DK1043317T3 - Pyridazinderivater og medikamenter indeholdende dem som aktiv bestanddel - Google Patents

Pyridazinderivater og medikamenter indeholdende dem som aktiv bestanddel

Info

Publication number: DK1043317T3
Authority: DK; Denmark
Prior art keywords: group; alkoxyl; active ingredient; drugs containing; pyridazine derivatives
Prior art date: 1997-11-19

Application number

DK98951732T

Other languages

Danish (da)

English (en)

Inventor

Masao Ohkuchi

Yoshinori Kyotani

Hiromichi Shigyo

Tomoyuki Koshi

Takayuki Matsuda

Hideo Yoshizaki

Takahiro Kitamura

Tadaaki Ohgiya

Yukiyoshi Yamazaki

Kyoko Kotaki

Yuriko Habata

Natsuyo Kumai

Original Assignee

Kowa Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-19

Filing date

1998-11-09

Publication date

2009-07-06

1997-11-19 Priority claimed from JP31813397A external-priority patent/JP3999861B2/ja

1998-11-09 Application filed by Kowa Co filed Critical Kowa Co

2009-07-06 Application granted granted Critical

2009-07-06 Publication of DK1043317T3 publication Critical patent/DK1043317T3/da

Links

150000004892 pyridazines Chemical class 0.000 title abstract 2
239000004480 active ingredient Substances 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000001424 substituent group Chemical group 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 2
125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 2
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/18—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK98951732T 1997-11-19 1998-11-09 Pyridazinderivater og medikamenter indeholdende dem som aktiv bestanddel DK1043317T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP31813397A JP3999861B2 (ja)	1997-11-19	1997-11-19	新規ピリダジン誘導体及びこれを有効成分とする医薬
JP31813297		1997-11-19
PCT/JP1998/005023 WO1999025697A1 (fr)	1997-11-19	1998-11-09	Nouveaux derives de pyridazine et medicaments contenant ces composes comme principe actif

Publications (1)

Publication Number	Publication Date
DK1043317T3 true DK1043317T3 (da)	2009-07-06

Family

ID=26569260

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98951732T DK1043317T3 (da)	1997-11-19	1998-11-09	Pyridazinderivater og medikamenter indeholdende dem som aktiv bestanddel

Country Status (20)

