DK1029548T3 - Fremgangsmåde til opretholdelse af kvaliteten af vandige, parenterale oplösninger af thrombomodulin under lagring og transport - Google Patents

Fremgangsmåde til opretholdelse af kvaliteten af vandige, parenterale oplösninger af thrombomodulin under lagring og transport

Info

Publication number
DK1029548T3
DK1029548T3 DK98947842T DK98947842T DK1029548T3 DK 1029548 T3 DK1029548 T3 DK 1029548T3 DK 98947842 T DK98947842 T DK 98947842T DK 98947842 T DK98947842 T DK 98947842T DK 1029548 T3 DK1029548 T3 DK 1029548T3
Authority
DK
Denmark
Prior art keywords
thrombomodulin
aqueous
solution
quality
aqueous parenteral
Prior art date
Application number
DK98947842T
Other languages
English (en)
Inventor
Masaki Yui
Akira Yokozawa
Tomoyo Murata
Kazuhisa Tsuruta
Hirotomo Shimizu
Original Assignee
Asahi Kasei Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26554271&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1029548(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Asahi Kasei Pharma Corp filed Critical Asahi Kasei Pharma Corp
Application granted granted Critical
Publication of DK1029548T3 publication Critical patent/DK1029548T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/57Protease inhibitors from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/7455Thrombomodulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DK98947842T 1997-10-15 1998-10-13 Fremgangsmåde til opretholdelse af kvaliteten af vandige, parenterale oplösninger af thrombomodulin under lagring og transport DK1029548T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP28165997 1997-10-15
JP30852397 1997-11-11
PCT/JP1998/004609 WO1999018994A1 (en) 1997-10-15 1998-10-13 Method for keeping the quality of aqueous parenteral solution of thrombomodulin in storage and distribution

Publications (1)

Publication Number Publication Date
DK1029548T3 true DK1029548T3 (da) 2007-07-02

Family

ID=26554271

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98947842T DK1029548T3 (da) 1997-10-15 1998-10-13 Fremgangsmåde til opretholdelse af kvaliteten af vandige, parenterale oplösninger af thrombomodulin under lagring og transport

Country Status (13)

Country Link
US (1) US6808706B1 (da)
EP (1) EP1029548B1 (da)
JP (1) JP4460762B2 (da)
KR (1) KR100373480B1 (da)
CN (1) CN1275916A (da)
AT (1) ATE358496T1 (da)
AU (1) AU729876B2 (da)
CA (1) CA2306206A1 (da)
DE (1) DE69837493T2 (da)
DK (1) DK1029548T3 (da)
ES (1) ES2281137T3 (da)
PT (1) PT1029548E (da)
WO (1) WO1999018994A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006346494A (ja) * 1999-02-22 2006-12-28 Chugai Pharmaceut Co Ltd プレフィルドシリンジタンパク質溶液製剤
JP2011025068A (ja) * 1999-02-22 2011-02-10 Chugai Pharmaceut Co Ltd プレフィルドシリンジタンパク質溶液製剤
US6585971B1 (en) * 1999-11-12 2003-07-01 Harbor-Ucla Research And Education Institute Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof
WO2001045741A2 (en) * 1999-12-22 2001-06-28 Glaxo Group Limited Methods for preparing pharmaceutical formulations
RU2280075C2 (ru) * 2000-03-14 2006-07-20 Бавариан Нордик А/С Измененный штамм модифицированного вируса коровьей оспы ankara (mva)
WO2003061687A1 (fr) * 2002-01-18 2003-07-31 Asahi Kasei Pharma Corporation Preparation a concentration elevee de thrombomoduline soluble
JP2009534390A (ja) * 2006-04-21 2009-09-24 アムジェン インコーポレイテッド 生物医薬品製剤のための緩衝剤
ES2496596T3 (es) 2007-03-23 2014-09-19 Asahi Kasei Pharma Corporation Método para producir trombomodulina soluble de gran pureza
JP2011519347A (ja) * 2008-02-07 2011-07-07 アムジエン・インコーポレーテツド 安定化されたタンパク質組成物
JP2011178687A (ja) * 2010-02-26 2011-09-15 Kochi Univ 造血細胞移植に伴う疼痛の予防および/または治療剤
EA032336B1 (ru) * 2010-09-17 2019-05-31 Баксалта Инкорпорейтид Стабильная водная иммуноглобулиновая композиция и способ стабилизации иммуноглобулиновой композиции
PT3858405T (pt) 2012-06-01 2023-06-26 Novartis Ag Seringa
IL312865B2 (en) 2013-09-11 2025-06-01 Eagle Biologics Inc Liquid protein formulations containing viscosity-lowering agents
SG11201702614SA (en) 2014-10-01 2017-04-27 Eagle Biolog Inc Polysaccharide and nucleic acid formulations containing viscosity-lowering agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988005053A1 (fr) 1987-01-08 1988-07-14 Asahi Kasei Kogyo Kabushiki Kaisha Peptide servant a accelerer l'activation de la proteine c avec de la thrombine
JP2738428B2 (ja) * 1987-01-08 1998-04-08 旭化成工業株式会社 トロンビンによるプロテインcの活性化を促進する作用を有するペプチド
US4912207A (en) 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
JPH02255699A (ja) 1989-03-28 1990-10-16 Asahi Chem Ind Co Ltd 新規血液抗凝固物質及びその製法
JPH05213998A (ja) 1990-08-03 1993-08-24 Asahi Chem Ind Co Ltd 新規なポリペプチド及びこれを有効成分とする 医薬組成物
JPH05310787A (ja) 1992-05-01 1993-11-22 Asahi Chem Ind Co Ltd 新規なポリペプチド
JP3007785B2 (ja) * 1993-03-16 2000-02-07 旭化成工業株式会社 トロンボモジュリン組成物およびその変性防止方法
US5704959A (en) * 1993-12-13 1998-01-06 Lisec; Peter Device for dividing laminated glass
ATE249234T1 (de) 1993-12-17 2003-09-15 Mochida Pharm Co Ltd Lösliches thrombomodulin enthaltende zubereitung

