DK0980387T3 - PRRSV-antigene sites, der identificerer peptidsekvenser af PRRS-virus, til anvendelse i vacciner eller diagnostiske assays - Google Patents

PRRSV-antigene sites, der identificerer peptidsekvenser af PRRS-virus, til anvendelse i vacciner eller diagnostiske assays

Info

Publication number
DK0980387T3
DK0980387T3 DK98921916T DK98921916T DK0980387T3 DK 0980387 T3 DK0980387 T3 DK 0980387T3 DK 98921916 T DK98921916 T DK 98921916T DK 98921916 T DK98921916 T DK 98921916T DK 0980387 T3 DK0980387 T3 DK 0980387T3
Authority
DK
Denmark
Prior art keywords
vaccines
peptide sequences
diagnostic assays
prrs virus
antigenic sites
Prior art date
Application number
DK98921916T
Other languages
English (en)
Inventor
Nieuwstadt Antonie Paul Van
Jan Langeveld
Janneke Meulenberg
Original Assignee
Boehringer Ingelheim Vetmed
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmed filed Critical Boehringer Ingelheim Vetmed
Application granted granted Critical
Publication of DK0980387T3 publication Critical patent/DK0980387T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK98921916T 1997-05-06 1998-05-05 PRRSV-antigene sites, der identificerer peptidsekvenser af PRRS-virus, til anvendelse i vacciner eller diagnostiske assays DK0980387T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97201343 1997-05-06
PCT/NL1998/000251 WO1998050426A1 (en) 1997-05-06 1998-05-05 Prrsv antigenic sites identifying peptide sequences of prrs virus for use in vaccines or diagnostic assays

Publications (1)

Publication Number Publication Date
DK0980387T3 true DK0980387T3 (da) 2007-10-22

Family

ID=8228298

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98921916T DK0980387T3 (da) 1997-05-06 1998-05-05 PRRSV-antigene sites, der identificerer peptidsekvenser af PRRS-virus, til anvendelse i vacciner eller diagnostiske assays

Country Status (21)