Country	Link
US (11)	US6348468B1 (fr)
EP (2)	EP2017266A1 (fr)
KR (1)	KR100626605B1 (fr)
CN (1)	CN1142148C (fr)
AT (1)	ATE428700T1 (fr)
AU (1)	AU738595B2 (fr)
BR (1)	BR9813998A (fr)
CA (1)	CA2307111C (fr)
DE (1)	DE69840755D1 (fr)
DK (1)	DK1043317T3 (fr)
ES (1)	ES2324126T3 (fr)
HU (1)	HUP0100059A3 (fr)
ID (1)	ID24166A (fr)
MX (1)	MXPA00004955A (fr)
NO (1)	NO316021B1 (fr)
NZ (1)	NZ504045A (fr)
PT (1)	PT1043317E (fr)
RU (1)	RU2209813C2 (fr)
TW (1)	TW502025B (fr)
WO (1)	WO1999025697A1 (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2017266A1 (fr) *	1997-11-19	2009-01-21	Kowa Co., Ltd.	Dérivés de pyridazine et medicaments les contenant comme principe actif
TW587079B (en)	1998-09-25	2004-05-11	Almirall Prodesfarma Ag	2-phenylpyran-4-one derivatives
JP2000247959A (ja) *	1999-02-26	2000-09-12	Kowa Co	ピリダジン−３−オン誘導体及びこれを含有する医薬
ES2162731B1 (es) *	1999-06-04	2003-02-16	Faes Fabrica Espanola De Produ	Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas.
PE20011333A1 (es)	2000-03-16	2002-01-16	Almirall Prodesfarma Ag	Derivados de 2-fenilpiran-4-ona como inhibidores de ciclooxigenasa 2
US6664256B1 (en) *	2000-07-10	2003-12-16	Kowa Co., Ltd.	Phenylpyridazine compounds and medicines containing the same
AU761191B2 (en) *	2001-05-24	2003-05-29	Pfizer Products Inc.	Therapies for tissue damage resulting from ischemia
AU2002332286B2 (en) *	2001-09-26	2007-10-18	Kowa Co., Ltd	Water-soluble phenylpyridazine derivatives and medicines containing the same
MY128945A (en) *	2002-04-16	2007-03-30	Kowa Co	Solid dispersion composition
US7074959B2 (en) *	2002-08-01	2006-07-11	New Mexico Highlands University	Methods and systems for remediating hydrazine-contaminated equipment and/or surfaces
EP1602655A4 (fr) *	2003-03-07	2010-06-09	Kowa Co	Derive benzofurane
BRPI0408359A (pt) *	2003-03-18	2006-03-21	Kowa Co	derivados de fenilpiridazina solúveis em água e medicamentos contendo os mesmos
MY147403A (en) *	2003-04-29	2012-11-30	Kowa Co	Composition containing medicine extremely slightly solube in water and method for preparation thereof
JP4579825B2 (ja) *	2003-04-29	2010-11-10	興和株式会社	溶出性に優れた超難水溶性薬物含有組成物及びその製造法
EP1650195A4 (fr) *	2003-07-30	2008-09-17	Kowa Co	Methode servant a inhiber la production d'osteopontine
EP1604988A1 (fr) *	2004-05-18	2005-12-14	Sanofi-Aventis Deutschland GmbH	Dérivés de pyridazinone, méthodes de leur préparation et leur utilisation comme pharmaceutiques
CN101031305A (zh) *	2004-09-29	2007-09-05	兴和株式会社	类风湿性关节炎的预防和/或治疗药物
JPWO2006104172A1 (ja) *	2005-03-29	2008-09-11	興和株式会社	関節リウマチの予防及び／又は治療薬
HRP20100633T1 (hr) *	2005-07-21	2011-01-31	F. Hoffmann - La Roche Ag	Derivati piridazinona kao agonisti receptora tiroidnih hormona
KR20080038339A (ko) *	2005-08-31	2008-05-06	코와 가부시키가이샤	관절 류머티즘의 예방 및/또는 치료법
WO2007044796A2 (fr) *	2005-10-11	2007-04-19	Nps Pharmaceuticals, Inc.	Composes de pyridazinone servant de calcilytiques
US20090131443A1 (en) *	2005-10-28	2009-05-21	Kowa Co., Ltd.	Method for prevention and/or treatment of rheumatoid arthritis
DE102005057924A1 (de) *	2005-12-05	2007-06-06	Merck Patent Gmbh	Pyridazinonderivate
JPWO2008001499A1 (ja)	2006-06-29	2009-11-26	興和株式会社	関節リウマチの予防及び／又は治療薬
DE102006037478A1 (de) *	2006-08-10	2008-02-14	Merck Patent Gmbh	2-(Heterocyclylbenzyl)-pyridazinonderivate
AU2007336781C1 (en) *	2006-12-21	2014-10-09	Sloan-Kettering Institute For Cancer Research	Pyridazinones and furan-containing compounds
EP2127653A1 (fr) *	2007-01-29	2009-12-02	Kowa Co., Ltd.	Agent de traitement de la sclérose en plaques
EP2123280A1 (fr) *	2007-03-09	2009-11-25	Kowa Co., Ltd.	Agent destiné à la prévention et/ou au traitement du lupus érythémateux systémique
DE102007025717A1 (de)	2007-06-01	2008-12-11	Merck Patent Gmbh	Arylether-pyridazinonderivate
DE102007025718A1 (de)	2007-06-01	2008-12-04	Merck Patent Gmbh	Pyridazinonderivate
DE102007032507A1 (de)	2007-07-12	2009-04-02	Merck Patent Gmbh	Pyridazinonderivate
DE102007038957A1 (de)	2007-08-17	2009-02-19	Merck Patent Gmbh	6-Thioxo-pyridazinderivate
DE102007041115A1 (de)	2007-08-30	2009-03-05	Merck Patent Gmbh	Thiadiazinonderivate
DE102007061963A1 (de)	2007-12-21	2009-06-25	Merck Patent Gmbh	Pyridazinonderivate
DE102008019907A1 (de)	2008-04-21	2009-10-22	Merck Patent Gmbh	Pyridazinonderivate
DE102008062826A1 (de)	2008-12-23	2010-07-01	Merck Patent Gmbh	Pyridazinonderivate
DE102009003954A1 (de)	2009-01-07	2010-07-08	Merck Patent Gmbh	Pyridazinonderivate
DE102009004061A1 (de)	2009-01-08	2010-07-15	Merck Patent Gmbh	Pyridazinonderivate
TWI510241B (zh) *	2010-02-18	2015-12-01	Vtv Therapeutice Llc	苯基－雜芳基衍生物及其使用方法
WO2013097052A1 (fr)	2011-12-30	2013-07-04	Abbott Laboratories	Inhibiteurs de bromodomaine
CN102603676B (zh) *	2012-02-20	2014-02-12	徐江平	一种能避免呕吐反应的磷酸二酯酶4抑制剂
ES2793239T3 (es)	2016-04-15	2020-11-13	Abbvie Inc	Inhibidores del bromodominio
EP3532467A1 (fr) *	2016-10-26	2019-09-04	Proteostasis Therapeutics, Inc.	Composés de pyridazine, compositions et méthodes permettant de moduler cftr
US20230095836A1 (en)	2020-02-14	2023-03-30	Fmc Corporation	Substituted 5,6-diphenyl-3(2h)-pyridazinones for use as fungicides
KR20230035049A (ko) *	2020-07-02	2023-03-10	데날리 테라퓨틱스 인크.	화합물, 조성물 및 방법
PY2167565A (es) *	2020-08-14	2022-08-08	Syngenta Crop Protection Ag	Proceso químico

