DK0964874T3 - CAML-bindende lymfocytoverfladereceptor, nukleinsyrer, som koder derfor, og fremgangsmåder til anvendelse deraf - Google Patents
CAML-bindende lymfocytoverfladereceptor, nukleinsyrer, som koder derfor, og fremgangsmåder til anvendelse derafInfo
- Publication number
- DK0964874T3 DK0964874T3 DK98908948T DK98908948T DK0964874T3 DK 0964874 T3 DK0964874 T3 DK 0964874T3 DK 98908948 T DK98908948 T DK 98908948T DK 98908948 T DK98908948 T DK 98908948T DK 0964874 T3 DK0964874 T3 DK 0964874T3
- Authority
- DK
- Denmark
- Prior art keywords
- caml
- methods
- nucleic acids
- encoding nucleic
- surface receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/810,572 US5969102A (en) | 1997-03-03 | 1997-03-03 | Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof |
| PCT/US1998/004270 WO1998039361A1 (fr) | 1997-03-03 | 1998-03-03 | Recepteur de surface de lymphocyte liant une cyclophiline de modulation de signal de calcium (caml), acides nucleiques codant pour celle-ci, et procedes d'utilisation de ceux-ci |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0964874T3 true DK0964874T3 (da) | 2007-12-10 |
Family
ID=25204137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98908948T DK0964874T3 (da) | 1997-03-03 | 1998-03-03 | CAML-bindende lymfocytoverfladereceptor, nukleinsyrer, som koder derfor, og fremgangsmåder til anvendelse deraf |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US5969102A (fr) |
| EP (3) | EP0964874B1 (fr) |
| JP (1) | JP3594975B2 (fr) |
| AT (1) | ATE373012T1 (fr) |
| AU (1) | AU732119B2 (fr) |
| CA (1) | CA2284078C (fr) |
| DE (1) | DE69838417T2 (fr) |
| DK (1) | DK0964874T3 (fr) |
| ES (2) | ES2552095T3 (fr) |
| PT (1) | PT964874E (fr) |
| WO (1) | WO1998039361A1 (fr) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6830751B1 (en) | 1994-03-14 | 2004-12-14 | Genetics Institute, Llc | Use of IL-12 antagonists in the treatment of rheumatoid arthritis |
| ZA95960B (en) * | 1994-03-14 | 1995-10-10 | Genetics Inst | Use of interleukin-12 antagonists in the treatment of autoimmune diseases |
| US6812327B1 (en) * | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
| US8212004B2 (en) * | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
| US5969102A (en) | 1997-03-03 | 1999-10-19 | St. Jude Children's Research Hospital | Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| GB9828628D0 (en) | 1998-12-23 | 1999-02-17 | Glaxo Group Ltd | Novel ligand |
| US20060067933A1 (en) * | 1999-01-07 | 2006-03-30 | Gross Jane A | Soluble receptor BR43x2 and methods of using |
| DE60043626D1 (de) * | 1999-01-07 | 2010-02-11 | Zymogenetics Inc | Verfahren zur therapeutischen Verwendung von löslichen rezeptoren BR43X2 |
| US7833529B1 (en) * | 1999-01-07 | 2010-11-16 | Zymogenetics, Inc. | Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor |
| AU2005200008B2 (en) * | 1999-01-07 | 2008-03-06 | Zymogenetics, Inc. | Soluble receptor BR43x2 and methods of using |
| US20050100548A1 (en) * | 2001-07-24 | 2005-05-12 | Biogen Idec Ma Inc. | BAFF, inhibitors thereof and their use in the modulation of B-cell response |