Country Link
US (1) US6495138B1 (da)
EP (2) EP1882696A3 (da)
JP (1) JP2000512313A (da)
KR (1) KR100388257B1 (da)
CN (1) CN1259141B (da)
AT (1) ATE365746T1 (da)
AU (1) AU754938B2 (da)
BR (1) BR9809221A (da)
CA (2) CA2289980C (da)
CZ (1) CZ297371B6 (da)
DE (1) DE69837992T2 (da)
DK (1) DK0980387T3 (da)
ES (1) ES2289781T3 (da)
HU (1) HU228704B1 (da)
ID (1) ID23399A (da)
PL (1) PL197057B1 (da)
PT (1) PT980387E (da)
RU (1) RU2220978C2 (da)
SK (1) SK286063B6 (da)
UA (1) UA73915C2 (da)
WO (1) WO1998050426A1 (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6380376B1 (en) * 1992-10-30 2002-04-30 Iowa State University Research Foundation Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US6773908B1 (en) 1992-10-30 2004-08-10 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US6592873B1 (en) 1992-10-30 2003-07-15 Iowa State University Research Foundation, Inc. Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
US5695766A (en) * 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
EP0839912A1 (en) 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
US20040224327A1 (en) * 1996-10-30 2004-11-11 Meulenberg Johanna Jacoba Maria Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
DE19850718C1 (de) * 1998-11-03 2000-05-18 Hildt Eberhardt Zellpermeabilität-vermittelndes Polypeptid
CA2366072C (en) * 1999-03-08 2007-07-10 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Prrsv vaccines
ES2348159T3 (es) 1999-04-22 2010-11-30 United States Department Of Agriculture Vacuna contra el sindrome respiratorio y reproductivo porcino basada en el aislado ja-142.
EP1421184A2 (en) * 2001-03-09 2004-05-26 Boehringer Ingelheim Vetmedica Gmbh Live attenuated strains of prrs virus
US7335361B2 (en) * 2003-06-09 2008-02-26 Animal Technology Institute Taiwan Fusion antigen used as vaccine
TW200604526A (en) 2004-06-18 2006-02-01 Unviersity Of Minnesota Identifying virally infected and vaccinated organisms
US7632636B2 (en) 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
KR20130105750A (ko) * 2005-02-25 2013-09-25 아이덱스 래보러토리즈, 인코포레이티드 돼지 생식기 호흡기 증후군 바이러스에 대한 항체를 검출하기 위한 펩티드
PT2369001T (pt) 2005-06-24 2016-10-25 Univ Minnesota Vírus srrp, clones infecciosos, os seus mutantes e processos de utilização
CA2630648C (en) 2005-11-29 2016-01-19 Iowa State University Research Foundation, Inc. Identification of protective antigenic determinants of porcine reproductive and respiratory syndrome virus (prrsv) and uses thereof
US20100227339A1 (en) * 2005-12-02 2010-09-09 Iowa State University Research Foundation, Inc. Differential immunoassay for prrs vaccine antibody
KR101653177B1 (ko) * 2008-08-25 2016-09-01 베링거잉겔하임베트메디카인코퍼레이티드 고병원성 돼지 생식기 및 호흡기 증후군(ｈｐ ｐｒｒｓ)에 대한 백신
KR101101386B1 (ko) * 2008-12-04 2012-01-02 주식회사 바이오리쏘스 북미형 ｐｒｒｓｖ에 특이적인 면역원성 펩티드 및 그의 용도
TWI627281B (zh) 2009-09-02 2018-06-21 百靈佳殷格翰家畜藥品公司 降低ｐｃｖ－２組合物殺病毒活性之方法及具有改良免疫原性之ｐｃｖ－２組合物
EP2576789A4 (en) * 2010-06-02 2014-01-22 Virginia Tech Intell Prop NEW MODIFIED LIVESTINE VACCINES (MLV) AND SUB-VEIN VACCINES OBTAINED BY DNA SHUFFLING AGAINST PRRS VIRUS
CN101885759B (zh) * 2010-06-25 2013-01-09 国家兽用生物制品工程技术研究中心 一种特异性结合猪繁殖与呼吸综合症病毒的多肽及其筛选方法和应用
ES2692809T3 (es) 2011-02-17 2018-12-05 Boehringer Ingelheim Vetmedica Gmbh Nueva cepa del PRRSV europea
CA2827337C (en) 2011-02-17 2019-07-09 Boehringer Ingelheim Vetmedica Gmbh Commercial scale process for production of prrsv
US9315781B2 (en) 2011-07-29 2016-04-19 Boehringer Ingelheim Vetmedica Gmbh Infectious CDNA clone of european PRRS virus and uses thereof
US9187731B2 (en) 2011-07-29 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh PRRS virus inducing type I interferon in susceptible cells
