ATE354644T1 - Katalytischer antikörper gegen aldolase - Google Patents

Katalytischer antikörper gegen aldolase

Info

Publication number: ATE354644T1
Authority: AT; Austria
Prior art keywords: antibody against; catalytic; catalytic antibody; antibody; antibodies
Prior art date: 1995-12-15

Application number

AT96943772T

Other languages

English (en)

Inventor

Carlos F Barbas Iii

Richard A Lerner

Juergen Wagner

Original Assignee

Scripps Research Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-15

Filing date

1996-12-16

Publication date

2007-03-15

1996-12-16 Application filed by Scripps Research Inst filed Critical Scripps Research Inst

2007-03-15 Application granted granted Critical

2007-03-15 Publication of ATE354644T1 publication Critical patent/ATE354644T1/de

Links

230000003197 catalytic effect Effects 0.000 title abstract 4
102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 title abstract 2
108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 title abstract 2
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
239000004472 Lysine Substances 0.000 abstract 1
238000005575 aldol reaction Methods 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000003053 immunization Effects 0.000 abstract 1
238000002649 immunization Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/901—Antibodies with enzymatic activity; e.g. abzymes

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Enzymes And Modification Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT96943772T 1995-12-15 1996-12-16 Katalytischer antikörper gegen aldolase ATE354644T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/573,415 US5733757A (en)	1995-12-15	1995-12-15	Aldolase catalytic antibody

Publications (1)

Publication Number	Publication Date
ATE354644T1 true ATE354644T1 (de)	2007-03-15

Family

ID=24291910

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96943772T ATE354644T1 (de)	1995-12-15	1996-12-16	Katalytischer antikörper gegen aldolase

Country Status (12)

Country	Link
US (3)	US5733757A (de)
EP (1)	EP0870014B9 (de)
JP (1)	JP3996642B2 (de)
AT (1)	ATE354644T1 (de)
AU (1)	AU729055B2 (de)
CA (1)	CA2239167C (de)
DE (1)	DE69636923T2 (de)
DK (1)	DK0870014T3 (de)
ES (1)	ES2283009T3 (de)
PT (1)	PT870014E (de)
SI (1)	SI0870014T1 (de)
WO (1)	WO1997021803A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6326176B1 (en) *	1997-12-18	2001-12-04	The Scripps Research Institute	Aldol condensations by catalytic antibodies
JP2002508188A (ja) *	1997-12-18	2002-03-19	ザスクリップスリサーチインスティテュート	触媒性抗体によるアルドール縮合
US6440710B1 (en)	1998-12-10	2002-08-27	The Scripps Research Institute	Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
US6294374B1 (en) *	1999-10-08	2001-09-25	The Scripps Research Institute	Use of catalytic antibodies for synthesizing epothilone
WO2003087340A2 (en) *	2002-04-12	2003-10-23	Raven Biotechnologies, Inc.	Antibodies that bind to integrin alpha-v-beta-6 and methods of use thereof
AU2006235781B2 (en) *	2004-04-27	2008-04-03	Teddy Yeung Man Lo	LED illuminated glow stick
JP5167473B2 (ja) *	2005-03-03	2013-03-21	コヴェックス・テクノロジーズ・アイルランド・リミテッド	抗血管新生化合物
BRPI0718591A2 (pt) *	2006-11-10	2013-12-03	Covx Technologies Ireland Ltd	Compostos antiangiogênicos.
US20090098130A1 (en) *	2007-01-05	2009-04-16	Bradshaw Curt W	Glucagon-like protein-1 receptor (glp-1r) agonist compounds
EP2190861A4 (de)	2007-08-22	2011-03-30	Univ California	Aktivierbare bindende polypeptide und verfahren zu deren identifikation und anwendung
US8637435B2 (en) *	2007-11-16	2014-01-28	Merck Sharp & Dohme Corp.	Eukaryotic cell display systems
US8340951B2 (en) *	2007-12-13	2012-12-25	University Of Washington	Synthetic enzymes derived from computational design
CA2715212A1 (en)	2008-03-03	2009-09-11	Glycofi, Inc.	Surface display of recombinant proteins in lower eukaryotes
US8293714B2 (en)	2008-05-05	2012-10-23	Covx Technology Ireland, Ltd.	Anti-angiogenic compounds
US8067339B2 (en) *	2008-07-09	2011-11-29	Merck Sharp & Dohme Corp.	Surface display of whole antibodies in eukaryotes
EP3543256A1 (de)	2009-01-12	2019-09-25	Cytomx Therapeutics Inc.	Modifizierte antikörperzusammensetzungen, verfahren zur herstellung und verwendung davon
US8399219B2 (en)	2009-02-23	2013-03-19	Cytomx Therapeutics, Inc.	Protease activatable interferon alpha proprotein
EP2401378B1 (de)	2009-02-25	2013-08-14	Merck Sharp & Dohme Corp.	Stoffwechselmanipulation eines galaktoseassimilationswegs bei der glycoengineerten hefe pichia pastoris
US20120148586A1 (en)	2009-08-27	2012-06-14	Joyce Ching Tsu Chou	Glucagon-like protein-1 receptor (glp-1r) agonists for treating autoimmune disorders
BR112012020882A2 (pt)	2010-02-24	2015-11-03	Merck Sharp & Dohme	métodos para produzir uma glicoproteína heteróloga e para produzir uma composição de glicoproteína, célula hospedeira, composição de glicoproteína, e, uso da pichia pastoris recombinante.
SG186451A1 (en)	2010-07-12	2013-01-30	Covx Technologies Ireland Ltd	Multifunctional antibody conjugates
WO2012009705A1 (en)	2010-07-15	2012-01-19	Zyngenia, Inc.	Ang-2 binding complexes and uses thereof
US9688735B2 (en)	2010-08-20	2017-06-27	Wyeth Llc	Designer osteogenic proteins
PH12013500294A1 (en)	2010-08-20	2017-08-23	Wyeth Llc	Designer osteogenic proteins
SG190082A1 (en)	2010-11-05	2013-06-28	Covx Technologies Ireland Ltd	Anti-diabetic compounds
DK2714738T3 (en)	2011-05-24	2019-01-28	Zyngenia Inc	MULTIVALENT AND MONOVALENT MULTISPECIFIC COMPLEXES AND THEIR APPLICATIONS
SG11201403324TA (en)	2011-12-20	2014-07-30	Pfizer	Improved processes for preparing peptide conjugates and linkers
JP6165168B2 (ja)	2011-12-22	2017-07-19	ファイザー・インク	抗糖尿病化合物
JP2015508638A (ja)	2012-02-03	2015-03-23	ザガバナーズオブザユニバーシティオブアルバータ	ファージディスプレイを用いてペプチド誘導体ライブラリーを定量化するための方法
MX2015013163A (es)	2013-03-15	2016-04-04	Zyngenia Inc	Complejos multiespecificos multivalente y monovalentes y sus usos.
US12391939B2 (en)	2018-07-23	2025-08-19	The Governors Of The University Of Alberta	Genetically-encoded bicyclic peptide libraries
EP3863672A4 (de) *	2018-10-11	2022-06-29	The Scripps Research Institute	Antikörperverbindungen mit reaktivem arginin und verwandte antikörperarzneimittelkonjugate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5571681A (en) *	1994-03-10	1996-11-05	The Scripps Research Institute	Chemical event selection by suicide substrate conjugates

