IL128546A0 - Cycloalkyl inhibitors of protein farnesyltransferase - Google Patents

Cycloalkyl inhibitors of protein farnesyltransferase

Info

Publication number: IL128546A0
Authority: IL; Israel
Prior art keywords: protein farnesyltransferase; inhibitors; cycloalkyl; cycloalkyl inhibitors; protein
Prior art date: 1996-12-17

Application number

IL12854697A

Other languages

English (en)

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-17

Filing date

1997-12-16

Publication date

2000-01-31

1997-12-16 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2000-01-31 Publication of IL128546A0 publication Critical patent/IL128546A0/xx

Links

239000003112 inhibitor Substances 0.000 title abstract 2
108010054353 p21(ras) farnesyl-protein transferase Proteins 0.000 title abstract 2
125000000753 cycloalkyl group Chemical group 0.000 title 1
201000001320 Atherosclerosis Diseases 0.000 abstract 1
201000009273 Endometriosis Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
201000004681 Psoriasis Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1
208000037803 restenosis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL12854697A 1996-12-17 1997-12-16 Cycloalkyl inhibitors of protein farnesyltransferase IL128546A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US3366196P	1996-12-17	1996-12-17
US5683197P	1997-08-22	1997-08-22
PCT/US1997/023280 WO1998027109A1 (en)	1996-12-17	1997-12-16	Cycloalkyl inhibitors of protein farnesyltransferase

Publications (1)

Publication Number	Publication Date
IL128546A0 true IL128546A0 (en)	2000-01-31

Family

ID=26709973

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12854697A IL128546A0 (en)	1996-12-17	1997-12-16	Cycloalkyl inhibitors of protein farnesyltransferase

Country Status (21)

Country	Link
US (1)	US6281194B1 (de)
EP (1)	EP0951471B1 (de)
JP (1)	JP2001506265A (de)
KR (1)	KR20000057601A (de)
AT (1)	ATE261987T1 (de)
AU (1)	AU721786C (de)
BR (1)	BR9713744A (de)
CA (1)	CA2264207A1 (de)
CO (1)	CO4920227A1 (de)
DE (1)	DE69728165T2 (de)
DK (1)	DK0951471T3 (de)
ES (1)	ES2216189T3 (de)
HR (1)	HRP970693B1 (de)
ID (1)	ID19142A (de)
IL (1)	IL128546A0 (de)
NO (1)	NO992933L (de)
NZ (1)	NZ334702A (de)
PE (1)	PE46999A1 (de)
PT (1)	PT951471E (de)
TW (1)	TW552259B (de)
WO (1)	WO1998027109A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0951471B1 (de)	1996-12-17	2004-03-17	Warner-Lambert Company Llc	Cycloalkyl inhibitoren der protein-farnesyltransferase
EP1076663B1 (de)	1998-04-27	2004-02-18	Warner-Lambert Company LLC	Glycinamidederivate mit funktionalisierter alkyl- und alkenylseitenkette als inhibitoren der farnesyltransferase
US6455734B1 (en) *	2000-08-09	2002-09-24	Magnesium Diagnostics, Inc.	Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
AU2007229363B2 (en) *	2001-08-24	2009-06-04	University Of South Florida	Piperazinone Compounds as Anti-Tumor and Anti-Cancer Agents and the Methods of Treatment
EP1427418B1 (de) *	2001-08-24	2009-11-11	Yale University	Piperazinon-verbindungen als antitumorale und krebsbekämpfende mittel
US20070275956A1 (en) *	2003-10-14	2007-11-29	Lohray Braj B	Novel Heterocyclic Compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ275691A (en) *	1993-11-05	1998-03-25	Warner Lambert Co	Di and tripeptides and compositions thereof which inhibit farnesyl transferase
US5571792A (en)	1994-06-30	1996-11-05	Warner-Lambert Company	Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
EP0951471B1 (de)	1996-12-17	2004-03-17	Warner-Lambert Company Llc	Cycloalkyl inhibitoren der protein-farnesyltransferase

