DK0925295T3 - Derivater af N-benzensulfonyl-L-prolin som antagonister af receptoren B2 for bradykinin - Google Patents

Derivater af N-benzensulfonyl-L-prolin som antagonister af receptoren B2 for bradykinin

Info

Publication number: DK0925295T3
Authority: DK; Denmark
Prior art keywords: group; pct; bradykinin; benzenesulfonyl; proline
Prior art date: 1996-07-24

Application number

DK97935612T

Other languages

English (en)

Inventor

Pierre Dodey

Michel Bondoux

Patrick Houziaux

Martine Barth

Khan Ou

Original Assignee

Fournier Ind & Sante

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-24

Filing date

1997-07-23

Publication date

2002-01-28

1997-07-23 Application filed by Fournier Ind & Sante filed Critical Fournier Ind & Sante

2002-01-28 Application granted granted Critical

2002-01-28 Publication of DK0925295T3 publication Critical patent/DK0925295T3/da

Links

101800004538 Bradykinin Proteins 0.000 title abstract 2
QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 title abstract 2
102100035792 Kininogen-1 Human genes 0.000 title abstract 2
QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title 1
229960002429 proline Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
125000000320 amidine group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pyrrole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK97935612T 1996-07-24 1997-07-23 Derivater af N-benzensulfonyl-L-prolin som antagonister af receptoren B2 for bradykinin DK0925295T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9609327A FR2751650B1 (fr)	1996-07-24	1996-07-24	Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique
PCT/FR1997/001377 WO1998003503A1 (fr)	1996-07-24	1997-07-23	Derives de n-benzenesulfonyl-l-proline en tant qu'agonistes de la bradykinine b2

Publications (1)

Publication Number	Publication Date
DK0925295T3 true DK0925295T3 (da)	2002-01-28

Family

ID=9494439

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97935612T DK0925295T3 (da)	1996-07-24	1997-07-23	Derivater af N-benzensulfonyl-L-prolin som antagonister af receptoren B2 for bradykinin

Country Status (14)

Country	Link
US (1)	US6071917A (da)
EP (1)	EP0925295B1 (da)
JP (1)	JP2000514818A (da)
AT (1)	ATE206419T1 (da)
AU (1)	AU3853697A (da)
CA (1)	CA2261743A1 (da)
DE (1)	DE69707141T2 (da)
DK (1)	DK0925295T3 (da)
ES (1)	ES2167768T3 (da)
FR (1)	FR2751650B1 (da)
PL (1)	PL186396B1 (da)
PT (1)	PT925295E (da)
TR (1)	TR199900096T2 (da)
WO (1)	WO1998003503A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2765222B1 (fr) *	1997-06-27	1999-12-31	Fournier Ind & Sante	Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique
KR100579792B1 (ko)	1998-05-13	2006-05-12	동화약품공업주식회사	신규 2,5-피리딘디카복실산 유도체
FR2790260B1 (fr) *	1999-02-26	2001-05-04	Fournier Ind & Sante	Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique
CA2364178C (en) *	2000-12-05	2006-01-10	Yasuhiro Katsu	N-benzenesulfonyl l-proline compounds as bradykinin antagonists
FR2819254B1 (fr) *	2001-01-08	2003-04-18	Fournier Lab Sa	Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques
EP1914236A1 (en)	2002-04-10	2008-04-23	Ortho-McNeil Pharmaceutical, Inc.	Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators
ITMI20021247A1 (it)	2002-06-07	2003-12-09	Menarini Ricerche Spa	Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche
FR2840897B1 (fr) *	2002-06-14	2004-09-10	Fournier Lab Sa	Nouveaux derives d'arylsulfonamides et leur utilisation en therapeutique
DE10304994A1 (de) *	2003-02-07	2004-09-02	Aventis Pharma Deutschland Gmbh	Die Verwendung von Antagonisten des Bradykinin-B2 Rezeptors zur Behandlung von Osteoarthrose
DE602004021358D1 (de)	2003-03-25	2009-07-16	Fournier Lab Sa	Benzosulfonamide derivate, deren verfahren zum herstellung, und deren verwendung zur behandlung von schmerzen
DE102005013967A1 (de) *	2004-11-05	2006-10-05	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Bradykinin-B1-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
WO2025124698A1 (en)	2023-12-12	2025-06-19	Idorsia Pharmaceuticals Ltd	Aryl sulfone and sulfanone derivatives as orexin receptor modulators
WO2025132542A1 (en)	2023-12-19	2025-06-26	Idorsia Pharmaceuticals Ltd	Macrocyclic orexin agonists

