DK0982301T3 - Delta 6,7-taxoler antineoplastisk anvendelse og farmaceutiske præparater indeholdende disse - Google Patents

Delta 6,7-taxoler antineoplastisk anvendelse og farmaceutiske præparater indeholdende disse

Info

Publication number: DK0982301T3
Authority: DK; Denmark
Prior art keywords: substd; opt; nhcoocme3; substits; succinyl
Prior art date: 1993-06-11

Application number

DK99118033T

Other languages

English (en)

Inventor

Robert C Kelly

Roy A Johnson

Harvey I Skulnick

Eldon G Nidy

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-11

Filing date

1994-06-03

Publication date

2003-12-08

1993-12-13 Priority claimed from PCT/US1993/011827 external-priority patent/WO1994013655A1/en

1994-06-03 Application filed by Upjohn Co filed Critical Upjohn Co

2003-12-08 Application granted granted Critical

2003-12-08 Publication of DK0982301T3 publication Critical patent/DK0982301T3/da

Links

230000000118 anti-neoplastic effect Effects 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
-1 amino, p-toluene-sulphonamido Chemical group 0.000 abstract 5
150000007513 acids Chemical class 0.000 abstract 3
125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 abstract 2
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 abstract 1
KNWCDYSKJSREAQ-UHFFFAOYSA-N 1,3-oxazolidine-2-carboxylic acid Chemical class OC(=O)C1NCCO1 KNWCDYSKJSREAQ-UHFFFAOYSA-N 0.000 abstract 1
125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000004080 3-carboxypropanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C(O[H])=O 0.000 abstract 1
125000004042 4-aminobutyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] 0.000 abstract 1
SBQWITJAJITAMM-UHFFFAOYSA-N 4-oxo-4-(2-sulfoethylamino)butanoic acid Chemical compound OC(=O)CCC(=O)NCCS(O)(=O)=O SBQWITJAJITAMM-UHFFFAOYSA-N 0.000 abstract 1
101100173726 Arabidopsis thaliana OR23 gene Proteins 0.000 abstract 1
229930012538 Paclitaxel Natural products 0.000 abstract 1
229910006069 SO3H Inorganic materials 0.000 abstract 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
125000002905 alkanoylamido group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000005281 alkyl ureido group Chemical group 0.000 abstract 1
229930014667 baccatin III Natural products 0.000 abstract 1
150000003935 benzaldehydes Chemical class 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
230000020176 deacylation Effects 0.000 abstract 1
238000005947 deacylation reaction Methods 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229960001592 paclitaxel Drugs 0.000 abstract 1
125000005544 phthalimido group Chemical group 0.000 abstract 1
125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK99118033T 1993-06-11 1994-06-03 Delta 6,7-taxoler antineoplastisk anvendelse og farmaceutiske præparater indeholdende disse DK0982301T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US7633793A	1993-06-11	1993-06-11
US12297493A	1993-09-17	1993-09-17
PCT/US1993/011827 WO1994013655A1 (en)	1992-12-15	1993-12-13	7-HALO- AND 7β,8β-METHANO-TAXOLS, ANTINEOPLASTIC USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number	Publication Date
DK0982301T3 true DK0982301T3 (da)	2003-12-08

Family

ID=26757982

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK94920688T DK0703909T3 (da)	1993-06-11	1994-06-03	Delta6,7-taxoler, antineoplastisk anvendelse og farmaceutiske præparater indeholdende dem
DK99118034T DK0982302T3 (da)	1993-06-11	1994-06-03	Delta-6,7-taxolers antineoplastiske anvendelse og farmaceutiske sammensætninger, der indeholder dem
DK99118033T DK0982301T3 (da)	1993-06-11	1994-06-03	Delta 6,7-taxoler antineoplastisk anvendelse og farmaceutiske præparater indeholdende disse

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DK94920688T DK0703909T3 (da)	1993-06-11	1994-06-03	Delta6,7-taxoler, antineoplastisk anvendelse og farmaceutiske præparater indeholdende dem
DK99118034T DK0982302T3 (da)	1993-06-11	1994-06-03	Delta-6,7-taxolers antineoplastiske anvendelse og farmaceutiske sammensætninger, der indeholder dem

Country Status (18)

