DK1019507T3 - Aminoterminalt afkortede RANTES som kemokinantagonister - Google Patents

Aminoterminalt afkortede RANTES som kemokinantagonister

Info

Publication number: DK1019507T3
Authority: DK; Denmark
Prior art keywords: amino; terminally truncated; chemokine antagonists; truncated rantes; rantes
Prior art date: 1997-09-29

Application number

DK98951476T

Other languages

English (en)

Inventor

Paul Proost

Sofie Struyf

Damme Jo Van

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-29

Filing date

1998-09-28

Publication date

2004-07-19

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8227408&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1019507(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-09-28 Application filed by Applied Research Systems filed Critical Applied Research Systems

2004-07-19 Application granted granted Critical

2004-07-19 Publication of DK1019507T3 publication Critical patent/DK1019507T3/da

Links

102000001327 Chemokine CCL5 Human genes 0.000 title 1
108010055166 Chemokine CCL5 Proteins 0.000 title 1
102000019034 Chemokines Human genes 0.000 title 1
108010012236 Chemokines Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Virology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Cardiology (AREA)
Tropical Medicine & Parasitology (AREA)
Hematology (AREA)
Diabetes (AREA)
AIDS & HIV (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DK98951476T 1997-09-29 1998-09-28 Aminoterminalt afkortede RANTES som kemokinantagonister DK1019507T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP97116863A EP0906954A1 (en)	1997-09-29	1997-09-29	Amino-terminal truncated c-c chemokines as chemokine antagonist
EP97122471A EP0905240A1 (en)	1997-09-29	1997-12-19	Amino-terminally truncated c-c chemokines as chemokine antagonists
EP98104216A EP0905241A1 (en)	1997-09-29	1998-03-10	Amino-terminally truncated c-c chemokines as chemokine antagonists

Publications (1)

Publication Number	Publication Date
DK1019507T3 true DK1019507T3 (da)	2004-07-19

Family

ID=8227408

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK98947553T DK1021541T3 (da)	1997-09-29	1998-09-28	Aminoterminalt trunkeret MCP-2 som chemokinantagonister
DK98951476T DK1019507T3 (da)	1997-09-29	1998-09-28	Aminoterminalt afkortede RANTES som kemokinantagonister
DK04007579T DK1439231T3 (da)	1997-09-29	1998-09-28	Aminoterminalt afkortede RANTES som kemokinantagonister

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK98947553T DK1021541T3 (da)	1997-09-29	1998-09-28	Aminoterminalt trunkeret MCP-2 som chemokinantagonister

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK04007579T DK1439231T3 (da)	1997-09-29	1998-09-28	Aminoterminalt afkortede RANTES som kemokinantagonister

Country Status (28)

