DK0970074T3 - Fremgangsmåde og sammensætninger til syntesen af dioxolannukleosider med beta-konfiguration - Google Patents

Fremgangsmåde og sammensætninger til syntesen af dioxolannukleosider med beta-konfiguration

Info

Publication number: DK0970074T3
Authority: DK; Denmark
Prior art keywords: synthesis; compositions; methods; beta configuration; dioxolane nucleosides
Prior art date: 1995-12-14

Application number

DK96941539T

Other languages

Danish (da)

English (en)

Inventor

Tarek Mansour

Alex Cimpoia

Krzystof Bednarski

Original Assignee

Shire Biochem Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-14

Filing date

1996-12-13

Publication date

2002-07-15

1996-12-13 Application filed by Shire Biochem Inc filed Critical Shire Biochem Inc

2002-07-15 Application granted granted Critical

2002-07-15 Publication of DK0970074T3 publication Critical patent/DK0970074T3/da

Links

230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
239000002777 nucleoside Substances 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK96941539T 1995-12-14 1996-12-13 Fremgangsmåde og sammensætninger til syntesen af dioxolannukleosider med beta-konfiguration DK0970074T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9525606.1A GB9525606D0 (en)	1995-12-14	1995-12-14	Method and compositions for the synthesis of dioxolane nucleosides with - configuration
PCT/CA1996/000845 WO1997021706A1 (en)	1995-12-14	1996-12-13	METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION

Publications (1)

Publication Number	Publication Date
DK0970074T3 true DK0970074T3 (da)	2002-07-15

Family

ID=10785435

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96941539T DK0970074T3 (da)	1995-12-14	1996-12-13	Fremgangsmåde og sammensætninger til syntesen af dioxolannukleosider med beta-konfiguration

Country Status (27)

Country	Link
US (4)	US5922867A (de)
EP (1)	EP0970074B1 (de)
JP (1)	JP3229990B2 (de)
KR (1)	KR100406159B1 (de)
CN (1)	CN1080263C (de)
AP (1)	AP879A (de)
AT (1)	ATE214699T1 (de)
AU (1)	AU706328B2 (de)
BR (1)	BR9612351A (de)
CA (1)	CA2237730C (de)
DE (1)	DE69620042T2 (de)
DK (1)	DK0970074T3 (de)
EA (1)	EA000844B1 (de)
ES (1)	ES2172697T3 (de)
GB (1)	GB9525606D0 (de)
HU (1)	HU224076B1 (de)
IL (3)	IL124663A (de)
IN (1)	IN187349B (de)
MX (1)	MX9804701A (de)
NO (1)	NO309901B1 (de)
NZ (1)	NZ323855A (de)
OA (1)	OA11094A (de)
PL (1)	PL188447B1 (de)
PT (1)	PT970074E (de)
TW (1)	TW341574B (de)
WO (1)	WO1997021706A1 (de)
ZA (1)	ZA9610544B (de)

