UA43323C2 - Антибіотичні похідні глікопептидів, спосіб отримання та фармацевтична композиція - Google Patents

Антибіотичні похідні глікопептидів, спосіб отримання та фармацевтична композиція

Info

Publication number
UA43323C2
UA43323C2 UA95018070A UA95018070A UA43323C2 UA 43323 C2 UA43323 C2 UA 43323C2 UA 95018070 A UA95018070 A UA 95018070A UA 95018070 A UA95018070 A UA 95018070A UA 43323 C2 UA43323 C2 UA 43323C2
Authority
UA
Ukraine
Prior art keywords
glycopeptide antibiotic
preparation
pharmaceutical composition
antibiotic derivatives
derivative compounds
Prior art date
Application number
UA95018070A
Other languages
English (en)
Russian (ru)
Inventor
Робін Девід Грей Купер
Робин Девид Грей Купер
Брет Юджин Хафф
Талія Іоанна Нікас
Талия Иоанна Никас
Джон Томас Куотроуш
Майкл Джон Родрігес
Майкл Джон Родригес
Ненсі Джун Снайдер
Ненси Джун Снайдер
Майкл Александер Стащак
Річард Крейг Томпсон
Ричард Крейг Томпсон
Стівен Чарльз Уілкі
Стивен Чарльз Уилки
Марк Джеймс Звейфель
Original Assignee
Елі Ліллі Енд Компані
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Елі Ліллі Енд Компані, Эли Лилли Энд Компани filed Critical Елі Ліллі Енд Компані
Publication of UA43323C2 publication Critical patent/UA43323C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Даний винахід стосується антибіотичних похідних глікопептидів, що мають антибактеріальну активність, включаючи активність стосовно ізолятів, стійких до ванкоміцину. Запропоновано також способи виготовлення й використання цих сполук.
UA95018070A 1994-01-28 1995-01-24 Антибіотичні похідні глікопептидів, спосіб отримання та фармацевтична композиція UA43323C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18939394A 1994-01-28 1994-01-28
US35641394A 1994-12-15 1994-12-15

Publications (1)

Publication Number Publication Date
UA43323C2 true UA43323C2 (uk) 2001-12-17

Family

ID=26885101

Family Applications (1)

Application Number Title Priority Date Filing Date
UA95018070A UA43323C2 (uk) 1994-01-28 1995-01-24 Антибіотичні похідні глікопептидів, спосіб отримання та фармацевтична композиція

Country Status (30)

Country Link
US (1) US5843889A (uk)
EP (3) EP1031576B1 (uk)
JP (1) JP3756539B2 (uk)
KR (1) KR100388867B1 (uk)
CN (1) CN1071334C (uk)
AT (3) ATE248856T1 (uk)
AU (1) AU703106B2 (uk)
BR (1) BR9500365A (uk)
CA (3) CA2546910C (uk)
CO (1) CO4600679A1 (uk)
CZ (2) CZ292895B6 (uk)
DE (3) DE69531709T2 (uk)
DK (3) DK0667353T3 (uk)
EG (1) EG25884A (uk)
ES (3) ES2204444T3 (uk)
FI (3) FI117095B (uk)
HU (1) HU225164B1 (uk)
IL (1) IL112457A (uk)
MY (1) MY128335A (uk)
NO (1) NO323103B1 (uk)
NZ (1) NZ270387A (uk)
PE (1) PE40996A1 (uk)
PL (1) PL180961B1 (uk)
PT (3) PT1031576E (uk)
RU (1) RU2145609C1 (uk)
SG (1) SG52719A1 (uk)
SI (2) SI1016670T1 (uk)
TW (1) TW457248B (uk)
UA (1) UA43323C2 (uk)
YU (1) YU4995A (uk)