Country	Link
US (5)	US6905676B2 (da)
EP (6)	EP0906954A1 (da)
JP (2)	JP4233214B2 (da)
KR (2)	KR100542934B1 (da)
CN (3)	CN1148447C (da)
AR (2)	AR013529A1 (da)
AT (3)	ATE264390T1 (da)
AU (2)	AU750606B2 (da)
BG (2)	BG64679B1 (da)
BR (2)	BR9812565A (da)
CA (2)	CA2304827A1 (da)
CY (1)	CY1110927T1 (da)
CZ (2)	CZ299479B6 (da)
DE (3)	DE69823218T2 (da)
DK (3)	DK1021541T3 (da)
EA (2)	EA003940B1 (da)
EE (2)	EE200000152A (da)
ES (3)	ES2218860T3 (da)
HU (2)	HU226414B1 (da)
IL (2)	IL135352A (da)
NO (2)	NO20001584L (da)
NZ (3)	NZ516027A (da)
PL (2)	PL197569B1 (da)
PT (3)	PT1021541E (da)
SK (2)	SK286495B6 (da)
UA (2)	UA73081C2 (da)
WO (2)	WO1999016876A1 (da)
ZA (2)	ZA988675B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6989435B2 (en)	1997-09-11	2006-01-24	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
US7067117B1 (en)	1997-09-11	2006-06-27	Cambridge University Technical Services, Ltd.	Compounds and methods to inhibit or augment an inflammatory response
WO1999028474A2 (en) *	1997-12-01	1999-06-10	The Government Of The United States Of America, Represented By The Secretary Of Health And Human Services	Chemokine variants and methods of use
US7238711B1 (en)	1999-03-17	2007-07-03	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
EP1167527A1 (en) *	2000-06-22	2002-01-02	Euroscreen S.A.	Processed human chemokines PHC-1 and PHC-2
CA2387378A1 (en) *	1999-10-25	2001-05-03	Euroscreen S.A.	Processed human chemokines phc-1 and phc-2
AU2505601A (en) *	1999-11-15	2001-05-30	Wolf-Georg Forssmann	Novel use of hcc-2
CA2316405A1 (en) *	2000-05-26	2001-11-26	Ian Clark-Lewis	Modulation of inflammation by protease products
EP1176200A3 (de)	2000-06-20	2005-01-12	Switch Biotech Aktiengesellschaft	Verwendung von Polypeptiden oder diese kodierende Nukleinsäuren zur Diagnose oder Behandlung von Hauterkrankung oder Wundheilung sowie ihre Verwendung zur Indentifizierung von pharmakologisch aktiven Substanzen
UA77950C2 (en) *	2000-10-04	2007-02-15	Applied Research Systems	Use of mutants of cc chemokines for treatment of multiple sclerosis
GB2373785A (en) *	2001-03-28	2002-10-02	Rega Inst For Medical Res	Truncating chemokines using dipeptidyl peptidase IV
US7553483B2 (en)	2001-12-17	2009-06-30	Merck Serono Sa	Chemokine mutants acting as chemokine antagonists
WO2004104216A2 (en) *	2003-05-21	2004-12-02	Bayer Healthcare Ag	Diagnostics and therapeutics for diseases associated with dipeptidylpeptidase iv (dpp4)
DE102005049637A1 (de) *	2005-10-14	2007-04-26	Rheinisch-Westfälische Technische Hochschule Aachen	Antagonisten gegen die Interaktion von PF4 und RANTES
EP2185719B1 (en)	2007-08-02	2013-11-13	NovImmune SA	Anti-rantes antibodies and methods of use thereof
WO2011097567A1 (en) *	2010-02-08	2011-08-11	Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University	Rantes multiplexed assay, rantes variants related to disease, and rantes variants related to enzymatice activity
WO2011112915A2 (en)	2010-03-11	2011-09-15	Health Research, Inc.	Methods and compositions containing fc fusiong proteins for enhancing immune responses
TW201718851A (zh) *	2015-09-18	2017-06-01	通用醫院公司	具有抗化學排斥(anti-fugetactic)性質之經修飾自然殺手細胞及其用途
EP3813869B1 (en)	2018-05-28	2023-10-18	Université de Genève	Ccr5 inhibitor for use in treating a neuroinflammatory disorder that involves cerebral inflammation
US11629196B2 (en)	2020-04-27	2023-04-18	Incelldx, Inc.	Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
US11402391B2 (en)	2020-12-21	2022-08-02	Incelldx, Inc.	Methods of treating a long-hauler subject for chronic COVID-19 by administering a CCR5 or CCL5 antagonist

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH01265099A (ja)	1987-10-08	1989-10-23	Stichting Rega Vzw	抗ｈｉｖ活性をもつ３’，−フルオロプリン−２’，３’−ジデオキシリボシド類
US5739103A (en) *	1993-11-12	1998-04-14	Dana-Farber Cancer Institute	Chemokine N-terminal deletion mutations
HU221089B1 (en) *	1994-12-08	2002-08-28	Glaxo Group Ltd	Rantes peptide derivates with antagonistic effect and uses thereof
WO1997025427A1 (en) *	1996-01-12	1997-07-17	Genetics Institute, Inc.	Beta-chemokine, h1305 (mcp-2)
WO1997035982A2 (en) *	1996-03-27	1997-10-02	Icos Corporation	Monocyte chemotactic protein-5 materials and methods
FR2748938B1 (fr) *	1996-05-22	1998-07-31	Pasteur Institut	Utilisation de molecules antagonistes de chemokines pour leur activite antivirale notamment contre un retrovirus de type vih
US6168784B1 (en) *	1997-09-03	2001-01-02	Gryphon Sciences	N-terminal modifications of RANTES and methods of use

