DK0960944T3 - Forbedret produktion af taxol og taxaner fra cellekulturer af taxus-arter - Google Patents

Forbedret produktion af taxol og taxaner fra cellekulturer af taxus-arter

Info

Publication number: DK0960944T3
Authority: DK; Denmark
Prior art keywords: taxanes; taxol; taxus species; cell cultures; improved production
Prior art date: 1992-02-20

Application number

DK99202507T

Other languages

English (en)

Inventor

Christopher L Prince

Eugene J Kane

Braden Roach

Prakash G Kadkade

Barry F Schubmehl

Venkataraman Bringi

Original Assignee

Phyton Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-20

Filing date

1993-02-22

Publication date

2004-04-05

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27126086&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0960944(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-02-22 Application filed by Phyton Inc filed Critical Phyton Inc

2004-04-05 Application granted granted Critical

2004-04-05 Publication of DK0960944T3 publication Critical patent/DK0960944T3/da

Links

229930012538 Paclitaxel Natural products 0.000 title abstract 3
229940123237 Taxane Drugs 0.000 title abstract 3
241001116500 Taxus Species 0.000 title abstract 3
238000004113 cell culture Methods 0.000 title abstract 3
229960001592 paclitaxel Drugs 0.000 title abstract 3
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 3
238000004114 suspension culture Methods 0.000 abstract 2
206010020649 Hyperkeratosis Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
235000015097 nutrients Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0025—Culture media for plant cell or plant tissue culture
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/04—Plant cells or tissues

Landscapes

Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Botany (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DK99202507T 1992-02-20 1993-02-22 Forbedret produktion af taxol og taxaner fra cellekulturer af taxus-arter DK0960944T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US83914492A	1992-02-20	1992-02-20
US07/874,344 US5407816A (en)	1992-02-20	1992-04-24	Enhanced production of taxol and taxanes by cell cultures of taxus species

Publications (1)

Publication Number	Publication Date
DK0960944T3 true DK0960944T3 (da)	2004-04-05

Family

ID=27126086

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK99202507T DK0960944T3 (da)	1992-02-20	1993-02-22	Forbedret produktion af taxol og taxaner fra cellekulturer af taxus-arter
DK93906156T DK0672162T3 (da)	1992-02-20	1993-02-22	Forøget produktion af taxol og taxaner ved hjælp af cellekulturer af Taxus-arter

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK93906156T DK0672162T3 (da)	1992-02-20	1993-02-22	Forøget produktion af taxol og taxaner ved hjælp af cellekulturer af Taxus-arter

Country Status (15)

Country	Link
US (1)	US5407816A (da)
EP (3)	EP0672162B1 (da)
JP (5)	JP3513151B2 (da)
KR (6)	KR20090116792A (da)
AT (3)	ATE256197T1 (da)
AU (1)	AU672194B2 (da)
CA (1)	CA2130745C (da)
DE (3)	DE69334352D1 (da)
DK (2)	DK0960944T3 (da)
ES (3)	ES2361150T3 (da)
GR (1)	GR3034722T3 (da)
NZ (1)	NZ249734A (da)
PT (2)	PT960944E (da)
SG (1)	SG46427A1 (da)
WO (1)	WO1993017121A1 (da)

Families Citing this family (58)

