DK0901465T3 - Forbindelser med antiinflammatoriske og immunosuppressive aktiviteter - Google Patents

Forbindelser med antiinflammatoriske og immunosuppressive aktiviteter

Info

Publication number
DK0901465T3
DK0901465T3 DK97923053T DK97923053T DK0901465T3 DK 0901465 T3 DK0901465 T3 DK 0901465T3 DK 97923053 T DK97923053 T DK 97923053T DK 97923053 T DK97923053 T DK 97923053T DK 0901465 T3 DK0901465 T3 DK 0901465T3
Authority
DK
Denmark
Prior art keywords
inflammatory
compounds
immunosuppressive activities
immunosuppressive
activities
Prior art date
Application number
DK97923053T
Other languages
English (en)
Inventor
Giorgio Bertolini
Mauro Biffi
Flavio Leoni
Jacques Mizrahi
Gianfranco Pavich
Paolo Mascagni
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11374259&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0901465(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Application granted granted Critical
Publication of DK0901465T3 publication Critical patent/DK0901465T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
DK97923053T 1996-05-14 1997-05-12 Forbindelser med antiinflammatoriske og immunosuppressive aktiviteter DK0901465T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI000968A IT1283637B1 (it) 1996-05-14 1996-05-14 Composti ad attivita' antinfiammatoria ed immunosoppressiva
PCT/EP1997/002407 WO1997043251A1 (en) 1996-05-14 1997-05-12 Compounds with anti-inflammatory and immunosuppressive activities

Publications (1)

Publication Number Publication Date
DK0901465T3 true DK0901465T3 (da) 2000-12-18

Family

ID=11374259

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97923053T DK0901465T3 (da) 1996-05-14 1997-05-12 Forbindelser med antiinflammatoriske og immunosuppressive aktiviteter

Country Status (19)

Country Link
US (1) US6034096A (da)
EP (1) EP0901465B1 (da)
JP (1) JP4108127B2 (da)
CN (1) CN1105100C (da)
AU (1) AU713300B2 (da)
BR (1) BR9709234B8 (da)
CA (1) CA2254066C (da)
CZ (1) CZ293233B6 (da)
DE (1) DE69703207T2 (da)
DK (1) DK0901465T3 (da)
ES (1) ES2151267T3 (da)
GR (1) GR3035128T3 (da)
HU (2) HU225650B1 (da)
IT (1) IT1283637B1 (da)
PL (1) PL187527B1 (da)
PT (1) PT901465E (da)
RU (1) RU2177473C2 (da)
SK (1) SK282174B6 (da)
WO (1) WO1997043251A1 (da)

Families Citing this family (30)