WO2013101195A1 (en) * 2011-12-30 2013-07-04 United Biomedical, Inc. Synthetic peptide-based marker vaccine and diagnostic system for effective control of porcine reproductive and respiratory syndrome (prrs)
KR101430223B1 (ko) * 2012-10-09 2014-09-25 전북대학교산학협력단 면역유도능이 증가된 돼지생식기호흡기증후군 바이러스
CN103421817B (zh) * 2012-10-15 2016-01-13 华中农业大学 人工合成的猪繁殖与呼吸综合征病毒多表位基因及应用
CN105308178B (zh) 2012-12-07 2019-06-07 伊利诺伊大学评议会 猪繁殖与呼吸综合征病毒组合物及其用途
CN103059142B (zh) * 2012-12-17 2015-02-25 重庆市畜牧科学院 猪圆环病毒的抗原和猪繁殖与呼吸综合征病毒的抗原的重组蛋白及其制备方法与应用
US9579373B2 (en) 2013-03-15 2017-02-28 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use
EP2804000A1 (en) * 2013-05-15 2014-11-19 Prionics AG Method for the detection and classification of PRRSV-infections in swine herds and diagnostic antigen compositions for such methods
CN105829528B (zh) 2013-12-20 2019-10-22 勃林格殷格翰动物保健有限公司 PRRS病毒变体、欧洲PRRS病毒cDNA克隆及其用途
CN107635579A (zh) 2014-03-21 2018-01-26 纽泰克温图斯公司 非天然发生的猪生殖和呼吸综合征病毒(prrsv)和使用方法
ES3050936T3 (en) 2015-06-23 2025-12-23 Boehringer Ingelheim Vetmedica Gmbh Prrsv minor protein-containing recombinant viral vectors and methods of making and use thereof
CN106442968B (zh) * 2016-09-21 2018-03-06 福建省农业科学院畜牧兽医研究所 猪繁殖与呼吸综合征血清学鉴别诊断试剂盒
CN109022613A (zh) * 2018-04-24 2018-12-18 上海申亚动物保健品阜阳有限公司 一种检测猪繁殖与呼吸综合征病毒的试剂盒及检测方法
KR102091279B1 (ko) * 2018-08-07 2020-03-20 대한민국 돼지 생식기 및 호흡기 증후군 바이러스 진단용 재조합 항원 단백질 및 이의 용도
KR102138287B1 (ko) * 2018-08-07 2020-07-29 대한민국 돼지 생식기 및 호흡기 증후군 바이러스 진단용 유전형별 재조합 항원 단백질 및 이의 용도
CN110894243B (zh) * 2019-12-16 2021-07-13 中国农业大学 一种猪蓝耳病毒嵌合抗原以及检测猪蓝耳病毒抗体的胶体金免疫层析试纸条
CN112458115B (zh) * 2020-10-21 2022-06-07 天津农学院 一种基因构建重组质粒pEGFP-GRE-GP5gB及应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2290906C (en) 1991-06-06 2003-04-01 Stichting Centraal Diergeneeskundig Instituut Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits
KR100241221B1 (ko) 1991-08-26 2000-03-02 에드워드 콜린스 제임스 돼지 불임 및 호흡기계 중후백신 및 그의 진단법
KR0138092B1 (ko) 1991-08-26 1998-04-30 제임스 씨. 데세사레 미확인(Mystery) 돼지 질병 관련 바이러스제
US5846805A (en) 1991-08-26 1998-12-08 Boehringer Ingelheim Animal Health, Inc. Culture of swine infertility and respiratory syndrome virus in simian cells
CA2121241C (en) 1991-10-14 2007-12-04 Nicolaas Visser Porcine reproductive respiratory syndrome vaccine and diagnostic
US5695766A (en) 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
US6592873B1 (en) * 1992-10-30 2003-07-15 Iowa State University Research Foundation, Inc. Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
US6251397B1 (en) * 1992-10-30 2001-06-26 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus and immunogenic compositions containing the same
NZ261992A (en) 1993-02-08 1996-06-25 Bayer Ag Porcine reproductive and respiratory syndrome virus, cultures, attenuated forms and vaccines thereof
ES2074950B1 (es) 1993-09-17 1996-03-16 Iberica Cyanamid Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda.
DK53595A (da) * 1994-05-13 1995-11-14 Iberica Cyanamid Rekombinante PRRSV-proteiner, diagnostiske kits og vaccine indeholdende sådanne rekombinante PRRSV-proteiner
MX9700817A (es) * 1994-08-05 1997-05-31 Univ Minnesota Secuencia viral de nucleotidos de "vr-2332" y metodos de uso.
US5690940A (en) 1995-06-21 1997-11-25 Regents Of The University Of Minnesota Low pathogencity PRRS live virus vaccines and methods of preparation thereof
ES2122921B1 (es) * 1996-12-30 1999-09-16 Inmunologia & Genetica Aplic Proteinas recombinantes de fusion del virus reproductivo y respiratorio porcino (prrsv) y su empleo en diagnostico.