| BR0007719A (pt) * | 1999-01-25 | 2001-11-13 | Biogen Inc | Baff, agentes de bloqueio relacionados e uso dosmesmos no estìmulo e na inibição de células b e deimunoglobulinas em respostas imunológicas |
| US20030095967A1 (en) * | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
| WO2000058362A1 (fr) * | 1999-03-26 | 2000-10-05 | Human Genome Sciences, Inc. | Nouvelles proteines capables de liaison avec la neutrokine alpha et procedes bases sur lesdites proteines |
| US20030022233A1 (en) * | 1999-04-30 | 2003-01-30 | Raymond G. Goodwin | Methods of use of the taci/taci-l interaction |
| UA75049C2 (uk) * | 1999-08-17 | 2006-03-15 | Байоджен Айдек Ма Інк. | Фармацевтична композиція, що містить поліпептид, який являє собою білковий фактор дозрівання в-клітин (всма), що зв'язується з фактором активації в-клітин (baff), спосіб інгібування росту в-клітин, спосіб лікування аутоімунного захворювання, спосіб лікування гіпертонії, спосіб інгібування запалення та спосіб модулювання імунної відповіді у ссавця за допомогою всма |
| UA74798C2 (uk) * | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
| CA2400214A1 (fr) * | 2000-02-11 | 2001-11-15 | Amgen Inc. | Recepteur de la famille tnf |
| CA2396793A1 (fr) * | 2000-02-16 | 2001-08-23 | Genentech, Inc. | Utilisation d'agonistes ou d'antagonistes pour moduler l'activite de molecules associees au tnf |
| US6969519B2 (en) * | 2000-03-10 | 2005-11-29 | Human Genome Sciences, Inc. | Methods of using an agonistic antibody human tumor necrosis factor receptor (TR17) |
| CN101289511A (zh) | 2000-04-11 | 2008-10-22 | 杰南技术公司 | 多价抗体及其应用 |
| JP2004513876A (ja) * | 2000-04-27 | 2004-05-13 | バイオジェン インコーポレーテッド | 抗−腫瘍剤としてのtaci |
| US20040013674A1 (en) * | 2001-04-27 | 2004-01-22 | Christine Ambrose | Taci as an anti-tumor agent |
| EP1746106A3 (fr) * | 2000-04-27 | 2007-03-14 | Biogen Idec MA Inc. | TACI utilisée en tant qu'agent antitumoral |
| US20020086018A1 (en) * | 2000-05-12 | 2002-07-04 | Theill Lars Eyde | Methods and compositions of matter concerning APRIL/G70, BCMA, BLYS/AGP-3, and TACI |
| CA2413160A1 (fr) * | 2000-06-15 | 2001-12-20 | Human Genome Sciences, Inc. | Facteur de necrose tumorale humain delta et epsilon |
| AU2001268427B2 (en) * | 2000-06-16 | 2007-03-29 | Glaxosmithkline Intellectual Property Limited | Antibodies that immunospecifically bind to blys |
| US7879328B2 (en) | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
| NZ548265A (en) * | 2000-07-07 | 2008-06-30 | Eisai R&D Man Co Ltd | Antifungal compounds and agents able to inhibit transport of the GPI-anchored protein to the cell wall |
| PT1303293E (pt) | 2000-07-27 | 2009-03-11 | Genentech Inc | Administração sequencial de cpt-11 e polipéptido apo-2l |
| WO2002016411A2 (fr) | 2000-08-18 | 2002-02-28 | Human Genome Sciences, Inc. | Polypeptides de fixation et procedes associes |
| UA83458C2 (uk) * | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
| AU2002215753A1 (en) * | 2000-12-07 | 2002-06-18 | The University Of British Columbia | Caml-binding peptides |
| US20030012783A1 (en) * | 2001-02-20 | 2003-01-16 | Wayne Kindsvogel | Antibodies that bind both BCMA and TACI |
| ATE549354T1 (de) | 2001-05-11 | 2012-03-15 | Amgen Inc | Peptide und damit zusammenhängende an tall-1 bindende moleküle |