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CN1330661A (zh) 1998-12-10 2002-01-09 霍夫曼-拉罗奇有限公司 原胶原c端蛋白酶抑制剂
AU765198B2 (en) * 1999-02-04 2003-09-11 Sk Holdings Co., Ltd. Tetrahydro isoquino linealkanol derivatives and pharmaceutical compositions containing same
RU2221786C2 (ru) * 1999-02-04 2004-01-20 СК Корпорейшн Производные тетрагидроизохинолиналканола, способы лечения и фармацевтические композиции на их основе
AU3631500A (en) * 1999-03-19 2000-10-09 Du Pont Pharmaceuticals Company N-adamant-1-yl-n'-(4-chlorobenzothiazol-2-yl) urea useful in the treatment of inflammation and as an anticancer radiosensitizing agent
ES2353020T3 (es) 2000-05-31 2011-02-24 Santen Pharmaceutical Co., Ltd. (piridinil)alquil-amidas o -ureas como inhibidores de la producción del tnf-alfa.
CA2423868C (en) * 2000-09-29 2011-06-07 Prolifix Limited Carbamic acid compounds comprising an amide linkage as hdac inhibitors
ITMI20011733A1 (it) * 2001-08-07 2003-02-07 Italfarmaco Spa Derivati dell'acido idrossamico inibitori degli enzimi istone deacetilasi, quali nuovi farmaci antiinfiammatori inibenti la sintesi di citoc
PE20030701A1 (es) * 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
AU2003211362A1 (en) * 2002-02-21 2003-09-09 Osaka Industrial Promotion Organization N-hydroxycarboxamide derivative
ITMI20030025A1 (it) * 2003-01-10 2004-07-11 Italfarmaco Spa Derivati dell'acido idrossammico ad attivita' antinfiammatoria.
ITMI20030063A1 (it) * 2003-01-17 2004-07-18 Italfarmaco Spa Cloridrato monoidrato dell'estere (6-dietilamminometil-naftalen-2-il)metilico dell'acido (4-idrossicarbammoil-fenil)carbammico.
ITMI20030064A1 (it) * 2003-01-17 2004-07-18 Italfarmaco Spa Uso dei derivati dell'acido idrossamico per la preparazione
US7291744B2 (en) 2003-11-13 2007-11-06 Bristol-Myers Squibb Company N-ureidoalkyl-amino compounds as modulators of chemokine receptor activity
CA2552279C (en) * 2003-12-02 2014-07-15 The Ohio State University Research Foundation Zn2+-chelating motif-tethered short -chain fatty acids as a novel class of histone deacetylase inhibitors
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
ITMI20041347A1 (it) * 2004-07-05 2004-10-05 Italfarmaco Spa Derivati di alfa-amminoacidi ad attivita'antiinfiammatoria
TW200615273A (en) * 2004-11-10 2006-05-16 Nicholas Piramal India Ltd Fused tricyclic compounds as inhibitors of tumor necrosis factor-alpha
WO2007017728A2 (en) * 2005-08-05 2007-02-15 Orchid Research Laboratories Limited Novel heterocyclic compounds
IT1392908B1 (it) 2008-09-29 2012-04-02 Italfarmaco Spa Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negative
WO2010043904A2 (en) 2008-10-15 2010-04-22 Generics [Uk] Limited Improved process
WO2010061219A2 (en) 2008-11-26 2010-06-03 Generics [Uk] Limited Polymorphs
KR101168801B1 (ko) 2009-03-27 2012-07-25 주식회사종근당 신규한 하이드록사메이트 유도체, 이의 제조방법, 및 이를 함유하는 약제학적 조성물
IT1396915B1 (it) 2009-10-23 2012-12-20 Italfarmaco Spa Dietil-[6-(4-idrossicarbamoil-fenil-carbamoilossimetil)-naftalen-2-il-metil]-ammonio cloruro ed altri derivati della n-idrossi-benzammide per l'uso nel trattamento di infezioni da hiv.
IT1397912B1 (it) * 2010-01-28 2013-02-04 Chemi Spa Nuovo polimorfo dell'estere 6-dietilamminometil-2-naftilico dell'acido 4-idrossicarbamoil-fenil-carbammico cloridrato.
US8217079B2 (en) * 2010-03-26 2012-07-10 Italfarmaco Spa Method for treating Philadelphia-negative myeloproliferative syndromes
PL2683371T3 (pl) 2011-03-09 2021-04-19 Cereno Scientific Ab Związki i sposoby poprawy zaburzonej funkcji wewnątrzustrojowej fibrynolizy przy zastosowaniu inhibitorów deacetylazy histonowej
PL3858340T3 (pl) 2012-02-03 2026-07-06 Italfarmaco Spa Chlorek dietylo-[6-(4-hydroksykarbamoilofenylokarbamoiloksymetylo)naftaleno-2-ylometylo]amoniowy w połączeniu z co najmniej jednym kortykosteroidem glukokortykoidowym do zastosowania w leczeniu dystrofii mięśniowej
ITUB20155193A1 (it) 2015-11-03 2017-05-03 Italfarmaco Spa Sospensioni orali di Givinostat fisicamente e chimicamente stabili
WO2018054960A1 (en) 2016-09-21 2018-03-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting and treating resistance to chemotherapy in npm-alk(+) alcl
IT201900003281A1 (it) * 2019-03-06 2020-09-06 Chemi Spa Processo per preparare {6-[(dietilammino)metil]naftalen-2-il}metil [4-(idrossicarbamoil)fenil]carbammato ad elevata purezza

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US2800498A (en) * 1954-09-12 1957-07-23 Lab Dausse Carbamates of dialkylaminoalkyl p-aminobenzoates
NO134946C (da) * 1970-09-09 1977-01-12 Ciba Geigy Ag
US3804888A (en) * 1971-05-17 1974-04-16 Morton Norwich Products Inc 2-p-nitrobenzamidoacetohydroxamic acid
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FR2354315A1 (fr) * 1976-06-10 1978-01-06 Eisai Co Ltd Nouveaux derives d'acide hydroxamique et medicaments en contenant
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US4792560A (en) * 1985-04-03 1988-12-20 Rorer Pharmaceutical Corporation Quinoline hydroxamates and their use as modulators of arachidonic acid metabolic pathways
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Also Published As

Publication number Publication date
EP0901465A1 (en) 1999-03-17
EP0901465B1 (en) 2000-09-27
PL329873A1 (en) 1999-04-12
GR3035128T3 (en) 2001-04-30
CZ366798A3 (cs) 1999-06-16
HUP9902818A3 (en) 2001-10-29
WO1997043251A1 (en) 1997-11-20
SK282174B6 (sk) 2001-11-06
SK157998A3 (en) 1999-04-13
CZ293233B6 (cs) 2004-03-17
JP4108127B2 (ja) 2008-06-25
ES2151267T3 (es) 2000-12-16
CA2254066A1 (en) 1997-11-20
AU2896497A (en) 1997-12-05
RU2177473C2 (ru) 2001-12-27
CN1105100C (zh) 2003-04-09
JP2000510472A (ja) 2000-08-15
CN1221403A (zh) 1999-06-30
DE69703207D1 (de) 2000-11-02
AU713300B2 (en) 1999-11-25
BR9709234B8 (pt) 2014-04-15
CA2254066C (en) 2007-09-11
IT1283637B1 (it) 1998-04-23
PL187527B1 (pl) 2004-07-30
DE69703207T2 (de) 2001-02-01
HU225650B1 (en) 2007-05-29
US6034096A (en) 2000-03-07
BR9709234B1 (pt) 2009-01-13
PT901465E (pt) 2001-01-31
BR9709234A (pt) 1999-08-10
ITMI960968A1 (it) 1997-11-14
ITMI960968A0 (da) 1996-05-14

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