DK1032581T3 - Kemisk syntese af 6-O-alkyl-erythromycin A - Google Patents

Kemisk syntese af 6-O-alkyl-erythromycin A

Info

Publication number: DK1032581T3
Authority: DK; Denmark
Prior art keywords: chemical synthesis; protecting; erythromycin; hydroxyl; alkyl erythromycin
Prior art date: 1997-11-17

Application number

DK98958048T

Other languages

Danish (da)

English (en)

Inventor

Hemantkumar H Patel

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-17

Filing date

1998-11-17

Publication date

2004-08-02

1998-11-17 Application filed by Abbott Lab filed Critical Abbott Lab

2004-08-02 Application granted granted Critical

2004-08-02 Publication of DK1032581T3 publication Critical patent/DK1032581T3/da

Links

229930006677 Erythromycin A Natural products 0.000 title abstract 3
229960003276 erythromycin Drugs 0.000 title abstract 3
238000003786 synthesis reaction Methods 0.000 title 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
HOSGXJWQVBHGLT-UHFFFAOYSA-N 6-hydroxy-3,4-dihydro-1h-quinolin-2-one Chemical group N1C(=O)CCC2=CC(O)=CC=C21 HOSGXJWQVBHGLT-UHFFFAOYSA-N 0.000 abstract 1
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 1
230000002152 alkylating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK98958048T 1997-11-17 1998-11-17 Kemisk syntese af 6-O-alkyl-erythromycin A DK1032581T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/972,155 US5852180A (en)	1997-11-17	1997-11-17	Chemical synthesis of 6-O-alkyl erythromycin A
PCT/US1998/024539 WO1999025723A1 (fr)	1997-11-17	1998-11-17	Synthese chimique de la 6-o-alkyl erythromycine a

Publications (1)

Publication Number	Publication Date
DK1032581T3 true DK1032581T3 (da)	2004-08-02

Family

ID=25519256

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98958048T DK1032581T3 (da)	1997-11-17	1998-11-17	Kemisk syntese af 6-O-alkyl-erythromycin A

Country Status (13)

Country	Link
US (1)	US5852180A (fr)
EP (1)	EP1032581B1 (fr)
JP (1)	JP2001523685A (fr)
KR (1)	KR100565025B1 (fr)
AT (1)	ATE263181T1 (fr)
AU (1)	AU1416699A (fr)
CA (2)	CA2628019A1 (fr)
DE (1)	DE69822871T2 (fr)
DK (1)	DK1032581T3 (fr)
ES (1)	ES2221225T3 (fr)
IL (2)	IL135517A0 (fr)
PT (1)	PT1032581E (fr)
WO (1)	WO1999025723A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6437106B1 (en)	1999-06-24	2002-08-20	Abbott Laboratories	Process for preparing 6-o-substituted erythromycin derivatives
GB9915745D0 (en) *	1999-07-06	1999-09-08	Biochemie Sa	Organic compounds
WO2001044262A1 (fr)	1999-12-16	2001-06-21	Teva Pharmaceutical Industries Ltd.	Procedes de preparation de polymorphes de clarithromycine et nouveau polymorphe iv
AU2261901A (en)	2000-01-11	2001-07-24	Teva Pharma	Processes for preparing clarithromycin polymorphs
US6544555B2 (en)	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
US6565882B2 (en)	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
KR20030047873A (ko) *	2000-02-29	2003-06-18	테바 파마슈티컬 인더스트리즈 리미티드	클라리트로마이신 및 클라리트로마이신 중간체의 제조방법, 실질적으로는 옥심이 제거된 클라리트로마이신 및이를 포함하는 약학적 조성물
US20020068078A1 (en)	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
US6541014B2 (en)	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
US6455680B1 (en) *	2000-12-21	2002-09-24	Abbott Laboratories	Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
AU2004258949B2 (en)	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
JP2006528185A (ja)	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
AU2004258953B2 (en)	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
CA2535177A1 (fr)	2003-08-11	2005-02-24	Advancis Pharmaceutical Corporation	Pastille robuste
US8062672B2 (en)	2003-08-12	2011-11-22	Shionogi Inc.	Antibiotic product, use and formulation thereof
AU2004270170B2 (en)	2003-08-29	2011-01-27	Shionogi, Inc.	Antibiotic product, use and formulation thereof
CA2538064C (fr)	2003-09-15	2013-12-17	Advancis Pharmaceutical Corporation	Antibiotique, son utilisation et sa formulation
CA2572292A1 (fr)	2004-07-02	2006-02-09	Advancis Pharmaceutical Corporation	Comprime pour distribution par impulsion
US8778924B2 (en)	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
US7595300B2 (en)	2005-12-13	2009-09-29	Kosan Biosciences Incorporated	7-quinolyl ketolide antibacterial agents
US8299052B2 (en)	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
US20090054634A1 (en) *	2007-08-09	2009-02-26	Vinod Kumar Kansal	Process for the preparation of clarithromycin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1221088A (en) *	1967-08-03	1971-02-03	Pliva Pharm & Chem Works	Improvements in or relating to erythromycin oxime acyl derivatives
US3869444A (en) *	1972-10-10	1975-03-04	Abbott Lab	Esters of erythromycin oxime
ES434842A1 (es) *	1975-02-19	1976-12-01	Andreu Sa Dr	Procedimiento para la preparacion de esteres de la oxima deeritromicina.
US4331803A (en) *	1980-06-04	1982-05-25	Taisho Pharmaceutical Co., Ltd.	Novel erythromycin compounds
JPS60214796A (ja) *	1984-04-06	1985-10-28	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja) *	1984-10-26	1986-05-22	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシンａ誘導体
US4670549A (en) *	1985-03-18	1987-06-02	Taisho Pharmaceutical Co., Ltd.	Method for selective methylation of erythromycin a derivatives
JPS61229895A (ja) *	1985-04-03	1986-10-14	Nippon Zeon Co Ltd	保護化デス−ｎ−メチルエリスロマイシン誘導体
EP0260938B1 (fr) *	1986-09-18	1992-12-09	Taisho Pharmaceutical Co. Ltd	Dérivés de l'érythromycine A et leur méthode de préparation
KR960000434B1 (ko) *	1986-12-17	1996-01-06	다이쇼 세이야꾸 가부시끼가이샤	에리스로마이신 a유도체 및 그의 제조 방법
JP2751385B2 (ja) *	1988-05-19	1998-05-18	大正製薬株式会社	エリスロマイシンａオキシム及びその塩の製造方法