Country	Link
US (2)	US5965739A (da)
EP (3)	EP0982302B1 (da)
JP (1)	JPH09511212A (da)
AT (3)	ATE192147T1 (da)
AU (1)	AU7138894A (da)
CA (1)	CA2161328A1 (da)
DE (3)	DE69433146T2 (da)
DK (3)	DK0703909T3 (da)
ES (3)	ES2219968T3 (da)
GR (1)	GR3033836T3 (da)
IL (1)	IL109957A (da)
LV (2)	LV12692B (da)
NZ (2)	NZ330671A (da)
PT (3)	PT982301E (da)
SI (2)	SI0703909T1 (da)
TW (1)	TW401407B (da)
WO (1)	WO1994029288A1 (da)
ZA (1)	ZA944034B (da)

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FR2601676B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US4876399A (en) *	1987-11-02	1989-10-24	Research Corporation Technologies, Inc.	Taxols, their preparation and intermediates thereof
US4942184A (en) *	1988-03-07	1990-07-17	The United States Of America As Represented By The Department Of Health And Human Services	Water soluble, antineoplastic derivatives of taxol
US5157049A (en) *	1988-03-07	1992-10-20	The United States Of America As Represented By The Department Of Health & Human Services	Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
FR2629818B1 (fr) *	1988-04-06	1990-11-16	Centre Nat Rech Scient	Procede de preparation du taxol
FR2629819B1 (fr) *	1988-04-06	1990-11-16	Rhone Poulenc Sante	Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
EP0366841A1 (en) *	1988-11-03	1990-05-09	Dresser-Rand Company	A crosshead and crosshead pin coupling arrangement
US4960790A (en) *	1989-03-09	1990-10-02	University Of Kansas	Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
IL95436A (en) *	1989-08-23	1996-07-23	Centre Nat Rech Scient	Method for the preparation of phenzlisoserine derivatives
US5136060A (en) *	1989-11-14	1992-08-04	Florida State University	Method for preparation of taxol using an oxazinone
US5015744A (en) *	1989-11-14	1991-05-14	Florida State University	Method for preparation of taxol using an oxazinone
FR2658510B1 (fr) *	1990-02-21	1992-04-30	Rhone Poulenc Sante	Nouveau derive de la beta-phenylisoserine, sa preparation et son emploi.
FR2658513B1 (fr) *	1990-02-21	1994-02-04	Rhone Poulenc Sante	Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r).
FR2662440B1 (fr) *	1990-05-22	1992-07-31	Rhone Poulenc Sante	Procede de preparation stereoselective de derives de la phenylisoserine.
FR2662441B1 (fr) *	1990-05-22	1992-10-23	Rhone Poulenc Sante	Procede de preparation enantioselective de derives de la phenylisoserine.
US5059699A (en) *	1990-08-28	1991-10-22	Virginia Tech Intellectual Properties, Inc.	Water soluble derivatives of taxol
MX9102128A (es) *	1990-11-23	1992-07-08	Rhone Poulenc Rorer Sa	Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
FR2679230B1 (fr) *	1991-07-16	1993-11-19	Rhone Poulenc Rorer Sa	Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent.
US5227400A (en) *	1991-09-23	1993-07-13	Florida State University	Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5250683A (en) *	1991-09-23	1993-10-05	Florida State University	Certain substituted taxanes and pharmaceutical compositions containing them
FR2687151B1 (fr) *	1992-02-07	1994-03-25	Rhone Poulenc Rorer Sa	Nouveaux derives de la baccatine iii et de la desacetyl-10 baccatine iii, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5248796A (en) *	1992-06-18	1993-09-28	Bristol-Myers Squibb Company	Taxol derivatives
US5294637A (en) *	1992-07-01	1994-03-15	Bristol-Myers Squibb Company	Fluoro taxols
PL174374B1 (pl) *	1992-07-01	1998-07-31	Bristol Myers Squibb Co	Fluorotaksole
US5254580A (en) *	1993-01-19	1993-10-19	Bristol-Myers Squibb Company	7,8-cyclopropataxanes
FR2696458B1 (fr) *	1992-10-05	1994-11-10	Rhone Poulenc Rorer Sa	Procédé de préparation de dérivés du taxane.
FR2696460B1 (fr) *	1992-10-05	1994-11-25	Rhone Poulenc Rorer Sa	Procédé de préparation de dérivés du taxane.
FR2696459B1 (fr) *	1992-10-05	1994-11-25	Rhone Poulenc Rorer Sa	Procédé de préparation de dérivés du taxane.
FR2696464B1 (fr) *	1992-10-05	1994-11-10	Rhone Poulenc Rorer Sa	Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2697522B1 (fr) *	1992-10-30	1994-11-25	Rhone Poulenc Rorer Sa	Procédé de préparation de dérivés du taxane.
US5380751A (en) *	1992-12-04	1995-01-10	Bristol-Myers Squibb Company	6,7-modified paclitaxels
CA2109861C (en) *	1992-12-04	1999-03-16	Shu-Hui Chen	6,7-modified paclitaxels
FR2698871B1 (fr) *	1992-12-09	1995-02-24	Rhone Poulenc Rorer Sa	Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.