1995
- 1995-12-15 US US08/573,415 patent/US5733757A/en not_active Expired - Lifetime
1996
- 1996-12-16 PT PT96943772T patent/PT870014E/pt unknown
- 1996-12-16 AU AU12923/97A patent/AU729055B2/en not_active Expired
- 1996-12-16 WO PCT/US1996/020052 patent/WO1997021803A1/en not_active Ceased
- 1996-12-16 DK DK96943772T patent/DK0870014T3/da active
- 1996-12-16 SI SI9630754T patent/SI0870014T1/sl unknown
- 1996-12-16 CA CA002239167A patent/CA2239167C/en not_active Expired - Lifetime
- 1996-12-16 ES ES96943772T patent/ES2283009T3/es not_active Expired - Lifetime
- 1996-12-16 JP JP52226397A patent/JP3996642B2/ja not_active Expired - Lifetime
- 1996-12-16 DE DE69636923T patent/DE69636923T2/de not_active Expired - Lifetime
- 1996-12-16 EP EP96943772A patent/EP0870014B9/de not_active Expired - Lifetime
- 1996-12-16 AT AT96943772T patent/ATE354644T1/de active
1998
- 1998-03-31 US US09/053,818 patent/US5985626A/en not_active Expired - Lifetime
1999
- 1999-11-16 US US09/440,995 patent/US6368839B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
SI0870014T1 (sl)	2007-08-31
DK0870014T3 (da)	2007-06-11
EP0870014B9 (de)	2007-10-10
DE69636923D1 (de)	2007-04-05
ES2283009T3 (es)	2007-10-16
JP3996642B2 (ja)	2007-10-24
AU1292397A (en)	1997-07-03
CA2239167A1 (en)	1997-06-19
AU729055B2 (en)	2001-01-25
US6368839B1 (en)	2002-04-09
US5985626A (en)	1999-11-16
EP0870014B1 (de)	2007-02-21
DE69636923T2 (de)	2007-11-08
CA2239167C (en)	2009-09-22
PT870014E (pt)	2007-05-31
US5733757A (en)	1998-03-31
EP0870014A1 (de)	1998-10-14
WO1997021803A1 (en)	1997-06-19
EP0870014A4 (de)	2002-03-13
JPH11510063A (ja)	1999-09-07

Legal Events

Date

Code

Title

Description

2007-09-15

UEP

Publication of translation of european patent specification

Ref document number: 0870014

Country of ref document: EP

Publication	Publication Date	Title
DE69636923D1 (de)	2007-04-05	Katalytischer antikörper gegen aldolase
AU563356B2 (en)	1987-07-09	Conjugate of enzyme and antibody
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