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* Cited by examiner, † Cited by third party
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WO1998044913A2 (en)	1997-04-07	1998-10-15	Triangle Pharmaceuticals, Inc.	Compositions containing mkc-442 in combination with other antiviral agents
JP4249393B2 (ja)	1998-08-12	2009-04-02	トライアングル・ファーマシューティカルズ，インコーポレイテッド	１，３−オキサチオランヌクレオチドの製造方法
US6979561B1 (en)	1998-10-09	2005-12-27	Gilead Sciences, Inc.	Non-homogeneous systems for the resolution of enantiomeric mixtures
DK1140937T3 (da) *	1998-12-23	2004-03-22	Shire Biochem Inc	Antivirale nucleosid-analoger
WO2000047759A1 (en) *	1999-02-11	2000-08-17	Shire Biochem Inc.	Stereoselective synthesis of nucleoside analogues
DE60011637T2 (de) *	1999-09-24	2004-11-11	Shire Biochem Inc., Laval	Dioxolan nukleosidanalogen zur behandlung und vorbeugung von viralen infektionen
AU1262001A (en)	1999-11-04	2001-05-14	Biochem Pharma Inc.	Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
ATE397001T1 (de) *	2000-02-10	2008-06-15	Mitsui Chemicals Inc	Verfahren zur selektiven herstellung eines 1- phosphoryliertem zuckerderivativ-anomers und verfahren zur herstellung von nukleosiden
CA2399062C (en)	2000-02-11	2010-01-12	Shire Biochem Inc.	Stereoselective synthesis of nucleoside analogues
WO2002051852A1 (fr) *	2000-12-27	2002-07-04	Mitsui Chemicals, Inc.	Procede de production d'un derive de saccharide non naturel
PT1574512E (pt)	2001-03-01	2008-03-05	Abbott Lab	Formas polimórficas e outras formas cristalinas de cis-ftc
WO2003020222A2 (en) *	2001-09-04	2003-03-13	Merck & Co., Inc.	PYRROLO[2,3-d]PYRIMIDINES FOR INHIBITING RNA-DEPENDENT RNA VIRAL POLYMERASE
AU2002336864B2 (en) *	2001-11-02	2006-08-17	Shire Biochem Inc.	Pharmaceutical compositions for the treatment of leukemia comprising dioxolane nucleosides analogs
EP1569652A4 (de) *	2001-12-14	2008-07-02	Pharmasset Inc	N sp 4 /sp acylcytosin-nukleoside zur behandlung von virusinfektionen
ATE548366T1 (de)	2002-01-25	2012-03-15	Shire Biochem Inc	Verfahren zur herstellung von dioxolan nukleosidanalogavorstufen
US6855821B2 (en)	2002-08-06	2005-02-15	Pharmasset, Ltd.	Processes for preparing 1,3-dioxolane nucleosides
BR0315341B1 (pt)	2002-10-15	2014-02-18		Adesivos compreendendo poliolefina.
DE10335061B4 (de) *	2003-07-31	2005-11-17	Wacker-Chemie Gmbh	Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
CN101044122A (zh) *	2004-02-03	2007-09-26	埃莫里大学	制备1,3－二氧戊环核苷的方法
US7749531B2 (en) *	2005-06-08	2010-07-06	Indicator Systems International	Apparatus and method for detecting bacterial growth beneath a wound dressing
BRPI0813036A2 (pt) *	2007-07-30	2017-10-24	Rfs Pharma Llc	processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina.
CN101862676B (zh) *	2009-04-17	2012-01-25	中国石油化工股份有限公司	大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用
CN103288806A (zh) *	2013-07-02	2013-09-11	山东大学	一种曲沙他滨的合成方法
WO2018022263A1 (en)	2016-07-29	2018-02-01	Exxonmobil Chemical Patents Inc.	Polymerization processes using high molecular weight polyhydric quenching agents
WO2019245444A1 (en)	2018-06-21	2019-12-26	Medivir Ab	Base-modified cytidine nucleotides for leukemia therapy
JP7337539B2 (ja)	2018-06-21	2023-09-04	メディヴィル・アクチエボラーグ	白血病療法のための塩基修飾シチジンヌクレオチド

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5276151A (en) *	1990-02-01	1994-01-04	Emory University	Method of synthesis of 1,3-dioxolane nucleosides
ES2101231T3 (es) *	1992-06-22	1997-07-01	Lilly Co Eli	Procedimiento estereoselectivo de glicosilacion de anion.