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US5407816A (en) *	1992-02-20	1995-04-18	Phyton Catalytic, Inc.	Enhanced production of taxol and taxanes by cell cultures of taxus species
US7264951B1 (en)	1992-02-20	2007-09-04	Phyton, Inc.	Enhanced production of taxol and taxanes by cell cultures of Taxus species
US5850032A (en) *	1992-04-01	1998-12-15	Union Camp Corporation	Method for production of plant biological products in precocious neomorphic embryoids
CA2434692A1 (en) *	1992-04-07	1993-10-08	Paul M. Cino	Callus cell induction and the preparation of taxanes
JPH08500973A (ja) *	1992-05-21	1996-02-06	ザペンステイトリサーチファウンデーション	タキソール、関連タキサン及び他の新規な抗癌／抗ウイルス性化合物原料としてのイチイ培養組織
JP2967532B2 (ja) *	1992-06-11	1999-10-25	日石三菱株式会社	タキサン類化合物の製造方法
US5981568A (en)	1993-01-28	1999-11-09	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
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CN1166780C (zh) *	1995-04-29	2004-09-15	(株)三养吉尼克斯	从紫杉属植物大量生产紫杉醇的方法
AU2435695A (en) *	1995-05-05	1996-11-21	Union Camp Corporation	Method for production of plant biological products in precoc ious neomorphic embryoids
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AU727425B2 (en) *	1996-05-24	2000-12-14	Phyton, Inc.	Enhanced production of taxanes by cell cultures of Taxus species
ATE278397T1 (de)	1997-03-31	2004-10-15	Boston Scient Ltd	Verwendung von cytoskelettinhibitoren zur vorbeugung der restenose
US5801193A (en) *	1997-04-15	1998-09-01	Immune Modulation, Inc.	Compositions and methods for immunosuppressing
KR100287465B1 (ko)	1997-06-25	2001-05-02	나까니시 히로유끼	탁산형 디테르펜의 제조방법
KR100266448B1 (ko) *	1997-06-26	2000-09-15	박종헌	식물세포 배양 중의 온도변화에 의한 택솔의 대량생산 방법
EP1068192B1 (en)	1998-01-14	2002-06-12	Bristol-Myers Squibb Company	Novel crystalline complexes of baccatin iii with imidazole, 2-methylimidazole or isopropanol
US6093422A (en) *	1998-01-23	2000-07-25	Zodiac Pool Care, Inc.	Biocidal compositions for treating water
CA2385528C (en)	1999-10-01	2013-12-10	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
FR2800740B1 (fr) *	1999-11-08	2002-10-11	Lorraine Inst Nat Polytech	Procede de production de metabolites a partir de vegetaux en culture hors sol
DE60131537T2 (de)	2000-06-22	2008-10-23	Nitromed, Inc., Lexington	Nitrosierte und nitrosylierte taxane, zubereitungen und methoden der verwendung
US7045354B2 (en) *	2000-11-14	2006-05-16	The Regents Of The University Of California	Process for scaled-up production of recombinant proteins using transgenic plant suspension cultures
US6365407B1 (en) *	2001-03-05	2002-04-02	Council Of Scientific & Industrial Research	Culture medium composition useful for induction and proliferation of Taxus calli
US6613083B2 (en)	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
US20030091659A1 (en) *	2001-11-09	2003-05-15	Avon Products, Inc.	Topical composition having undifferentiated plant seed cells and method for using same
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TW200304947A (en) *	2002-02-08	2003-10-16	Bristol Myers Squibb Co	Compositions and methods for latering biosynthesis of taxanes and taxane-related compounds
WO2005079355A2 (en) *	2004-02-13	2005-09-01	Phyton Biotech, Inc.	Use of indanoyl amide to stimulate secondary metabolism in taxus sp.
JP2008541755A (ja)	2005-06-03	2008-11-27	サムヤンジェネックスコーポレイション	植物細胞培養培地で混合糖処理による二次代謝産物の量産方法
US8053238B2 (en) *	2005-10-31	2011-11-08	Unhwa Corporation	Isolated population of plant single cells and method of preparing the same
ES2546108T3 (es) *	2005-10-31	2015-09-18	Unhwa Corporation	Estabilidad de la producción masiva de metabolitos secundarios mediante cultivos sincronizados de células vegetales
GB0605900D0 (en) *	2006-03-23	2006-05-03	Lipigen As	Modulators of nuclear receptors
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AU2008202078B2 (en) *	2007-10-10	2012-05-31	Wellkey Holdings Limited	Stability of secondary metabolite mass production through synchronized plant cell cultures
KR101100867B1 (ko) *	2008-05-14	2012-01-02	주식회사 운화	주목의 형성층 또는 전형성층 유래 식물줄기세포주를 유효성분으로 함유하는 항산화, 항염증 또는 항노화용 조성물
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KR20160054015A (ko)	2009-04-03	2016-05-13	다이아나플랜트사이언스, 아이엔씨.	식물 세포 배양 유래 프로시아니딘의 생산 및 추출
RU2011152866A (ru) *	2009-05-26	2013-07-10	Юнхва Корпорейшн	Растительная стволовая клетка, происходящая из камбия семейства asteraceae, способ ее выделения и культивирования
WO2010137879A2 (ko) *	2009-05-26	2010-12-02	주식회사 운화	버드나무과의 형성층 유래 식물줄기세포 및 이의 분리배양방법
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CN101671319B (zh) *	2009-09-18	2012-02-29	应成杰	红豆杉无毒提取物的提取工艺
WO2012047817A1 (en)	2010-10-04	2012-04-12	Dianaplantsciences, Inc.	Production and extraction of procyanidins from plant cells cultures
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CN102715085B (zh) *	2012-06-19	2014-04-16	湖南农业大学	一种诱导红豆杉种子种胚获得愈伤组织和悬浮细胞的方法
CN102715086B (zh) *	2012-06-19	2014-04-16	湖南农业大学	一种红豆杉试管苗诱导获得愈伤组织和悬浮细胞的方法
CN103058961B (zh) *	2013-01-28	2015-04-29	普洱市红宝生物科技有限公司	从云南红豆杉中提取紫杉醇的方法
CN103570647A (zh) *	2013-11-06	2014-02-12	湖南农业大学	从红豆杉细胞培养液中制备高纯度紫杉醇的方法
KR101603539B1 (ko) *	2014-08-11	2016-03-15	영남대학교 산학협력단	택솔을 생산하는 콜레토트리쿰 데마티움 균주 및 그 용도
KR101786448B1 (ko)	2015-08-24	2017-10-18	영남대학교 산학협력단	택솔을 생산하는 트라이코더마 비리데슨스 tx1 균주 및 이의 용도
CN109022510A (zh) *	2018-08-23	2018-12-18	吉首大学	一种利用南方红豆杉菌根菌与活组织细胞共培养生产紫杉醇及10-dabⅲ的方法
CN110441439B (zh) *	2019-07-01	2022-03-01	杭州师范大学	区分密叶红豆杉和云南红豆杉的代谢标志物及其检测方法
WO2022162101A1 (en) *	2021-01-28	2022-08-04	Phyto-Technics Bv	Production of taxol from taxus cuttings

