DK0982307T3 - 9-Amino- og 9-nitro-camptothecin derivater, fremgangsmåde til deres fremstilling og anvendelse som antitumormidler - Google Patents

9-Amino- og 9-nitro-camptothecin derivater, fremgangsmåde til deres fremstilling og anvendelse som antitumormidler

Info

Publication number: DK0982307T3
Authority: DK; Denmark
Prior art keywords: formula; compound; chem; amino; nitro
Prior art date: 1993-09-28

Application number

DK99202203T

Other languages

Danish (da)

English (en)

Inventor

Walter Cabri

Ilaria Candiani

Franco Zarini

Angelo Bedeschi

Sergio Penco

Original Assignee

Pharmacia Italia Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-28

Filing date

1994-09-15

Publication date

2003-03-24

1994-09-15 Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa

2003-03-24 Application granted granted Critical

2003-03-24 Publication of DK0982307T3 publication Critical patent/DK0982307T3/da

Links

FUXVKZWTXQUGMW-FQEVSTJZSA-N 9-Aminocamptothecin Chemical group C1=CC(N)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 FUXVKZWTXQUGMW-FQEVSTJZSA-N 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
239000002246 antineoplastic agent Substances 0.000 title 1
VHXNKPBCCMUMSW-FQEVSTJZSA-N rubitecan Chemical class C1=CC([N+]([O-])=O)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VHXNKPBCCMUMSW-FQEVSTJZSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 8
230000000259 anti-tumor effect Effects 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000000802 nitrating effect Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F23—COMBUSTION APPARATUS; COMBUSTION PROCESSES
- F23C—METHODS OR APPARATUS FOR COMBUSTION USING FLUID FUEL OR SOLID FUEL SUSPENDED IN A CARRIER GAS OR AIR
- F23C5/00—Disposition of burners with respect to the combustion chamber or to one another; Mounting of burners in combustion apparatus
- F23C5/02—Structural details of mounting

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Combustion & Propulsion (AREA)
Mechanical Engineering (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Oncology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK99202203T 1993-09-28 1994-09-15 9-Amino- og 9-nitro-camptothecin derivater, fremgangsmåde til deres fremstilling og anvendelse som antitumormidler DK0982307T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939319944A GB9319944D0 (en)	1993-09-28	1993-09-28	Process for the preparation of 9-amino camptothecin

Publications (1)

Publication Number	Publication Date
DK0982307T3 true DK0982307T3 (da)	2003-03-24

Family

ID=10742611

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK99202203T DK0982307T3 (da)	1993-09-28	1994-09-15	9-Amino- og 9-nitro-camptothecin derivater, fremgangsmåde til deres fremstilling og anvendelse som antitumormidler
DK94927618T DK0670839T3 (da)	1993-09-28	1994-09-15	Fremgangsmåde til fremstilling af 9-aminocamptothecin

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK94927618T DK0670839T3 (da)	1993-09-28	1994-09-15	Fremgangsmåde til fremstilling af 9-aminocamptothecin

Country Status (21)

