DK0870768T3 - Azaindol-ethylaminderivater som nikotinacetylcholinreceptor-bindingsmidler - Google Patents
Azaindol-ethylaminderivater som nikotinacetylcholinreceptor-bindingsmidlerInfo
- Publication number
- DK0870768T3 DK0870768T3 DK98302610T DK98302610T DK0870768T3 DK 0870768 T3 DK0870768 T3 DK 0870768T3 DK 98302610 T DK98302610 T DK 98302610T DK 98302610 T DK98302610 T DK 98302610T DK 0870768 T3 DK0870768 T3 DK 0870768T3
- Authority
- DK
- Denmark
- Prior art keywords
- azaindole
- receptor binding
- binding agents
- acetylcholine receptor
- nicotinic acetylcholine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4341797P | 1997-04-09 | 1997-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0870768T3 true DK0870768T3 (da) | 2002-07-01 |
Family
ID=21927078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98302610T DK0870768T3 (da) | 1997-04-09 | 1998-04-02 | Azaindol-ethylaminderivater som nikotinacetylcholinreceptor-bindingsmidler |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5977131A (de) |
| EP (1) | EP0870768B1 (de) |
| JP (1) | JP3342403B2 (de) |
| AT (2) | ATE241623T1 (de) |
| BR (1) | BR9801020A (de) |
| CA (1) | CA2234567C (de) |
| DE (2) | DE69815161T2 (de) |
| DK (1) | DK0870768T3 (de) |
| ES (2) | ES2197133T3 (de) |
| PT (2) | PT870768E (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6335342B1 (en) * | 2000-06-19 | 2002-01-01 | Pharmacia & Upjohn S.P.A. | Azaindole derivatives, process for their preparation, and their use as antitumor agents |
| US20030134844A1 (en) * | 2001-10-31 | 2003-07-17 | Pfizer Inc. | Nicontinic acetylcholine receptor antagonists in the treatment of restless legs syndrome |
| PL370549A1 (en) * | 2001-10-31 | 2005-05-30 | Pfizer Products Inc. | Nicotinic acetylcholine receptor agonists in the treatment of restless legs syndrome |
| DE60228478D1 (de) | 2001-11-30 | 2008-10-02 | Pfizer Prod Inc | Aryl-annellierte azapolyzyklische verbindungen |
| TW200301251A (en) | 2001-12-20 | 2003-07-01 | Wyeth Corp | Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands |
| US20070191815A1 (en) | 2004-09-13 | 2007-08-16 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery |
| PL1696920T3 (pl) | 2003-12-19 | 2015-03-31 | Plexxikon Inc | Związki i sposoby opracowywania modulatorów Ret |
| US20050234024A1 (en) * | 2004-04-14 | 2005-10-20 | Clarke David E | Materials and methods for the treatment of ulcerative colitis |
| BG65536B1 (bg) * | 2004-04-16 | 2008-11-28 | "Софарма" Ад | Лекарствена форма, съдържаща цитизин |
| GB0412893D0 (en) | 2004-06-10 | 2004-07-14 | Univ Hull | Novel antiviral macrocycle derivatives and metal complexes, incorporating bridged macrocycles |
| US7498342B2 (en) | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
| DE102004060659A1 (de) * | 2004-12-15 | 2006-07-06 | Lanxess Deutschland Gmbh | Neue substituierte 1H-Pyrrolo[2,3-b]pyridine und deren Herstellung |
| DK2395004T3 (en) | 2005-06-22 | 2016-03-21 | Plexxikon Inc | Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors |
| US7964728B2 (en) | 2006-07-06 | 2011-06-21 | Solvay Pharmaceuticals B.V. | Azaindole derivatives with a combination of partial nicotinic acetyl-choline receptor agonism and dopamine reuptake inhibition |
| ATE526327T1 (de) * | 2006-07-06 | 2011-10-15 | Abbott Healthcare Products Bv | Azaindolderivate mit einer kombination eines teilweisen agonismus am nikotinischen acetylcholinrezeptor und einer inhibierung der dopaminwiederaufnahme |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| WO2008080015A2 (en) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| PE20081581A1 (es) | 2006-12-21 | 2008-11-12 | Plexxikon Inc | COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA |
| WO2008079909A1 (en) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
| ES2521494T3 (es) | 2007-04-02 | 2014-11-12 | Parkinson's Institute | Métodos y composiciones para la reducción de los efectos secundarios de tratamientos terapéuticos |
| US20100190777A1 (en) | 2007-07-17 | 2010-07-29 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| HUE027598T2 (en) | 2009-04-03 | 2016-10-28 | Hoffmann La Roche | Propane-1-sulfonic acid {3- [5- (4-chlorophenyl) -1H-pyrrolo [2,3-B] pyridine-3-carbonyl] -2,4-difluorophenyl} amide compositions and their uses |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| JO3348B1 (ar) | 2009-08-11 | 2019-03-13 | Acorda Therapeutics Inc | استخدام 4- بايريدين امينو لتحسين الادراك العصبي و/او التلف النفسي لدى مرضى يعانون من نقص النُخاعين وغير ذلك من امراض الجهاز العصبي |
| ES2633317T3 (es) | 2009-11-06 | 2017-09-20 | Plexxikon, Inc. | Compuestos y métodos para la modulación de quinasas, e indicaciones para ello |
| MA34948B1 (fr) | 2011-02-07 | 2014-03-01 | Plexxikon Inc | Composes et procedes de modulation de kinase, et leurs indications |
| TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| WO2016123406A1 (en) | 2015-01-28 | 2016-08-04 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
| WO2018129304A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| CA3101966A1 (en) | 2018-05-29 | 2019-12-05 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| US12397141B2 (en) | 2018-11-16 | 2025-08-26 | Morningside Venture Investments Limited | Thermally regulated transdermal drug delivery system |
| WO2023115165A1 (en) * | 2021-12-24 | 2023-06-29 | Psylo Pty Ltd | Compounds |
| EP4735441A1 (de) | 2023-06-28 | 2026-05-06 | Psylo Pty Ltd | Pyrrolopyridinverbindungen zur behandlung von geisteskrankheiten |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
| US5401629A (en) * | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
| DE4414569A1 (de) * | 1994-04-27 | 1995-11-02 | Bayer Ag | Verwendung von substituierten Aminen zur Behandlung von Hirnleistungsstörungen |
| US5547960A (en) * | 1994-09-07 | 1996-08-20 | Mayo Foundation For Medical Education And Research | C-10 analogs of huperzine a |
| FR2732969B1 (fr) * | 1995-04-14 | 1997-05-16 | Adir | Nouveaux composes pyridiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US5583140A (en) * | 1995-05-17 | 1996-12-10 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of central nervous system disorders |
-
1998
- 1998-03-31 US US09/052,172 patent/US5977131A/en not_active Expired - Fee Related
- 1998-04-02 ES ES01124408T patent/ES2197133T3/es not_active Expired - Lifetime
- 1998-04-02 DE DE69815161T patent/DE69815161T2/de not_active Expired - Fee Related
- 1998-04-02 PT PT98302610T patent/PT870768E/pt unknown
- 1998-04-02 EP EP98302610A patent/EP0870768B1/de not_active Expired - Lifetime
- 1998-04-02 DE DE69805361T patent/DE69805361T2/de not_active Expired - Fee Related
- 1998-04-02 DK DK98302610T patent/DK0870768T3/da active
- 1998-04-02 PT PT01124408T patent/PT1178045E/pt unknown
- 1998-04-02 ES ES98302610T patent/ES2175615T3/es not_active Expired - Lifetime
- 1998-04-02 AT AT01124408T patent/ATE241623T1/de not_active IP Right Cessation
- 1998-04-02 AT AT98302610T patent/ATE217623T1/de not_active IP Right Cessation
- 1998-04-06 JP JP13925998A patent/JP3342403B2/ja not_active Expired - Fee Related
- 1998-04-07 CA CA002234567A patent/CA2234567C/en not_active Expired - Fee Related
- 1998-04-09 BR BR9801020-4A patent/BR9801020A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69805361D1 (de) | 2002-06-20 |
| PT870768E (pt) | 2002-09-30 |
| DE69815161T2 (de) | 2003-11-27 |
| MX9802932A (es) | 1998-12-31 |
| EP0870768A1 (de) | 1998-10-14 |
| BR9801020A (pt) | 2000-02-29 |
| ATE241623T1 (de) | 2003-06-15 |
| CA2234567A1 (en) | 1998-10-09 |
| ES2175615T3 (es) | 2002-11-16 |
| EP0870768B1 (de) | 2002-05-15 |
| DE69815161D1 (de) | 2003-07-03 |
| ES2197133T3 (es) | 2004-01-01 |
| ATE217623T1 (de) | 2002-06-15 |
| JPH1149772A (ja) | 1999-02-23 |
| PT1178045E (pt) | 2003-10-31 |
| CA2234567C (en) | 2001-10-02 |
| US5977131A (en) | 1999-11-02 |
| JP3342403B2 (ja) | 2002-11-11 |
| DE69805361T2 (de) | 2002-08-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9801020A (pt) | Derivados de azaindol-etilamina como agentes de ligação do receptor de acetilcolina nicotìnico. | |
| DE69719350D1 (de) | 2-pyrimidinamin derivaten und verfahrens zu deren herstellung | |
| ATE139233T1 (de) | Annelierte thiophen-derivate, ihre herstellung und verwendung | |
| EP0896533A4 (de) | Pentafluorobenzensulfonamiden und analoge | |
| MY119150A (en) | Azetidine derivatives, their preparation and medicaments containing them | |
| NZ336302A (en) | Quinoline and quinazoline compounds useful in therapy, particularly in the treatment of benign prostatic hyperplasia | |
| DK0842661T3 (da) | Anvendelse af estrogenagonister og -antagonister til fremstilling af et lægemiddel til behandling af atherosclerose, uafhængigt af lipidsænkning | |
| DK0918776T3 (da) | Totalsyntese af antitumor acylfulvener | |
| DE69529418D1 (de) | Cyclopropachromencarbonsäure derivate | |
| ATE172463T1 (de) | Pyrrolocarbazol | |
| EE200000059A (et) | Tetrahüdro-gamma-karboliinid | |
| EP0259835A3 (en) | Pyridazinone derivatives | |
| ATE215555T1 (de) | 17-beta.-allyloxy(thio)alkyl-androstan derivative zur modulation von meiose | |
| EP1034783A4 (de) | Amidederivaten | |
| DE69430839D1 (de) | Trizyklische Indol-2-carbonsäure Derivate als selektive NMDA Rezeptor Antagonisten | |
| DK0765322T3 (da) | Indolderivater som pro-drugs for 5-HT1-lignende receptoragonister | |
| DE69806640D1 (de) | 17beta-aryl(arylmethyl)oxy(thio)alkyl-androstanderivative | |
| PL344406A1 (en) | Cyanoiminoquinoxaline derivatives | |
| DE60239324D1 (de) | Phenyl- und pyridyl-piperidine mit tnf-wirkung | |
| ES2077697T3 (es) | Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos. | |
| TW288015B (en) | New chromene derivatives | |
| TW254937B (en) | Benzocycloheptene derivative and process for preparation thereof |