1997
- 1997-12-16 EP EP97954575A patent/EP0951471B1/de not_active Expired - Lifetime
- 1997-12-16 WO PCT/US1997/023280 patent/WO1998027109A1/en not_active Ceased
- 1997-12-16 NZ NZ334702A patent/NZ334702A/xx unknown
- 1997-12-16 CO CO97073366A patent/CO4920227A1/es unknown
- 1997-12-16 CA CA002264207A patent/CA2264207A1/en not_active Abandoned
- 1997-12-16 PE PE1997001119A patent/PE46999A1/es not_active Application Discontinuation
- 1997-12-16 IL IL12854697A patent/IL128546A0/xx unknown
- 1997-12-16 US US09/319,422 patent/US6281194B1/en not_active Expired - Fee Related
- 1997-12-16 AU AU58990/98A patent/AU721786C/en not_active Ceased
- 1997-12-16 AT AT97954575T patent/ATE261987T1/de not_active IP Right Cessation
- 1997-12-16 KR KR1019990705384A patent/KR20000057601A/ko not_active Ceased
- 1997-12-16 BR BR9713744A patent/BR9713744A/pt not_active Application Discontinuation
- 1997-12-16 DE DE69728165T patent/DE69728165T2/de not_active Expired - Fee Related
- 1997-12-16 JP JP52794298A patent/JP2001506265A/ja not_active Abandoned
- 1997-12-16 ES ES97954575T patent/ES2216189T3/es not_active Expired - Lifetime
- 1997-12-16 DK DK97954575T patent/DK0951471T3/da active
- 1997-12-16 PT PT97954575T patent/PT951471E/pt unknown
- 1997-12-17 HR HR970693A patent/HRP970693B1/xx not_active IP Right Cessation
- 1997-12-17 ID IDP973902A patent/ID19142A/id unknown
1998
- 1998-05-26 TW TW086119079A patent/TW552259B/zh active
1999
- 1999-06-16 NO NO992933A patent/NO992933L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20000057601A (ko)	2000-09-25
ID19142A (id)	1998-06-18
EP0951471A1 (de)	1999-10-27
AU5899098A (en)	1998-07-15
DE69728165D1 (de)	2004-04-22
DE69728165T2 (de)	2005-01-20
DK0951471T3 (da)	2004-07-19
HRP970693B1 (en)	2002-06-30
TW552259B (en)	2003-09-11
NO992933D0 (no)	1999-06-16
AU721786B2 (en)	2000-07-13
CO4920227A1 (es)	2000-05-29
BR9713744A (pt)	2000-03-21
WO1998027109A1 (en)	1998-06-25
US6281194B1 (en)	2001-08-28
PT951471E (pt)	2004-08-31
HRP970693A2 (en)	1998-10-31
JP2001506265A (ja)	2001-05-15
PE46999A1 (es)	1999-05-20
AU721786C (en)	2001-08-02
NO992933L (no)	1999-06-16
ATE261987T1 (de)	2004-04-15
ES2216189T3 (es)	2004-10-16
NZ334702A (en)	2000-11-24
EP0951471B1 (de)	2004-03-17
CA2264207A1 (en)	1998-06-25

Publication	Publication Date	Title
ZA955411B (en)	1996-02-05	Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
DE69427127D1 (de)	2001-05-23	Substituierte tetra- und pentapeptid hemmstoffe der farnesyl protein transferase
CA2315647A1 (en)	1999-07-01	Inhibition of p38 kinase activity using aryl and heteroaryl substituted heterocyclic ureas
AU7585498A (en)	1998-12-11	Inhibition of p38 kinase activity by aryl ureas
AU2003200722A1 (en)	2003-05-01	Compositions and methods for the treatment of tumor
AU5186799A (en)	2000-02-07	Peptides of il-2 and derivatives thereof and their use as therapeutic agents
EP1978031A3 (de)	2008-10-22	Tropoelastin-Derivate
WO2001079164A3 (en)	2002-05-23	N-substituted dithiocarbamates for the treatment of biological disorders
AU2002350623A1 (en)	2003-05-06	Targeted thrombosis by tissue factor polypeptides
BG105003A (en)	2001-07-31	Combinations of protein farnesyltransfer and hmg coa reductase inhibitors and their use to treat cancer
IL128546A0 (en)	2000-01-31	Cycloalkyl inhibitors of protein farnesyltransferase
AU7525398A (en)	1998-11-11	Inhibitors for urokinase receptor
CA2293808A1 (en)	1998-12-17	Methods and compositions for diagnosis and treatment of iron overload diseases and iron deficiency diseases
AU2821000A (en)	2000-09-28	Matrix protein compositions for induction of apoptosis
WO2001023522A3 (en)	2001-08-23	Compositions and methods for p53-mediated repression of gene expression
AU2990300A (en)	2000-08-29	Deglycosylated kringle 1-5 region fragments of plasminogen and methods of use
MX9703208A (es)	1997-07-31	Tetra-y pentapeptidos substituidos inhibidores de proteina; farnesil transferasa.
GB9723824D0 (en)	1998-01-07	Cytostatic agents
ECSP972339A (es)	1999-01-12	Inhibidores de cicloalquilo de la farnesil transferasa de las proteinas
AU2003200721A1 (en)	2003-05-01	Compositions and methods for the treatment of tumor