1997
- 1997-11-17 US US08/972,155 patent/US5852180A/en not_active Expired - Lifetime
1998
- 1998-11-17 IL IL13551798A patent/IL135517A0/xx active IP Right Grant
- 1998-11-17 EP EP98958048A patent/EP1032581B1/fr not_active Expired - Lifetime
- 1998-11-17 AU AU14166/99A patent/AU1416699A/en not_active Abandoned
- 1998-11-17 DE DE69822871T patent/DE69822871T2/de not_active Expired - Fee Related
- 1998-11-17 CA CA002628019A patent/CA2628019A1/fr not_active Abandoned
- 1998-11-17 ES ES98958048T patent/ES2221225T3/es not_active Expired - Lifetime
- 1998-11-17 KR KR1020007005327A patent/KR100565025B1/ko not_active Expired - Fee Related
- 1998-11-17 CA CA002309256A patent/CA2309256C/fr not_active Expired - Fee Related
- 1998-11-17 PT PT98958048T patent/PT1032581E/pt unknown
- 1998-11-17 WO PCT/US1998/024539 patent/WO1999025723A1/fr not_active Ceased
- 1998-11-17 JP JP2000521103A patent/JP2001523685A/ja active Pending
- 1998-11-17 DK DK98958048T patent/DK1032581T3/da active
- 1998-11-17 AT AT98958048T patent/ATE263181T1/de not_active IP Right Cessation
2000
- 2000-04-06 IL IL135517A patent/IL135517A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1032581B1 (fr)	2004-03-31
KR100565025B1 (ko)	2006-03-30
CA2309256C (fr)	2008-05-20
ATE263181T1 (de)	2004-04-15
AU1416699A (en)	1999-06-07
IL135517A (en)	2008-06-05
WO1999025723A1 (fr)	1999-05-27
IL135517A0 (en)	2001-05-20
PT1032581E (pt)	2004-08-31
US5852180A (en)	1998-12-22
JP2001523685A (ja)	2001-11-27
ES2221225T3 (es)	2004-12-16
EP1032581A1 (fr)	2000-09-06
CA2309256A1 (fr)	1999-05-27
CA2628019A1 (fr)	1999-05-27
DE69822871T2 (de)	2005-03-03
DE69822871D1 (en)	2004-05-06
KR20010032140A (ko)	2001-04-16

Publication	Publication Date	Title
DK1032581T3 (da)	2004-08-02	Kemisk syntese af 6-O-alkyl-erythromycin A
DE69023566D1 (de)	1995-12-21	Metastabile Silanhydrolysat-Lösungen und Verfahren zu ihrer Herstellung.
EP0743047A3 (fr)	1997-03-26	Dispositif de vaso-occlusion de forme anatomique, et son procédé de fabrication
BR9711949B1 (pt)	2009-05-05	sistema de telecomunicações tendo a faculdade de relocalização de número de assinante, e, processo de operar um sistema de telecomunicações.
ATE296893T1 (de)	2005-06-15	Erythromycine und verfahren zu ihrer herstellung
CA2160016A1 (fr)	1994-10-27	Methode de formation d'oligonucleotides
ATE216826T1 (de)	2002-05-15	Kodemultiplexvielfachzugriffsnachrichtenübertra unssystem
DE68919650D1 (de)	1995-01-12	3'-Hydroxysubstituiertes Benzoxazinorifamycinderivat, Verfahren zu seiner Herstellung und dieses enthaltendes antibakterielles Mittel.
NO993876D0 (no)	1999-08-11	3'-N-oksid, 3'-N-dimetylamin, 9-oksim erytromycin A derivater
DE69108815D1 (de)	1995-05-18	Aufnahmeeinrichtung und Verfahren zu ihrer Herstellung.
BR9104862A (pt)	1992-04-14	Processo e sistema de comunicacao,processo de transmissao de informacoes de sincronizacao
DE68909625D1 (de)	1993-11-11	Cyclomaltodextrin-Glucanotransferase, Verfahren zu ihrer Herstellung und für das Verfahren nützlicher Mikroorganismus.
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ATE287410T1 (de)	2005-02-15	Kristalline macrolide und verfahren zu ihrer herstellung
IT1285854B1 (it)	1998-06-24	Gruppo di albero di guida per stampante.
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DE69628532D1 (de)	2003-07-10	Bioabbaubare Zusammensetzung, Verfahren und Einrichtung zu ihrer Herstellung
IE830410L (en)	1983-09-01	Erythromycin derivatives
DE69102171D1 (de)	1994-07-07	Dünne Kohlenstoffplatte und Verfahren zu ihrer Herstellung.
GB2296939B (en)	1998-07-08	Holding device for rods, tubes, etc
MX9606111A (es)	1997-08-30	Antibioticos macrolidos.
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ZA966661B (en)	1997-02-10	Catalyst, use thereof and preparation process.