DK1008588T3 - 11,15-O-dialkylprostaglandin E derivater, fremgangsmåder til fremstilling deraf og farmaceutiske sammensætninger, der omfatter dem som virksom bestanddel - Google Patents

11,15-O-dialkylprostaglandin E derivater, fremgangsmåder til fremstilling deraf og farmaceutiske sammensætninger, der omfatter dem som virksom bestanddel

Info

Publication number
DK1008588T3
DK1008588T3 DK98901576T DK98901576T DK1008588T3 DK 1008588 T3 DK1008588 T3 DK 1008588T3 DK 98901576 T DK98901576 T DK 98901576T DK 98901576 T DK98901576 T DK 98901576T DK 1008588 T3 DK1008588 T3 DK 1008588T3
Authority
DK
Denmark
Prior art keywords
derivatives
processes
preparation
active ingredient
pharmaceutical compositions
Prior art date
Application number
DK98901576T
Other languages
Danish (da)
English (en)
Inventor
Shuichi Ono Pharm Co Ohuchida
Takayuki Ono Pharm Co Maruyama
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Application granted granted Critical
Publication of DK1008588T3 publication Critical patent/DK1008588T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK98901576T 1997-02-10 1998-02-10 11,15-O-dialkylprostaglandin E derivater, fremgangsmåder til fremstilling deraf og farmaceutiske sammensætninger, der omfatter dem som virksom bestanddel DK1008588T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4157197 1997-02-10
PCT/JP1998/000544 WO1998034916A1 (fr) 1997-02-10 1998-02-10 Derives de 11,15-o-dialkylprostaglandine e, leur procede de production, et medicaments renfermant ceux-ci comme principe actif

Publications (1)

Publication Number Publication Date
DK1008588T3 true DK1008588T3 (da) 2003-07-28

Family

ID=12612138

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98901576T DK1008588T3 (da) 1997-02-10 1998-02-10 11,15-O-dialkylprostaglandin E derivater, fremgangsmåder til fremstilling deraf og farmaceutiske sammensætninger, der omfatter dem som virksom bestanddel

Country Status (10)