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR206496A1 (es)	1972-07-03	1976-07-30	Riker Laboratories Inc	Procedimiento para la preparacion de 2-fenoxi-4-nitro-alquil o haloalquilsulfonanilidas
WO1983000863A1 (fr) *	1981-09-11	1983-03-17	Diamond Shamrock Corp	4-pyridylpyridazin(2h)-3-ones antiinflammatoires et analgesiques
JPH0753725B2 (ja)	1987-10-08	1995-06-07	富山化学工業株式会社	４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤
JPH01258671A (ja) *	1987-12-01	1989-10-16	Morishita Pharmaceut Co Ltd	５−（１ｈ−イミダゾール−１−イル）−３（２ｈ）−ピリダジノン誘導体
FI91062C (fi)	1988-12-28	1994-05-10	Eisai Co Ltd	Menetelmä lääkeaineena käyttökelpoisten naftaleenijohdannaisten valmistamiseksi
US5380718A (en) *	1990-05-15	1995-01-10	E. I. Du Pont De Nemours And Company	Arthropodicidal fused tetrahydropyridazines
MX9300141A (es)	1992-01-13	1994-07-29	Smithkline Beecham Corp	Compuestos de imidazol novedosos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
ES2114654T3 (es) *	1993-06-08	1998-06-01	Vertex Pharma	Piridazinas como inhibidores de la enzima de conversion de la interleuquina-1beta.
JPH08311032A (ja) *	1995-05-18	1996-11-26	Eisai Co Ltd	α，β−不飽和ケトン誘導体
AU699148B2 (en)	1995-08-10	1998-11-26	Merck & Co., Inc.	2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use
CA2283399C (fr)	1997-03-14	2006-02-21	Merck Frosst Canada & Co.	Pyridazinones utilises comme inhibiteurs de cyclo-oxygenase-2
BR9812127A (pt)	1997-08-22	2000-07-18	Abbott Lab	Arilpiridazinonas como inibidores da biossìntese de prostagleina endoperóxido h sintase
WO1999010332A1 (fr)	1997-08-22	1999-03-04	Abbott Laboratories	Inhibiteurs de la biosynthese de la prostaglandine h2 synthetase
EP2017266A1 (fr) *	1997-11-19	2009-01-21	Kowa Co., Ltd.	Dérivés de pyridazine et medicaments les contenant comme principe actif
TWI241295B (en) *	1998-03-02	2005-10-11	Kowa Co	Pyridazine derivative and medicine containing the same as effect component
KR100666838B1 (ko)	1998-10-27	2007-01-11	아보트 러보러터리즈	프로스타글란딘 엔도퍼옥사이드 ｈ 신타제 생합성 억제제 및 이를 포함하는 약제학적 조성물
JP2000247959A (ja) *	1999-02-26	2000-09-12	Kowa Co	ピリダジン−３−オン誘導体及びこれを含有する医薬
US6664256B1 (en) *	2000-07-10	2003-12-16	Kowa Co., Ltd.	Phenylpyridazine compounds and medicines containing the same

