANGIOGENIC COMPOUNDS |
| EP2368908A3 (en) | 2006-11-10 | 2011-10-12 | CovX Technologies Ireland Limited | Anti- angiogenic compounds |
| US20090098130A1 (en) * | 2007-01-05 | 2009-04-16 | Bradshaw Curt W | Glucagon-like protein-1 receptor (glp-1r) agonist compounds |
| US20090304719A1 (en) | 2007-08-22 | 2009-12-10 | Patrick Daugherty | Activatable binding polypeptides and methods of identification and use thereof |
| US8637435B2 (en) * | 2007-11-16 | 2014-01-28 | Merck Sharp & Dohme Corp. | Eukaryotic cell display systems |
| WO2009076655A2 (en) | 2007-12-13 | 2009-06-18 | University Of Washington | Synthetic enzymes derived from computational design |
| JP5731827B2 (ja) | 2008-03-03 | 2015-06-10 | グライコフィ， インコーポレイテッド | 下等真核生物中での組換えタンパク質の表面ディスプレイ |
| US8293714B2 (en) | 2008-05-05 | 2012-10-23 | Covx Technology Ireland, Ltd. | Anti-angiogenic compounds |
| US8067339B2 (en) * | 2008-07-09 | 2011-11-29 | Merck Sharp & Dohme Corp. | Surface display of whole antibodies in eukaryotes |
| RU2636046C2 (ru) | 2009-01-12 | 2017-11-17 | Сайтомкс Терапьютикс, Инк | Композиции модифицированных антител, способы их получения и применения |
| AU2010215761B2 (en) | 2009-02-23 | 2017-04-06 | Cytomx Therapeutics, Inc | Proproteins and methods of use thereof |
| AU2010218139B2 (en) | 2009-02-25 | 2012-11-01 | Merck Sharp & Dohme Corp. | Metabolic engineering of a galactose assimilation pathway in the glycoengineered yeast Pichia pastoris |
| US20120148586A1 (en) | 2009-08-27 | 2012-06-14 | Joyce Ching Tsu Chou | Glucagon-like protein-1 receptor (glp-1r) agonists for treating autoimmune disorders |
| RU2012140429A (ru) | 2010-02-24 | 2014-03-27 | Мерк Шарп Энд Домэ Корп. | Способ увеличения занятости участков n-ликозилирования на терапевтических гликопротеинах, продуцируемых в p pastoris |
| RU2012157167A (ru) | 2010-07-12 | 2014-08-20 | КовЭкс Текнолоджиз Айэлэнд Лимитед | Полифункциональные антительные конъюгаты |
| WO2012009705A1 (en) | 2010-07-15 | 2012-01-19 | Zyngenia, Inc. | Ang-2 binding complexes and uses thereof |
| US9688735B2 (en) | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
| CN105198981B (zh) | 2010-08-20 | 2019-07-16 | 惠氏有限责任公司 | 经设计的成骨蛋白 |
| JP2014500248A (ja) | 2010-11-05 | 2014-01-09 | コヴェックス・テクノロジーズ・アイルランド・リミテッド | 抗糖尿病化合物 |
| EP2714738B1 (en) | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| CN104125838B (zh) | 2011-12-20 | 2016-12-14 | 辉瑞公司 | 制备肽缀合物和连接基的改进方法 |
| BR112014014898A2 (pt) | 2011-12-22 | 2020-10-27 | Pfizer Inc. | processo para purificar uma amostra de anticorpo h38c2, ou variante do mesmo, e composição compreendendo o referido h38c2 |
| JP2015508638A (ja) | 2012-02-03 | 2015-03-23 | ザ ガバナーズ オブ ザ ユニバーシティ オブ アルバータ | ファージディスプレイを用いてペプチド誘導体ライブラリーを定量化するための方法 |
| US10150800B2 (en) | 2013-03-15 | 2018-12-11 | Zyngenia, Inc. | EGFR-binding modular recognition domains |
| SG11202100721SA (en) | 2018-07-23 | 2021-02-25 | Univ Alberta | Genetically-encoded bicyclic peptide libraries |
| CN113329769A (zh) * | 2018-10-11 | 2021-08-31 | 斯克里普斯研究学院 | 具有反应性精氨酸的抗体化合物及相关的抗体药物缀合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5571681A (en) * | 1994-03-10 | 1996-11-05 | The Scripps Research Institute | Chemical event selection by suicide substrate conjugates |
-
1995
- 1995-12-15 US US08/573,415 patent/US5733757A/en not_active Expired - Lifetime
-
1996
- 1996-12-16 JP JP52226397A patent/JP3996642B2/ja not_active Expired - Lifetime
- 1996-12-16 DE DE69636923T patent/DE69636923T2/de not_active Expired - Lifetime
- 1996-12-16 WO PCT/US1996/020052 patent/WO1997021803A1/en not_active Ceased
- 1996-12-16 EP EP96943772A patent/EP0870014B9/en not_active Expired - Lifetime
- 1996-12-16 CA CA002239167A patent/CA2239167C/en not_active Expired - Lifetime
- 1996-12-16 AT AT96943772T patent/ATE354644T1/de active
- 1996-12-16 AU AU12923/97A patent/AU729055B2/en not_active Expired
- 1996-12-16 DK DK96943772T patent/DK0870014T3/da active
- 1996-12-16 SI SI9630754T patent/SI0870014T1/sl unknown
- 1996-12-16 PT PT96943772T patent/PT870014E/pt unknown
- 1996-12-16 ES ES96943772T patent/ES2283009T3/es not_active Expired - Lifetime
-
1998
- 1998-03-31 US US09/053,818 patent/US5985626A/en not_active Expired - Lifetime
-
1999
- 1999-11-16 US US09/440,995 patent/US6368839B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69636923D1 (de) | 2007-04-05 |
| EP0870014A1 (en) | 1998-10-14 |
| CA2239167C (en) | 2009-09-22 |
| AU1292397A (en) | 1997-07-03 |
| EP0870014B9 (en) | 2007-10-10 |
| US6368839B1 (en) | 2002-04-09 |
| DE69636923T2 (de) | 2007-11-08 |
| WO1997021803A1 (en) | 1997-06-19 |
| ES2283009T3 (es) | 2007-10-16 |
| US5733757A (en) | 1998-03-31 |
| CA2239167A1 (en) | 1997-06-19 |
| ATE354644T1 (de) | 2007-03-15 |
| JPH11510063A (ja) | 1999-09-07 |
| EP0870014B1 (en) | 2007-02-21 |
| EP0870014A4 (en) | 2002-03-13 |
| JP3996642B2 (ja) | 2007-10-24 |
| AU729055B2 (en) | 2001-01-25 |
| US5985626A (en) | 1999-11-16 |
| PT870014E (pt) | 2007-05-31 |
| SI0870014T1 (sl) | 2007-08-31 |
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