1995
- 1995-12-14 GB GBGB9525606.1A patent/GB9525606D0/en active Pending
1996
- 1996-12-13 NZ NZ323855A patent/NZ323855A/xx unknown
- 1996-12-13 JP JP52157397A patent/JP3229990B2/ja not_active Expired - Lifetime
- 1996-12-13 WO PCT/CA1996/000845 patent/WO1997021706A1/en not_active Ceased
- 1996-12-13 AP APAP/P/1998/001252A patent/AP879A/en active
- 1996-12-13 IL IL12466396A patent/IL124663A/en not_active IP Right Cessation
- 1996-12-13 EA EA199800555A patent/EA000844B1/ru not_active IP Right Cessation
- 1996-12-13 DK DK96941539T patent/DK0970074T3/da active
- 1996-12-13 AU AU10893/97A patent/AU706328B2/en not_active Expired
- 1996-12-13 IN IN2810DE1996 patent/IN187349B/en unknown
- 1996-12-13 DE DE69620042T patent/DE69620042T2/de not_active Expired - Lifetime
- 1996-12-13 IL IL14415596A patent/IL144155A/xx not_active IP Right Cessation
- 1996-12-13 AT AT96941539T patent/ATE214699T1/de not_active IP Right Cessation
- 1996-12-13 BR BR9612351A patent/BR9612351A/pt not_active Application Discontinuation
- 1996-12-13 KR KR10-1998-0704473A patent/KR100406159B1/ko not_active Expired - Fee Related
- 1996-12-13 CA CA002237730A patent/CA2237730C/en not_active Expired - Lifetime
- 1996-12-13 CN CN96199879A patent/CN1080263C/zh not_active Expired - Lifetime
- 1996-12-13 ZA ZA9610544A patent/ZA9610544B/xx unknown
- 1996-12-13 PT PT96941539T patent/PT970074E/pt unknown
- 1996-12-13 TW TW085115392A patent/TW341574B/zh active
- 1996-12-13 HU HU9901050A patent/HU224076B1/hu active IP Right Grant
- 1996-12-13 ES ES96941539T patent/ES2172697T3/es not_active Expired - Lifetime
- 1996-12-13 EP EP96941539A patent/EP0970074B1/de not_active Expired - Lifetime
- 1996-12-13 US US08/849,722 patent/US5922867A/en not_active Expired - Lifetime
- 1996-12-13 PL PL96327443A patent/PL188447B1/pl not_active IP Right Cessation
1998
- 1998-06-09 OA OA9800077A patent/OA11094A/en unknown
- 1998-06-11 MX MX9804701A patent/MX9804701A/es unknown
- 1998-06-12 NO NO982716A patent/NO309901B1/no unknown
1999
- 1999-02-17 US US09/251,431 patent/US6069250A/en not_active Expired - Lifetime
2001
- 2001-07-05 IL IL14415501A patent/IL144155A0/xx unknown
- 2001-11-16 US US09/987,845 patent/US20020058670A1/en not_active Abandoned
2002
- 2002-10-02 US US10/262,107 patent/US20030060476A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20020058670A1 (en)	2002-05-16
US6069250A (en)	2000-05-30
TW341574B (en)	1998-10-01
DE69620042T2 (de)	2002-10-17
ZA9610544B (en)	1997-07-29
EP0970074A1 (de)	2000-01-12
AP9801252A0 (en)	1998-06-30
MX9804701A (es)	1998-10-31
CN1080263C (zh)	2002-03-06
OA11094A (en)	2003-03-13
KR19990072141A (ko)	1999-09-27
EA000844B1 (ru)	2000-06-26
PL188447B1 (pl)	2005-02-28
WO1997021706A1 (en)	1997-06-19
HUP9901050A3 (en)	2001-05-28
JP2000501714A (ja)	2000-02-15
CA2237730A1 (en)	1997-06-19
HK1017886A1 (en)	1999-12-03
NZ323855A (en)	1999-11-29
NO309901B1 (no)	2001-04-17
IL124663A0 (en)	1998-12-06
IN187349B (de)	2002-03-30
CA2237730C (en)	2001-12-04
IL144155A0 (en)	2002-05-23
PL327443A1 (en)	1998-12-07
NO982716D0 (no)	1998-06-12
CN1208414A (zh)	1999-02-17
US5922867A (en)	1999-07-13
ES2172697T3 (es)	2002-10-01
AP879A (en)	2000-10-02
PT970074E (pt)	2002-09-30
BR9612351A (pt)	1999-07-13
AU706328B2 (en)	1999-06-17
IL124663A (en)	2001-10-31
JP3229990B2 (ja)	2001-11-19
AU1089397A (en)	1997-07-03
EA199800555A1 (ru)	1999-02-25
GB9525606D0 (en)	1996-02-14
HUP9901050A2 (hu)	2001-04-28
US20030060476A1 (en)	2003-03-27
IL144155A (en)	2003-07-06
KR100406159B1 (ko)	2004-11-16
DE69620042D1 (de)	2002-04-25
EP0970074B1 (de)	2002-03-20
ATE214699T1 (de)	2002-04-15
NO982716L (no)	1998-06-12
HU224076B1 (hu)	2005-05-30

