DK1031576T3 - Derivater af glycopeptidantibiotika - Google Patents

Derivater af glycopeptidantibiotika

Info

Publication number
DK1031576T3
DK1031576T3 DK00201724T DK00201724T DK1031576T3 DK 1031576 T3 DK1031576 T3 DK 1031576T3 DK 00201724 T DK00201724 T DK 00201724T DK 00201724 T DK00201724 T DK 00201724T DK 1031576 T3 DK1031576 T3 DK 1031576T3
Authority
DK
Denmark
Prior art keywords
derivatives
glycopeptide antibiotics
glycopeptide
antibiotics
mixed
Prior art date
Application number
DK00201724T
Other languages
Danish (da)
English (en)
Inventor
Robin David Grey Cooper
Thalia Ioanna Nicas
John Thomas Quatroche
Nancy June Snyder
Michael Alexander Staszak
Richard Craig Thompson
Mark James Zweifel
Bret Eugene Huff
Michael John Rodriguez
Stephen Charles Wilkie
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK1031576T3 publication Critical patent/DK1031576T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K9/00Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K9/00Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK00201724T 1994-01-28 1995-01-25 Derivater af glycopeptidantibiotika DK1031576T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18939394A 1994-01-28 1994-01-28
US35641394A 1994-12-15 1994-12-15
EP95300429A EP0667353B1 (en) 1994-01-28 1995-01-25 Glycopeptide antibiotic derivatives

Publications (1)

Publication Number Publication Date
DK1031576T3 true DK1031576T3 (da) 2004-08-16

Family

ID=26885101

Family Applications (3)

Application Number Title Priority Date Filing Date
DK00201724T DK1031576T3 (da) 1994-01-28 1995-01-25 Derivater af glycopeptidantibiotika
DK95300429T DK0667353T3 (da) 1994-01-28 1995-01-25 Antibiotiske glycopeptidderivater
DK00200988T DK1016670T3 (da) 1994-01-28 1995-01-25 Glycopeptidantibiotiske derivater

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK95300429T DK0667353T3 (da) 1994-01-28 1995-01-25 Antibiotiske glycopeptidderivater
DK00200988T DK1016670T3 (da) 1994-01-28 1995-01-25 Glycopeptidantibiotiske derivater

Country Status (30)