| BRPI0209933B8 (pt) | 2001-05-24 | 2021-05-25 | Zymogenetics Inc | proteína de fusão, e, molécula de ácido nucleico |
| PH12012502440A1 (en) | 2001-06-26 | 2013-06-17 | Amgen Inc | Antibodies to opgl |
| DE10131922A1 (de) * | 2001-07-02 | 2003-01-30 | Brahms Ag | Verwendung des Calcineurin B Homologen Proteins (CHP) für die Diagnose und Therapie von Entzündungserkrankungen und Sepsis |
| WO2003066661A2 (fr) | 2001-07-03 | 2003-08-14 | Genentech, Inc. | Anticorps humains du dr4 et utilisations |
| EP1414948B1 (fr) * | 2001-07-10 | 2009-09-16 | Biogen Idec Inc. | Inhibition de l'apoptose et amelioration de la performance cellulaire |
| BR0211614A (pt) * | 2001-08-03 | 2006-10-31 | Genentech Inc | polipeptìdeo tacis e br3 e empregos dos mesmos |
| US6551615B1 (en) * | 2001-10-18 | 2003-04-22 | M/S. Strides Arcolab Limited | Dexibuprofen-containing soft gelatin capsules and process for preparing the same |
| AU2003221256A1 (en) * | 2002-02-21 | 2003-09-09 | Biogen Idec Ma Inc. | Use of bcma as an immunoregulatory agent |
| US20040038303A1 (en) * | 2002-04-08 | 2004-02-26 | Unger Gretchen M. | Biologic modulations with nanoparticles |
| US8025873B2 (en) * | 2002-06-20 | 2011-09-27 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
| US6890725B2 (en) * | 2002-07-23 | 2005-05-10 | Rigel Pharmaceuticals, Inc. | Modulators of B-lymphocyte activation, myosin-1F compositions and methods of use |
| CN1692127A (zh) * | 2002-07-25 | 2005-11-02 | 健泰科生物技术公司 | Taci抗体及其用途 |
| EP1558278B1 (fr) * | 2002-10-11 | 2009-09-02 | ZymoGenetics, Inc. | Production de proteines hybrides homo-trimeriques |
| WO2004094620A2 (fr) | 2003-03-28 | 2004-11-04 | Biogen Idec Ma Inc. | Recepteurs baff tronques |
| US20050163775A1 (en) * | 2003-06-05 | 2005-07-28 | Genentech, Inc. | Combination therapy for B cell disorders |
| PL1631313T3 (pl) | 2003-06-05 | 2015-08-31 | Genentech Inc | Terapia skojarzona zaburzeń z komórek B |
| US7211407B2 (en) * | 2003-07-15 | 2007-05-01 | Chan Test, Inc. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
| CA2554526A1 (fr) * | 2004-01-29 | 2005-08-18 | Genentech, Inc. | Variants du domaine extracellulaire de bcma et utilisations de ceux-ci |
| ATE517914T1 (de) | 2004-03-08 | 2011-08-15 | Zymogenetics Inc | Dimere fusionsproteine und materialien und verfahren zu deren herstellung |
| CA2585927A1 (fr) * | 2004-11-04 | 2006-05-18 | Genentech, Inc. | Polypeptides se liant avec baff et/ou april |
| AU2006209237B2 (en) * | 2005-01-28 | 2010-06-24 | Biogen Ma Inc. | Use of BAFF to treat Th2-mediated conditions |
| AU2006278229B2 (en) * | 2005-08-09 | 2011-10-27 | Ares Trading S.A. | Methods for treating B-cell malignancies using TACI-Ig fusion molecule |
| EP1922079A2 (fr) * | 2005-08-09 | 2008-05-21 | ZymoGenetics, Inc. | Procedes pour le traitement et la prevention de proliferation cellulaire anormale par le biais de molecules de fusion taci |
| EA015860B1 (ru) * | 2005-10-13 | 2011-12-30 | Хьюман Дженом Сайенсиз, Инк. | Способы лечения аутоиммунных заболеваний при использовании антагониста нейтрокина-альфа |
| US9168286B2 (en) * | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