1998
- 1998-11-09 EP EP08019558A patent/EP2017266A1/fr not_active Withdrawn
- 1998-11-09 AU AU97626/98A patent/AU738595B2/en not_active Ceased
- 1998-11-09 ES ES98951732T patent/ES2324126T3/es not_active Expired - Lifetime
- 1998-11-09 MX MXPA00004955A patent/MXPA00004955A/es not_active IP Right Cessation
- 1998-11-09 NZ NZ504045A patent/NZ504045A/en unknown
- 1998-11-09 WO PCT/JP1998/005023 patent/WO1999025697A1/fr not_active Ceased
- 1998-11-09 BR BR9813998-3A patent/BR9813998A/pt active Search and Examination
- 1998-11-09 AT AT98951732T patent/ATE428700T1/de not_active IP Right Cessation
- 1998-11-09 ID IDW20000931A patent/ID24166A/id unknown
- 1998-11-09 KR KR1020007004967A patent/KR100626605B1/ko not_active Expired - Fee Related
- 1998-11-09 HU HU0100059A patent/HUP0100059A3/hu unknown
- 1998-11-09 PT PT98951732T patent/PT1043317E/pt unknown
- 1998-11-09 EP EP98951732A patent/EP1043317B1/fr not_active Expired - Lifetime
- 1998-11-09 DK DK98951732T patent/DK1043317T3/da active
- 1998-11-09 DE DE69840755T patent/DE69840755D1/de not_active Expired - Lifetime
- 1998-11-09 RU RU2000115577/04A patent/RU2209813C2/ru not_active IP Right Cessation
- 1998-11-09 CN CNB988113015A patent/CN1142148C/zh not_active Expired - Fee Related
- 1998-11-09 US US09/530,949 patent/US6348468B1/en not_active Expired - Fee Related
- 1998-11-09 CA CA002307111A patent/CA2307111C/fr not_active Expired - Fee Related
- 1998-11-17 TW TW087119032A patent/TW502025B/zh not_active IP Right Cessation
2000
- 2000-04-27 NO NO20002169A patent/NO316021B1/no not_active IP Right Cessation
2001
- 2001-11-30 US US09/996,804 patent/US20020123496A1/en not_active Abandoned
2004
- 2004-01-15 US US10/757,525 patent/US20040147516A1/en not_active Abandoned
- 2004-11-12 US US10/986,350 patent/US20050065155A1/en not_active Abandoned
2005
- 2005-08-15 US US11/203,174 patent/US20050267113A1/en not_active Abandoned
2006
- 2006-03-22 US US11/385,995 patent/US20060160804A1/en not_active Abandoned
- 2006-11-01 US US11/590,811 patent/US20070049595A1/en not_active Abandoned
2007
- 2007-04-30 US US11/741,947 patent/US20070208025A1/en not_active Abandoned
2008
- 2008-01-14 US US12/013,691 patent/US20080119474A1/en not_active Abandoned
- 2008-11-03 US US12/263,816 patent/US20090069332A1/en not_active Abandoned
2009
- 2009-07-06 US US12/497,797 patent/US20090270399A1/en not_active Abandoned