1994
- 1994-06-03 EP EP99118034A patent/EP0982302B1/en not_active Expired - Lifetime
- 1994-06-03 AT AT94920688T patent/ATE192147T1/de not_active IP Right Cessation
- 1994-06-03 NZ NZ330671A patent/NZ330671A/xx unknown
- 1994-06-03 DK DK94920688T patent/DK0703909T3/da active
- 1994-06-03 DE DE69433146T patent/DE69433146T2/de not_active Expired - Fee Related
- 1994-06-03 SI SI9430317T patent/SI0703909T1/xx unknown
- 1994-06-03 AT AT99118033T patent/ATE249448T1/de not_active IP Right Cessation
- 1994-06-03 PT PT99118033T patent/PT982301E/pt unknown
- 1994-06-03 PT PT99118034T patent/PT982302E/pt unknown
- 1994-06-03 ES ES99118034T patent/ES2219968T3/es not_active Expired - Lifetime
- 1994-06-03 AU AU71388/94A patent/AU7138894A/en not_active Abandoned
- 1994-06-03 DE DE69433715T patent/DE69433715T2/de not_active Expired - Fee Related
- 1994-06-03 ES ES94920688T patent/ES2145829T3/es not_active Expired - Lifetime
- 1994-06-03 NZ NZ268475A patent/NZ268475A/en unknown
- 1994-06-03 WO PCT/US1994/006035 patent/WO1994029288A1/en not_active Ceased
- 1994-06-03 EP EP99118033A patent/EP0982301B1/en not_active Expired - Lifetime
- 1994-06-03 PT PT94920688T patent/PT703909E/pt unknown
- 1994-06-03 JP JP7501878A patent/JPH09511212A/ja not_active Ceased
- 1994-06-03 DE DE69424166T patent/DE69424166T2/de not_active Expired - Fee Related
- 1994-06-03 DK DK99118034T patent/DK0982302T3/da active
- 1994-06-03 ES ES99118033T patent/ES2205663T3/es not_active Expired - Lifetime
- 1994-06-03 DK DK99118033T patent/DK0982301T3/da active
- 1994-06-03 US US08/557,034 patent/US5965739A/en not_active Expired - Fee Related
- 1994-06-03 CA CA002161328A patent/CA2161328A1/en not_active Abandoned
- 1994-06-03 SI SI9430464T patent/SI0982302T1/xx unknown
- 1994-06-03 AT AT99118034T patent/ATE264316T1/de not_active IP Right Cessation
- 1994-06-03 EP EP94920688A patent/EP0703909B1/en not_active Expired - Lifetime
- 1994-06-08 ZA ZA944034A patent/ZA944034B/xx unknown
- 1994-06-09 IL IL10995794A patent/IL109957A/en not_active IP Right Cessation
- 1994-06-09 TW TW083105245A patent/TW401407B/zh not_active IP Right Cessation
- 1994-06-10 US US08/258,019 patent/US5556878A/en not_active Expired - Fee Related
2000
- 2000-06-30 GR GR20000401537T patent/GR3033836T3/el not_active IP Right Cessation
2001
- 2001-04-26 LV LV010064A patent/LV12692B/xx unknown
2005
- 2005-04-14 LV LVP-05-45A patent/LV13319B/en unknown

