DK0929566T3 - Fremgangsmåde til R-epimerberigelse af 16,17-acetal-derivater af 21-acyloxy-pregan-1,4-dien-11beta,16alfa,17alfa-triol-3,20-dion-derivater - Google Patents

Fremgangsmåde til R-epimerberigelse af 16,17-acetal-derivater af 21-acyloxy-pregan-1,4-dien-11beta,16alfa,17alfa-triol-3,20-dion-derivater

Info

Publication number
DK0929566T3
DK0929566T3 DK97942897T DK97942897T DK0929566T3 DK 0929566 T3 DK0929566 T3 DK 0929566T3 DK 97942897 T DK97942897 T DK 97942897T DK 97942897 T DK97942897 T DK 97942897T DK 0929566 T3 DK0929566 T3 DK 0929566T3
Authority
DK
Denmark
Prior art keywords
derivatives
16alpha
11beta
17alpha
triol
Prior art date
Application number
DK97942897T
Other languages
English (en)
Inventor
Hermann Amschler
Dieter Flockerzi
Beate Schmidt
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7804358&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0929566(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of DK0929566T3 publication Critical patent/DK0929566T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK97942897T 1996-09-03 1997-08-29 Fremgangsmåde til R-epimerberigelse af 16,17-acetal-derivater af 21-acyloxy-pregan-1,4-dien-11beta,16alfa,17alfa-triol-3,20-dion-derivater DK0929566T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19635498A DE19635498A1 (de) 1996-09-03 1996-09-03 Verfahren zur Epimerenanreicherung
PCT/EP1997/004716 WO1998009982A1 (en) 1996-09-03 1997-08-29 Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.-triol-3,20-dione derivatives

Publications (1)

Publication Number Publication Date
DK0929566T3 true DK0929566T3 (da) 2003-04-07

Family

ID=7804358

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97942897T DK0929566T3 (da) 1996-09-03 1997-08-29 Fremgangsmåde til R-epimerberigelse af 16,17-acetal-derivater af 21-acyloxy-pregan-1,4-dien-11beta,16alfa,17alfa-triol-3,20-dion-derivater

Country Status (18)

