DK1009436T3 - Acridinderivat til forøgelse af taxols orale biotilgængelighed - Google Patents

Acridinderivat til forøgelse af taxols orale biotilgængelighed

Info

Publication number: DK1009436T3
Authority: DK; Denmark
Prior art keywords: taxol; increasing; oral bioavailability; acridine derivative; acridine
Prior art date: 1997-09-05

Application number

DK98947501T

Other languages

Danish (da)

English (en)

Inventor

Jan H M Schellens

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-05

Filing date

1998-09-03

Publication date

2004-03-08

1998-09-03 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2004-03-08 Application granted granted Critical

2004-03-08 Publication of DK1009436T3 publication Critical patent/DK1009436T3/da

Links

229930012538 Paclitaxel Natural products 0.000 title abstract 2
229960001592 paclitaxel Drugs 0.000 title abstract 2
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 2
125000000641 acridinyl group Chemical class C1(=CC=CC2=NC3=CC=CC=C3C=C12)* 0.000 title 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oil, Petroleum & Natural Gas (AREA)
Tropical Medicine & Parasitology (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines Containing Plant Substances (AREA)

DK98947501T 1997-09-05 1998-09-03 Acridinderivat til forøgelse af taxols orale biotilgængelighed DK1009436T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9718903.9A GB9718903D0 (en)	1997-09-05	1997-09-05	Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents
PCT/EP1998/005557 WO1999012570A2 (fr)	1997-09-05	1998-09-03	Procede, compositions et trousses servant a augmenter la biodisponibilite orale d'agents pharmaceutiques

Publications (1)

Publication Number	Publication Date
DK1009436T3 true DK1009436T3 (da)	2004-03-08

Family

ID=10818634

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98947501T DK1009436T3 (da)	1997-09-05	1998-09-03	Acridinderivat til forøgelse af taxols orale biotilgængelighed

Country Status (15)

