DK0958280T3 - Arylpiperidinopropanol- og arylpiperazinopropanolderivater og farmaceutiske midler der indeholder disse - Google Patents

Arylpiperidinopropanol- og arylpiperazinopropanolderivater og farmaceutiske midler der indeholder disse

Info

Publication number: DK0958280T3
Authority: DK; Denmark
Prior art keywords: group; formula; chem; compound; arylpiperidinopropanol
Prior art date: 1997-10-31

Application number

DK98950482T

Other languages

English (en)

Inventor

Hirokazu Annoura

Kyoko Nakanishi

Shigeki Tamura

Original Assignee

Daiichi Suntory Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-31

Filing date

1998-10-30

Publication date

2005-08-29

1998-10-30 Application filed by Daiichi Suntory Pharma Co Ltd filed Critical Daiichi Suntory Pharma Co Ltd

2005-08-29 Application granted granted Critical

2005-08-29 Publication of DK0958280T3 publication Critical patent/DK0958280T3/da

Links

239000008177 pharmaceutical agent Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
-1 p-methoxybenzyl group Chemical group 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical class C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
238000010511 deprotection reaction Methods 0.000 abstract 1
125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000004885 piperazines Chemical class 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
- C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Obesity (AREA)
Cardiology (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK98950482T 1997-10-31 1998-10-30 Arylpiperidinopropanol- og arylpiperazinopropanolderivater og farmaceutiske midler der indeholder disse DK0958280T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP30115497		1997-10-31
PCT/JP1998/004943 WO1999023072A1 (en)	1997-10-31	1998-10-30	Arylpiperidinopropanol and arylpiperazinopropanol derivatives and pharmaceuticals containing the same

Publications (1)

Publication Number	Publication Date
DK0958280T3 true DK0958280T3 (da)	2005-08-29

Family

ID=17893439

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98950482T DK0958280T3 (da)	1997-10-31	1998-10-30	Arylpiperidinopropanol- og arylpiperazinopropanolderivater og farmaceutiske midler der indeholder disse

Country Status (14)

Country	Link
US (4)	US6407099B1 (da)
EP (2)	EP0958280B1 (da)
JP (2)	JP4036484B2 (da)
KR (2)	KR100795326B1 (da)
CN (1)	CN1157376C (da)
AT (2)	ATE285403T1 (da)
AU (1)	AU754656B2 (da)
CA (2)	CA2276373C (da)
DE (2)	DE69828317T2 (da)
DK (1)	DK0958280T3 (da)
ES (2)	ES2230209T3 (da)
HU (1)	HU226767B1 (da)
PT (1)	PT958280E (da)
WO (1)	WO1999023072A1 (da)

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US7119184B2 (en) *	1991-08-12	2006-10-10	Isis Pharmaceuticals, Inc.	Oligonucleotides having A-DNA form and B-DNA form conformational geometry
EP0867183B1 (en) *	1996-07-22	2004-10-06	Daiichi Suntory Pharma Co., Ltd.	Arylpiperidinol and arylpiperidine derivatives and drugs containing the same
WO1999023072A1 (en) *	1997-10-31	1999-05-14	Suntory Limited	Arylpiperidinopropanol and arylpiperazinopropanol derivatives and pharmaceuticals containing the same
GB9912416D0 (en)	1999-05-28	1999-07-28	Pfizer Ltd	Compounds useful in therapy
US7074934B2 (en) *	2000-06-13	2006-07-11	Tularik Limited	Serine protease inhibitors
UA81749C2 (uk) *	2001-10-04	2008-02-11	Х. Луннбек А/С	Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
JP2005518346A (ja) *	2001-11-07	2005-06-23	メディカルリサーチカウンセル	ドパミン作動性ニューロンの調節
GB0130696D0 (en) *	2001-12-21	2002-02-06	Smithkline Beecham Plc	Chemical Compounds
US7166603B2 (en)	2003-07-23	2007-01-23	Bristol-Myers Squibb Co.	Dihydropyrimidone inhibitors of calcium channel function
WO2005007124A2 (en)	2003-07-23	2005-01-27	Bristol-Myers Squibb Company	Substituted dihydropyrimidine inhibitors of calcium channel function
US7504401B2 (en)	2003-08-29	2009-03-17	Locus Pharmaceuticals, Inc.	Anti-cancer agents and uses thereof
US7504431B2 (en)	2004-04-16	2009-03-17	Bristol-Myers Squibb Company	Sulfonyl amide inhibitors of calcium channel function
US7781478B2 (en)	2004-07-14	2010-08-24	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
EP2054033A2 (en) *	2006-07-31	2009-05-06	Asubio Pharma Co., Ltd.	Liquid preparation
JP2010502565A (ja) *	2006-08-30	2010-01-28	アスビオファーマ株式会社	凍結乾燥製剤
WO2009137843A2 (en) *	2008-05-09	2009-11-12	Emory University	Nmda receptor antagonists for the treatment of neuropsychiatric disorders
KR101476379B1 (ko) *	2011-11-30	2014-12-29	한국과학기술연구원	페녹시프로판올 유도체 및 이를 함유하는 약학적 조성물

