DK0923576T3 - 4-Aminoethoxy-indolderivater som dopamin D2-agonister - Google Patents

4-Aminoethoxy-indolderivater som dopamin D2-agonister

Info

Publication number: DK0923576T3
Authority: DK; Denmark
Prior art keywords: hydrogen; dopamine; aminoethoxy; agonists; indole derivatives
Prior art date: 1996-08-27

Application number

DK97938630T

Other languages

English (en)

Inventor

Richard Eric Mewshaw

Michael Byron Webb

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-27

Filing date

1997-08-26

Publication date

2003-03-03

1997-08-26 Application filed by Wyeth Corp filed Critical Wyeth Corp

2003-03-03 Application granted granted Critical

2003-03-03 Publication of DK0923576T3 publication Critical patent/DK0923576T3/da

Links

VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title abstract 4
229960003638 dopamine Drugs 0.000 title abstract 2
FZXIBIRCACCXGD-UHFFFAOYSA-N 2-(1h-indol-4-yloxy)ethanamine Chemical class NCCOC1=CC=CC2=C1C=CN2 FZXIBIRCACCXGD-UHFFFAOYSA-N 0.000 title 1
239000000556 agonist Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
208000007848 Alcoholism Diseases 0.000 abstract 1
208000022497 Cocaine-Related disease Diseases 0.000 abstract 1
206010012335 Dependence Diseases 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
208000000323 Tourette Syndrome Diseases 0.000 abstract 1
208000016620 Tourette disease Diseases 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
201000006145 cocaine dependence Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
206010013663 drug dependence Diseases 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Addiction (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK97938630T 1996-08-27 1997-08-26 4-Aminoethoxy-indolderivater som dopamin D2-agonister DK0923576T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US70360696A	1996-08-27	1996-08-27
PCT/US1997/015027 WO1998008843A1 (en)	1996-08-27	1997-08-26	4-aminoethoxy-indolone derivatives as dopamine d2 agonists

Publications (1)

Publication Number	Publication Date
DK0923576T3 true DK0923576T3 (da)	2003-03-03

Family

ID=24826054

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97938630T DK0923576T3 (da)	1996-08-27	1997-08-26	4-Aminoethoxy-indolderivater som dopamin D2-agonister

Country Status (12)

Country	Link
EP (1)	EP0923576B1 (da)
JP (1)	JP2000517318A (da)
KR (1)	KR20000035822A (da)
CN (1)	CN1077890C (da)
AT (1)	ATE227284T1 (da)
AU (1)	AU4091797A (da)
CA (1)	CA2264072A1 (da)
DE (1)	DE69716932T2 (da)
DK (1)	DK0923576T3 (da)
ES (1)	ES2185985T3 (da)
PT (1)	PT923576E (da)
WO (1)	WO1998008843A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR9807703A (pt) *	1997-02-18	2000-05-02	American Home Prod	Derivados de 4-aminoalcóxi-1,3-diidrobenzoimidazol-2-ona, suas preparações e seus usos como agonistas (d2) auto-receptores da dopamina
US5990144A (en) *	1997-02-18	1999-11-23	American Home Products Corporation	4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one dopamine autoreceptor agonists
CN114507162A (zh) *	2020-11-16	2022-05-17	尚科生物医药（上海）有限公司	一种制备2-氟-5-甲氧基苯磺酰氯的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5541199A (en) *	1995-06-02	1996-07-30	American Home Products Corporation	Chroman-2-ylmethylamino derivatives
AR004523A1 (es) *	1995-11-06	1998-12-16	American Home Prod	2-(AMINOMETIL)-3,4,7,9-TETRAHIDRO-2H-PIRANO-[2,3e] INDOL-8-ONAS Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN

1997
- 1997-08-26 PT PT97938630T patent/PT923576E/pt unknown
- 1997-08-26 DK DK97938630T patent/DK0923576T3/da active
- 1997-08-26 DE DE69716932T patent/DE69716932T2/de not_active Expired - Fee Related
- 1997-08-26 CA CA002264072A patent/CA2264072A1/en not_active Abandoned
- 1997-08-26 ES ES97938630T patent/ES2185985T3/es not_active Expired - Lifetime
- 1997-08-26 AT AT97938630T patent/ATE227284T1/de not_active IP Right Cessation
- 1997-08-26 EP EP97938630A patent/EP0923576B1/en not_active Expired - Lifetime
- 1997-08-26 WO PCT/US1997/015027 patent/WO1998008843A1/en not_active Ceased
- 1997-08-26 CN CN97198975A patent/CN1077890C/zh not_active Expired - Fee Related
- 1997-08-26 JP JP10511857A patent/JP2000517318A/ja active Pending
- 1997-08-26 KR KR1019997001478A patent/KR20000035822A/ko not_active Withdrawn
- 1997-08-26 AU AU40917/97A patent/AU4091797A/en not_active Abandoned

Also Published As

Publication number	Publication date
KR20000035822A (ko)	2000-06-26
EP0923576B1 (en)	2002-11-06
DE69716932D1 (de)	2002-12-12
ATE227284T1 (de)	2002-11-15
CA2264072A1 (en)	1998-03-05
CN1234033A (zh)	1999-11-03
CN1077890C (zh)	2002-01-16
AU4091797A (en)	1998-03-19
EP0923576A1 (en)	1999-06-23
DE69716932T2 (de)	2003-03-27
PT923576E (pt)	2003-02-28
ES2185985T3 (es)	2003-05-01
JP2000517318A (ja)	2000-12-26
WO1998008843A1 (en)	1998-03-05

Publication	Publication Date	Title
DK0923548T3 (da)	2003-06-23	4-Aminoethoxyindoler som dopamin-D2-agonister og som 5HT 1A-ligander
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
ATE266013T1 (de)	2004-05-15	1-phenyl-4-benzylpiperazine: spezifische liganden für den dopamin rezeptor (d4)
SG128491A1 (en)	2007-01-30	Heterocyclic sulfonamide inhibitors of beta amyloid production
CA2297011A1 (en)	1999-02-04	Sulfonamide derivatives as therapeutic or prophylactic agent for glomerulopathy
ES8404990A1 (es)	1984-05-16	Un procedimiento para la preparacion de derivados de prolina.
WO2001062705A3 (en)	2003-01-16	Aminoalcohol derivatives
SE0302573D0 (sv)	2003-09-26	Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE9903997D0 (sv)	1999-11-03	New compounds
DK1189900T3 (da)	2004-04-26	Heterocykliske aminopyrrolidinderivater som melatonerge lægemidler
NZ512851A (en)	2004-02-27	Derivatives of monosaccharides as cell adhesion inhibitors
DK1202954T3 (da)	2004-02-09	Nye aminobenzophenoner
TR200001909T2 (tr)	2000-12-21	Matris metaloprotez inhibitörleri.
DE60128100D1 (de)	2007-06-06	Analgetisches arzneimittel
AU6220300A (en)	2001-02-19	Benzofurylpiperazine serotonin agonists
CS183791A3 (en)	1992-01-15	Derivatives of 2-(aminoalkyl)-5-(arylalkyl)-1,3-dioxanes, process for their preparation and their therapeutical application
SE0302572D0 (sv)	2003-09-26	Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
DK0923576T3 (da)	2003-03-03	4-Aminoethoxy-indolderivater som dopamin D2-agonister
DK0923551T3 (da)	2002-09-16	4-Aminoethoxy-indolon-derivater
CO5160328A1 (es)	2002-05-30	Derivados de etan sulfonil-piperidina
ATE344237T1 (de)	2006-11-15	Hydroxyacetamidobenzolsulfonamidderivate
SE9704770D0 (sv)	1997-12-19	New use
ATE238300T1 (de)	2003-05-15	(3,4-dihydro-2h-benzo(1,4)oxazinyl-methyl)-3-(1 - indol-3-yl)-alkylamine
EP1567508A4 (en)	2008-12-10	1,2,4-TRIAZOLE DERIVATIVE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
NZ336969A (en)	2001-03-30	Substituted 4-aminoalkoxy-1H-benzimidazole derivatives useful as dopamine autoreceptor (D2) agonists