| AR056806A1 (es) | 2005-11-14 | 2007-10-24 | Amgen Inc | Moleculas quimericas de anticuerpo rankl- pth/ pthrp |
| WO2007062090A2 (fr) * | 2005-11-23 | 2007-05-31 | Genentech, Inc. | Procedes et compositions lies a des analyses de lymphocytes b |
| US8211649B2 (en) | 2006-03-31 | 2012-07-03 | Human Genome Sciences, Inc. | Methods of diagnosing and prognosing hodgkin's lymphoma |
| JP2009537563A (ja) * | 2006-05-15 | 2009-10-29 | アレス トレーディング ソシエテ アノニム | Taci融合分子を使用する自己免疫疾患を治療するための方法 |
| DK2061803T4 (da) | 2006-08-28 | 2022-12-05 | Ares Trading Sa | Fremgangsmåde til oprensning af fc-holdige proteiner |
| EA017733B1 (ru) * | 2006-08-28 | 2013-02-28 | Арес Трейдинг С.А. | СПОСОБ ОЧИСТКИ Fc-СЛИТЫХ БЕЛКОВ |
| CA2674213A1 (fr) | 2007-01-26 | 2008-07-31 | Merck Serono S.A. | Purification de proteines hybrides fc-tact utilisant la technologie a base de corps huileux |
| EP2200631A1 (fr) | 2007-10-16 | 2010-06-30 | Zymogenetics, Inc. | Combinaison d'agents d'inhibition de blys et d'agents anti-cd 20 pour le traitement d'une maladie auto-immune |
| WO2010093993A2 (fr) * | 2009-02-12 | 2010-08-19 | Human Genome Sciences, Inc. | Utilisation d'antagonistes de la protéine stimulant les lymphocytes b afin de favoriser la tolérance aux greffes |
| WO2011109280A1 (fr) | 2010-03-05 | 2011-09-09 | Lerner Research Institute | Procédés et compositions permettant de traiter les troubles d'origines immunes |
| EP2934532B1 (fr) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Cellules t exprimant un récepteur d'antigène chimérique et produits thérapeutiques anticancéreux |
| US9458246B2 (en) | 2013-03-13 | 2016-10-04 | Amgen Inc. | Proteins specific for BAFF and B7RP1 |
| PH12022550138A1 (en) | 2013-03-13 | 2023-03-06 | Amgen Inc | Proteins specific for baff and b7rp1 and uses thereof |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Car t細胞療法のための方法および組成物 |
| CN110612119B (zh) | 2017-02-07 | 2024-10-29 | 西雅图儿童医院(Dba西雅图儿童研究所) | 磷脂醚(ple)car t细胞肿瘤靶向(ctct)剂 |
| JP7178355B2 (ja) | 2017-02-28 | 2022-11-25 | エンドサイト・インコーポレイテッド | Car t細胞療法のための組成物および方法 |
| CN111655280B (zh) * | 2017-09-01 | 2025-01-14 | 达纳-法伯癌症研究所股份有限公司 | 用于治疗癌症的bcma和taci抗原特异的免疫原性肽 |
| JP7549303B2 (ja) | 2018-01-22 | 2024-09-11 | エンドサイト・インコーポレイテッド | Car t細胞の使用方法 |
| SG11202007426XA (en) | 2018-02-06 | 2020-09-29 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors |
| CN112105382A (zh) | 2018-02-23 | 2020-12-18 | 恩多塞特公司 | 用于car t细胞疗法的顺序方法 |
| AU2021217003A1 (en) | 2020-02-04 | 2022-09-15 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Anti-dinitrophenol chimeric antigen receptors |
| JP7748393B2 (ja) | 2020-05-08 | 2025-10-02 | アルパイン イミューン サイエンシズ インコーポレイテッド | Aprilおよびbaff阻害免疫調節タンパク質、ならびにその使用方法 |
| WO2022131889A1 (fr) * | 2020-12-16 | 2022-06-23 | 주식회사 굳티셀 | Utilisation de protéine taci |
| US20240002468A1 (en) | 2021-08-10 | 2024-01-04 | Remegen Co., Ltd. | Method for treating iga nephropathy with taci-fc fusion protein |
| AU2022358137B2 (en) | 2021-09-30 | 2026-02-12 | Remegen Co., Ltd. | Method for treating sjogren’s syndrome using taci-fc fusion protein |
| IL317055A (en) | 2022-06-08 | 2025-01-01 | Remegen Co Ltd | METHOD FOR TREATING MYASTHENIA GRAVIS WITH TACI-FC FUSION PROTEIN |
