DK0970095T3 - Hidtil ukendte benzimidazolinhibitorer for fructose-1,6-bisphosphase - Google Patents

Hidtil ukendte benzimidazolinhibitorer for fructose-1,6-bisphosphase

Info

Publication number
DK0970095T3
DK0970095T3 DK98909031T DK98909031T DK0970095T3 DK 0970095 T3 DK0970095 T3 DK 0970095T3 DK 98909031 T DK98909031 T DK 98909031T DK 98909031 T DK98909031 T DK 98909031T DK 0970095 T3 DK0970095 T3 DK 0970095T3
Authority
DK
Denmark
Prior art keywords
fructose
inhibitors
novel
bisphosphase
benzimidazoline
Prior art date
Application number
DK98909031T
Other languages
English (en)
Inventor
Srinivas Rao Kasibhatla
K Raja Reddy
Mark D Erion
Qun Dang
Gerard R Scarlato
M Rami Reddy
Original Assignee
Metabasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabasis Therapeutics Inc filed Critical Metabasis Therapeutics Inc
Application granted granted Critical
Publication of DK0970095T3 publication Critical patent/DK0970095T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK98909031T 1997-03-07 1998-03-06 Hidtil ukendte benzimidazolinhibitorer for fructose-1,6-bisphosphase DK0970095T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4062797P 1997-03-07 1997-03-07
PCT/US1998/004498 WO1998039343A1 (en) 1997-03-07 1998-03-06 Novel benzimidazole inhibitors of fructose-1,6-bisphosphatase

Publications (1)

Publication Number Publication Date
DK0970095T3 true DK0970095T3 (da) 2004-03-08

Family

ID=21912034

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98909031T DK0970095T3 (da) 1997-03-07 1998-03-06 Hidtil ukendte benzimidazolinhibitorer for fructose-1,6-bisphosphase

Country Status (11)

Country Link
US (2) US6110903A (da)
EP (1) EP0970095B1 (da)
JP (1) JP2001515482A (da)
AT (1) ATE253073T1 (da)
AU (1) AU6691498A (da)
DE (1) DE69819311T2 (da)
DK (1) DK0970095T3 (da)
ES (1) ES2210728T3 (da)
PT (1) PT970095E (da)
WO (1) WO1998039343A1 (da)
ZA (1) ZA981936B (da)

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EP0970095B1 (en) 2003-10-29
AU6691498A (en) 1998-09-22
DE69819311D1 (de) 2003-12-04
US6399782B1 (en) 2002-06-04
DE69819311T2 (de) 2004-07-29
ATE253073T1 (de) 2003-11-15
ES2210728T3 (es) 2004-07-01
EP0970095A1 (en) 2000-01-12
ZA981936B (en) 1999-09-06
JP2001515482A (ja) 2001-09-18
US6110903A (en) 2000-08-29
PT970095E (pt) 2004-03-31
WO1998039343A1 (en) 1998-09-11

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