Also Published As

Publication number	Publication date
BR9813998A (pt)	2000-09-26
US6348468B1 (en)	2002-02-19
US20070049595A1 (en)	2007-03-01
EP1043317A4 (fr)	2003-03-05
US20040147516A1 (en)	2004-07-29
US20050267113A1 (en)	2005-12-01
CN1279672A (zh)	2001-01-10
US20060160804A1 (en)	2006-07-20
US20070208025A1 (en)	2007-09-06
RU2209813C2 (ru)	2003-08-10
CN1142148C (zh)	2004-03-17
NO20002169D0 (no)	2000-04-27
AU9762698A (en)	1999-06-07
HUP0100059A2 (hu)	2002-02-28
ID24166A (id)	2000-07-13
EP2017266A1 (fr)	2009-01-21
MXPA00004955A (es)	2002-10-17
KR100626605B1 (ko)	2006-09-22
TW502025B (en)	2002-09-11
WO1999025697A1 (fr)	1999-05-27
EP1043317B1 (fr)	2009-04-15
ATE428700T1 (de)	2009-05-15
DE69840755D1 (de)	2009-05-28
US20020123496A1 (en)	2002-09-05
HUP0100059A3 (en)	2002-08-28
NO20002169L (no)	2000-05-18
US20050065155A1 (en)	2005-03-24
AU738595B2 (en)	2001-09-20
CA2307111C (fr)	2009-06-30
NZ504045A (en)	2001-06-29
US20090069332A1 (en)	2009-03-12
ES2324126T3 (es)	2009-07-30
CA2307111A1 (fr)	1999-05-27
EP1043317A1 (fr)	2000-10-11
KR20010031880A (ko)	2001-04-16
US20090270399A1 (en)	2009-10-29
US20080119474A1 (en)	2008-05-22
PT1043317E (pt)	2009-05-11
NO316021B1 (no)	2003-12-01
HK1032969A1 (en)	2001-08-10

Publication	Publication Date	Title
PT1043317E (pt)	2009-05-11	Novos derivados de piridazina e fármacos que os contêm como ingrediente activo
PT976748E (pt)	2004-03-31	Derivados de pirrolidina com actividade inibidora de fosfolipase a2
DE69434136D1 (de)	2004-12-23	Dolastatin-derivate
PT705833E (pt)	2004-11-30	Derivado de dc-89
IL124944A (en)	2003-06-24	Quinolonecarboxylic acid derivatives or their salts and pharmaceutical compositions containing them
DE69624143D1 (de)	2002-11-07	Phosphonsaurediester-derivate
NO20014925L (no)	2001-12-13	Farmasöytiske forbindelser
DK0947504T3 (da)	2003-11-24	16-en-vitamin D-derivater
DE69623497D1 (de)	2002-10-10	1-methylcarbapenem-derivate
NO985202L (no)	1999-01-08	Anti-heliobacter pylori-preparater inneholdende 1-metylcarbapenemderivater
ES2140524T3 (es)	2000-03-01	Derivados de metotrexato.
DK0594941T3 (da)	1996-09-02	N-Substituerede carbonyloxyalkylpyrroler som insekticide, acaricide og molluskicide midler
DK1433480T3 (da)	2011-04-11	Lægemiddel indeholdende pyrimidin-derivat
ATE154243T1 (de)	1997-06-15	Hemmstoff der blutgefässhypertrophie
MX9704976A (es)	1998-01-31	Derivados de 1,2,3-benzotiadiazol.
ATE194621T1 (de)	2000-07-15	Pyrazolothiazolopyrimidin-derivate