1997
- 1997-09-29 EP EP97116863A patent/EP0906954A1/en not_active Withdrawn
- 1997-12-19 EP EP97122471A patent/EP0905240A1/en not_active Withdrawn
1998
- 1998-03-10 EP EP98104216A patent/EP0905241A1/en not_active Withdrawn
- 1998-09-22 ZA ZA9808675A patent/ZA988675B/xx unknown
- 1998-09-22 ZA ZA9808676A patent/ZA988676B/xx unknown
- 1998-09-28 CA CA002304827A patent/CA2304827A1/en not_active Abandoned
- 1998-09-28 PT PT98947553T patent/PT1021541E/pt unknown
- 1998-09-28 UA UA2000042499A patent/UA73081C2/uk unknown
- 1998-09-28 JP JP2000513947A patent/JP4233214B2/ja not_active Expired - Fee Related
- 1998-09-28 EE EEP200000152A patent/EE200000152A/xx unknown
- 1998-09-28 AT AT98947553T patent/ATE264390T1/de active
- 1998-09-28 SK SK451-2000A patent/SK286495B6/sk not_active IP Right Cessation
- 1998-09-28 DK DK98947553T patent/DK1021541T3/da active
- 1998-09-28 NZ NZ516027A patent/NZ516027A/en unknown
- 1998-09-28 KR KR1020007003020A patent/KR100542934B1/ko not_active Expired - Fee Related
- 1998-09-28 WO PCT/EP1998/006142 patent/WO1999016876A1/en not_active Ceased
- 1998-09-28 DK DK98951476T patent/DK1019507T3/da active
- 1998-09-28 CN CNB988095726A patent/CN1148447C/zh not_active Expired - Fee Related
- 1998-09-28 HU HU0003505A patent/HU226414B1/hu not_active IP Right Cessation
- 1998-09-28 EP EP04007579A patent/EP1439231B1/en not_active Expired - Lifetime
- 1998-09-28 HU HU0003563A patent/HU226468B1/hu not_active IP Right Cessation
- 1998-09-28 AU AU94420/98A patent/AU750606B2/en not_active Ceased
- 1998-09-28 EP EP98947553A patent/EP1021541B1/en not_active Expired - Lifetime
- 1998-09-28 CZ CZ20001147A patent/CZ299479B6/cs not_active IP Right Cessation
- 1998-09-28 EA EA200000379A patent/EA003940B1/ru not_active IP Right Cessation
- 1998-09-28 DK DK04007579T patent/DK1439231T3/da active
- 1998-09-28 PT PT04007579T patent/PT1439231E/pt unknown
- 1998-09-28 EE EEP200000151A patent/EE200000151A/xx unknown
- 1998-09-28 EA EA200000378A patent/EA003942B1/ru not_active IP Right Cessation
- 1998-09-28 SK SK450-2000A patent/SK286439B6/sk not_active IP Right Cessation
- 1998-09-28 DE DE69823218T patent/DE69823218T2/de not_active Expired - Lifetime
- 1998-09-28 KR KR1020007003019A patent/KR100560275B1/ko not_active Expired - Fee Related
- 1998-09-28 WO PCT/EP1998/006143 patent/WO1999016877A1/en not_active Ceased
- 1998-09-28 PT PT98951476T patent/PT1019507E/pt unknown
- 1998-09-28 CZ CZ20001146A patent/CZ299478B6/cs not_active IP Right Cessation