Also Published As

Publication number Publication date
JP4460762B2 (ja) 2010-05-12
CN1275916A (zh) 2000-12-06
HK1027514A1 (en) 2001-01-19
KR100373480B1 (ko) 2003-02-25
US6808706B1 (en) 2004-10-26
EP1029548A4 (en) 2004-07-14
KR20010031153A (ko) 2001-04-16
EP1029548B1 (en) 2007-04-04
PT1029548E (pt) 2007-05-31
WO1999018994A1 (en) 1999-04-22
AU9460398A (en) 1999-05-03
AU729876B2 (en) 2001-02-15
ES2281137T3 (es) 2007-09-16
ATE358496T1 (de) 2007-04-15
CA2306206A1 (en) 1999-04-22
DE69837493D1 (de) 2007-05-16
DE69837493T2 (de) 2007-12-13
EP1029548A1 (en) 2000-08-23

Similar Documents

Publication Publication Date Title
EP1029548A4 (en) PROCESS FOR MAINTAINING THE QUALITY OF AN AQUEOUS PARENTERAL THROMBOMODULIN SOLUTION FOR STORAGE OR DISTRIBUTION
GR3015340T3 (en) Stable aqueous preparation.
ES2057731T3 (es) Preparaciones que contienen gonadotropinas estabilizadas.
IL152745A0 (en) Microinjection of cryoprotectants for preservation of cells
ATE345277T1 (de) Injizierbare pharmazeutische suspension in einer phiole mit zwei kammern
ATE274347T1 (de) Stabile injizierbare paclitaxel lösung
CA2258041A1 (en) Solvent resupply method for use with a carbon dioxide cleaning system
SE8703300D0 (sv) Nonaqueous liquid automatic dishwashing detergent composition with improved rinse properties and method of use
ATE113493T1 (de) Schaumkontrollmittel in granulierter form.
IT8748705A0 (it) Composizione liquida acquosa per lavastoviglie,contenente enzimi stabilizzati
KR900011887A (ko) 효소 및 효소 안정화 시스템을 함유하는 액체 세제 조성물
DE68909208D1 (de) Abgedichtete, mit flüssigkeit gefüllte lagervorrichtung.
DK1352654T3 (da) Famotidininjektioner
KR950005986A (ko) 안정화된 형태로 금속 프로테아제 효소를 사용, 저장 및 이송하는 방법
EP0109191A3 (en) Bulk bag stacking
ATE177141T1 (de) Verfahren zur stabilisierung eines kontaktlinsenpräparats
ES2070120T3 (es) Articulo higienico de celulosa.
ES2096835T3 (es) Composicion insecticida.
DE68922258D1 (de) Flüssige Waschmittel.
DE3875843D1 (de) Fluessigwaschmittel.
EP0435632A3 (en) Phenylpyrimidine derivatives, process for preparing the same, liquid crystal compositions containing said derivatives as active ingredient, and liquid crystal elements using such compositions
SE8803481D0 (sv) Low viscosity stable non-aqueous suspension containing organophilic clay and low density filler
JPS544088A (en) Manufacture for semiconductor laser
WO1988003378A3 (en) Cut flower storage and display unit and system
CA2114747A1 (en) Method for Stabilizing an Agent for Contact Lenses