Country Link
US (1) US5843889A (cs)
EP (3) EP1031576B1 (cs)
JP (1) JP3756539B2 (cs)
KR (1) KR100388867B1 (cs)
CN (1) CN1071334C (cs)
AT (3) ATE248856T1 (cs)
AU (1) AU703106B2 (cs)
BR (1) BR9500365A (cs)
CA (3) CA2546625C (cs)
CO (1) CO4600679A1 (cs)
CZ (2) CZ292895B6 (cs)
DE (3) DE69531709T2 (cs)
DK (3) DK1031576T3 (cs)
EG (1) EG25884A (cs)
ES (3) ES2220335T3 (cs)
FI (3) FI117095B (cs)
HU (1) HU225164B1 (cs)
IL (1) IL112457A (cs)
MY (1) MY128335A (cs)
NO (1) NO323103B1 (cs)
NZ (1) NZ270387A (cs)
PE (1) PE40996A1 (cs)
PL (1) PL180961B1 (cs)
PT (3) PT1031576E (cs)
RU (1) RU2145609C1 (cs)
SG (1) SG52719A1 (cs)
SI (2) SI0667353T1 (cs)
TW (1) TW457248B (cs)
UA (1) UA43323C2 (cs)
YU (1) YU4995A (cs)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
US5919756A (en) * 1996-06-28 1999-07-06 Eli Lilly And Company Amides
ID18900A (id) * 1996-11-21 1998-05-20 Lilly Co Eli Alkilasi menurun dari gliko peptida anti biotik
US5939382A (en) * 1996-11-21 1999-08-17 Eli Lilly And Company Reducing agent for reductive alkylation of glycopeptide antibiotics
US5952466A (en) * 1997-11-12 1999-09-14 Eli Lilly And Company Reductive alkylation of glycopeptide antibiotics
US5977063A (en) * 1997-05-20 1999-11-02 Eli Lilly And Company Alkylated hexapeptides
US5919771A (en) * 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
US5952310A (en) * 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
US5994297A (en) * 1997-08-22 1999-11-30 Eli Lilly And Company Therapy for Staphylococcus aureus
US6518242B1 (en) 1998-02-20 2003-02-11 Theravance, Inc. Derivatives of glycopeptide antibacterial agents
WO1999056760A1 (en) 1998-05-01 1999-11-11 Eli Lilly And Company N1-modified glycopeptides
NZ509165A (en) * 1998-07-14 2003-08-29 Univ Princeton Glycopeptide antobiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
US6710168B1 (en) 1999-05-19 2004-03-23 The Trustees Of The University Of Princeton Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
DE69908819T2 (de) 1998-12-23 2004-05-06 Theravance, Inc., South San Francisco Glycopeptid-derivate und pharmazeutische zusammensetzungen, die sie enthalten
WO2001081373A2 (en) * 2000-04-25 2001-11-01 Merck & Co., Inc. Glycopeptide antibacterial compounds and methods of using same
JP4870314B2 (ja) 2000-05-02 2012-02-08 セラヴァンス, インコーポレーテッド シクロデキストリンを含むグリコペプチド抗生物質組成物
US6770621B2 (en) 2000-05-02 2004-08-03 Theravance, Inc. Polyacid glycopeptide derivatives
KR100856479B1 (ko) 2000-05-02 2008-09-04 세라밴스 인코포레이티드 환원성 알킬화 방법
US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
WO2001098329A1 (en) 2000-06-22 2001-12-27 Theravance, Inc. Polyhydroxy glycopeptide derivatives
US6620781B2 (en) 2000-06-22 2003-09-16 Theravance, Inc. Glycopeptide carboxy-saccharide derivatives
TWI233932B (en) * 2001-08-24 2005-06-11 Theravance Inc Process for purifying glycopeptide phosphonate derivatives
TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
EP1534316A2 (en) * 2002-08-30 2005-06-01 K.U. Leuven Research and Development Glycopeptide antibiotics and semisynthetic derivatives thereof and their use as antiviral agents
EP1624858B1 (en) 2003-04-09 2018-06-06 Rutgers, the State University of New Jersey Novel encochleation methods
US7521418B2 (en) 2003-05-27 2009-04-21 Theravance, Inc. Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
ATE381957T1 (de) 2003-07-22 2008-01-15 Theravance Inc Verwendung eines antimykotischen echinocandin- mittels in kombination mit einem antibakteriellen glycopeptid-mittel
CA2588285A1 (en) * 2004-11-29 2006-06-01 National University Corporation Nagoya University Glycopeptide antibiotic monomer derivatives
US7632918B2 (en) 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
CN102963107B (zh) 2005-04-01 2015-09-23 博凯技术公司 用于隔音的非织造材料和制造工艺
JP5192384B2 (ja) 2005-09-22 2013-05-08 メディバス エルエルシー ビス−(α−アミノ)−ジオール−ジエステル含有ポリ(エステルアミド)およびポリ(エステルウレタン)組成物および使用の方法