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5019504A (en) *	1989-03-23	1991-05-28	The United States Of America As Represented By The Secretary Of Agriculture	Production of taxol or taxol-like compounds in cell culture
JPH03216123A (ja) *	1990-01-17	1991-09-24	Nitsusen Kagaku Kogyo Kk	培養植物体の増殖促進方法
DE69216003D1 (de) *	1991-02-12	1997-01-30	Nippon Steel Corp	Verfahren zur herstellung von taxol mittels taxusspezies-zellkultur
US5407816A (en) *	1992-02-20	1995-04-18	Phyton Catalytic, Inc.	Enhanced production of taxol and taxanes by cell cultures of taxus species

1992
- 1992-04-24 US US07/874,344 patent/US5407816A/en not_active Expired - Lifetime
1993
- 1993-02-22 JP JP51501693A patent/JP3513151B2/ja not_active Expired - Lifetime
- 1993-02-22 KR KR1020097019012A patent/KR20090116792A/ko not_active Ceased
- 1993-02-22 KR KR10-2000-7011030A patent/KR100392036B1/ko not_active Ceased
- 1993-02-22 ES ES03021426T patent/ES2361150T3/es not_active Expired - Lifetime
- 1993-02-22 DK DK99202507T patent/DK0960944T3/da active
- 1993-02-22 KR KR1020117014841A patent/KR20110079863A/ko not_active Withdrawn
- 1993-02-22 EP EP93906156A patent/EP0672162B1/en not_active Revoked
- 1993-02-22 DE DE69334352T patent/DE69334352D1/de not_active Expired - Lifetime
- 1993-02-22 EP EP99202507A patent/EP0960944B1/en not_active Revoked
- 1993-02-22 PT PT99202507T patent/PT960944E/pt unknown
- 1993-02-22 CA CA002130745A patent/CA2130745C/en not_active Expired - Lifetime
- 1993-02-22 ES ES93906156T patent/ES2150938T3/es not_active Expired - Lifetime
- 1993-02-22 PT PT93906156T patent/PT672162E/pt unknown
- 1993-02-22 EP EP03021426A patent/EP1378574B1/en not_active Revoked
- 1993-02-22 DK DK93906156T patent/DK0672162T3/da active
- 1993-02-22 DE DE69333358T patent/DE69333358T2/de not_active Expired - Lifetime
- 1993-02-22 ES ES99202507T patent/ES2213328T3/es not_active Expired - Lifetime
- 1993-02-22 AT AT99202507T patent/ATE256197T1/de not_active IP Right Cessation
- 1993-02-22 DE DE69329154T patent/DE69329154T2/de not_active Revoked
- 1993-02-22 AT AT03021426T patent/ATE504659T1/de not_active IP Right Cessation
- 1993-02-22 AU AU37291/93A patent/AU672194B2/en not_active Expired
- 1993-02-22 NZ NZ249734A patent/NZ249734A/en not_active IP Right Cessation
- 1993-02-22 KR KR10-2003-7001795A patent/KR20040000390A/ko not_active Ceased
- 1993-02-22 SG SG1996004612A patent/SG46427A1/en unknown
- 1993-02-22 KR KR1020077022817A patent/KR20070104684A/ko not_active Ceased
- 1993-02-22 AT AT93906156T patent/ATE195146T1/de not_active IP Right Cessation
- 1993-02-22 WO PCT/US1993/001576 patent/WO1993017121A1/en not_active Ceased
- 1993-02-22 KR KR1019940702908A patent/KR100285788B1/ko not_active Expired - Lifetime
2000
- 2000-10-30 GR GR20000402411T patent/GR3034722T3/el not_active IP Right Cessation
2003
- 2003-09-10 JP JP2003318959A patent/JP2004000285A/ja active Pending
2005
- 2005-09-09 JP JP2005262536A patent/JP2005348751A/ja active Pending
2008
- 2008-02-12 JP JP2008031160A patent/JP2008131955A/ja active Pending
2009
- 2009-05-25 JP JP2009125857A patent/JP2009183305A/ja active Pending