Publication	Publication Date	Title
NO982716D0 (no)	1998-06-12	FremgangsmÕte og blandinger for syntese av dioksalan-nukleotider med <beta>-konfigurasjon
DE69303166D1 (de)	1996-07-18	Klebstoffabweisende silikonzusammensetzungen
DK0797542T3 (da)	2002-05-27	Fremgangsmåde til fremstilling af aluminosilikatderivater
DK0443479T3 (da)	1994-10-17	Fremgangsmåde til fremstilling af actinium-225 og bismuth-213
DK0876392T3 (da)	2000-11-06	Lacton-derivater af 17.beta.-carboxy, carbothio og amidandrostanforbindelser
DK230789D0 (da)	1989-05-11	Fremgangsmaade til fremstilling af cytidinderivater
DK59586D0 (da)	1986-02-06	Selektive nikkelfjernelseskompositioner og fremgangsmaade til fjernelse af nikkelbelaegninger
DK0411084T3 (da)	1994-02-14	Syntese af hydrocarbylaminer
DK0522269T3 (da)	2000-04-17	Fremgangsmåde til fremstilling af enzymsammensætninger
DE69420878D1 (de)	1999-11-04	Synchrongeschalteter Taktgeber
DK0983249T3 (da)	2002-07-08	Fremgangsmåder og mellemprodukter til fremstilling af substituerede indazolderivater
DK0648738T3 (da)	1997-06-16	Fremgangsmåde til fremstilling af acetoacetarylamider
DK352489D0 (da)	1989-07-17	Fremgangsmaade og mellemprodukter til fremstilling af isofluran
DK169386D0 (da)	1986-04-14	Fremgangsmaade til fremstilling af azetidinderivater og mellemprodukter dertil
DK614789A (da)	1990-06-08	Fremgangsmaade til fremstilling af beskyttede mono- og oligosukkerhalogenider
DK0648748T3 (da)	1997-10-13	Fremgangsmåde til fremstilling af 5-acetoacetylaminobenzimidazolon-2
NO912509L (no)	1991-12-30	Fremgangsmaate for fremstilling av substituerte acykliske nukleosider og mellomprodukter derav.
FI912513A7 (fi)	1991-11-25	Nukleotidi ja nukleosidijohdannaisten synteesi
DK0411624T3 (da)	1993-08-16	Saccharidderivater af protocatechualdehyl
DK0857720T3 (da)	2004-07-26	Fremgangsmåde til syntese af desoxypyridinolin
DK0569701T3 (da)	2000-10-23	Fremgangsmåde til fremstilling af 2-amino-5-methyl-pyridin
DK0747365T3 (da)	2004-09-06	Fremgangsmåde og mellemprodukter til fremstilling af
DK76093D0 (da)	1993-06-25	Anvendelse af glycosider
DK105491D0 (da)	1991-06-03	Modificerede nucleosider og nucleotider samt fremgangsmaade til fremstilling heraf og anvendelse af samme
DK0743961T3 (da)	1999-05-03	Fremgangsmåde til fremstilling af lignocellulose-legemer