Country Link
US (1) US6787533B1 (da)
EP (1) EP0929566B1 (da)
JP (1) JP3807509B2 (da)
AT (1) ATE229539T1 (da)
AU (1) AU736840B2 (da)
CA (1) CA2264863C (da)
CL (1) CL2004001297A1 (da)
CY (2) CY2454B1 (da)
CZ (1) CZ298789B6 (da)
DE (2) DE19635498A1 (da)
DK (1) DK0929566T3 (da)
EE (1) EE03927B1 (da)
ES (1) ES2188984T3 (da)
HU (1) HU228766B1 (da)
IL (1) IL128535A (da)
PL (1) PL186063B1 (da)
PT (1) PT929566E (da)
WO (1) WO1998009982A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6264923B1 (en) * 1998-05-13 2001-07-24 3M Innovative Properties Company Medicinal aerosol formulation of ciclesonide and related compounds
ES2351184T3 (es) 2000-11-10 2011-02-01 Nycomed Gmbh Procedimiento para la producción de 16,17-[(ciclohexilmetilen)bis(oxil)]-11,21-dihidroxi-pregna-1,4-dien-3,20-diona o su 21-isobutirato mediante transcetalización.
DE10055820C1 (de) * 2000-11-10 2002-07-25 Byk Gulden Lomberg Chem Fab Verfahren zur Herstellung eines Glucocorticoids
AU2003291634A1 (en) 2002-10-08 2004-05-04 Sepracor Inc. Fatty acid modified forms of glucocorticoids and their use as anti-inflammatory
US7879833B2 (en) 2002-12-12 2011-02-01 Nycomed Gmbh Combination medicament
MY143936A (en) * 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
PT1670482E (pt) 2003-09-16 2014-03-12 Takeda Gmbh Utilização de ciclesonida para o tratamento de doenças respiratórias
PE20050941A1 (es) 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
CN100345864C (zh) * 2004-10-29 2007-10-31 天津药业研究院有限公司 一种治疗呼吸道疾病的甾体药物的制备方法及其中间体
JP2009512733A (ja) * 2005-11-02 2009-03-26 シコール インコーポレイティド シクレソニドの改良された製造法
WO2007092574A2 (en) * 2006-02-08 2007-08-16 Sicor, Inc. Crystalline forms of ciclesonide
WO2008015696A2 (en) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Process for preparing ciclesonide
WO2008062450A2 (en) * 2006-09-18 2008-05-29 Cadila Healthcare Limited Crystalline polymorphs of ciclesonide
CA2663737A1 (en) 2006-09-19 2008-03-27 Cipla Limited Processes for the preparation of ciclesonide and its crystal form
IT1397499B1 (it) * 2009-01-09 2013-01-16 Farmabios Spa Processo per la preparazione di ciclesonide
JP2011513469A (ja) * 2008-03-13 2011-04-28 ファルマビオス ソシエタ ペル アチオニ プレグナン誘導体の製造法
US20100120737A1 (en) * 2008-11-10 2010-05-13 Martin Feth Amorphous ciclesonide
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
US20180126000A1 (en) 2016-06-02 2018-05-10 Abbvie Inc. Glucocorticoid receptor agonist and immunoconjugates thereof
BR112020010694A2 (pt) 2017-12-01 2020-11-10 Abbvie Inc. agonista de receptor de glicocorticoides e imunoconjugados do mesmo
CN109293730A (zh) * 2018-10-23 2019-02-01 山东泰华生物科技股份有限公司 一种环索奈德的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
SE378110B (da) * 1972-05-19 1975-08-18 Bofors Ab
US4036831A (en) * 1975-10-28 1977-07-19 Steroid Development Company Establishment Trimethyl siloxane steroid intermediates
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
GR1001529B (el) 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
PL164294B1 (pl) * 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL
US5482935A (en) 1993-01-05 1996-01-09 American Home Product Corporation Anti-atherosclerotic use of 17 alpha-dihydroequilin
DK0701565T3 (da) * 1993-04-02 1999-07-12 Byk Gulden Lomberg Chem Fab Nye prednisolonderivater
ATE198074T1 (de) * 1994-03-09 2000-12-15 Byk Gulden Lomberg Chem Fab Neue silylverbindungen und ihre verwendung

Also Published As

Publication number Publication date
DE69717836D1 (de) 2003-01-23
CA2264863C (en) 2007-07-31
AU736840B2 (en) 2001-08-02
JP3807509B2 (ja) 2006-08-09
EP0929566A1 (en) 1999-07-21
CZ72799A3 (cs) 1999-09-15
PL186063B1 (pl) 2003-09-30
WO1998009982A1 (en) 1998-03-12
CZ298789B6 (cs) 2008-01-30
ATE229539T1 (de) 2002-12-15
CY2009010I1 (el) 2010-07-28
PL331699A1 (en) 1999-08-02
HUP9904127A2 (hu) 2000-04-28
IL128535A0 (en) 2000-01-31
DE69717836T2 (de) 2003-09-18
CY2454B1 (en) 2005-06-03
CL2004001297A1 (es) 2005-04-15
AU4456797A (en) 1998-03-26
HU228766B1 (hu) 2013-05-28
US6787533B1 (en) 2004-09-07
DE19635498A1 (de) 1998-03-26
EP0929566B1 (en) 2002-12-11
ES2188984T3 (es) 2003-07-01
PT929566E (pt) 2003-04-30
CY2009010I2 (el) 2010-07-28
EE03927B1 (et) 2002-12-16
IL128535A (en) 2003-07-06
EE9900079A (et) 1999-10-15
JP2000517330A (ja) 2000-12-26
HUP9904127A3 (en) 2001-02-28
CA2264863A1 (en) 1998-03-12

