DK1011717T3 - Arginin-deiminase afledt af mycoplasma-arthritidis og polymere konjugater indeholdende dette - Google Patents

Arginin-deiminase afledt af mycoplasma-arthritidis og polymere konjugater indeholdende dette

Info

Publication number: DK1011717T3
Authority: DK; Denmark
Prior art keywords: arginine deiminase; adi; mycoplasma arthritidis; seq; expressing
Prior art date: 1997-01-31

Application number

DK98903799T

Other languages

English (en)

Inventor

Maoling Wang

David Ray Filpula

Original Assignee

Enzon Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-31

Filing date

1998-01-27

Publication date

2006-05-15

1998-01-27 Application filed by Enzon Inc filed Critical Enzon Inc

2006-05-15 Application granted granted Critical

2006-05-15 Publication of DK1011717T3 publication Critical patent/DK1011717T3/da

Links

108010082340 Arginine deiminase Proteins 0.000 title abstract 7
241000202956 Mycoplasma arthritidis Species 0.000 title abstract 2
150000001413 amino acids Chemical group 0.000 abstract 2
229920000642 polymer Polymers 0.000 abstract 2
239000004475 Arginine Substances 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
241000204003 Mycoplasmatales Species 0.000 abstract 1
230000000890 antigenic effect Effects 0.000 abstract 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000013604 expression vector Substances 0.000 abstract 1
108020004707 nucleic acids Proteins 0.000 abstract 1
150000007523 nucleic acids Chemical class 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
230000000717 retained effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

DK98903799T 1997-01-31 1998-01-27 Arginin-deiminase afledt af mycoplasma-arthritidis og polymere konjugater indeholdende dette DK1011717T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/792,283 US5804183A (en)	1997-01-31	1997-01-31	Arginine deminase derived from mycoplasma arthritidis and polymer conjugates containing the same

Publications (1)

Publication Number	Publication Date
DK1011717T3 true DK1011717T3 (da)	2006-05-15

Family

ID=25156365

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98903799T DK1011717T3 (da)	1997-01-31	1998-01-27	Arginin-deiminase afledt af mycoplasma-arthritidis og polymere konjugater indeholdende dette

Country Status (9)

Country	Link
US (3)	US5804183A (da)
EP (1)	EP1011717B1 (da)
JP (1)	JP4126097B2 (da)
AT (1)	ATE314086T1 (da)
AU (1)	AU6047598A (da)
DE (1)	DE69832993T2 (da)
DK (1)	DK1011717T3 (da)
ES (1)	ES2255147T3 (da)
WO (1)	WO1998033519A1 (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6183738B1 (en) *	1997-05-12	2001-02-06	Phoenix Pharamacologics, Inc.	Modified arginine deiminase
US6635462B1 (en) *	1997-05-12	2003-10-21	Phoenix Pharmacologies, Inc.	Mutated form of arginine deiminase
WO2002044360A2 (en) *	2000-11-28	2002-06-06	Phoenix Pharmacologics, Inc.	Modified arginine deiminase
US6645739B2 (en) *	2001-07-26	2003-11-11	Phoenix Pharmacologies, Inc.	Yeast expression systems, methods of producing polypeptides in yeast, and compositions relating to same
US8129330B2 (en)	2002-09-30	2012-03-06	Mountain View Pharmaceuticals, Inc.	Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US20040062748A1 (en)	2002-09-30	2004-04-01	Mountain View Pharmaceuticals, Inc.	Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
AU2003282883B2 (en) *	2002-11-18	2008-12-04	Polaris Group	Methods for inhibiting viral replication in vivo
FR2884717B1 (fr) *	2005-04-25	2009-07-03	Erytech Pharma Soc Par Actions	Erythrocytes renfermant de l'arginine deiminase
EP2444499A3 (en)	2006-05-02	2012-05-09	Allozyne, Inc.	Amino acid substituted molecules
US20080096819A1 (en) *	2006-05-02	2008-04-24	Allozyne, Inc.	Amino acid substituted molecules
FR2919804B1 (fr)	2007-08-08	2010-08-27	Erytech Pharma	Composition et vaccin therapeutique anti-tumoral
CA2707840A1 (en) *	2007-08-20	2009-02-26	Allozyne, Inc.	Amino acid substituted molecules
JP2009044997A (ja) *	2007-08-20	2009-03-05	Sony Corp	ビリルビンオキシダーゼ（ｂｏｄ）の被覆方法
EP2295560A1 (en)	2009-09-14	2011-03-16	RWTH Aachen University	Directed evolution of arginine deiminase for increased activity at physiological pH
US9255262B2 (en) *	2013-03-06	2016-02-09	Vision Global Holdings Ltd.	Albumin-binding arginine deminase and the use thereof
USRE48805E1 (en)	2013-03-06	2021-11-02	Vision Global Holdings Ltd.	Method for cancer targeting treatment and detection of arginine using albumin-binding arginine deiminase fusion protein
EP3744341A1 (en)	2013-03-15	2020-12-02	TDW Group	Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment
KR102523031B1 (ko) *	2014-03-18	2023-04-19	티디더블유 그룹	조작된 키메라성 페길화된 adi 및 사용 방법
JP6782230B2 (ja)	2014-09-16	2020-11-11	ティーディーダブリューグループ	癌治療のためのａｄｉ−ｐｅｇ２０抗体に対する交差反応性が低減したアルギニンデイミナーゼ
EP3344575B1 (en)	2015-09-04	2020-04-15	SQZ Biotechnologies Company	Intracellular delivery of biomolecules to cells comprising a cell wall
JP7602702B2 (ja)	2016-05-03	2024-12-19	ステムセルテクノロジーズカナダインコーポレーテッド	寛容性を誘導するための生体分子の細胞内送達
TWI847958B (zh)	2016-07-05	2024-07-11	英屬開曼群島商北極星藥業集團股份有限公司	用精胺酸耗盡劑進行之組合癌症免疫療法
TWI784982B (zh)	2016-11-02	2022-12-01	開曼群島商北極星藥業集團股份有限公司	聚乙二醇化精胺酸脫亞胺酶之調配物
CA3042442C (en)	2016-11-14	2024-01-02	Hangzhou Dac Biotech Co., Ltd	Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses of such conjugates with the linkers
TWI911136B (zh)	2017-03-29	2026-01-11	開曼群島商北極星藥業集團股份有限公司	蛋白質結合物
EP3449935A1 (en)	2017-08-31	2019-03-06	Erytech Pharma	Arginine deiminase encapsulated inside erythrocytes and their use in treating cancer and arginase-1 deficiency
WO2019042628A1 (en)	2017-08-31	2019-03-07	Erytech Pharma	ARGININE DEIMINASE ENCAPSULATED WITHIN ERYTHROCYTES AND THEIR USE IN THE TREATMENT OF CANCER AND ARGINASE-1 DEFICIENCY
MX2022001425A (es) *	2019-08-01	2022-05-02	Univ North Carolina Chapel Hill	Composiciones y metodos para la union de anticuerpos y la inhibicion de anticuerpos neutralizantes.
EP3954393A1 (en)	2020-08-13	2022-02-16	Bioasis Technologies Inc.	Combination therapies for delivery across the blood brain barrier
EP4288445A1 (en) *	2021-02-03	2023-12-13	The University of North Carolina at Chapel Hill	Protein m analogs and fusion proteins and their use for inhibiting antibody function
CN117980327A (zh)	2021-11-03	2024-05-03	杭州多禧生物科技有限公司	抗体的特异性偶联