| JP2025532251A (ja) | 2022-09-30 | 2025-09-29 | レメゲン シーオー.,エルティーディー. | TACI-Fc融合タンパク質を用いた膜性腎症の治療方法 |
| EP4527375A1 (fr) | 2022-12-07 | 2025-03-26 | RemeGen Co., Ltd. | Préparation pharmaceutique liquide de protéine de fusion taci-fc |
| WO2025007943A1 (fr) | 2023-07-06 | 2025-01-09 | 荣昌生物制药(烟台)股份有限公司 | Procédé de traitement de la vascularite associée aux anca à l'aide d'une protéine de fusion taci-fc |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| NL7807532A (nl) | 1978-07-13 | 1980-01-15 | Akzo Nv | Metaal-immunotest. |
| NL8000173A (nl) | 1980-01-11 | 1981-08-03 | Akzo Nv | Toepassing van in water dispergeerbare, hydrofobe kleurstoffen als label in immunochemische testen. |
| US4650764A (en) | 1983-04-12 | 1987-03-17 | Wisconsin Alumni Research Foundation | Helper cell |
| US4703017C1 (en) | 1984-02-14 | 2001-12-04 | Becton Dickinson Co | Solid phase assay with visual readout |
| US4751181A (en) * | 1984-12-31 | 1988-06-14 | Duke University | Methods and compositions useful in the diagnosis and treatment of autoimmune diseases |
| US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
| CA1338860C (fr) | 1987-04-13 | 1997-01-21 | Peter Parker | Marquage de proteines a l'aide de radio-isotopes |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| DE3882058T2 (de) | 1987-02-27 | 1994-01-13 | Eastman Kodak Co | Immunoreaktives Reagens, Verfahren zu seiner Herstellung und seine Verwendung zur Bestimmung einer immunoreaktiven Spezies. |
| EP0280559B1 (fr) | 1987-02-27 | 1993-10-20 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Essai immunologique d'agglutination et trousse de réactifs pour la détermination d'une espèce immunollogique polyvalente utilisant une solution saline de nettoyage tamponnée |
| US4857453A (en) | 1987-04-07 | 1989-08-15 | Syntex (U.S.A.) Inc. | Immunoassay device |
| ATE195022T1 (de) | 1987-04-27 | 2000-08-15 | Unilever Nv | Spezifische bindungstestverfahren |
| US4980289A (en) | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
| ATE243754T1 (de) | 1987-05-21 | 2003-07-15 | Micromet Ag | Multifunktionelle proteine mit vorbestimmter zielsetzung |
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5010175A (en) | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
| IL92124A (en) | 1988-10-28 | 1996-10-31 | Sidney Pestka | Recombinant proteins modified to contain post-phosphorylation that do not occur in nature |
| US5124263A (en) | 1989-01-12 | 1992-06-23 | Wisconsin Alumni Research Foundation | Recombination resistant retroviral helper cell and products produced thereby |
| US5354844A (en) | 1989-03-16 | 1994-10-11 | Boehringer Ingelheim International Gmbh | Protein-polycation conjugates |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US5139749A (en) | 1990-06-22 | 1992-08-18 | Tas, Inc. | Fluidized calcining process |
| DE69123241T2 (de) | 1990-12-14 | 1997-04-17 | Cell Genesys Inc | Chimärische ketten zur transduktion von rezeptorverbundenen signalwegen |
| WO1992013878A2 (fr) | 1991-02-07 | 1992-08-20 | Board Of Trustees Of The University Of Illinois | Produits mimetiques de conformation restreinte de tours beta et bombements beta, et peptides les contenant |