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CA967965A (en) *	1968-12-24	1975-05-20	Hoffmann-La Roche Limited	Aromatic ethers and process for the manufacture thereof
GB1317034A (en)	1970-11-06	1973-05-16	Pfizer Ltd	1-2-hydroxy-3-phenoxy- or -phenylthiopropyl-piperazine derivatives
JPS5840551B2 (ja)	1976-08-06	1983-09-06	田辺製薬株式会社	プロパノ−ル誘導体及びその製法
JPS5321227A (en)	1976-08-09	1978-02-27	Chugoku Marine Paints	Production of soilproof paints
JPS5697227A (en)	1979-12-28	1981-08-05	Tanabe Seiyaku Co Ltd	Intracranial hypotensor
US4882330A (en) *	1986-11-21	1989-11-21	A. H. Robins Company, Incorporated	1-aryloxy-4-[((4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents
ES2004809A6 (es) *	1987-07-29	1989-02-01	Ferrer Int	Procedimiento de obtencion de nuevas 1-(2-(fenilmetil)fenil)piperazinas
US5064838A (en)	1988-01-21	1991-11-12	Merrell Dow Pharmaceuticals	1,4-disubstituted-piperidinyl compounds as pain relievers
EP0576766A1 (en) *	1992-06-29	1994-01-05	Novo Nordisk A/S	Propanolamine derivatives, their preparation and use
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WO1999023072A1 (en) *	1997-10-31	1999-05-14	Suntory Limited	Arylpiperidinopropanol and arylpiperazinopropanol derivatives and pharmaceuticals containing the same

1998
- 1998-10-30 WO PCT/JP1998/004943 patent/WO1999023072A1/en not_active Ceased
- 1998-10-30 EP EP98950482A patent/EP0958280B1/en not_active Expired - Lifetime
- 1998-10-30 CA CA002276373A patent/CA2276373C/en not_active Expired - Fee Related
- 1998-10-30 PT PT98950482T patent/PT958280E/pt unknown
- 1998-10-30 ES ES01115281T patent/ES2230209T3/es not_active Expired - Lifetime
- 1998-10-30 AT AT01115281T patent/ATE285403T1/de not_active IP Right Cessation
- 1998-10-30 AU AU96516/98A patent/AU754656B2/en not_active Ceased
- 1998-10-30 AT AT98950482T patent/ATE294779T1/de active
- 1998-10-30 ES ES98950482T patent/ES2241169T3/es not_active Expired - Lifetime
- 1998-10-30 CA CA002681877A patent/CA2681877A1/en not_active Abandoned
- 1998-10-30 DK DK98950482T patent/DK0958280T3/da active
- 1998-10-30 DE DE69828317T patent/DE69828317T2/de not_active Expired - Lifetime
- 1998-10-30 JP JP52593199A patent/JP4036484B2/ja not_active Expired - Fee Related
- 1998-10-30 US US09/331,712 patent/US6407099B1/en not_active Expired - Fee Related
- 1998-10-30 KR KR1020067003065A patent/KR100795326B1/ko not_active Expired - Fee Related
- 1998-10-30 EP EP01115281A patent/EP1138678B1/en not_active Expired - Lifetime
- 1998-10-30 KR KR1019997005955A patent/KR100599022B1/ko not_active Expired - Fee Related
- 1998-10-30 CN CNB988021854A patent/CN1157376C/zh not_active Expired - Fee Related
- 1998-10-30 HU HU0000719A patent/HU226767B1/hu not_active IP Right Cessation
- 1998-10-30 DE DE69830045T patent/DE69830045T2/de not_active Expired - Lifetime
2002
- 2002-04-09 US US10/118,045 patent/US6525199B1/en not_active Expired - Fee Related
- 2002-12-31 US US10/331,508 patent/US6838470B2/en not_active Expired - Fee Related
2004
- 2004-12-03 US US11/002,793 patent/US7642262B2/en not_active Expired - Fee Related
2007
- 2007-08-13 JP JP2007211113A patent/JP4785807B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN1157376C (zh)	2004-07-14
AU754656B2 (en)	2002-11-21
DE69828317D1 (de)	2005-01-27
EP1138678B1 (en)	2004-12-22
HU226767B1 (en)	2009-09-28
HUP0000719A2 (hu)	2000-09-28
JP2008001712A (ja)	2008-01-10
ATE294779T1 (de)	2005-05-15
ATE285403T1 (de)	2005-01-15
US6838470B2 (en)	2005-01-04
JP4785807B2 (ja)	2011-10-05
DE69830045D1 (de)	2005-06-09
DE69828317T2 (de)	2005-05-25
CA2681877A1 (en)	1999-05-14
US6407099B1 (en)	2002-06-18
KR20060021942A (ko)	2006-03-08
CA2276373A1 (en)	1999-05-14
KR100599022B1 (ko)	2006-07-12
CN1246110A (zh)	2000-03-01
US20050101610A1 (en)	2005-05-12
JP4036484B2 (ja)	2008-01-23
EP0958280B1 (en)	2005-05-04
JP2001507721A (ja)	2001-06-12
ES2230209T3 (es)	2005-05-01
EP0958280A1 (en)	1999-11-24
DE69830045T2 (de)	2006-01-12
AU9651698A (en)	1999-05-24
KR20000069806A (ko)	2000-11-25
WO1999023072A1 (en)	1999-05-14
US20030236269A1 (en)	2003-12-25
US7642262B2 (en)	2010-01-05
CA2276373C (en)	2010-01-12
EP1138678A2 (en)	2001-10-04
PT958280E (pt)	2005-09-30
KR100795326B1 (ko)	2008-01-21
EP1138678A3 (en)	2001-10-17
US6525199B1 (en)	2003-02-25
ES2241169T3 (es)	2005-10-16
HUP0000719A3 (en)	2000-10-30

Publication	Publication Date	Title
PT958280E (pt)	2005-09-30	Derivados de arilpiperidinopropanol e arilpiperazinopropanol e farmacos contendo os mesmos
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