Country	Link
US (2)	US6469022B1 (fr)
EP (1)	EP1009436B1 (fr)
JP (2)	JP4516688B2 (fr)
KR (1)	KR100579030B1 (fr)
AT (1)	ATE253360T1 (fr)
AU (1)	AU751085B2 (fr)
BR (1)	BR9812179A (fr)
CA (1)	CA2302568C (fr)
DE (1)	DE69819525T2 (fr)
DK (1)	DK1009436T3 (fr)
ES (1)	ES2210823T3 (fr)
GB (1)	GB9718903D0 (fr)
PT (1)	PT1009436E (fr)
TR (1)	TR200000586T2 (fr)
WO (1)	WO1999012570A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6964946B1 (en)	1995-10-26	2005-11-15	Baker Norton Pharmaceuticals, Inc.	Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same
CN1261275A (zh) *	1997-05-27	2000-07-26	巴克·诺顿药物有限公司	给予病人口服紫杉烷类药物的方法和组合物
GB9718903D0 (en) *	1997-09-05	1997-11-12	Glaxo Group Ltd	Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents
GB9812189D0 (en) *	1998-06-05	1998-08-05	Glaxo Group Ltd	Methods and compositions for increasing penetration of HIV protease inhibitors
DE60030283T2 (de) *	1999-05-17	2007-09-20	Cancer Research Ventures Ltd.	Zusammensetzungen zur erhöhung der bioverfügbarkeit von oral verabreichten pharmazeutischen verbindungen
EP1479382A1 (fr) *	1999-06-18	2004-11-24	IVAX Research, Inc.	Compositions pharmaceutiques orales contenant des taxanes et méthodes de traitement dans lesquelles lesdites compositions sont utilisées
JP2003512443A (ja) *	1999-10-27	2003-04-02	ベーカーノートンファーマシューティカルズインコーポレイテッド	タキサンをヒト患者に経口投与するための方法及び組成物
US6887842B1 (en)	1999-11-19	2005-05-03	The Board Of Trustees Of The Leland Stanford Junior University	Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
ES2622471T5 (es)	2003-05-22	2020-07-23	United Therapeutics Corp	Compuestos y procedimientos para la administración de análogos de prostaciclina
WO2005099680A2 (fr) *	2004-04-12	2005-10-27	United Therapeutics, Inc.	Utilisation de treprostinile pour traiter des ulceres diabetiques neuropathiques du pied
US8518022B2 (en)	2004-08-27	2013-08-27	Medimetrics Personalized Drug Delivery, Inc.	Electronically and remotely controlled pill and system for delivering at least one medicament
US20090234331A1 (en) *	2004-11-29	2009-09-17	Koninklijke Philips Electronics, N.V.	Electronically controlled pill and system having at least one sensor for delivering at least one medicament
US20100331827A1 (en) *	2008-02-18	2010-12-30	Koninklijke Philips Electronics N.V.	Administration of drugs to a patient
WO2009122323A1 (fr) *	2008-03-31	2009-10-08	Koninklijke Philips Electronics N.V.	Procédé de préparation d'une capsule avalable comprenant un détecteur
JP5500600B2 (ja)	2008-06-19	2014-05-21	コーニンクレッカフィリップスエヌヴェ	湿った環境における粉状薬物の供給のためのデバイス
RU2011102576A (ru) *	2008-06-25	2012-07-27	Конинклейке Филипс Электроникс Н.В. (Nl)	Электронная таблетка, содержащая множество емкостей с лекарственным средствами
JP5497176B2 (ja)	2009-08-12	2014-05-21	コーニンクレッカフィリップスエヌヴェ	圧縮可能な薬品貯槽を備える薬品送出装置
JP2016517410A (ja)	2013-03-14	2016-06-16	ユナイテッドセラピューティクスコーポレイション	トレプロスチニルの固体形態
WO2015035218A1 (fr) *	2013-09-05	2015-03-12	Howard University	Procédé renforçant la biodisponibilité d'un médicament anti-vih
TWI838700B (zh) *	2015-09-30	2024-04-11	香港商慧源香港創新有限公司	口服紫杉烷組合物及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100220538B1 (ko)	1991-01-11	1999-09-15	뮈쉘 쥐르밀	아크리딘 유도체
US6245805B1 (en)	1995-10-26	2001-06-12	Baker Norton Pharmaceuticals, Inc.	Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
CN1261275A (zh) *	1997-05-27	2000-07-26	巴克·诺顿药物有限公司	给予病人口服紫杉烷类药物的方法和组合物
GB9718903D0 (en) *	1997-09-05	1997-11-12	Glaxo Group Ltd	Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents
DE60030283T2 (de) *	1999-05-17	2007-09-20	Cancer Research Ventures Ltd.	Zusammensetzungen zur erhöhung der bioverfügbarkeit von oral verabreichten pharmazeutischen verbindungen

1997
- 1997-09-05 GB GBGB9718903.9A patent/GB9718903D0/en active Pending
1998
- 1998-09-03 AT AT98947501T patent/ATE253360T1/de active
- 1998-09-03 ES ES98947501T patent/ES2210823T3/es not_active Expired - Lifetime
- 1998-09-03 JP JP2000510467A patent/JP4516688B2/ja not_active Expired - Fee Related
- 1998-09-03 TR TR2000/00586T patent/TR200000586T2/xx unknown
- 1998-09-03 KR KR1020007002323A patent/KR100579030B1/ko not_active Expired - Fee Related
- 1998-09-03 US US09/486,938 patent/US6469022B1/en not_active Expired - Fee Related
- 1998-09-03 DE DE69819525T patent/DE69819525T2/de not_active Expired - Lifetime
- 1998-09-03 EP EP98947501A patent/EP1009436B1/fr not_active Expired - Lifetime
- 1998-09-03 BR BR9812179-0A patent/BR9812179A/pt not_active Application Discontinuation
- 1998-09-03 WO PCT/EP1998/005557 patent/WO1999012570A2/fr not_active Ceased
- 1998-09-03 AU AU94394/98A patent/AU751085B2/en not_active Ceased
- 1998-09-03 PT PT98947501T patent/PT1009436E/pt unknown
- 1998-09-03 CA CA2302568A patent/CA2302568C/fr not_active Expired - Fee Related
- 1998-09-03 DK DK98947501T patent/DK1009436T3/da active
2002
- 2002-09-03 US US10/233,864 patent/US6803373B2/en not_active Expired - Fee Related
2009
- 2009-11-10 JP JP2009257246A patent/JP2010059185A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
KR100579030B1 (ko)	2006-05-12
US6803373B2 (en)	2004-10-12
CA2302568C (fr)	2010-06-22
AU751085B2 (en)	2002-08-08
EP1009436A2 (fr)	2000-06-21
US6469022B1 (en)	2002-10-22
KR20010023670A (ko)	2001-03-26
PT1009436E (pt)	2004-03-31
BR9812179A (pt)	2000-07-18
DE69819525D1 (de)	2003-12-11
AU9439498A (en)	1999-03-29
WO1999012570A3 (fr)	1999-08-19
ATE253360T1 (de)	2003-11-15
US20030013731A1 (en)	2003-01-16
CA2302568A1 (fr)	1999-03-18
JP2001515872A (ja)	2001-09-25
TR200000586T2 (tr)	2000-09-21
ES2210823T3 (es)	2004-07-01
GB9718903D0 (en)	1997-11-12
WO1999012570A2 (fr)	1999-03-18
DE69819525T2 (de)	2004-09-23
EP1009436B1 (fr)	2003-11-05
JP2010059185A (ja)	2010-03-18
JP4516688B2 (ja)	2010-08-04