| JP3394777B2 (ja) | 1993-05-27 | 2003-04-07 | セレクタイド コーポレーション | 位相学的に分離された、コードされた固相ライブラリー |
| CA2168202A1 (fr) | 1993-07-30 | 1995-03-16 | Joseph Dougherty | Transfert genique efficace aboutissant a des lymphocytes primaires |
| US5650550A (en) * | 1993-10-01 | 1997-07-22 | The United States Of America As Represented By The Department Of Health And Human Services | Mutant mice having a deficit of functional estrogen receptors |
| WO1995028494A1 (fr) | 1994-04-15 | 1995-10-26 | Targeted Genetics Corporation | Proteine de fusion d'apport de gene |
| US5523227A (en) * | 1994-06-17 | 1996-06-04 | The Board Of Trustees Of The Leland Stanford Junior Univ. | DNA encoding calcium-signal modulating cyclophilin ligand |
| DE69535634T2 (de) * | 1994-12-15 | 2008-08-28 | Yeda Research And Development Co., Ltd. | Modulatoren der funktion des fas/ap01 rezeptors |
| US6077947A (en) | 1995-02-02 | 2000-06-20 | Cell Genesys, Inc. | DNA encoding an intracellular chimeric receptor comprising Janus kinase |
| US5712149A (en) | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
| US6103521A (en) | 1995-02-06 | 2000-08-15 | Cell Genesys, Inc. | Multispecific chimeric receptors |
| US5969102A (en) * | 1997-03-03 | 1999-10-19 | St. Jude Children's Research Hospital | Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof |
| US6685728B2 (en) * | 2002-01-25 | 2004-02-03 | Stryker Endoscopy | Threaded suture anchor and method of use |
| US9002545B2 (en) | 2011-01-07 | 2015-04-07 | Wabtec Holding Corp. | Data improvement system and method |
-
1997
- 1997-03-03 US US08/810,572 patent/US5969102A/en not_active Expired - Lifetime
-
1998
- 1998-03-03 EP EP98908948A patent/EP0964874B1/fr not_active Expired - Lifetime
- 1998-03-03 EP EP10179571A patent/EP2292654A3/fr not_active Withdrawn
- 1998-03-03 DE DE69838417T patent/DE69838417T2/de not_active Expired - Lifetime
- 1998-03-03 JP JP53877898A patent/JP3594975B2/ja not_active Expired - Lifetime
- 1998-03-03 EP EP05020384.3A patent/EP1632500B1/fr not_active Expired - Lifetime
- 1998-03-03 ES ES05020384.3T patent/ES2552095T3/es not_active Expired - Lifetime
- 1998-03-03 CA CA2284078A patent/CA2284078C/fr not_active Expired - Lifetime
- 1998-03-03 WO PCT/US1998/004270 patent/WO1998039361A1/fr not_active Ceased
- 1998-03-03 PT PT98908948T patent/PT964874E/pt unknown
- 1998-03-03 AU AU66854/98A patent/AU732119B2/en not_active Expired
- 1998-03-03 DK DK98908948T patent/DK0964874T3/da active
- 1998-03-03 ES ES98908948T patent/ES2292201T3/es not_active Expired - Lifetime
- 1998-03-03 AT AT98908948T patent/ATE373012T1/de active
-
1999
- 1999-04-12 US US09/290,333 patent/US6316222B1/en not_active Expired - Lifetime
-
2001
- 2001-02-14 US US09/782,857 patent/US6500428B1/en not_active Expired - Lifetime
-
2002
- 2002-11-12 US US10/293,816 patent/US20030082173A1/en not_active Abandoned
-
2005
- 2005-03-14 US US11/079,418 patent/US20050183148A1/en not_active Abandoned
- 2005-12-23 US US11/318,156 patent/US7355005B2/en not_active Expired - Fee Related
-
2008
- 2008-02-07 US US12/027,720 patent/US20090226473A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20030082173A1 (en) | 2003-05-01 |
| ES2292201T3 (es) | 2008-03-01 |
| EP0964874A1 (fr) | 1999-12-22 |
