DK0951471T3 - Cycloalkylinhibitorer af proteinfarnesyltransferase - Google Patents

Cycloalkylinhibitorer af proteinfarnesyltransferase

Info

Publication number
DK0951471T3
DK0951471T3 DK97954575T DK97954575T DK0951471T3 DK 0951471 T3 DK0951471 T3 DK 0951471T3 DK 97954575 T DK97954575 T DK 97954575T DK 97954575 T DK97954575 T DK 97954575T DK 0951471 T3 DK0951471 T3 DK 0951471T3
Authority
DK
Denmark
Prior art keywords
farnesyl transferase
protein farnesyl
inhibitors
cycloalkyl
cycloalkyl inhibitors
Prior art date
Application number
DK97954575T
Other languages
Danish (da)
English (en)
Inventor
James Stanley Kaltenbronn
Namara Dennis Joseph Mc
Annette Marian Doherty
Daniele M Leonard
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of DK0951471T3 publication Critical patent/DK0951471T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK97954575T 1996-12-17 1997-12-16 Cycloalkylinhibitorer af proteinfarnesyltransferase DK0951471T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3366196P 1996-12-17 1996-12-17
US5683197P 1997-08-22 1997-08-22

Publications (1)

Publication Number Publication Date
DK0951471T3 true DK0951471T3 (da) 2004-07-19

Family

ID=26709973

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97954575T DK0951471T3 (da) 1996-12-17 1997-12-16 Cycloalkylinhibitorer af proteinfarnesyltransferase

Country Status (21)

Country Link
US (1) US6281194B1 (de)
EP (1) EP0951471B1 (de)
JP (1) JP2001506265A (de)
KR (1) KR20000057601A (de)
AT (1) ATE261987T1 (de)
AU (1) AU721786C (de)
BR (1) BR9713744A (de)
CA (1) CA2264207A1 (de)
CO (1) CO4920227A1 (de)
DE (1) DE69728165T2 (de)
DK (1) DK0951471T3 (de)
ES (1) ES2216189T3 (de)
HR (1) HRP970693B1 (de)
ID (1) ID19142A (de)
IL (1) IL128546A0 (de)
NO (1) NO992933L (de)
NZ (1) NZ334702A (de)
PE (1) PE46999A1 (de)
PT (1) PT951471E (de)
TW (1) TW552259B (de)
WO (1) WO1998027109A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0951471B1 (de) 1996-12-17 2004-03-17 Warner-Lambert Company Llc Cycloalkyl inhibitoren der protein-farnesyltransferase
EP1076663B1 (de) 1998-04-27 2004-02-18 Warner-Lambert Company LLC Glycinamidederivate mit funktionalisierter alkyl- und alkenylseitenkette als inhibitoren der farnesyltransferase
US6455734B1 (en) * 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
AU2007229363B2 (en) * 2001-08-24 2009-06-04 University Of South Florida Piperazinone Compounds as Anti-Tumor and Anti-Cancer Agents and the Methods of Treatment
EP1427418B1 (de) * 2001-08-24 2009-11-11 Yale University Piperazinon-verbindungen als antitumorale und krebsbekämpfende mittel
US20070275956A1 (en) * 2003-10-14 2007-11-29 Lohray Braj B Novel Heterocyclic Compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ275691A (en) * 1993-11-05 1998-03-25 Warner Lambert Co Di and tripeptides and compositions thereof which inhibit farnesyl transferase
US5571792A (en) 1994-06-30 1996-11-05 Warner-Lambert Company Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
EP0951471B1 (de) 1996-12-17 2004-03-17 Warner-Lambert Company Llc Cycloalkyl inhibitoren der protein-farnesyltransferase

Also Published As

Publication number Publication date
KR20000057601A (ko) 2000-09-25
ID19142A (id) 1998-06-18
EP0951471A1 (de) 1999-10-27
AU5899098A (en) 1998-07-15
DE69728165D1 (de) 2004-04-22
DE69728165T2 (de) 2005-01-20
HRP970693B1 (en) 2002-06-30
TW552259B (en) 2003-09-11
NO992933D0 (no) 1999-06-16
AU721786B2 (en) 2000-07-13
CO4920227A1 (es) 2000-05-29
BR9713744A (pt) 2000-03-21
WO1998027109A1 (en) 1998-06-25
US6281194B1 (en) 2001-08-28
PT951471E (pt) 2004-08-31
HRP970693A2 (en) 1998-10-31
JP2001506265A (ja) 2001-05-15
PE46999A1 (es) 1999-05-20
AU721786C (en) 2001-08-02
NO992933L (no) 1999-06-16
ATE261987T1 (de) 2004-04-15
ES2216189T3 (es) 2004-10-16
NZ334702A (en) 2000-11-24
EP0951471B1 (de) 2004-03-17
IL128546A0 (en) 2000-01-31
CA2264207A1 (en) 1998-06-25

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