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3617183A1 (de) *	1985-11-16	1987-05-27	Bayer Ag	Substituierte benzylether
DE3632329A1 (de) *	1986-09-24	1988-03-31	Bayer Ag	Substituierte phenylsulfonamide
AU686115B2 (en) *	1992-11-02	1998-02-05	Fujisawa Pharmaceutical Co., Ltd.	Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation
AU680870B2 (en) *	1993-04-28	1997-08-14	Astellas Pharma Inc.	New heterocyclic compounds
WO1996013485A1 (en) *	1994-10-27	1996-05-09	Fujisawa Pharmaceutical Co., Ltd.	Pyridopyrimidones, quinolines and fused n-heretocycles as bradykinin antagonists
FR2735128B1 (fr) *	1995-06-07	1997-07-25	Fournier Ind & Sante	Nouveaux composes de benzenesulfonamide, leur procede de preparation et utilisation en therapeutique.
FR2737892B1 (fr) *	1995-08-17	1997-10-24	Fournier Ind & Sante	Nouveaux composes de benzenesulfonamide, procede de preparation et utilisation en therapeutique
FR2743073B1 (fr) *	1995-12-29	1998-02-20	Fournier Ind & Sante	Nouveaux composes de 1-benzenesulfonylpyrrolidine, procede de preparation et utilisation en therapeutique

1996
- 1996-07-24 FR FR9609327A patent/FR2751650B1/fr not_active Expired - Fee Related
1997
- 1997-07-23 DK DK97935612T patent/DK0925295T3/da active
- 1997-07-23 WO PCT/FR1997/001377 patent/WO1998003503A1/fr not_active Ceased
- 1997-07-23 US US09/230,334 patent/US6071917A/en not_active Expired - Fee Related
- 1997-07-23 AU AU38536/97A patent/AU3853697A/en not_active Abandoned
- 1997-07-23 TR TR1999/00096T patent/TR199900096T2/xx unknown
- 1997-07-23 CA CA002261743A patent/CA2261743A1/en not_active Abandoned
- 1997-07-23 PL PL97331347A patent/PL186396B1/pl not_active IP Right Cessation
- 1997-07-23 AT AT97935612T patent/ATE206419T1/de not_active IP Right Cessation
- 1997-07-23 ES ES97935612T patent/ES2167768T3/es not_active Expired - Lifetime
- 1997-07-23 DE DE69707141T patent/DE69707141T2/de not_active Expired - Fee Related
- 1997-07-23 PT PT97935612T patent/PT925295E/pt unknown
- 1997-07-23 JP JP10506663A patent/JP2000514818A/ja active Pending
- 1997-07-23 EP EP97935612A patent/EP0925295B1/fr not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2167768T3 (es)	2002-05-16
EP0925295B1 (fr)	2001-10-04
US6071917A (en)	2000-06-06
AU3853697A (en)	1998-02-10
PT925295E (pt)	2002-03-28
FR2751650B1 (fr)	1998-10-09
TR199900096T2 (xx)	1999-03-22
DE69707141T2 (de)	2002-06-27
CA2261743A1 (en)	1998-01-29
JP2000514818A (ja)	2000-11-07
EP0925295A1 (fr)	1999-06-30
FR2751650A1 (fr)	1998-01-30
WO1998003503A1 (fr)	1998-01-29
PL331347A1 (en)	1999-07-05
DE69707141D1 (de)	2001-11-08
ATE206419T1 (de)	2001-10-15
PL186396B1 (pl)	2004-01-30

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