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US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
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US5939382A (en) * 1996-11-21 1999-08-17 Eli Lilly And Company Reducing agent for reductive alkylation of glycopeptide antibiotics
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US5994297A (en) * 1997-08-22 1999-11-30 Eli Lilly And Company Therapy for Staphylococcus aureus
US6518242B1 (en) 1998-02-20 2003-02-11 Theravance, Inc. Derivatives of glycopeptide antibacterial agents
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EP1095058A4 (en) * 1998-07-14 2003-07-16 Univ Princeton GLYCOPEPTIDANTIBIOTICS, COMBINATIONAL LIBRARIES OF GLYCOPEPTIDANTIBIOTICS AND METHOD FOR THEIR PRODUCTION
US6710168B1 (en) * 1999-05-19 2004-03-23 The Trustees Of The University Of Princeton Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
US6392012B1 (en) 1998-12-23 2002-05-21 Advanced Medicine, Inc. Glycopeptide derivatives and pharmaceutical compositions containing the same
WO2001081373A2 (en) * 2000-04-25 2001-11-01 Merck & Co., Inc. Glycopeptide antibacterial compounds and methods of using same
DE60136926D1 (de) 2000-05-02 2009-01-22 Theravance Inc Zusammensetzung die eine zyklodextrin und ein glykopeptid-antibiotikum enthält
EP1276759B1 (en) * 2000-05-02 2008-07-30 Theravance, Inc. Reductive alkylation process on glycopeptides
WO2001083520A2 (en) 2000-05-02 2001-11-08 Theravance,Inc Polyacid glycopeptide derivatives
US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
AU2001259816A1 (en) 2000-06-22 2002-01-02 Advanced Medecine, Inc. Polyhydroxy glycopeptide derivatives
ES2302733T3 (es) 2000-06-22 2008-08-01 Theravance, Inc. Derivados carboxi-sacaridos de glucopeptido.
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TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI233932B (en) * 2001-08-24 2005-06-11 Theravance Inc Process for purifying glycopeptide phosphonate derivatives
WO2004019970A2 (en) * 2002-08-30 2004-03-11 K.U. Leuven Research And Development Glycopeptide antibiotic and semisynthetic derivatives thereof and their use as antiviral agents
US20050013854A1 (en) 2003-04-09 2005-01-20 Mannino Raphael J. Novel encochleation methods, cochleates and methods of use
WO2004110473A1 (en) 2003-05-27 2004-12-23 Theravance, Inc. Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
EP1654036B1 (en) 2003-07-22 2007-12-26 Theravance, Inc. Use of an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent
WO2006057303A1 (ja) 2004-11-29 2006-06-01 National University Corporation Nagoya University グリコペプチド抗生物質モノマー誘導体
US7632918B2 (en) 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
KR101474818B1 (ko) 2005-04-01 2014-12-19 부케예 테크놀로지스 인코포레이티드 방음용 부직포 재료 및 제조방법
CA2623198C (en) 2005-09-22 2014-08-05 Medivas, Llc Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
WO2007038246A2 (en) 2005-09-22 2007-04-05 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
TW200808818A (en) 2006-05-26 2008-02-16 Shionogi & Co Glycopeptide antibiotic derivatives
AU2008342149A1 (en) 2007-12-26 2009-07-02 Shionogi & Co., Ltd. Glycosylated glycopeptide antibiotic derivative
US8841440B2 (en) 2008-04-01 2014-09-23 Cornell University Organo-soluble chitosan salts and chitosan-derived biomaterials prepared thereof
CN101343313B (zh) * 2008-09-03 2011-11-16 南京农业大学 一种葡萄糖二肽类化合物及其制备方法和用途
EP2704688B1 (en) 2011-05-05 2019-07-10 Matinas BioPharma Nanotechnologies, Inc. Cochleate compositions and methods of making and using same
WO2014152332A1 (en) 2013-03-15 2014-09-25 Melinta Therapeutics, Inc. Methods of treating infections in overweight and obese patients using antibiotics
CN107759672A (zh) * 2013-08-19 2018-03-06 南京爱斯药业有限公司 万古霉素衍生物、制备方法及其应用
WO2015040467A1 (en) 2013-09-23 2015-03-26 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Vancomycin-sugar conjugates and uses thereof
MX385925B (es) 2014-07-17 2025-03-18 The Medicines Co Oritavancina de alta pureza y método para producir la misma.
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CA2972276A1 (en) * 2014-12-25 2016-06-30 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Glycopeptides and uses thereof
CN106188243B (zh) * 2015-05-05 2020-06-26 博瑞生物医药（苏州）股份有限公司 一种奥利万星的制备方法
CN106467570B (zh) * 2015-08-14 2020-04-07 正大天晴药业集团股份有限公司 糖肽类抗生素的还原烷基化方法
CN107434823B (zh) * 2016-05-26 2021-11-16 江苏恒瑞医药股份有限公司 一种奥利万星中间体a82846b的纯化方法
CN108409837B (zh) * 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用
CN109053864B (zh) * 2018-07-10 2021-08-24 丽珠集团新北江制药股份有限公司 一种制备奥利万星的方法
CN109053865B (zh) * 2018-07-20 2021-04-13 丽珠集团新北江制药股份有限公司 一种羧基保护制备奥利万星的方法
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Also Published As