Publication	Publication Date	Title
DK1009436T3 (da)	2004-03-08	Acridinderivat til forøgelse af taxols orale biotilgængelighed
DE60032780D1 (de)	2007-02-15	Tetrahydroquinolin-derivate
NO20012617L (no)	2001-09-14	Kinolin- og kinzolinderivater
DK1066269T3 (da)	2005-09-05	Trisubstituerede 1,3,5-triazinderivater til behandling af HIV-infektioner
DK0778277T3 (da)	2003-10-27	Substituerede heterocycliske derivater som CRF antagonister
DE69907964D1 (de)	2003-06-18	1,2-annelierte chinolinderivate
DK0851855T3 (da)	2002-09-23	Derivater af melatonin deraf som lægemiddel
NO20011350L (no)	2001-05-09	4-Karboksyaminosubstituerte 1,2,3,4-tetrahydrokinoliner som CETP inhibitorer
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
BR9912104B1 (pt)	2010-07-13	compostos derivados de quinolina, composições farmacêuticas, e, processo para a manufatura de um composto.
NO20022558D0 (no)	2002-05-29	4-karboksyamino-2-etyl-1,2,3,4-tetrahydrokinolinkrystall som CETP inhibitor
TR200403436T2 (tr)	2005-03-21	Kristalin 1-metilkarbapenem türevleri.
BR9609849B1 (pt)	2010-05-18	derivados de 2-(4-substituìda) -benzilamino-2-metila-propanamida.
EP1029860A4 (fr)	2001-09-19	Derives de benzofuranne
DE60027144D1 (de)	2006-05-18	Hydroxamsäure-derivate
DK1847534T3 (da)	2011-08-29	Thiadiazolin-derivater til behandling af kræft
BR0210746A (pt)	2004-07-20	Derivados de 6-'2-(fosfonometóxi)alcóxi-pirimidina tendo atividade antiviral
DK1059283T3 (da)	2003-09-15	Fremgangsmåde til fremstilling af neuraminidase-inhibitor ro-64-0796
DZ1576A1 (fr)	2002-02-17	Compostions therapeutiques à base de dérives de 1,2-dithiole-3-thione.
ATE255554T1 (de)	2003-12-15	Cyclopentenonderivate
EP0816366A4 (fr)	1998-07-08	Composes imidazothiazole
NO20006350D0 (no)	2000-12-13	Derivater av 3-(2-okso-[1,3']bipyrrolidinyl-3-ylidenmetyl)- cephemer
ATE165083T1 (de)	1998-05-15	N-arylalkylphenylacetamidderivate
AR027349A1 (es)	2003-03-26	Derivados de amidas heterociclicas
TW346483B (en)	1998-12-01	Benzene derivatives