Also Published As

Publication number Publication date
DE69837992T2 (de) 2008-03-20
ATE365746T1 (de) 2007-07-15
CN1259141B (zh) 2013-03-27
AU7457198A (en) 1998-11-27
EP0980387A1 (en) 2000-02-23
BR9809221A (pt) 2000-07-04
UA73915C2 (uk) 2005-10-17
RU2220978C2 (ru) 2004-01-10
SK286063B6 (sk) 2008-02-05
JP2000512313A (ja) 2000-09-19
HU228704B1 (en) 2013-05-28
HUP0002176A2 (hu) 2000-11-28
WO1998050426A1 (en) 1998-11-12
AU754938B2 (en) 2002-11-28
CN1259141A (zh) 2000-07-05
PL336714A1 (en) 2000-07-03
EP0980387B1 (en) 2007-06-27
PT980387E (pt) 2007-07-31
HUP0002176A3 (en) 2001-09-28
SK152699A3 (en) 2000-08-14
CZ297371B6 (cs) 2006-11-15
CA2703181A1 (en) 1998-11-12
EP1882696A3 (en) 2008-03-05
EP1882696A2 (en) 2008-01-30
DE69837992D1 (de) 2007-08-09
ES2289781T3 (es) 2008-02-01
ID23399A (id) 2000-04-20
CZ9903932A3 (cs) 2000-10-11
KR100388257B1 (ko) 2003-06-19
CA2289980C (en) 2010-07-20
KR20010012337A (ko) 2001-02-15
PL197057B1 (pl) 2008-02-29
CA2289980A1 (en) 1998-11-12
CA2703181C (en) 2016-06-28
US6495138B1 (en) 2002-12-17

Similar Documents

Publication Publication Date Title
HUP0002176A3 (en) Prrsv antigenic sites identifying peptide sequences of prrs virus for use in vaccines or diagnostic assays
ES2188583T3 (es) Polipeptidos para el virus de la hepatitis c (hcv).
DE69910580D1 (de) Von der telomerase abgeleitete antigene peptide
DK82784A (da) Fremgangsmaade til fremstilling af lyofiliserede, adsorberede polyvalente vacciner
DK0830142T3 (da) PRRS (porcint reproduktions- og respirationssyndrom) -virusvaccine
FI894580L (fi) Non-a, non-b -hepatitisvirusantigenpeptid.
ATE275631T1 (de) Rekombinanter venezolanische-equine- pferdeenzephalitis-virusimpstoff
ID21649A (id) Inhibitor serum protease, terutama virus hepatitis c ns3 protease
ITTO950367A0 (it) Proteine di prrsv ricombinanti, corredi diagnostici e vaccini contenenti tali proteine di prrsv ricombinanti.
PL348300A1 (en) Newcastle disease virus infectious clones, vaccines and diagnostic assays
PT698216E (pt) Metodos de tipificacao do virus da hepatite c e reagentes para utilizar nestes
DK0754704T3 (da) Syntetiske antigener til påvisning af antistoffer mod hepatitis c-virus
DK166087A (da) Htlv-iii-virusprotein, dna-sekvens, der koder herfor, fremgangsmaade til fremstilling heraf, fremgangsmaade til detektion af aids-virus samt antistoffer mod aids-virus
BR0114646A (pt) anticorpos anti-lt-beta-r humanizados
DK1021722T3 (da) Forbedringer i eller relateret til screening for papillomavira
FI913068L (fi) Non-a-, non-b-hepatitisviruspartiklar.
ID20581A (id) Antigen rotavirus, vaksin dan agen diagnostik untuk infeksi rotavirus, serta metode untuk menghasilkan antigen
FI911528A7 (fi) Non-A, Non-B -hepatiittivirusta vastaan suunattujen vasta-aineiden kanssa immunokemiallisesti reaktiivisia peptidejä
NO20011843L (no) Selektivt replikerende virusvektorer
BR9712067A (pt) Pept¡dios imunog-nicos de v¡rus da doen-a de febre aftosa
WO1997040147A8 (en) Antigenically reactive regions of the hepatitis a virus polyprotein
DK0716094T3 (da) Fremgangsmåde til oprensning af Hepatitis B-virus-overfladeantigen, som omfatter præS2-peptid
SE9604581D0 (sv) An agent against cancer and virus infections
ATE346087T1 (de) Hepatitis e-virus aus dem schwein und dessen verwendungen
TR200003235T2 (tr) Yeni kompozisyon