Similar Documents

Publication Publication Date Title
DK0929566T3 (da) Fremgangsmåde til R-epimerberigelse af 16,17-acetal-derivater af 21-acyloxy-pregan-1,4-dien-11beta,16alfa,17alfa-triol-3,20-dion-derivater
DK163433C (da) Fremgangsmaade til fremstilling af 16,17-acetaler af pregnanderivater
DK0767798T3 (da) Sterolderivater anvendt til regulering af meiose
DK0674641T3 (da) Pyrrolopyrimidiner som CRF-antagonister
AU8368691A (en) New pregna-1,4-diene-3,20-dione-16-17-acetal-21 esters, process for their preparation, compositions and method for the treatment of inflammatory conditions
DK0923599T3 (da) Fremgangsmåde til fremstilling af 17-estere af 9alfa, 21-dihalogenpregnan-11beta, 17alfa-diol-20-oner
HU9201190D0 (en) Method for producing new pregna-1,4-diene-3,20-dione derivatives
ATE478888T1 (de) Verfahren zur herstellung von 16,17- ä(cyclohexylmethylen)bis(oxy)ü -11,21-dihydroxy- pregna-1,4-dien-3,20-dion oder ihre 21-isobutyrat durch transketalisation
GB1531176A (en) Hydrogenated imidazothiazine derivatives
DK0935598T3 (da) 5-heteroatom-alkylsubstituerede 3-oxopyrido(1,2-a)benzimidazol-4-carboxamidderivater egnede til behandling af sygdomme i centralnervesystemet
SE436751B (sv) Forfarande enligt krav 1 i patentet 7613920-3 (publ.nr 423903) for framstellning av 17alfa-acyloxi-9alfa, 21-dihalogen-11beta-hydroxi-6alfa-fluor-16beta-metyl-pregna-1,4-dien-3,20-dion-foreningar
DK0608495T3 (da) Androstanderivater substitueret med en kvaternær ammoniumgruppe i 16-stillingen, farmaceutiske præparater indeholdende disse derivater og fremgangsmåde til deres fremstilling.
DK0520879T3 (da) 16-methylsubstituerede derivater af pregna-1,4-dien-3,20-dion, deres fremstilling, deres anvendelse til fremstilling af 16-methylensteroider og hidtil ukendte mellemprodukter
ATE73136T1 (de) Verfahren zur herstellung von 6alpha, 9alphadifluor-11beta, 17alpha-dihydroxy-16alpha-methyl4-pregnen-3,20-dion und dessen derivate.
DK0627431T3 (da) Fremgangsmåde til fremstilling af krystallinsk loracarbef-monohydrat
DK164478C (da) Anvendelse af 9alpha,11beta-dichlor-16alpha-methyl-21-oxycarbonyldicyclohexylmethyloxypregna-1,4-dien-3,20-dion til fremstilling af et farmaceutisk praeparat til behandling af betaendelsestilstande i retcum eller colon
DK159139C (da) Fremgangsmaade til fremstilling af flade emner, saasom luvforsynede maatter
DK0820435T3 (da) Fremgangsmåde til fremstilling af i det væsentlige rene isomerer af alpha-bisoximer
AR243198A1 (es) Procedimiento para la elaboracion de compuesto 9alfa-21-dihalogeno-11beta- hidroxi-17alfa-alcanoiloxi-6alfa-fluor-16beta-metilp regna-1,4-dien-3,20-diona
DK0387747T3 (da) Fremgangsmåde til fremstilling af 1,3-substitueret tetrahydro-1H-thieno-(3,4-d)-imidazol-2(3H)-on-4-yliden-pentansyreester
RO89499A2 (ro) Procedeu de purificare a acetatului de 17,21-di-hidroxipregna-1,4-dien-3,11,20-triona
NO933669L (no) Höykonsentrasjons ozon-generator
HU9503063D0 (en) New 16-(substituted methyl)-pregna-1,4-diene-3,20-dione derivatives and process for producing them