HRP970693B1 - Cycloalkyl inhibitors of protein farnesyltransferase - Google Patents

Cycloalkyl inhibitors of protein farnesyltransferase

Info

Publication number
HRP970693B1
HRP970693B1 HR970693A HRP970693A HRP970693B1 HR P970693 B1 HRP970693 B1 HR P970693B1 HR 970693 A HR970693 A HR 970693A HR P970693 A HRP970693 A HR P970693A HR P970693 B1 HRP970693 B1 HR P970693B1
Authority
HR
Croatia
Prior art keywords
protein farnesyltransferase
inhibitors
cycloalkyl
cycloalkyl inhibitors
protein
Prior art date
Application number
HR970693A
Other languages
English (en)
Inventor
Annette Marion Doherty
James Stanley Kaltenbronn
Daniele M Leonard
Dennis Joseph Mc Namara
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of HRP970693A2 publication Critical patent/HRP970693A2/hr
Publication of HRP970693B1 publication Critical patent/HRP970693B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
HR970693A 1996-12-17 1997-12-17 Cycloalkyl inhibitors of protein farnesyltransferase HRP970693B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3366196P 1996-12-17 1996-12-17
US5683197P 1997-08-22 1997-08-22

Publications (2)

Publication Number Publication Date
HRP970693A2 HRP970693A2 (en) 1998-10-31
HRP970693B1 true HRP970693B1 (en) 2002-06-30

Family

ID=26709973

Family Applications (1)

Application Number Title Priority Date Filing Date
HR970693A HRP970693B1 (en) 1996-12-17 1997-12-17 Cycloalkyl inhibitors of protein farnesyltransferase

Country Status (21)

Country Link
US (1) US6281194B1 (de)
EP (1) EP0951471B1 (de)
JP (1) JP2001506265A (de)
KR (1) KR20000057601A (de)
AT (1) ATE261987T1 (de)
AU (1) AU721786C (de)
BR (1) BR9713744A (de)
CA (1) CA2264207A1 (de)
CO (1) CO4920227A1 (de)
DE (1) DE69728165T2 (de)
DK (1) DK0951471T3 (de)
ES (1) ES2216189T3 (de)
HR (1) HRP970693B1 (de)
ID (1) ID19142A (de)
IL (1) IL128546A0 (de)
NO (1) NO992933L (de)
NZ (1) NZ334702A (de)
PE (1) PE46999A1 (de)
PT (1) PT951471E (de)
TW (1) TW552259B (de)
WO (1) WO1998027109A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE46999A1 (es) 1996-12-17 1999-05-20 Warner Lambert Co Inhibidores de cicloalquilo de la enzima farnesiltransferasa de las proteinas
NZ507165A (en) * 1998-04-27 2003-06-30 Warner Lambert Co Functionalized alkyl and alkenyl side chain derivatives of glycinamides as farnesyl transferase inhibitors
US6455734B1 (en) * 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
US7763620B2 (en) 2001-08-24 2010-07-27 Yale University Piperazinone compounds as anti-tumor and anti-cancer agents and methods of treatment
AU2007229363B2 (en) * 2001-08-24 2009-06-04 University Of South Florida Piperazinone Compounds as Anti-Tumor and Anti-Cancer Agents and the Methods of Treatment
US20070275956A1 (en) * 2003-10-14 2007-11-29 Lohray Braj B Novel Heterocyclic Compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995012612A1 (en) * 1993-11-05 1995-05-11 Warner-Lambert Company Substituted di- and tripeptide inhibitors of protein:farnesyl transferase
US5571792A (en) * 1994-06-30 1996-11-05 Warner-Lambert Company Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
PE46999A1 (es) 1996-12-17 1999-05-20 Warner Lambert Co Inhibidores de cicloalquilo de la enzima farnesiltransferasa de las proteinas

Also Published As

Publication number Publication date
AU721786C (en) 2001-08-02
BR9713744A (pt) 2000-03-21
ES2216189T3 (es) 2004-10-16
HRP970693A2 (en) 1998-10-31
IL128546A0 (en) 2000-01-31
TW552259B (en) 2003-09-11
PE46999A1 (es) 1999-05-20
CA2264207A1 (en) 1998-06-25
JP2001506265A (ja) 2001-05-15
NO992933D0 (no) 1999-06-16
WO1998027109A1 (en) 1998-06-25
US6281194B1 (en) 2001-08-28
NZ334702A (en) 2000-11-24
CO4920227A1 (es) 2000-05-29
AU5899098A (en) 1998-07-15
ATE261987T1 (de) 2004-04-15
AU721786B2 (en) 2000-07-13
DE69728165T2 (de) 2005-01-20
NO992933L (no) 1999-06-16
KR20000057601A (ko) 2000-09-25
DK0951471T3 (da) 2004-07-19
EP0951471B1 (de) 2004-03-17
ID19142A (id) 1998-06-18
DE69728165D1 (de) 2004-04-22
PT951471E (pt) 2004-08-31
EP0951471A1 (de) 1999-10-27

Similar Documents

Publication Publication Date Title
HRP950337B1 (en) Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
DE69427127D1 (de) Substituierte tetra- und pentapeptid hemmstoffe der farnesyl protein transferase
CA2315647A1 (en) Inhibition of p38 kinase activity using aryl and heteroaryl substituted heterocyclic ureas
AU7585498A (en) Inhibition of p38 kinase activity by aryl ureas
AU2003200722A1 (en) Compositions and methods for the treatment of tumor
EP1978031A3 (de) Tropoelastin-Derivate
WO2004006858A3 (en) Compounds, compositions, and methods employing same
WO2001079164A3 (en) N-substituted dithiocarbamates for the treatment of biological disorders
AU2002350623A1 (en) Targeted thrombosis by tissue factor polypeptides
BG105003A (en) Combinations of protein farnesyltransfer and hmg coa reductase inhibitors and their use to treat cancer
IL128546A0 (en) Cycloalkyl inhibitors of protein farnesyltransferase
AU7216498A (en) Inhibitors of the urokinase receptor
CA2293808A1 (en) Methods and compositions for diagnosis and treatment of iron overload diseases and iron deficiency diseases
AU2821000A (en) Matrix protein compositions for induction of apoptosis
WO2001023522A3 (en) Compositions and methods for p53-mediated repression of gene expression
AU2990300A (en) Deglycosylated kringle 1-5 region fragments of plasminogen and methods of use
MX9703208A (es) Tetra-y pentapeptidos substituidos inhibidores de proteina; farnesil transferasa.
GB9723824D0 (en) Cytostatic agents
AU2003200721A1 (en) Compositions and methods for the treatment of tumor

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20021217

Year of fee payment: 6

PBON Lapse due to non-payment of renewal fee

Effective date: 20031218