DK1009834T3 - Regulering af proteinsekretion - Google Patents

Regulering af proteinsekretion

Info

Publication number
DK1009834T3
DK1009834T3 DK98941592T DK98941592T DK1009834T3 DK 1009834 T3 DK1009834 T3 DK 1009834T3 DK 98941592 T DK98941592 T DK 98941592T DK 98941592 T DK98941592 T DK 98941592T DK 1009834 T3 DK1009834 T3 DK 1009834T3
Authority
DK
Denmark
Prior art keywords
normally
regulation
mammalian
secreted
protein secretion
Prior art date
Application number
DK98941592T
Other languages
English (en)
Inventor
Albert Tauler
Ian Fraser Pryme
John Edward Hesketh
Original Assignee
Uni Targeting Res As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uni Targeting Res As filed Critical Uni Targeting Res As
Application granted granted Critical
Publication of DK1009834T3 publication Critical patent/DK1009834T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK98941592T 1997-09-05 1998-09-04 Regulering af proteinsekretion DK1009834T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9718908.8A GB9718908D0 (en) 1997-09-05 1997-09-05 Proteins
PCT/GB1998/002664 WO1999013090A1 (en) 1997-09-05 1998-09-04 Regulation of protein secretion

Publications (1)

Publication Number Publication Date
DK1009834T3 true DK1009834T3 (da) 2007-02-12

Family

ID=10818638

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98941592T DK1009834T3 (da) 1997-09-05 1998-09-04 Regulering af proteinsekretion

Country Status (10)

Country Link
US (1) US6881832B1 (da)
EP (1) EP1009834B1 (da)
JP (1) JP4436563B2 (da)
AT (1) ATE344327T1 (da)
AU (1) AU8991098A (da)
DE (1) DE69836336T2 (da)
DK (1) DK1009834T3 (da)
ES (1) ES2273435T3 (da)
GB (1) GB9718908D0 (da)
WO (1) WO1999013090A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004094592A2 (en) * 2003-04-18 2004-11-04 Biogen Idec Ma Inc. Polymer-conjugated glycosylated neublastin
GB0314856D0 (en) 2003-06-25 2003-07-30 Unitargeting Res As Protein expression system
US7598059B2 (en) 2003-10-02 2009-10-06 Biogen Idec Ma Inc. Neublastin expression constructs
KR101241551B1 (ko) 2004-08-19 2013-03-11 바이오겐 아이덱 엠에이 인코포레이티드 전환 성장 인자 베타 패밀리 단백질의 리폴딩
TWI501774B (zh) 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
US20090075925A1 (en) * 2006-11-16 2009-03-19 Smith Harold C Methods and Compositions Related to APOBEC-1 Expression
ES2476253T3 (es) 2007-05-01 2014-07-14 Biogen Idec Ma Inc. P�ptidos de neublastina para su uso en el aumento de la vascularizaci�n en tejido con flujo sanguíneo deteriorado
MX357803B (es) * 2012-03-27 2018-07-24 Curevac Ag Moléculas de ácido nucleico artificiales.
WO2013151663A1 (en) * 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of membrane proteins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3540505C2 (de) 1985-11-15 1995-11-09 Natronag Verpackung Sackfüllmaschine
AU613876B2 (en) * 1986-10-01 1991-08-15 Merck & Co., Inc. Synthetic genes encoding proteins from plasmid containing eucaryotic secretory signal peptides and process for secreting encoded proteins
EP0279582A3 (en) * 1987-02-17 1989-10-18 Pharming B.V. Dna sequences to target proteins to the mammary gland for efficient secretion
WO1991013151A1 (en) * 1990-02-22 1991-09-05 Biogen, Inc. Improved expression of polypeptides
JP3698369B2 (ja) * 1991-08-13 2005-09-21 ウィスコンシン ミルク マーケティング ボード αラクトアルブミンを符号化するＤＮＡ配列及び使用方法

Also Published As

Publication number Publication date
JP2001515725A (ja) 2001-09-25
ATE344327T1 (de) 2006-11-15
DE69836336D1 (de) 2006-12-14
JP4436563B2 (ja) 2010-03-24
EP1009834B1 (en) 2006-11-02
EP1009834A1 (en) 2000-06-21
WO1999013090A1 (en) 1999-03-18
AU8991098A (en) 1999-03-29
ES2273435T3 (es) 2007-05-01
DE69836336T2 (de) 2007-05-24
GB9718908D0 (en) 1997-11-12
US6881832B1 (en) 2005-04-19

Similar Documents

Publication Publication Date Title
DE59903410D1 (de) Hybridprotein zur hemmung der mastzelldegranulation und dessen verwendung
DE69832293D1 (de) Zubereitungen zur abgabe von negativ geladenen molekülen
EP0653940A4 (en) GLIALMITOGENIC FACTORS, THEIR PRODUCTION AND USE.
ATE335078T1 (de) Überexpression von säugetier- und virusproteinen
DK0851868T3 (da) Höjniveau-ekspression af proteiner
DK0929564T3 (da) Höjniveau-ekspression af proteiner
TR200003181T2 (tr) Gelişmiş çoğaltılabilirliğe sahip FAP alfa'ya özgü antikor
ATE275628T1 (de) Expressionssteigernde sequenzelemente (ease) für eukaryontische expressionssysteme
NO990086L (no) Avkortete, l°selige tumornekrosefaktorreseptorer av type I og type II
DE69707903D1 (de) Verwendung von zirkulatoren in zeitduplex-funksystemen
DE69630955D1 (de) Immortalisierung bzw. desimmortalisierung von zellen
WO2003065003A3 (en) Nuclear matrix protein alterations associated with colon cancer and colon metastasis to the liver, and uses thereof
ATE344327T1 (de) Regulation der ausschleusung von proteinen
WO1999025878A3 (en) Methods for modulating and identifying cellular senescence
DE69631972D1 (de) Proliferationsinhibitor von endothellzellen und dessen verwendung
DK1082423T3 (da) Cyclin E2-gener og -proteiner
FI970097A7 (fi) Proteiinit, jotka ovat peräisin nisäkkäiden maksasta ja niiden käyttö onkologiassa
DE59508100D1 (de) Verwendung von zelladhäsions-peptiden zur modifikation des haftungsvermögens eukaryontischer zellen untereinander
WO2000018909A3 (en) NUCLEIC ACIDS AND PROTEINS FROM $i(CENARCHAEUM SYMBIOSUM)
DE69734596D1 (de) "smoothened" proteine aus wirbeltieren
CA2146240A1 (en) Increased production of secreted proteins by recombinant eukaryotic cells
ATE432292T1 (de) Antitumorantikörper, proteine und deren verwendung
WO2002094992A3 (en) Directed evolution of protein in mammalian cells
ATE302282T1 (de) Erhöhte herstellung von sekretierten proteinen durch rekombinante hefezellen
WO2001032696A3 (en) Traf family proteins