Country Link
US (1) US6288119B1 (fr)
EP (1) EP1008588B1 (fr)
JP (1) JP4044967B2 (fr)
KR (1) KR20000070903A (fr)
AT (1) ATE237587T1 (fr)
DE (1) DE69813571T2 (fr)
DK (1) DK1008588T3 (fr)
ES (1) ES2196527T3 (fr)
PT (1) PT1008588E (fr)
WO (1) WO1998034916A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE281432T1 (de) 1999-03-05 2004-11-15 Univ Duke C-16 ungesätigte fp-selektive prostaglandin analoge
US6894175B1 (en) 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20060128810A1 (en) * 2002-10-10 2006-06-15 Kyoto University Remedies for allergic diseases
ES2584606T3 (es) 2002-10-10 2016-09-28 Ono Pharmaceutical Co., Ltd. Microesferas que comprenden ONO-1301
WO2004074842A2 (fr) * 2003-02-24 2004-09-02 Bayer Healthcare Ag Diagnostics et therapies de maladies associees au recepteur de la prostaglandine e2 ep3 (prostaglandine e2 ep3) lie a la proteine g
US20070167403A1 (en) * 2003-04-03 2007-07-19 Yoshifumi Takenobu Remedy for spinal canal stenosis
EP2422814A1 (fr) 2003-07-25 2012-02-29 Ono Pharmaceutical Co., Ltd. Remède pour maladies associées aux cartilages
EP1707208A4 (fr) * 2003-12-05 2010-03-17 Ono Pharmaceutical Co Promoteur du flux sanguin dans les tissus de la queue de cheval
WO2005080367A1 (fr) 2004-02-12 2005-09-01 Pharmagene Laboratories Limited Agonistes des recepteurs ep2
AR053710A1 (es) * 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
AR056968A1 (es) * 2005-04-11 2007-11-07 Xenon Pharmaceuticals Inc Compuestos espiro-oxindol y composiciones farmacéuticas
RU2420316C2 (ru) 2005-06-03 2011-06-10 Оно Фармасьютикал Ко., Лтд. Агент для регенерации и/или защиты нервов
CA2618486A1 (fr) 2005-08-09 2007-02-15 Asterand Uk Limited Agonistes des recepteurs ep2
LT1976828T (lt) 2005-12-29 2017-04-25 Celtaxsys, Inc. Diamino dariniai, kaip leukotrieno a4 hidrolazės inhibitoriai
US20110294842A9 (en) * 2006-10-12 2011-12-01 Xenon Pharmaceuticals Inc. Spiro (furo [3, 2-c] pyridine-3-3' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain
WO2008060789A2 (fr) 2006-10-12 2008-05-22 Xenon Pharmaceuticals Inc. Utilisation de composés de spiro-oxindole comme agents thérapeutiques
EP2220057A4 (fr) 2007-11-14 2011-10-12 Cayman Chem Co Analogues de prostaglandine e1 et e2 pour le traitement de diverses affections médicales
JO3032B1 (ar) * 2008-10-17 2016-09-05 Xenon Pharmaceuticals Inc مركبات سبيرو – اوكسندول وإستعمالاتها كعوامل علاجية.
CA2741024A1 (fr) * 2008-10-17 2010-04-22 Xenon Pharmaceuticals Inc. Composes spiro-oxindole et leur utilisation comme agents therapeutiques
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
BRPI1013152B1 (pt) 2009-06-10 2019-06-18 Ono Pharmaceutical Co., Ltd. Composto, composição farmacêutica e medicamento que tem atividade de contração muscular destrusora e atividade muscular relaxante dos esfincteres uretais
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
US20110086899A1 (en) * 2009-10-14 2011-04-14 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
KR20120099429A (ko) 2009-10-14 2012-09-10 제논 파마슈티칼스 인크. 스피로-옥스인돌 화합물의 합성 방법
WO2011106729A2 (fr) 2010-02-26 2011-09-01 Xenon Pharmaceuticals Inc. Compositions pharmaceutiques de composé spiro-oxindole pour administration topique et leur utilisation en tant qu'agents thérapeutiques.
HK1205114A1 (en) 2012-04-12 2015-12-11 Xenon Pharmaceuticals Inc. Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents
PL2891651T3 (pl) 2012-08-31 2017-08-31 Ono Pharmaceutical Co., Ltd. Sól aminy i jej kryształy
CA2906035A1 (fr) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibiteurs de la leucotriene a4 hydrolase
EP2818484A1 (fr) 2013-06-28 2014-12-31 Universitat Autònoma de Barcelona Combinaison synergique d'un anticorps anti-IgE et d'un agoniste du récepteur EP2
WO2016127068A1 (fr) 2015-02-05 2016-08-11 Teva Pharmaceuticals International Gmbh Procédés de traitement d'une névralgie post-herpétique à l'aide d'une formule topique d'un composé de spiro-oxindole
US10100060B2 (en) 2016-06-16 2018-10-16 Xenon Pharmaceuticals Inc. Asymmetric synthesis of funapide
AU2017371348B2 (en) 2016-12-09 2022-02-03 Celltaxis, Llc Inhibitors of leukotriene A4 hydrolase
US10385007B2 (en) 2016-12-09 2019-08-20 Celtaxsys, Inc. Monamine and monoamine derivatives as inhibitors of leukotriene A4 hydrolase
US10202334B2 (en) 2016-12-09 2019-02-12 Celtaxsys, Inc. Pendant amines and derivatives as inhibitors of leukotriene A4 hydrolase

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US3835180A (en) * 1971-05-04 1974-09-10 Upjohn Co 15 alkoxy pge compounds
US3876690A (en) * 1973-05-11 1975-04-08 American Cyanamid Co 1-alkoxy-9-keto-prostenoic acid derivatives
GB1451798A (en) * 1973-08-02 1976-10-06 Ici Ltd Prostanoic acid derivatives
US4236027A (en) * 1977-10-17 1980-11-25 American Cyanamid Company Novel 11-alkoxy-9-keto (or hydroxy)-prostenoic acid derivatives and method for preparing same
JPS55115836A (en) * 1979-03-02 1980-09-06 Toray Ind Inc Preparation of methyl ether derivative
DE3510978A1 (de) * 1985-03-22 1986-09-25 Schering AG, Berlin und Bergkamen, 1000 Berlin Neue 9-halogenprostaglandine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPH03101622A (ja) * 1989-09-11 1991-04-26 Green Cross Corp:The 肝炎予防治療剤

Also Published As

Publication number Publication date
ATE237587T1 (de) 2003-05-15
DE69813571D1 (de) 2003-05-22
EP1008588A4 (fr) 2000-06-14
EP1008588A1 (fr) 2000-06-14
JP4044967B2 (ja) 2008-02-06
ES2196527T3 (es) 2003-12-16
DE69813571T2 (de) 2004-02-12
EP1008588B1 (fr) 2003-04-16
KR20000070903A (ko) 2000-11-25
US6288119B1 (en) 2001-09-11
PT1008588E (pt) 2003-09-30
WO1998034916A1 (fr) 1998-08-13

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