Country	Link
US (2)	US5614628A (fr)
EP (2)	EP0670839B1 (fr)
JP (3)	JP3754068B2 (fr)
KR (1)	KR950704323A (fr)
CN (2)	CN1046283C (fr)
AT (2)	ATE189221T1 (fr)
AU (1)	AU676089B2 (fr)
CA (1)	CA2150382C (fr)
DE (2)	DE69422795T2 (fr)
DK (2)	DK0982307T3 (fr)
ES (2)	ES2144059T3 (fr)
FI (1)	FI952549A7 (fr)
GB (1)	GB9319944D0 (fr)
GR (1)	GR3033197T3 (fr)
HU (1)	HUT71267A (fr)
IL (3)	IL111066A (fr)
MY (1)	MY131618A (fr)
PT (2)	PT670839E (fr)
RU (1)	RU2137774C1 (fr)
WO (1)	WO1995009169A1 (fr)
ZA (1)	ZA947522B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9319944D0 (en) *	1993-09-28	1993-11-17	Erba Carlo Spa	Process for the preparation of 9-amino camptothecin
GB9410388D0 (en) *	1994-05-24	1994-07-13	Erba Carlo Spa	Method for the preparation of 9-amino camptothecin
TW438775B (en) *	1995-04-07	2001-06-07	Pharmacia & Upjohn Co Llc	Novel intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds
US6504029B1 (en) *	1995-04-10	2003-01-07	Daiichi Pharmaceutical Co., Ltd.	Condensed-hexacyclic compounds and a process therefor
GB9510716D0 (en) *	1995-05-26	1995-07-19	Pharmacia Spa	Substituted camptothecin derivatives and process for their preparation
GB9600438D0 (en) *	1996-01-10	1996-03-13	Pharmacia Spa	Hexacyclic camptothecin analogues, and process for preparing them
US5731316A (en) *	1996-01-30	1998-03-24	The Stehlin Foundation For Cancer Research	Derivatives of camptothecin and methods of treating cancer using these derivatives
GB9601779D0 (en) *	1996-01-30	1996-04-03	Pharmacia Spa	9, 10 Disubstituted camptothecin derivatives
US6395541B1 (en)	1996-05-23	2002-05-28	The Rockefeller University	Methods for the identification of compounds capable of inhibiting HIV-1 viral replication employing murine cell lines expressing human topoisomerase I
GB9702807D0 (en)	1997-02-12	1997-04-02	Pharmacia & Upjohn Spa	Alkynyl-substituted camptothecins and process for their preparation
GB9715821D0 (en) *	1997-07-25	1997-10-01	Pharmacia & Upjohn Spa	Amidino-camptothecin derivatives
USRE38408E1 (en)	1997-08-05	2004-01-27	The Stehlin Foundation For Cancer Research	Methods of preparing and purifying 9-nitro-20-camptothecin
US5922877A (en) *	1997-08-05	1999-07-13	The Stehlin Foundation For Cancer Research	Methods of preparing and purifying 9-nitro-20-camptothecin
AU775373B2 (en)	1999-10-01	2004-07-29	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6756381B2 (en) *	2002-02-21	2004-06-29	Supergen, Inc.	Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use thereof
CN100334089C (zh) *	2004-07-21	2007-08-29	王洋	一种9－硝基喜树碱的生产方法
US20060135546A1 (en) *	2004-12-16	2006-06-22	Jagadevappa Basavaraja	Methods for the purification of 20(S)- camptothecin
CN1312155C (zh) *	2005-01-21	2007-04-25	华东理工大学	一种分离纯化9－硝基喜树碱的方法
CN102470237A (zh)	2009-06-26	2012-05-23	塔里斯生物医药公司	用于可植入药物递送装置的固体药物片剂
JP2024033912A (ja) *	2022-08-31	2024-03-13	トヨタ自動車株式会社	銀ナノ粒子の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5053512A (en) *	1987-04-14	1991-10-01	Research Triangle Institute	Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US4981968A (en) *	1987-03-31	1991-01-01	Research Triangle Institute	Synthesis of camptothecin and analogs thereof
US4894456A (en) *	1987-03-31	1990-01-16	Research Triangle Institute	Synthesis of camptothecin and analogs thereof
GB9316352D0 (en) *	1993-08-06	1993-09-22	Erba Carlo Spa	Process for the preparation of 9-amino camptothecin
GB9319944D0 (en) *	1993-09-28	1993-11-17	Erba Carlo Spa	Process for the preparation of 9-amino camptothecin
GB9402934D0 (en) *	1994-02-16	1994-04-06	Erba Carlo Spa	Camptothecin derivatives and process for their preparation