CA2623239C (en) 2005-09-22 2016-07-12 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
TW200808818A (en) 2006-05-26 2008-02-16 Shionogi & Co Glycopeptide antibiotic derivatives
CN101959900A (zh) 2007-12-26 2011-01-26 盐野义制药株式会社 糖肽类抗生素糖基化衍生物
EP2260060A4 (en) 2008-04-01 2013-01-16 Univ Cornell ORGANIC SOLUBLE CHITOSA SALT AND CHITOSAN DERIVED BIOMATERIALS MANUFACTURED THEREFROM
CN101343313B (zh) * 2008-09-03 2011-11-16 南京农业大学 一种葡萄糖二肽类化合物及其制备方法和用途
EP2704688B1 (en) 2011-05-05 2019-07-10 Matinas BioPharma Nanotechnologies, Inc. Cochleate compositions and methods of making and using same
CA2904387C (en) 2013-03-15 2021-12-07 Melinta Therapeutics, Inc. Methods of treating infections in overweight and obese patients using antibiotics
CN104418941B (zh) * 2013-08-19 2017-11-07 爱斯医药科技(南京)有限公司 万古霉素衍生物、制备方法及其应用
IN2013CH04314A (cs) 2013-09-23 2015-08-28 Jawaharlal Nehru Ct For Advanced Scient Res Jncasr
EP4509178A3 (en) 2014-07-17 2025-06-25 Melinta Therapeutics, LLC High purity oritavancin and method of producing same
HUE053347T2 (hu) 2014-11-06 2021-06-28 Xellia Pharmaceuticals Aps Glikopeptid-készítmények
US20170342110A1 (en) * 2014-12-25 2017-11-30 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Glycopeptides and uses thereof
CN106188243B (zh) * 2015-05-05 2020-06-26 博瑞生物医药(苏州)股份有限公司 一种奥利万星的制备方法
CN106467570B (zh) * 2015-08-14 2020-04-07 正大天晴药业集团股份有限公司 糖肽类抗生素的还原烷基化方法
CN107434823B (zh) * 2016-05-26 2021-11-16 江苏恒瑞医药股份有限公司 一种奥利万星中间体a82846b的纯化方法
CN108409837B (zh) * 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用
CN109053864B (zh) * 2018-07-10 2021-08-24 丽珠集团新北江制药股份有限公司 一种制备奥利万星的方法
CN109053865B (zh) * 2018-07-20 2021-04-13 丽珠集团新北江制药股份有限公司 一种羧基保护制备奥利万星的方法
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3067099A (en) * 1955-09-16 1962-12-04 Lilly Co Eli Vancomycin and method for its preparation
US3338786A (en) * 1966-07-29 1967-08-29 American Cyanamid Co Antibiotic av290 and production thereof
US4552886A (en) * 1982-06-07 1985-11-12 Eli Lilly And Company Fungicidal pyridylmethyl-amines
IT1173329B (it) * 1984-02-21 1987-06-24 Lepetit Spa Procedimento per la trasformazione quantitativa di teicoplanina a2 fattore 1 in teicoplanina a2 fattore 3
GB8415093D0 (en) * 1984-06-13 1984-07-18 Lepetit Spa Antibiotic l 17392
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
IL78597A0 (en) * 1985-04-25 1986-08-31 Lilly Co Eli Novel glycopeptide derivatives
US4648327A (en) * 1985-07-01 1987-03-10 Cubic Western Data Safe locking mechanism
US4639433A (en) * 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
US4946941A (en) * 1986-01-24 1990-08-07 Shionogi & Co., Ltd. Novel glycopeptide antibiotics
EG18377A (en) * 1986-09-19 1993-04-30 Lilly Co Eli Process for preparing glycopeptide antibiotics
GB8701872D0 (en) * 1987-01-28 1987-03-04 Lepetit Spa N15-alkyl & n15,n15-dialkyl derivatives
US5071749A (en) * 1987-04-16 1991-12-10 Shionogi & Co., Ltd. Glycopetide antibiotic pa-45052-b
GB8726859D0 (en) * 1987-11-17 1987-12-23 Lepetit Spa 22-dechlorotei-coplanins
PT90366A (pt) * 1988-04-28 1989-11-10 Beecham Group Plc Processo para a producao de compostos glicopeptidicos
CA1339808C (en) * 1988-10-19 1998-04-07 Manuel Debono Glycopeptide antibiotics
US5194424A (en) * 1988-12-27 1993-03-16 Gruppo Lepetit Spa C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
US5185320A (en) * 1989-04-03 1993-02-09 Gruppo Lepetit S.P.A. O56 -alkyl derivatives of aglycone and pseudo aglycones of teicoplanin
DE69001241T2 (de) * 1989-12-11 1993-07-22 De Beers Ind Diamond Schleifprodukte.
CA2031803C (en) * 1989-12-13 2001-05-29 Ramakrishnan Nagarajan Improvements in or relating to glycopeptide deriveratives
US5187082A (en) * 1990-08-16 1993-02-16 Eli Lilly And Company Process for producing A83850 antibiotics
KR100242682B1 (ko) * 1991-07-29 2000-02-01 클라우디오 쿼르타 항생물질 a 40926의 아미드 유도체