Publication number Publication date
DK0667353T3 (da) 2004-03-22
PL306976A1 (en) 1995-08-07
FI950374A0 (fi) 1995-01-27
ES2220335T3 (es) 2004-12-16
MY128335A (en) 2007-01-31
DE69533004T2 (de) 2005-04-07
HU9500230D0 (en) 1995-03-28
ES2210274T3 (es) 2004-07-01
RU2145609C1 (ru) 2000-02-20
FI20050512L (fi) 2005-05-13
CZ292921B6 (cs) 2004-01-14
ATE253077T1 (de) 2003-11-15
DK1031576T3 (da) 2004-08-16
PT1016670E (pt) 2003-12-31
CA2546625C (en) 2008-09-09
IL112457A (en) 2004-06-20
FI20050513L (fi) 2005-05-13
DE69531709T2 (de) 2004-07-15
SG52719A1 (en) 1998-09-28
CZ18495A3 (en) 1995-08-16
PT1031576E (pt) 2004-08-31
CO4600679A1 (es) 1998-05-08
CA2546625A1 (en) 1995-07-29
NO323103B1 (no) 2007-01-02
PE40996A1 (es) 1996-10-14
HUT68715A (en) 1995-07-28
NO950298L (no) 1995-07-31
CA2141106A1 (en) 1995-07-29
DK1016670T3 (da) 2004-01-05
EP1031576A3 (en) 2000-12-27
AU1138995A (en) 1995-08-10
KR100388867B1 (ko) 2003-10-08
SI0667353T1 (en) 2004-04-30
EG25884A (en) 2012-09-24
FI117096B (fi) 2006-06-15
PL180961B1 (pl) 2001-05-31
YU4995A (sh) 1998-07-10
FI950374L (fi) 1995-07-29
ATE248856T1 (de) 2003-09-15
EP0667353A1 (en) 1995-08-16
CA2546910C (en) 2010-09-14
FI117097B (fi) 2006-06-15
SI1016670T1 (en) 2004-02-29
DE69533004D1 (de) 2004-06-09
EP1016670A1 (en) 2000-07-05
PT667353E (pt) 2004-03-31
ES2204444T3 (es) 2004-05-01
BR9500365A (pt) 1995-10-17
DE69532013T2 (de) 2004-07-08
JP3756539B2 (ja) 2006-03-15
US5843889A (en) 1998-12-01
DE69532013D1 (de) 2003-12-04
EP0667353B1 (en) 2003-10-29
KR950032274A (ko) 1995-12-20
EP1016670B1 (en) 2003-09-03
JPH07258289A (ja) 1995-10-09
IL112457A0 (en) 1995-03-30
RU95101039A (ru) 1996-10-27
EP1031576B1 (en) 2004-05-06
FI117095B (fi) 2006-06-15
HU225164B1 (en) 2006-07-28
DE69531709D1 (de) 2003-10-09
CN1119649A (zh) 1996-04-03
CN1071334C (zh) 2001-09-19
ATE266042T1 (de) 2004-05-15
CZ292895B6 (cs) 2003-12-17
NZ270387A (en) 1996-11-26
NO950298D0 (no) 1995-01-26
TW457248B (en) 2001-10-01
CA2141106C (en) 2007-01-23
EP1031576A2 (en) 2000-08-30
AU703106B2 (en) 1999-03-18
CA2546910A1 (en) 1995-07-29

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