Also Published As

Publication number	Publication date
PT982302E (pt)	2004-07-30
NZ268475A (en)	1998-08-26
DE69433715T2 (de)	2005-03-24
DE69433146D1 (de)	2003-10-16
EP0982302A3 (en)	2000-07-19
EP0982301A2 (en)	2000-03-01
DE69424166T2 (de)	2000-10-05
DE69433146T2 (de)	2004-06-09
NZ330671A (en)	2000-01-28
US5556878A (en)	1996-09-17
ZA944034B (en)	1995-12-08
US5965739A (en)	1999-10-12
EP0982302A2 (en)	2000-03-01
ATE249448T1 (de)	2003-09-15
PT703909E (pt)	2000-10-31
GR3033836T3 (en)	2000-10-31
EP0982301B1 (en)	2003-09-10
EP0703909A1 (en)	1996-04-03
SI0982302T1 (en)	2004-08-31
JPH09511212A (ja)	1997-11-11
PT982301E (pt)	2004-02-27
ES2205663T3 (es)	2004-05-01
SI0703909T1 (en)	2000-08-31
ATE264316T1 (de)	2004-04-15
EP0703909B1 (en)	2000-04-26
AU7138894A (en)	1995-01-03
CA2161328A1 (en)	1994-12-22
WO1994029288A1 (en)	1994-12-22
DK0982302T3 (da)	2004-08-02
ATE192147T1 (de)	2000-05-15
EP0982301A3 (en)	2000-11-08
IL109957A (en)	2001-01-11
IL109957A0 (en)	1994-10-07
DK0703909T3 (da)	2000-09-11
LV13319B (en)	2005-08-20
ES2219968T3 (es)	2004-12-01
DE69424166D1 (de)	2000-05-31
EP0982302B1 (en)	2004-04-14
DE69433715D1 (de)	2004-05-19
TW401407B (en)	2000-08-11
LV12692A (lv)	2001-07-20
ES2145829T3 (es)	2000-07-16
LV12692B (lv)	2001-09-20

Publication	Publication Date	Title
LV12692A (lv)	2001-07-20	Delta 6,7-taxols antineoplastic use and pharmaceutical compositions containing them
FI915282A0 (fi)	1991-11-08	Mono-n-substituerade 1,4,7,10-tetra -azacyklododekanderivat, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska aemnen.
SE9102462D0 (sv)	1991-08-28	New isosteric peptides
FI935778A0 (fi)	1993-12-21	HIV-proteasinhibitorer som aer anvaendbara foer behandling av AIDS
ATE177743T1 (de)	1999-04-15	Langkettiger carbonsäureimidester
ES2039522T3 (es)	1993-10-01	Procedimiento para preparar un nuevo benzotiazol.
DK0699191T3 (da)	1999-08-23	Sulfonamider og derivater deraf, der modulerer aktiviteten af endotelin
DE59706313D1 (de)	2002-03-21	Acylierte n-hydroxymethyl thalidomid-prodrugs mit immunomodulatorischer wirkung
FI841181A0 (fi)	1984-03-23	Nya n-fenyl-n'- cykloalkylalkanoylpiperaziner och foerfarande foer deras framstaellning.
FR2840897B1 (fr)	2004-09-10	Nouveaux derives d'arylsulfonamides et leur utilisation en therapeutique
ATE116000T1 (de)	1995-01-15	Lichtaktivierte acylenzyme.
ID23053A (id)	2000-01-20	Karboksamida yang digunakan sebagai agonis 5-ht <if>
FI932683A0 (fi)	1993-06-11	Skoetselmedel foer haorda och mjuka kontaktlinser
MY129537A (en)	2007-04-30	Amino acid ester containing azole antifungals
DE69936527D1 (de)	2007-08-23	Verwendung von modifiziertem lysozyme c in der herstellung von pharmazeutika zur krankheitsbehandlung
RU97105810A (ru)	1999-04-10	Адъюванты
DK215886A (da)	1986-11-11	1,3-oxathianderivater
ATE95172T1 (de)	1993-10-15	Cyclopropanthiocarbonsaeureamide.
ATE148343T1 (de)	1997-02-15	Spritzfertige azosemid-injektionslösungen
JPS56142260A (en)	1981-11-06	2-azetidinone and its preparation
NO20004774D0 (no)	2000-09-25	Alifatiske aminokarboksyl- og aminofosfonsyrer, aminonitriler og aminotetrazoler som cellulære redningsmidler
TH28211B (th)	1998-03-25	อนุพันธ์ของคาร์บอกซิลิค แอซิดชนิดใหม่ การเตรียมและการใช้สารเหล่านี้