Also Published As

Publication number	Publication date
AU672194B2 (en)	1996-09-26
KR20040000390A (ko)	2004-01-03
JP3513151B2 (ja)	2004-03-31
CA2130745A1 (en)	1993-09-02
JPH07506721A (ja)	1995-07-27
ES2213328T3 (es)	2004-08-16
DE69329154D1 (de)	2000-09-07
ES2150938T3 (es)	2000-12-16
ATE504659T1 (de)	2011-04-15
DE69333358D1 (de)	2004-01-22
ES2361150T3 (es)	2011-06-14
PT960944E (pt)	2004-04-30
KR950700996A (ko)	1995-02-20
JP2009183305A (ja)	2009-08-20
DK0672162T3 (da)	2000-12-18
HK1003718A1 (en)	1998-11-06
AU3729193A (en)	1993-09-13
KR20090116792A (ko)	2009-11-11
EP1378574A1 (en)	2004-01-07
KR20110079863A (ko)	2011-07-08
EP0960944B1 (en)	2003-12-10
EP1378574B1 (en)	2011-04-06
EP0672162A4 (en)	1995-11-29
KR20070104684A (ko)	2007-10-26
EP0960944A1 (en)	1999-12-01
JP2005348751A (ja)	2005-12-22
DE69334352D1 (de)	2011-05-19
PT672162E (pt)	2001-01-31
GR3034722T3 (en)	2001-01-31
NZ249734A (en)	1996-08-27
CA2130745C (en)	2008-01-22
DE69333358T2 (de)	2004-08-19
JP2004000285A (ja)	2004-01-08
DE69329154T2 (de)	2001-06-07
WO1993017121A1 (en)	1993-09-02
JP2008131955A (ja)	2008-06-12
ATE195146T1 (de)	2000-08-15
HK1024936A1 (en)	2000-10-27
KR100285788B1 (ko)	2001-05-02
EP0672162A1 (en)	1995-09-20
KR100392036B1 (ko)	2003-07-16
SG46427A1 (en)	1998-02-20
ATE256197T1 (de)	2003-12-15
EP0672162B1 (en)	2000-08-02
US5407816A (en)	1995-04-18

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DK0672162T3 (da)	2000-12-18	Forøget produktion af taxol og taxaner ved hjælp af cellekulturer af Taxus-arter
BR9709361A (pt)	1999-08-10	Produção aumentada de taxanos por culturas de espécie taxus
DE60130737T8 (de)	2008-10-30	Verstaerkte produktion von lipiden enthaltend mehrfachungesaettigte fettsaeuren durch hochdichte kulturen von eukariotischen mikroben in gaervorrichtungen
RU2003131993A (ru)	2005-05-10	Бактерия, принадлежащая к роду escherichia - продуцент l-цистеина, и способ получения l-цистеина
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DK0568821T3 (da)	2000-03-06	Calluscelleinduktion og fremstilling af taxaner
EP0649900A3 (en)	1996-07-03	Process for the production of proteins.
KR970065723A (ko)	1997-10-13	L-아스파라긴산의 제조법
DE69216003D1 (de)	1997-01-30	Verfahren zur herstellung von taxol mittels taxusspezies-zellkultur
PT1212448E (pt)	2004-03-31	Processo de producao de exopolissacaridos
ATE216725T1 (de)	2002-05-15	Verfahren zur herstellung von l-isoleucin durch fermentation und l-homoserine als einzige stickstoffquelle
DE59105850D1 (de)	1995-08-03	Mikrobiologisches Verfahren zur Herstellung von hydroxylierten Heterocyclen.
ATE144554T1 (de)	1996-11-15	Mikrobiologisches verfahren zur herstellung von 6-hydroxypyrazincarbonsäure
DK0789754T3 (da)	2000-11-13	Fermenteringsproces for H. pylori
ATE154948T1 (de)	1997-07-15	Mikrobiologisches verfahren zur herstellung von 6-hydroxynikotinsäure
KR940013323A (ko)	1994-07-15	미세조류의 배양방법
TH12874A (th)	1993-07-10	กรรมวิธีสำหรับการผลิต l-ไลซีน โดยการหมัก
TH76753A3 (th)	2006-03-30	วิธีการสำหรับการเพาะเลี้ยงเซลล์จำนวนมากที่จะผลิตรีคอมบิแนนท์เอริโธรพอยเอทินของมนุษย์
KR930700671A (ko)	1993-03-15	탁수스 종의 세포배양에 의한 탁솔 생산방법