- 1998-09-28 ES ES98951476T patent/ES2218860T3/es not_active Expired - Lifetime
- 1998-09-28 PL PL339559A patent/PL197569B1/pl not_active IP Right Cessation
- 1998-09-28 DE DE69838188T patent/DE69838188T2/de not_active Expired - Lifetime
- 1998-09-28 CN CNB988095696A patent/CN1145693C/zh not_active Expired - Fee Related
- 1998-09-28 BR BR9812565-6A patent/BR9812565A/pt not_active Application Discontinuation
- 1998-09-28 AR ARP980104820A patent/AR013529A1/es active IP Right Grant
- 1998-09-28 NZ NZ503234A patent/NZ503234A/en unknown
- 1998-09-28 AU AU97474/98A patent/AU750341B2/en not_active Ceased
- 1998-09-28 BR BR9812394-7A patent/BR9812394A/pt not_active Application Discontinuation
- 1998-09-28 AT AT04007579T patent/ATE368742T1/de active
- 1998-09-28 ES ES04007579T patent/ES2287601T3/es not_active Expired - Lifetime
- 1998-09-28 JP JP2000513946A patent/JP4230659B2/ja not_active Expired - Fee Related
- 1998-09-28 CA CA002305017A patent/CA2305017A1/en not_active Abandoned
- 1998-09-28 DE DE69822856T patent/DE69822856T2/de not_active Expired - Lifetime
- 1998-09-28 ES ES98947553T patent/ES2215324T3/es not_active Expired - Lifetime
- 1998-09-28 AR ARP980104819A patent/AR013528A1/es active IP Right Grant
- 1998-09-28 EP EP98951476A patent/EP1019507B1/en not_active Expired - Lifetime
- 1998-09-28 PL PL339545A patent/PL196427B1/pl not_active IP Right Cessation
- 1998-09-28 CN CNB031492991A patent/CN1233415C/zh not_active Expired - Fee Related
- 1998-09-28 NZ NZ503235A patent/NZ503235A/xx unknown
- 1998-09-28 AT AT98951476T patent/ATE263242T1/de active
- 1998-09-28 UA UA2000042496A patent/UA73080C2/uk unknown
2000
- 2000-03-22 BG BG104266A patent/BG64679B1/bg unknown
- 2000-03-22 BG BG104267A patent/BG64757B1/bg unknown
- 2000-03-27 NO NO20001584A patent/NO20001584L/no not_active Application Discontinuation
- 2000-03-28 US US09/537,859 patent/US6905676B2/en not_active Expired - Fee Related
- 2000-03-28 US US09/537,858 patent/US6977071B2/en not_active Expired - Fee Related
- 2000-03-28 NO NO20001609A patent/NO20001609D0/no unknown
- 2000-03-29 IL IL135352A patent/IL135352A/en not_active IP Right Cessation
- 2000-03-29 IL IL135351A patent/IL135351A/en not_active IP Right Cessation
2005
- 2005-03-07 US US11/072,454 patent/US7326411B2/en not_active Expired - Fee Related
- 2005-05-06 US US11/123,089 patent/US7338653B2/en not_active Expired - Fee Related
- 2005-05-18 US US11/131,221 patent/US20050220790A1/en not_active Abandoned
2007
- 2007-10-08 CY CY20071101290T patent/CY1110927T1/el unknown