| US20090226473A1 (en) | 2009-09-10 |
| DE69838417D1 (de) | 2007-10-25 |
| JP2001518080A (ja) | 2001-10-09 |
| US20050183148A1 (en) | 2005-08-18 |
| ATE373012T1 (de) | 2007-09-15 |
| JP3594975B2 (ja) | 2004-12-02 |
| EP1632500B1 (fr) | 2015-08-05 |
| DE69838417T2 (de) | 2008-05-29 |
| AU732119B2 (en) | 2001-04-12 |
| WO1998039361A1 (fr) | 1998-09-11 |
| US6500428B1 (en) | 2002-12-31 |
| US20060101529A1 (en) | 2006-05-11 |
| AU6685498A (en) | 1998-09-22 |
| EP0964874B1 (fr) | 2007-09-12 |
| US6316222B1 (en) | 2001-11-13 |
| ES2552095T3 (es) | 2015-11-25 |
| CA2284078A1 (fr) | 1998-09-11 |
| CA2284078C (fr) | 2014-09-09 |
| PT964874E (pt) | 2007-12-21 |
| US5969102A (en) | 1999-10-19 |
| EP1632500A3 (fr) | 2007-05-30 |
| US7355005B2 (en) | 2008-04-08 |
| EP1632500A2 (fr) | 2006-03-08 |
| EP2292654A3 (fr) | 2012-07-25 |
| EP2292654A2 (fr) | 2011-03-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0964874T3 (da) | CAML-bindende lymfocytoverfladereceptor, nukleinsyrer, som koder derfor, og fremgangsmåder til anvendelse deraf | |
| NO20010320D0 (no) | Nukleinsyrer som koder for en G-proteinkoblet reseptor som er involvert i sensorisk transduksjon | |
| NO961115L (no) | Humane metabotrope glutamatreseptorsubtyper (HMR4, HMR6, HMR7) og relaterte DNA forbindelser | |
| ATE358178T1 (de) | Modulierung der tnf-rezeptoraktivität | |
| DK1482042T3 (da) | Aktive og inaktive CC-kemokinreceptorer og nukleinsyremolekyler der koder for receptoren | |
| FI972390A0 (fi) | Sytokiini nimeltä Lerk-7 | |
| DK1860187T3 (da) | Apo-2-receptor | |
| DE69434908D1 (de) | Rezeptor an der oberfläche von aktivierten t-zellen:act4 | |
| DE69431805D1 (de) | Struktur höherer ordnung und bindung von peptidnukleinsäuren | |
| NO961796D0 (no) | Rekombinante fedme (ob) proteiner | |
| DK0692025T3 (da) | Gærceller, der er konstrueret således, at de producerer surrogater for proteiner i feromonsystemet, og anvendelser deraf | |
| PL336306A1 (en) | Proteinous fusions of tgf-beta ii type receptor with a constant immunoglobulin area | |
| NO963818L (no) | Forhöyet utskillelse av polypeptider | |
| BR9912545A (pt) | ácidos nucleicos codificando um receptorcopulado a proteìna g envolvido em transduçãosensorial | |
| AU1846995A (en) | Heterologous g protein coupled receptors expressed in yeast, their fusion with g proteins and use thereof in bioassay | |
| ES557188A0 (es) | Un metodo para obtener un polipeptido complementario de al menos una porcion de un peptido o proteina original | |
| DE60335216D1 (de) | Adiponektin-rezeptor und dafür kodierendes gen | |
| NO970740L (no) | Glutamat reseptor | |
| ATE212055T1 (de) | Östrogen-rezeptor | |
| DK0840615T3 (da) | Kemokin-bindende protein og fremgangsmåder til anvendelse deraf | |
| AR010041A1 (es) | Agonistas multifuncionales quimericos de receptores de hematopoyetina | |
| NO973422D0 (no) | Recombinant C140-reseptor, dens agonister og antagonister og nukleinsyrer som koder for reseptoren | |
| DK0968288T3 (da) | z219a, en human homolog til 2-19 protein | |
| IL153818A0 (en) | Method with a wide range of applications, for identifying modulators of g-protein-coupled receptors | |
| SE9701010D0 (sv) | Antibody |