Also Published As

Publication number Publication date
DE69533004T2 (de) 2005-04-07
RU95101039A (ru) 1996-10-27
DE69531709T2 (de) 2004-07-15
FI117097B (fi) 2006-06-15
JP3756539B2 (ja) 2006-03-15
ATE266042T1 (de) 2004-05-15
PT1016670E (pt) 2003-12-31
HUT68715A (en) 1995-07-28
CO4600679A1 (es) 1998-05-08
SI1016670T1 (en) 2004-02-29
ES2204444T3 (es) 2004-05-01
PL180961B1 (pl) 2001-05-31
IL112457A (en) 2004-06-20
TW457248B (en) 2001-10-01
ES2220335T3 (es) 2004-12-16
EP1016670B1 (en) 2003-09-03
CN1071334C (zh) 2001-09-19
MY128335A (en) 2007-01-31
US5843889A (en) 1998-12-01
DE69533004D1 (de) 2004-06-09
BR9500365A (pt) 1995-10-17
CA2141106A1 (en) 1995-07-29
AU703106B2 (en) 1999-03-18
CA2546910C (en) 2010-09-14
CA2141106C (en) 2007-01-23
JPH07258289A (ja) 1995-10-09
EP1016670A1 (en) 2000-07-05
IL112457A0 (en) 1995-03-30
DE69532013T2 (de) 2004-07-08
DK0667353T3 (da) 2004-03-22
NO950298L (no) 1995-07-31
CZ292921B6 (cs) 2004-01-14
EP0667353B1 (en) 2003-10-29
SG52719A1 (en) 1998-09-28
EP1031576A3 (en) 2000-12-27
PT1031576E (pt) 2004-08-31
HU225164B1 (en) 2006-07-28
UA43323C2 (uk) 2001-12-17
FI117095B (fi) 2006-06-15
CA2546910A1 (en) 1995-07-29
FI20050513L (fi) 2005-05-13
AU1138995A (en) 1995-08-10
KR950032274A (ko) 1995-12-20
EP1031576A2 (en) 2000-08-30
HU9500230D0 (en) 1995-03-28
EP0667353A1 (en) 1995-08-16
DE69531709D1 (de) 2003-10-09
FI950374A0 (fi) 1995-01-27
CZ18495A3 (en) 1995-08-16
CA2546625C (en) 2008-09-09
ATE253077T1 (de) 2003-11-15
NZ270387A (en) 1996-11-26
RU2145609C1 (ru) 2000-02-20
CZ292895B6 (cs) 2003-12-17
CA2546625A1 (en) 1995-07-29
EP1031576B1 (en) 2004-05-06
DE69532013D1 (de) 2003-12-04
NO323103B1 (no) 2007-01-02
PE40996A1 (es) 1996-10-14
DK1016670T3 (da) 2004-01-05
KR100388867B1 (ko) 2003-10-08
SI0667353T1 (en) 2004-04-30
FI950374L (fi) 1995-07-29
CN1119649A (zh) 1996-04-03
ES2210274T3 (es) 2004-07-01
ATE248856T1 (de) 2003-09-15
EG25884A (en) 2012-09-24
FI117096B (fi) 2006-06-15
NO950298D0 (no) 1995-01-26
YU4995A (sh) 1998-07-10
PT667353E (pt) 2004-03-31
PL306976A1 (en) 1995-08-07
FI20050512L (fi) 2005-05-13

Similar Documents

Publication Publication Date Title
DK1031576T3 (da) Derivater af glycopeptidantibiotika
DE10199046I2 (de) Rapamycin-Zubereitungen zur oralen Verabreichung
AU1805397A (en) Antibiotic oxazolidinone derivatives
NO964139D0 (no) Cefalosporinantibiotika
DE69405388D1 (de) Multimedia synchronisationssystem
AU7865887A (en) Glycopeptide antibiotics
AU8410191A (en) Neon tube lighting system, support assembly and extrusion therefor
NO175873C (no) Mikrobiell fremgangsmåte for fremstilling av immunhemmende antibiotika
DE69618015D1 (de) Cephalosporinantibiotika
DE69611063D1 (de) Dichte Verbindung mit radialem Einsteckende
NO983691L (no) Forbindelser tilh°rende amidiniumfamilien, farmas°ytiske preparater inneholdende disse samt anvendelse derav
ATE66610T1 (de) Primycin enthaltendes kolloidales grundgel, verfahren zu dessen herstellung, dieses grundgel enthaltende pharmazeutische und pharmako- kosmetische kompositionen.
FI930378A0 (fi) Fosfenoxidavslutade allen-en-yn dna-spjaelkande, antitumoer och antibiotika molekyler
IT1207578B (it) Antibiotici carbapenem e relativo procedimento di preparazione.
AU4320297A (en) 2-amino-1-(4-hydroxy-2-methylphenyl)propanol derivatives
AU7653491A (en) Glycopeptides antibiotics
AU3901195A (en) Duct joiner and retaining clip therefor
AU2545499A (en) The regulatory sequence of gamma-4 germline (gl) transcript and its applications