Also Published As

Publication number	Publication date
NZ503235A (en)	2002-08-28
BG64757B1 (bg)	2006-02-28
US7326411B2 (en)	2008-02-05
WO1999016877A1 (en)	1999-04-08
EA003940B1 (ru)	2003-10-30
CZ299479B6 (cs)	2008-08-06
DE69838188T2 (de)	2007-11-22
DK1439231T3 (da)	2007-11-05
CY1110927T1 (el)	2015-06-10
EA003942B1 (ru)	2003-10-30
EP1439231A3 (en)	2004-12-22
NO20001609L (no)	2000-03-28
EP1019507A1 (en)	2000-07-19
CN1271386A (zh)	2000-10-25
JP4233214B2 (ja)	2009-03-04
EE200000151A (et)	2001-02-15
HK1032426A1 (en)	2001-07-20
EP0905241A1 (en)	1999-03-31
CN1148447C (zh)	2004-05-05
WO1999016876A1 (en)	1999-04-08
NO20001584D0 (no)	2000-03-27
KR20010024214A (ko)	2001-03-26
US7338653B2 (en)	2008-03-04
DK1021541T3 (da)	2004-08-02
UA73081C2 (en)	2005-06-15
EP1439231A2 (en)	2004-07-21
NO20001609D0 (no)	2000-03-28
DE69823218T2 (de)	2004-08-26
SK286439B6 (sk)	2008-10-07
CA2305017A1 (en)	1999-04-08
AU750341B2 (en)	2002-07-18
US20030124677A1 (en)	2003-07-03
KR20010024213A (ko)	2001-03-26
DE69822856D1 (de)	2004-05-06
SK4502000A3 (en)	2000-09-12
CZ20001146A3 (cs)	2000-09-13
BR9812565A (pt)	2000-08-01
CZ299478B6 (cs)	2008-08-06
US20050164936A1 (en)	2005-07-28
AU750606B2 (en)	2002-07-25
ATE263242T1 (de)	2004-04-15
NO20001584L (no)	2000-03-27
US6905676B2 (en)	2005-06-14
IL135351A (en)	2006-08-20
ATE368742T1 (de)	2007-08-15
US6977071B2 (en)	2005-12-20
EP1439231B1 (en)	2007-08-01
CZ20001147A3 (cs)	2000-09-13
JP2001518296A (ja)	2001-10-16
CN1145693C (zh)	2004-04-14
KR100560275B1 (ko)	2006-03-10
IL135352A (en)	2006-08-20
DE69823218D1 (de)	2004-05-19
JP2001518297A (ja)	2001-10-16
EP0906954A1 (en)	1999-04-07
DE69838188D1 (de)	2007-09-13
DE69822856T2 (de)	2004-08-19
NZ503234A (en)	2002-06-28
HUP0003505A3 (en)	2005-11-28
HUP0003563A3 (en)	2005-11-28
KR100542934B1 (ko)	2006-01-11
PT1019507E (pt)	2004-06-30
ATE264390T1 (de)	2004-04-15
AR013529A1 (es)	2000-12-27
JP4230659B2 (ja)	2009-02-25
HK1032425A1 (en)	2001-07-20
PT1021541E (pt)	2004-07-30
EP1021541B1 (en)	2004-04-14
AU9747498A (en)	1999-04-23
PL339559A1 (en)	2000-12-18
HUP0003505A2 (hu)	2001-02-28
EA200000379A1 (ru)	2000-10-30
UA73080C2 (en)	2005-06-15
ES2218860T3 (es)	2004-11-16
ES2215324T3 (es)	2004-10-01
BR9812394A (pt)	2000-09-12
EE200000152A (et)	2001-02-15
EP1021541A1 (en)	2000-07-26
SK286495B6 (sk)	2008-11-06
ZA988676B (en)	1999-12-03
BG64679B1 (bg)	2005-11-30
CN1271385A (zh)	2000-10-25
ZA988675B (en)	1999-11-24
US20050201977A1 (en)	2005-09-15
PL339545A1 (en)	2000-12-18
EP1019507B1 (en)	2004-03-31
EP0905240A1 (en)	1999-03-31
ES2287601T3 (es)	2007-12-16
PL196427B1 (pl)	2008-01-31
HUP0003563A2 (hu)	2001-02-28
BG104267A (en)	2000-11-30
PL197569B1 (pl)	2008-04-30
NZ516027A (en)	2003-05-30
SK4512000A3 (en)	2000-09-12
EA200000378A1 (ru)	2000-10-30
BG104266A (en)	2000-11-30
US20030119148A1 (en)	2003-06-26
CN1233415C (zh)	2005-12-28
HU226468B1 (en)	2008-12-29
CA2304827A1 (en)	1999-04-08
CN1490049A (zh)	2004-04-21
HK1062637A1 (en)	2004-11-19
AU9442098A (en)	1999-04-23
AR013528A1 (es)	2000-12-27
HU226414B1 (en)	2008-11-28
PT1439231E (pt)	2007-08-20
US20050220790A1 (en)	2005-10-06

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