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4179337A (en) *	1973-07-20	1979-12-18	Davis Frank F	Non-immunogenic polypeptides
JPH0253490A (ja) *	1988-08-16	1990-02-22	Agency Of Ind Science & Technol	アルギニン・デイミナーゼ遺伝子
US5122614A (en) *	1989-04-19	1992-06-16	Enzon, Inc.	Active carbonates of polyalkylene oxides for modification of polypeptides
JP2900279B2 (ja) *	1989-08-02	1999-06-02	株式会社ジャパンエナジー	新規なアルギニンデイミナーゼ、その製造法及び該酵素を有効成分とする制癌剤
JP3209338B2 (ja) *	1990-09-10	2001-09-17	株式会社ジャパンエナジー	ポリエチレングリコール修飾アルギニンデイミナーゼおよびその製造法
US5372942A (en) *	1992-02-10	1994-12-13	Coriell Institute For Medical Research	Protease K resistant arginine deiminase, its method of preparation and its use as an anti-neoplastic agent
US5349001A (en) *	1993-01-19	1994-09-20	Enzon, Inc.	Cyclic imide thione activated polyalkylene oxides
US5359030A (en) *	1993-05-10	1994-10-25	Protein Delivery, Inc.	Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same

1997
- 1997-01-31 US US08/792,283 patent/US5804183A/en not_active Expired - Lifetime
1998
- 1998-01-27 AT AT98903799T patent/ATE314086T1/de not_active IP Right Cessation
- 1998-01-27 JP JP53303298A patent/JP4126097B2/ja not_active Expired - Fee Related
- 1998-01-27 EP EP98903799A patent/EP1011717B1/en not_active Expired - Lifetime
- 1998-01-27 ES ES98903799T patent/ES2255147T3/es not_active Expired - Lifetime
- 1998-01-27 AU AU60475/98A patent/AU6047598A/en not_active Abandoned
- 1998-01-27 WO PCT/US1998/001635 patent/WO1998033519A1/en not_active Ceased
- 1998-01-27 DE DE69832993T patent/DE69832993T2/de not_active Expired - Lifetime
- 1998-01-27 DK DK98903799T patent/DK1011717T3/da active
- 1998-06-26 US US09/105,908 patent/US5916793A/en not_active Expired - Lifetime
1999
- 1999-03-18 US US09/271,713 patent/US6132713A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US6132713A (en)	2000-10-17
EP1011717A4 (en)	2003-02-19
ES2255147T3 (es)	2006-06-16
US5916793A (en)	1999-06-29
ATE314086T1 (de)	2006-01-15
US5804183A (en)	1998-09-08
WO1998033519A1 (en)	1998-08-06
DE69832993D1 (de)	2006-02-02
DE69832993T2 (de)	2006-09-07
JP2001512965A (ja)	2001-08-28
AU6047598A (en)	1998-08-25
EP1011717A1 (en)	2000-06-28
EP1011717B1 (en)	2005-12-28
JP4126097B2 (ja)	2008-07-30

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