1993
- 1993-09-28 GB GB939319944A patent/GB9319944D0/en active Pending
1994
- 1994-09-15 DK DK99202203T patent/DK0982307T3/da active
- 1994-09-15 AT AT94927618T patent/ATE189221T1/de not_active IP Right Cessation
- 1994-09-15 AU AU76969/94A patent/AU676089B2/en not_active Ceased
- 1994-09-15 FI FI952549A patent/FI952549A7/fi unknown
- 1994-09-15 RU RU95112485A patent/RU2137774C1/ru active
- 1994-09-15 KR KR1019950702120A patent/KR950704323A/ko not_active Ceased
- 1994-09-15 DE DE69422795T patent/DE69422795T2/de not_active Expired - Fee Related
- 1994-09-15 CN CN94190731A patent/CN1046283C/zh not_active Expired - Fee Related
- 1994-09-15 ES ES94927618T patent/ES2144059T3/es not_active Expired - Lifetime
- 1994-09-15 DE DE69431856T patent/DE69431856T2/de not_active Expired - Fee Related
- 1994-09-15 PT PT94927618T patent/PT670839E/pt unknown
- 1994-09-15 DK DK94927618T patent/DK0670839T3/da active
- 1994-09-15 AT AT99202203T patent/ATE229022T1/de not_active IP Right Cessation
- 1994-09-15 PT PT99202203T patent/PT982307E/pt unknown
- 1994-09-15 HU HU9501898A patent/HUT71267A/hu unknown
- 1994-09-15 JP JP51008495A patent/JP3754068B2/ja not_active Expired - Fee Related
- 1994-09-15 CA CA002150382A patent/CA2150382C/fr not_active Expired - Fee Related
- 1994-09-15 EP EP94927618A patent/EP0670839B1/fr not_active Expired - Lifetime
- 1994-09-15 EP EP99202203A patent/EP0982307B1/fr not_active Expired - Lifetime
- 1994-09-15 WO PCT/EP1994/003098 patent/WO1995009169A1/fr not_active Ceased
- 1994-09-15 ES ES99202203T patent/ES2189345T3/es not_active Expired - Lifetime
- 1994-09-26 IL IL11106694A patent/IL111066A/xx not_active IP Right Cessation
- 1994-09-26 IL IL12007394A patent/IL120073A/xx not_active IP Right Cessation
- 1994-09-27 ZA ZA947522A patent/ZA947522B/xx unknown
- 1994-09-28 MY MYPI94002582A patent/MY131618A/en unknown
- 1994-09-28 US US08/313,906 patent/US5614628A/en not_active Expired - Fee Related
1996
- 1996-12-31 US US08/775,605 patent/US5916897A/en not_active Expired - Fee Related
1997
- 1997-01-24 IL IL12007397A patent/IL120073A0/xx unknown
1999
- 1999-01-06 CN CN99100920A patent/CN1273974A/zh active Pending
2000
- 2000-04-12 GR GR20000400891T patent/GR3033197T3/el not_active IP Right Cessation
2004
- 2004-07-14 JP JP2004206842A patent/JP2005036004A/ja not_active Withdrawn
- 2004-07-14 JP JP2004206841A patent/JP2005036003A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
RU95112485A (ru)	1997-04-20
IL120073A (en)	1999-07-14
DK0670839T3 (da)	2002-12-23
GR3033197T3 (en)	2000-08-31
CN1046283C (zh)	1999-11-10
FI952549A7 (fi)	1995-07-21
JPH08506834A (ja)	1996-07-23
IL120073A0 (en)	1997-04-15
DE69422795D1 (de)	2000-03-02
RU2137774C1 (ru)	1999-09-20
IL111066A (en)	1999-12-31
CN1115181A (zh)	1996-01-17
US5614628A (en)	1997-03-25
JP3754068B2 (ja)	2006-03-08
KR950704323A (ko)	1995-11-17
GB9319944D0 (en)	1993-11-17
JP2005036004A (ja)	2005-02-10
PT982307E (pt)	2003-04-30
AU676089B2 (en)	1997-02-27
ATE189221T1 (de)	2000-02-15
CA2150382C (fr)	2006-12-05
ATE229022T1 (de)	2002-12-15
EP0670839B1 (fr)	2000-01-26
PT670839E (pt)	2000-05-31
IL111066A0 (en)	1994-12-29
CA2150382A1 (fr)	1995-04-06
EP0982307B1 (fr)	2002-12-04
EP0982307A2 (fr)	2000-03-01
EP0670839A1 (fr)	1995-09-13
US5916897A (en)	1999-06-29
DE69431856T2 (de)	2003-08-21
AU7696994A (en)	1995-04-18
MY131618A (en)	2007-08-30
FI952549A0 (fi)	1995-05-24
HU9501898D0 (en)	1995-08-28
EP0982307A3 (fr)	2000-07-26
WO1995009169A1 (fr)	1995-04-06
ES2144059T3 (es)	2000-06-01
DE69422795T2 (de)	2000-07-20
CN1273974A (zh)	2000-11-22
ES2189345T3 (es)	2003-07-01
JP2005036003A (ja)	2005-02-10
DE69431856D1 (de)	2003-01-16
HUT71267A (en)	1995-11-28
ZA947522B (en)	1995-05-29

Publication	Publication Date	Title
DK0982307T3 (da)	2003-03-24	9-Amino- og 9-nitro-camptothecin derivater, fremgangsmåde til deres fremstilling og anvendelse som antitumormidler
NO882785L (no)	1988-12-27	Heksacyklisk forbindelse.
DOP2002000333A (es)	2002-09-30	Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz
PT94085A (pt)	1991-01-08	Processo para a preparacao de derivados de amino-fenol anti-inflamatorios
NO890567D0 (no)	1989-02-09	Anthracyklin-derivater.
DK0393493T3 (da)	1996-04-15	Fluorerede galdesyrederivater, fremgangsmåder til fremstilling heraf og farmaceutiske midler, som indeholder dem
NZ514662A (en)	2004-01-30	Amine derivatives
ES513420A0 (es)	1983-04-01	"procedimiento para preparar derivados de 2-oxoazetidina".
YU54189A (en)	1990-12-31	Process for obtaining cephem derivatives and midproducts for the same
ATE63921T1 (de)	1991-06-15	6-amino-anthracycline, verfahren zu ihrer herstellung und ihre verwendung.
HUT49887A (en)	1989-11-28	Process for producing new cefem compounds
CA2145514A1 (fr)	1995-02-16	Methode de preparation de 9-aminocamptothecine
FI96862B (fi)	1996-05-31	Analogiamenetelmä terapeuttisesti käyttökelpoisten oksadiatsolyylifenoksialkyyli-isoksatsolijohdannaisten valmistamiseksi
CA2282254A1 (fr)	1998-08-27	Hydroxyazepanes servant d'inhibiteurs de la glycosidase et de la vih-protease
JPS5610150A (en)	1981-02-02	Preparation of nitrotoluene derivative
CA2362632A1 (fr)	1990-06-29	R-substitue-2 ou 3-aminomethyle-4-amino-3,4-dihydro-2h-1,4-benzoxazines comme intermediaires pour produire des agents analgesiques